INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH最新文献_第3页

PLANT-MEDIATED GREEN SYNTHESIS OF GOLD NANOPARTICLES AND THEIR ANTICANCER APPLICATIONS: AN UPDATED REVIEW 植物介导的纳米金绿色合成及其抗癌应用综述

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-03-13 DOI: 10.31069/japsr.v4i4.1

Senthil Kumar Raju, Praveen Sekar, S. Kumar, Maruthamuthu Murugesan, M. Karthikeyan

引用次数: 0

NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PRAVASTATIN IN PURE AND PHARMACEUTICAL FORMULATION 新型反相高效液相色谱法测定普伐他汀纯制剂和制剂中普伐他汀的含量

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-01-08 DOI: 10.31069/japsr.v4i3.3

P. T, L. A, Reshma P, S. P., M. P, Ajay P

{"title":"NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PRAVASTATIN IN PURE AND PHARMACEUTICAL FORMULATION","authors":"P. T, L. A, Reshma P, S. P., M. P, Ajay P","doi":"10.31069/japsr.v4i3.3","DOIUrl":"https://doi.org/10.31069/japsr.v4i3.3","url":null,"abstract":"Introduction: A simple, rapid, precise, accurate, sensitive and stability indicating RP-HPLC method for the determination of Pravastatin in pure and tablet dosage form.Materials & Methods: HPLC Method was developed using Zorbax ODS (250×4.6 mm ×5 μ) with the mobile phase of 0.1% formic acid pH adjusted to 3 and methanol in the ratio 50:50 v/v. Pravastatin peak was monitored at 238 nm, and the retention time was 4.44 minutes.Results and Discussion: ICH guidelines were followed to validate the proposed method regarding specificity, precision, linearity, accuracy, system suitability, and robustness. The method was found to be linear in the range of 10–50 μg/mL, and also the regression equation was found to be y=124936 x+19884 R2=0.997. For intra- and inter-day precision, the %RSD for Pravastatin was 1.05 and 0.917%. Percentage mean recovery was found to be 98.36%. LOD and LOQ values were 0.231 and 0.701 μg/mL, respectively. Pravastatin stability was inspected under various forced degradation conditions, and it was found to be easily degraded in acidic and basic conditions.Conclusion: The developed method was found to be having a suitable application for routine quality control analysis of Pravastain in pharmaceutical formulations.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91542987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MOLECULAR MODELING STUDIES OF BENZIMIDAZOLYL-CHALCONES AS ANTILEISHMANIAL AGENTS USING QSAR, DOCKING, ADME AND MOLECULAR DYNAMICS STUDIES 利用qsar、对接、adme和分子动力学研究苯并咪唑查尔酮抗利什曼病药物的分子模型

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-01-08 DOI: 10.31069/japsr.v4i3.4

Deto N'guessan, A. A. Alzain, Eunice Melissa Adouko, Diomandé Sékou, S. Coulibaly, M. Ouattara

