International Forum of Allergy & Rhinology最新文献

{"title":"Response to the Letter to Editor Regarding “Tissue Eosinophils Threshold and Its Association With Adult-Onset Asthma in Chronic Rhinosinusitis”","authors":"Wirach Chitsuthipakorn, Kornkiat Snidvongs","doi":"10.1002/alr.23576","DOIUrl":"10.1002/alr.23576","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"473-474"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter Regarding “S100A9 Induces Tissue Remodeling of Human Nasal Epithelium in Chronic Rhinosinusitis With Nasal Polyp”","authors":"Sang Hyeon Ahn MD, PhD, Chang-Hoon Kim MD, PhD","doi":"10.1002/alr.23579","DOIUrl":"10.1002/alr.23579","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"475-476"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence for “Developing a Virtual Endoscopic Surgery Planning System to Optimize Surgical Outcomes”","authors":"Hyun Jin Min","doi":"10.1002/alr.23571","DOIUrl":"10.1002/alr.23571","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"466-467"},"PeriodicalIF":7.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Based Disparities in Sinonasal Outcomes: A Population-Based Study.","authors":"Victoria S Lee, Anthony I Dick, Khamis T Suleiman, Jiehuan Sun, Sharmilee M Nyenhuis, Kamal Eldeirawi","doi":"10.1002/alr.23556","DOIUrl":"10.1002/alr.23556","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical Olfactory Training for Smell Restoration: A Systematic Review","authors":"Gabrielly Oliveira Cunha Moura,&nbsp;Anthony Lucas Santos da Silva,&nbsp;Fábio Rafael Teixeira de Santana,&nbsp;Cristiani Isabel Banderó Walker","doi":"10.1002/alr.23564","DOIUrl":"10.1002/alr.23564","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Olfactory dysfunction is commonly treated with olfactory training, but there is a lack of standardization in its methods, leading to inconclusive results about its effectiveness. This systematic review aims to investigate the effectiveness of classical olfactory training in the treatment of olfactory dysfunction compared to modified training or no-intervention control groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This systematic literature review follows the PRISMA protocol and is registered with PROSPERO (CRD42022357528). The databases used for the search were PubMed MEDLINE, LILACS, Scopus, Web of Science, and Embase. Randomized clinical trials carried out in adults with olfactory disorders and published in all languages until December 2023 were included. The quality assessment of these studies was conducted using the Cochrane Risk of Bias tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of eight studies, involving 896 participants with olfactory dysfunction, were included in the analysis. Overall, these studies showed that classical olfactory training produces improvements in at least 20%–30% in olfactory function in patients affected by different etiologies of smell loss, with all of them reporting clinically significant post-treatment results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Classical olfactory training can be a promising intervention for the recovery of olfactory function in individuals with olfactory dysfunction. However, olfactory training should not be seen as a universal solution for anosmia, given the variability of results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"428-437"},"PeriodicalIF":7.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of LYR-220 Mometasone Sinonasal Implants in Patients With Chronic Rhinosinusitis and Prior Ethmoid Surgery: Results From the Randomized, Blinded, Controlled BEACON Phase 2 Study.","authors":"Brent A Senior, Randall A Ow, M Scott Major, Stacey L Silvers, Jeffrey S Rosenbloom, Amber U Luong, Zachary M Soler, Robert Naclerio, Robert C Kern, Lindsay Brayton, Marina Mihova, Ela Sajjadi, Misun Lee, Vineeta Belanger, Richard Nieman","doi":"10.1002/alr.23567","DOIUrl":"https://doi.org/10.1002/alr.23567","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic sinus surgery (ESS) often fails to directly manage the underlying inflammation in chronic rhinosinusitis (CRS), resulting in symptom recurrence in a significant number of patients. LYR-220 is a long-acting (24-week) corticosteroid sinonasal implant being developed for treatment of these patients.