益生菌复合物与植物药联合治疗丙戊酸致自闭症的协同作用潜力:产前模型

K. Sunand, G. K. Mohan, V. Bakshi
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引用次数: 1

摘要

背景:自闭症谱系障碍(Autism spectrum disorder, ASD)是一种发展中的神经障碍,表现为社会沟通障碍和重复性行为。遗传和生态因素与这个问题有关,包括在怀孕期间引入丙戊酸。生态失调是自闭症中最常见的合并症,已知许多益生菌菌株可以预防自闭症的社交障碍。方法:在Wistar大鼠妊娠第12天,以丙戊酸400mg /kg / ig的剂量建立产前自闭症模型,选取有自闭症症状的子代进行研究,在产后(PND) 08-50天内给予多酚、益生菌及其联合治疗。结果:产前模型动物表现出明显的自闭症和生态失调症状。通过益生菌和多酚联合治疗,了解了多酚的生物活化在纠正神经化学异常、氧化应激、行为缺陷和神经保护方面的重要作用。与乙酰-左旋肉碱组合的益生菌复合物对肠道细菌的生长和大脑的功能也是必不可少的。通过这种联合研究,行为和生化改变得以恢复。结论:利用益生菌和多酚类化合物在肠道中建立良好的生态系统是必不可少的,肠道靶向脑功能是挑战自闭症的一种显着方式,这种组合的建议可能有助于以正确的方式进入肠-脑轴,并有助于自闭症的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synergetic Potential of Combination Probiotic Complex with Phytopharmaceuticals in Valproic Acid Induced Autism: Prenatal Model
Background: Autism spectrum disorder (ASD) is a developing neuronal disorder with hindered social correspondence and repetitive behaviors. Hereditary and ecological factors have been related to this problem, including the introduction of valproic acid during pregnancy. Dysbiosis is the most common comorbid condition in autism, numerous probiotic strains have been known to forestall social impairments in autism. Method: Prenatal autism model was done on 12th embryonic day of pregnancy in Wistar rats with the valproic acid dose 400 mg/kg, i.p. Those offspring exhibiting autistic symptoms were selected for study and were treated with polyphenols, probiotics and their combination for the study period of postnatal day (PND) 08-50. Results: Prenatal model showed significant autistic and dysbiotic symptoms in the animals. With the probiotic and polyphenols treatment combination it was understood that bio-activation of polyphenols are crucial in the correction of neurochemical abnormality, oxidative stress, behavioral deficits and neuroprotection. Probiotic complex with acetyl-l-carnitine combination was also essential for the growth of gut bacteria, functionality of brain. Through this combination study behavioral and biochemical alterations were recovered. Conclusion: Establishing a good ecosystem in the gut with good probiotics and polyphenols-like compounds is essential, gut targeted brain functionality is a remarkable way to challenge autistic disorder, advice on this combination may be helpful in the right way of accessing the gut-brain-axis and useful in amending of autism.
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