{"title":"MOLECULAR MODELING STUDIES OF BENZIMIDAZOLYL-CHALCONES AS ANTILEISHMANIAL AGENTS USING QSAR, DOCKING, ADME AND MOLECULAR DYNAMICS STUDIES","authors":"Deto N'guessan, A. A. Alzain, Eunice Melissa Adouko, Diomandé Sékou, S. Coulibaly, M. Ouattara","doi":"10.31069/japsr.v4i3.4","DOIUrl":"https://doi.org/10.31069/japsr.v4i3.4","url":null,"abstract":"Introduction: Present leishmaniasis treatment regimen has many limitations including severe adverse effects, toxicity, and Leishmania strains resistance. In the present study, the objective is to perform QSAR, molecular docking and ADME prediction studies on benzimidazolylchalcones in order to select an antileishmanial drug candidate.Materials & methods: QSAR models were performed on 12 benzimidazolylchalcones with antileishmanial activities against promastigote strains of L. donovani. Binding free energy calculations were performed using MM-GBSA to assess the affinity of the ligands for the proteins. In addition, the three most active compounds (4a-c, IC50 <1-μM) were docked with the protein phosphodiesterase B1 (PDB ID: 2JK6).Results and Discussion: The optimum model has squared correlation coefficient (R2) of 0.983, and leave-one-out (LOO) cross-validation coefficient (Q2CV) value of 0.942. The number of descriptors involved in the model is acceptable (R2 - Q2CV = 0.041), which confirms the model’s stability and validates the developed model’s predictive power. Docking studies revealed that the best compound 4c formed hydrogen bond with SER 464, pi-cation contact with LYS 61 and hydrophobic interactions with LEU 62, TYR 64 and LEU72 of the active site of L. donovani phosphodiesterase B1. ADME properties results showed that all three molecules have good pharmacokinetic properties.Conclusion: Finally, molecular dynamics simulation studies at 30 ns revealed stable interactions with the 2JK6 protein. This study validates the choice of the ortho-chlorinated derivative of benzimidazolylchalcones as the lead compound for developing new derivatives with optimized antileishmanial properties.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89346154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A CRITICAL REVIEW ON NANOEMULSION: ADVANTAGES, TECHNIQUES AND CHARACTERIZATION 纳米乳的优点、技术及表征

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-01-08 DOI: 10.31069/japsr.v4i3.2

Mrs. Gunjan Pranav Malode, Sarin A Chauhan, Shivam A. Bartare, Lochana M Malode, J. Manwar, R. Bakal

{"title":"A CRITICAL REVIEW ON NANOEMULSION: ADVANTAGES, TECHNIQUES AND CHARACTERIZATION","authors":"Mrs. Gunjan Pranav Malode, Sarin A Chauhan, Shivam A. Bartare, Lochana M Malode, J. Manwar, R. Bakal","doi":"10.31069/japsr.v4i3.2","DOIUrl":"https://doi.org/10.31069/japsr.v4i3.2","url":null,"abstract":"Nanoemulsions have small droplet size and are kinetically stable colloidal systems. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of appropriate surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20–200 nm and shows narrow size distribution. They have enhanced functional properties in comparison to conventional emulsions. The composition and structure of the nanoemulsions can be controlled for the encapsulation and effective delivery of bioactive lipophilic compounds. Nanoemulsions have potential application in the food industry for the delivery of nutraceuticals, coloring and flavoring agents, and antimicrobials. This review aims to provide consolidated information regarding various formulation and characterization techniques developed for nanoemulsions. Various characterization techniques for nanoemulsions include determination of entrapment efficiency, particle size, polydispersity index, zeta potential as well as characterization through differential scanning calorimetry, Fourier-transform infrared spectroscopy and transmission electron microscopy.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90635656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

HIV-AN INFECTIOUS DISEASE THAT IMPOSES THREAT TO LIFE 艾滋病毒是一种威胁生命的传染病

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-01-08 DOI: 10.31069/japsr.v4i3.1

Reenoo Jauhari, Bhawna Chauhan, Ankita Singh

引用次数: 0

EVALUATION OF PHARMACOLOGICAL EFFECT OF CASSIA SOPHERA LINN LEAVES EXTRACTS 决明子叶提取物的药理作用评价

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-01-08 DOI: 10.31069/japsr.v4i3.5