</p><p><strong>Methods: </strong>Forty-two adults with CRS and prior ESS were enrolled in the multicenter, randomized, controlled Phase 2 (BEACON) study. Patients received LYR-220 or a sham procedure bilaterally. The primary endpoint was occurrence of any treatment-related serious adverse events (SAEs). Efficacy endpoints included change from baseline (CFBL) in Sino-Nasal Outcome Test (SNOT-22); three cardinal symptoms (3CS) of CRS (nasal blockage, nasal discharge, and facial pain/pressure); loss-of-smell; ethmoid percent opacification volume; and need for rescue treatment (systemic corticosteroids [SCS] or sinonasal surgery).</p><p><strong>Results: </strong>No SAEs were reported in the study. SNOT-22 scores significantly improved with LYR-220 versus sham from week 2 onwards, with a between group difference of -16.8 at Week 24 (p = 0.007). Between group difference at Week 24 for 3CS was -1.50 (p = 0.02) and for ethmoid percent opacification volume was -8.14 (p = 0.035). Five patients from LYR-220 group and seven from sham group used SCS. LYR-220 showed improvement versus sham in the loss-of-smell from Week 8 through the end of treatment at 24 weeks (-0.87, p = 0.026).</p><p><strong>Conclusions: </strong>The BEACON study demonstrated safety, efficacy, feasibility, and tolerability of LYR-220 in patients with CRS who have had prior ESS. The primary endpoint was met, with no SAEs reported. LYR-220 demonstrated statistically significant, clinically relevant improvements in key symptomatic and objective efficacy endpoints.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23567"},"PeriodicalIF":7.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Systemic Bevacizumab on Epistaxis-Related Outcomes in Hereditary Hemorrhagic Telangiectasia: A Systematic Review and Meta-Analysis.","authors":"William Li, Jinzi Bai, Anna Symons, Jonathan Banting, Joanne Rimmer","doi":"10.1002/alr.23566","DOIUrl":"https://doi.org/10.1002/alr.23566","url":null,"abstract":"<p><strong>Background: </strong>The evidence-based recommendation for the use of systemic bevacizumab to treat refractory epistaxis in hereditary hemorrhagic telangiectasia (HHT) is based on limited and historical data. An updated synthesis of the available literature is warranted.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted using PRISMA guidelines to evaluate the use of systemic bevacizumab for HHT-related epistaxis. A search was conducted using three databases up to September 2024 for studies assessing the effect of systemic bevacizumab use on epistaxis outcomes in HHT. Outcome measures included epistaxis severity score (ESS), hemoglobin, red blood cell (RBC), and iron transfusion requirements and adverse effects. Random effects meta-analysis was performed for change in ESS (ΔESS) and change in hemoglobin (ΔHb). Literature quality was assessed using the Joanne Briggs Institute critical appraisal tools.</p><p><strong>Results: </strong>A total of 10 studies with 225 total patients were included. Systemic bevacizumab was associated with a significant posttreatment reduction in mean ESS of -3.33 (95% CI -3.62 to -3.03) and a significant increase in mean Hb of 2.38 g/dL (95% CI 1.45-3.30) compared to pretreatment. All cohort studies found a significant reduction in RBC and iron transfusions following systemic bevacizumab treatment. The most frequently reported adverse effect of systemic bevacizumab was hypertension.</p><p><strong>Conclusion: </strong>Systemic bevacizumab is associated with significant improvements in epistaxis severity, hemoglobin, and transfusion requirements in HHT-related epistaxis. Adequately powered studies are required to strengthen this finding. Patient selection criteria, standardized maintenance dosing, and long-term treatment data require further study.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23566"},"PeriodicalIF":7.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are There Effective Methods to Reduce Exposure to House Dust Mite Allergens? A Meta-Analysis of Randomized Clinical Trials.","authors":"Marharyta Sobczak, Krzysztof Kowal, Rafał Pawliczak","doi":"10.1002/alr.23565","DOIUrl":"https://doi.org/10.1002/alr.23565","url":null,"abstract":"<p><strong>Background: </strong>House dust mites (HDMs) are the most common cause of atopic sensitivities and allergic diseases worldwide. Therefore, we decided to conduct a meta-analysis of randomized clinical trials to evaluate the effect of different methods of HDM avoidance.