S. Shukla, Ashutosh Kumar Singh

{"title":"EVALUATION OF PHARMACOLOGICAL EFFECT OF CASSIA SOPHERA LINN LEAVES EXTRACTS","authors":"S. Shukla, Ashutosh Kumar Singh","doi":"10.31069/japsr.v4i3.5","DOIUrl":"https://doi.org/10.31069/japsr.v4i3.5","url":null,"abstract":"Instroduction: Cassia sophera Linn (C. sophera) is a medicinally important plant belonging to the family of Caesalpiniaceae. The whole part of the plant is used as traditional folk medicine and is reported to possess analgesic, anticonvulsant, antioxidant, anti-inflammatory, hepatoprotective and antiasthmatic activity. \u0000Materials and Methods: Eddy’s hot plate and Analgesiometer tests were used to asses the antinociceptive activity of Cassia sophera. Pentobarbitone narcosis potentiation test was used to evaluate the hypnotic and sedative effect, while anticonvulsant activity was evaluated by Maximum electroshock-induced seizure test and Pentylenetetrazol induced seizure test. \u0000Results and Discussion: Test drug (440 mg/kg) produced significant analgesia, potentiated the pentobarbitone induced sleeping time and exhibited anticonvulsant effect against hind limb tonic extension phase of maximum electroshock-induced seizure test and seizures induced by pentylenetetrazol. \u0000Conclusion: The preliminary screening of seed extract of Cassia sophera, Linn. exhibited analgesic, anticonvulsant effects and potentiated pentobarbitone sleeping time. The ethanol extract of seed of Cassia sophera, Linn. deserves further investigation to elucidate the mechanisms of action.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80331526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study of Potential Application of Cyanobacteria Leptolyngbya Valderiana in Skin Cosmeceuticals 蓝细菌在皮肤药妆中的潜在应用研究

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-10-01 DOI: 10.21477/ijapsr.6.4.01

Shraddha Ratnaparkhe, D. Mali, B. Nabar

{"title":"Study of Potential Application of Cyanobacteria Leptolyngbya Valderiana in Skin Cosmeceuticals","authors":"Shraddha Ratnaparkhe, D. Mali, B. Nabar","doi":"10.21477/ijapsr.6.4.01","DOIUrl":"https://doi.org/10.21477/ijapsr.6.4.01","url":null,"abstract":"Skin is the outermost cover and first line of defense of the human body. Skin cosmeceuticals are therapeutic agents used to maintain flawless skin and prevent skin disorders. Considering the ill effects of synthetic active agents, natural metabolites are preferred for skincare. Cyanobacterium was known to produce various secondary metabolites with therapeutic potential. This study focuses on screening whole-cell extract of Leptolyngbya valderiana for skincare. Isolation and identification of cyanobacteria were made. The whole-cell extract of Leptolyngbya valderiana was studied for its metabolite profile, mainly for proteins, carbohydrate, and lipid content. Screening of whole-cell extract was carried out for its (2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) (ABTS) radical scavenging ability and UV absorption potential. The antimicrobial effect of extracts was determined by agar cup and minimum inhibitory concentration (MIC) method using salicylic acid as a standard. Skin whitening potential was determined using tyrosinase inhibition assay. Leptolyngbya valderiana was isolated from the tree bark and selected for further study. The extract of Leptolyngbya valderiana was found to have 25.22% proteins, 36.65 % carbohydrates and 35.97% lipids. The extract was found to have antioxidant potential with 96.55% ABTS radical scavenging potential. Antimicrobial potency of the extract against Staphylococcus aureus ATCC 6538, Propionibacterium acne MTCC 1351, Candida albicans ATCC 10231 was equivalent to salicylic acid. The test extract was found to inhibit the tyrosinase enzyme by 43.46%. The test extract is rich in proteins, carbohydrates, and lipids. The extract has significant antioxidant potential, antimicrobial efficiency, ability to absorb ultraviolet B and ultraviolet A region, tyrosinase inhibition potential indicative photoprotective, and skin whitening potential. The isolate Leptolyngbya valderiana has a promising potential for skin cosmeceuticals.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73649567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sensor Applications in Analysis of Drugs and Formulations 传感器在药物和制剂分析中的应用

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-10-01 DOI: 10.21477/ijapsr.6.4.03

Rajan Thakur, A. Devi

引用次数: 0

Geographical Survey and Genetic Variation Studies of Few Chilly Varieties Collected from Different Regions of Karnataka, India 印度卡纳塔克邦不同地区少数寒性品种的地理调查及遗传变异研究

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-10-01 DOI: 10.21477/ijapsr.6.4.02

Devi Shree, Pavitra B. S. Rao, Surendra H. Gowda, S. S. Dakappa

{"title":"Geographical Survey and Genetic Variation Studies of Few Chilly Varieties Collected from Different Regions of Karnataka, India","authors":"Devi Shree, Pavitra B. S. Rao, Surendra H. Gowda, S. S. Dakappa","doi":"10.21477/ijapsr.6.4.02","DOIUrl":"https://doi.org/10.21477/ijapsr.6.4.02","url":null,"abstract":"Chillies are widely used throughout the world in the form of spice and are also used in making beverages and medicines. They are rich in vitamins, especially in vitamin A and C. Chillies contain lots of minerals like potassium, magnesium, and iron. They have been employed for pain relief as they are known to inhibit pain messengers and hence their extracts are used to alleviate the pain of arthritis, headaches, burns, and neuralgia. It is also claimed that they have the power to boost the immune system and lower cholesterol. They are also helpful in getting rid of gut parasites. In this regard we attempted to do a geographical survey about the chilly varieties and chilly growing states in India. We collected the local varieties of chillies available in Karnataka and performed genetic variation studies to understand their relationship at the genetic level. PCR analysis was done using the selected random amplified polymorphic DNA (RAPD) marker to identify the polymorphic loci between the genotypes taken. DNA Barcoding was done to validate the species using basic local alignment search tool (BLAST) and Clustal Omega, further dendrogram was constructed which guide the joining linkage rule of unweighted pair group average (UPGMA) and the genetic distance to compute from matrix table. The results obtained highlight the relationship between species of Capsicum annum, Capsicum frutescens which are closely related followed by Capsicum pubescens and Capsicum baccatum providing knowledge about its application in genetics and plant breeding in developing efficient hybrid variety.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77621645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY ON USE, ATTITUDE AND KNOWLEDGE OF HERBAL COSMETIC PRODUCTS AMONG CONSUMERS: HEALTH MANAGEMENT 消费者对草药化妆品的使用、态度和知识的研究:健康管理

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-09-27 DOI: 10.31069/japsr.v4i2.1

Poonam Bhadauriya, A. S. Jadon, Chandni Upadhyay

{"title":"STUDY ON USE, ATTITUDE AND KNOWLEDGE OF HERBAL COSMETIC PRODUCTS AMONG CONSUMERS: HEALTH MANAGEMENT","authors":"Poonam Bhadauriya, A. S. Jadon, Chandni Upadhyay","doi":"10.31069/japsr.v4i2.1","DOIUrl":"https://doi.org/10.31069/japsr.v4i2.1","url":null,"abstract":"Purpose: Herbs and spices have been used in maintaining and enhancing human beauty since time immemorial. Nowaday’s people prefer natural food, herbal medicines, and natural curing practices for a healthy life. Herbal cosmetics are the preparations, which represent cosmetics associated with active bioactive ingredients or pharmaceuticals. The present paper deals with the study of herbal cosmetics used for skin and hair care and the collection of data among the consumers of the Gwalior region. \u0000Methods: The survey was conducted with the help of a questionnaire provided to each consumer, and answers were collected, and data were analyzed on 100 people of both the sex and different age group of the Gwalior Region. \u0000Result: The results reveal that 67.50% were the consumers of herbal cosmetic products from the total number of populations. Among the consumers, 56% were female, and 44% of the total consumers in the study were male. The variation among the age group was also included in the study and the results showed that the age group of 20-30 years was the highest percentage of consumers i.e., 62%. \u0000Conclusion: This study concluded that the usage of herbal cosmetics has been increased to many folds in the personal care system, and there is a great demand for herbal cosmetics among people.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74893038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2