</p><p><strong>Methods: </strong>PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials databases were searched to find articles of control-compared randomized clinical trials, which investigated the following analyzed outcomes: total amount of dust (g); Der1 (Der p1 plus Der f1) concentrations (µg/g); Der p1 concentrations (µg/g); Der p2 concentrations (µg/g); Der f1 concentrations (µg/g); measurements of peak expiratory flow (PEF) (L/min); respiratory, pulmonary, or nasal symptoms according to various scales, including visual analog scale; exacerbations; Asthma Control Questionnaire score measurements; and change in quality of life scales (overall change, activity change, symptom change, and emotional function change). The relative risk with 95% confidence interval (CI) and the mean difference or the standardized mean difference with 95% CI were calculated to compare the effect. A random effects model was used to calculate effect sizes.</p><p><strong>Results: </strong>Our meta-analysis was based on 17 studies. We indicated the significant differences between interventional and control groups in total amount of dust (MD = ‒0.24; 95% CI [‒0.37; ‒0.11]; p < 0.001; I² = 57%) and Der1 (Der p1 plus Der f1) concentrations (MD = ‒0.97; 95% CI [‒1.81; ‒0.13]; p = 0.02; I² = 82%). However, they are not sufficient to improve diseases, such as asthma and allergic rhinitis, or to improve the quality of life of patients.</p><p><strong>Conclusions: </strong>HDM allergen avoidance methods are effective in reducing dust and Der1 concentrations.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"eLocator23565"},"PeriodicalIF":7.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Asthma on Quality of Life of Children With Chronic Rhinosinusitis.","authors":"Chadi A Makary, Connor Hunt, Melissa Cummins, Hassan H Ramadan","doi":"10.1002/alr.23568","DOIUrl":"https://doi.org/10.1002/alr.23568","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23568"},"PeriodicalIF":7.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Historic Residential Pesticide Proximity With Proinflammatory Cytokine Levels in a Patient Population With and Without Chronic Rhinosinusitis (CRS).","authors":"Melodyanne Y Cheng, Kimberly C Paul, Jakob L Fischer, Myles G Cockburn, Laura K Thompson, Hong-Ho Yang, Jeffrey D Suh, Marilene B Wang, Jivianne T Lee","doi":"10.1002/alr.23547","DOIUrl":"https://doi.org/10.1002/alr.23547","url":null,"abstract":"<p><strong>Background: </strong>Residential proximity to commercial pesticide application has been associated with increased odds of developing chronic rhinosinusitis (CRS) with in vitro studies demonstrating cytotoxic dose-dependent effects on sinonasal epithelia. This study's aim is to determine potential associations between residential proximity to commercial pesticide application sites and cytokine profiles in patients with and without CRS.</p><p><strong>Methods: </strong>A total of 55 patients were included (35 CRS and 20 control) with an average age of 55 ± 15 years. Ambient pesticide exposure was estimated through residential proximity to commercial pesticide applications using a validated computational geographic information system (GIS) algorithm. Sinonasal tissue samples were analyzed by an immune assessment core for 38 cytokine levels. Linear and logistic regression analysis was used to assess potential correlations between pesticide exposure and inflammatory cytokine levels.</p><p><strong>Results: </strong>A total of 32 (58%) patients resided within 2000 m of any reported commercial pesticide application, including 12 (63%) of the CRSsNP group, 9 (56%) of the CRSwNP group, and 11 (56%) of the control group. Adjusted model 4, which controlled for all covariates listed above, demonstrated associations between pesticide exposure and IL-1α (p = 0.01), TNFβ (p = 0.03), IL-10 (p = 0.03), and IFNα-2 (p = 0.05). When examining CRS and non-CRS participants while stratifying for age, sex, race, smoking history, year of evaluation, and county of residence, an association was found between TNFβ and CRS (p = 0.03) and IL-1α and CRS (p = 0.01), but not IL-10 or IFNα-2 and CRS (p > 0.05).</p><p><strong>Conclusion: </strong>This study revealed residential proximity to commercial pesticide applications was associated with increased levels of proinflammatory/cytokines with several exposure associations stronger among CRS patients.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}