International Forum of Allergy & Rhinology最新文献

{"title":"Stepwise Empty Nose Syndrome Evaluation (SENSE) test—A modified cotton test for reduced bias in office diagnosis of empty nose syndrome","authors":"Lirit Levi MD,&nbsp;Angela Yang BS,&nbsp;Esmond F. Tsai BS,&nbsp;Yifei Ma MS,&nbsp;Nour Ibrahim MD,&nbsp;Sachi S. Dholakia BS,&nbsp;Vidya K. Rao MD, MBA,&nbsp;Axel Renteria MD,&nbsp;Xueying Cao MS,&nbsp;Michael T. Chang MD,&nbsp;Jayakar V. Nayak MD, PhD","doi":"10.1002/alr.23442","DOIUrl":"10.1002/alr.23442","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Diagnosis of empty nose syndrome (ENS) relies on the ENS six-item questionnaire (ENS6Q) with a score of ≥11, followed by a “positive” cotton test yielding seven-point reduction from baseline ENS6Q score via cotton placement to the inferior meatus (IM). Given the intricacies of diagnosing ENS and the propensity for false positives with the standard cotton test, we modified the classic single-step cotton test into a four-part Stepwise Empty Nose Syndrome Evaluation (SENSE) cotton test to reduce bias and evaluate the placebo effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Individuals diagnosed with ENS underwent the SENSE test, a single-blinded, four-step, office-based cotton test, without topical anesthesia or decongestants. Conditions included: (1) placebo/no cotton placed; (2) complete cotton-blockade of nasal vestibule; (3) cotton placed medially against the nasal septum; and (4) cotton placed laterally in the IM (site of inferior turbinate tissue loss). With each condition, patients completed an ENS6Q.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-eight ENS patients were included. Twenty-nine percent demonstrated a placebo effect (<i>p</i> &lt; 0.001), 40.4% had a positive response to complete cotton-blockade (<i>p</i> &lt; 0.001), 64.4% to septum-placed cotton, and 79.1% to IM-placed cotton (<i>p</i> &lt; 0.001), corresponding to a mean ENS6Q reduction of 11.9 points (<i>p</i> &lt; 0.001). Notably, the mean difference in ENS6Q scores between septum and IM placement was 1.7 (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The SENSE test offers further insight into subtleties of nasal breathing experienced by ENS patients. The placebo effect can be prominent and important to consider with individual patients. While most ENS patients prefer any intranasal cotton placement over baseline, blinded testing reveals these patients can accurately discriminate minimal changes in nasal aerodynamics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"149-156"},"PeriodicalIF":7.2,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of noncoding RNA in allergic rhinitis","authors":"Xiangkun Zhao BS,&nbsp;Yuteng Yang BS,&nbsp;Yaqi Wang BS,&nbsp;Xi Chen BS,&nbsp;Yisong Yao BS,&nbsp;Ting Yuan BS,&nbsp;Jiaxuan Li BS,&nbsp;Yumei Li PhD,&nbsp;Xicheng Song PhD","doi":"10.1002/alr.23461","DOIUrl":"10.1002/alr.23461","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic rhinitis (AR) is one of the most common respiratory noninfectious diseases and chronic inflammatory diseases, the incidence of which has been increasing in recent years. The main pathological characteristics of AR are repeated inflammation, airway hyperreactivity, mucus hypersecretion, and reversible airway obstruction due to inflammatory cell response. AR occurrence is associated with various factors, including those of genetic and environmental origins. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Several recent studies have indicated the relationship of ncRNAs with the development of respiratory allergic diseases. NcRNAs, including miRNAs, lncRNAs, and circRNAs, are important gene expression regulatory factors. We review the expression and function of ncRNAs in AR, their role as disease biomarkers, and their prospective applicability in future research and clinically. We also discuss interactions between ncRNAs and their influence on AR comprehensively, these interactions are essential for determining the underlying pathological mechanisms further and discovering new drug therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NcRNAs can be used as biomarkers for early AR diagnosis, disease surveillance and prognosis assessment. Various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. They are also therapeutic targets and biomarkers in other allergic diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This article demonstrates ncRNAs have a wide range of applications in AR treatment. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore. With further research and technological development, ncRNAs may provide additional innovative, effective solutions for AR treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 11","pages":"1757-1775"},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S100A9 induces tissue remodeling of human nasal epithelium in chronic rhinosinusitis with nasal polyp","authors":"Sang Hyeon Ahn MD, PhD,&nbsp;Jun Taek Oh MD,&nbsp;Dae Hyun Kim MD,&nbsp;Eun Jung Lee MD, PhD,&nbsp;Min-Seok Rha MD, PhD,&nbsp;Hyung-Ju Cho MD, PhD,&nbsp;Chang-Hoon Kim MD, PhD","doi":"10.1002/alr.23460","DOIUrl":"10.1002/alr.23460","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic inflammation triggers tissue remodeling in human nasal epithelial (HNE) cells. S100A9, a protein secreted by inflammatory cells, exhibits potent proinflammatory activity. However, its effect on HNE cell remodeling, such as squamous metaplasia, remains unclear. Therefore, this study aimed to determine the effects and underlying pathways of S100A9 on HNE cell remodeling and investigate its clinical implications in chronic rhinosinusitis (CRS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cultured HNE cells were treated with S100A9. Bulk RNA sequencing was performed to analyze gene ontology (GO). Ingenuity pathway analysis (IPA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were also analyzed. Additionally, immunohistochemistry and multiplex immunofluorescence were performed on tissue samples obtained from 60 patients, whose clinical informations were also reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>GO enrichment analysis indicated that S100A9 induced tissue remodeling in HNE cells toward squamous metaplasia. IPA and KEGG commonly showed that S100A9 affected HNE cells associated with the IL-17 signaling pathway, including target molecules such as matrix metalloproteinase 1 (MMP1) and small proline-rich protein 2A (SPRR2A). Squamous metaplasia with a marked expression of S100A9 was observed in 50% of CRS with nasal polyps (CRSwNPs). In addition, in multiplex immunofluorescence, the S100A9 in sub-epithelium was co-expressed with myeloperoxidase, a neutrophil marker, and MMP1 and SPRR2A were strongly expressed in epithelial remodeling. Clinically, the expression of S100A9 correlated with sino-nasal outcome test-22 (<i>r</i> = 0.294, <i>p</i> = 0.022) and Lund–Mackay scores (<i>r</i> = 0.348, <i>p</i> = 0.006).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>S100A9 induces tissue remodeling in HNE cells. Its increased expression in CRSwNP, particularly squamous epithelium, correlates with disease severity. This suggests the clinical potential of S100A9 as a biomarker for CRS severity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"135-148"},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites”","authors":"","doi":"10.1002/alr.23465","DOIUrl":"10.1002/alr.23465","url":null,"abstract":"&lt;p&gt;Murao T, Kouzaki H, Arai H, et al. Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites. &lt;i&gt;Int Forum Allergy Rhinol&lt;/i&gt;. 2024;14:57−67. doi:10.1002/alr.23221&lt;/p&gt;&lt;p&gt;In the article cited above, the authors have determined that the legends for Figures 3 and 5 had incorrect parts, some methods were omitted in the online supplementary materials, and one reference was cited incorrectly.&lt;/p&gt;&lt;p&gt;The corrected figure legends appear below; the online supplementary materials have been revised and published online.&lt;/p&gt;&lt;p&gt;DISCUSSION&lt;/p&gt;&lt;p&gt;Page 64, right column, second paragraph, line 6: Yao et al.&lt;sup&gt;18&lt;/sup&gt; reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.&lt;sup&gt;21&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;Should be changed to: Yao et al.&lt;sup&gt;21&lt;/sup&gt; reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.&lt;sup&gt;21&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;Page 64, right column, second paragraph, line 14: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.&lt;sup&gt;18&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;Should be changed to: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.&lt;sup&gt;21&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Figure legend 3&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Serum concentrations of house dust mite (HDM)–specific IgA, IgE, and IgG4 antibodies. (A) Prior to treatment, the serum concentrations of HDM-specific IgE were significantly higher in patients with allergic rhinitis (AR) than in healthy controls (HCs; HC: 0.08 ± 0.01 optimal density [OD] value, AR: 0.99 ± 0.08 OD value), while no significant difference was detected in serum concentrations of HDM-specific IgA (HC: 0.68 ± 0.05 OD value, AR: 0.69 ± 0.04 OD value) and HDM-specific IgG4 (HC: 1.17 ± 0.14 OD value, AR: 1.31 ± 0.15 OD value). (B) Changes in serum concentrations of HDM-specific IgA, IgE, and IgG4 in patients with AR before and after sublingual immunotherapy (SLIT). Serum concentrations of HDM-specific IgA and IgG4 were significantly increased after 1 year of SLIT; those of HDM-specific IgE did not change significantly after SLIT. Comparisons of data from two independent groups were performed using a two-tailed Mann–Whitney &lt;i&gt;U-&lt;/i&gt;test. Paired data were analyzed by the Wilcoxon signed rank test. **&lt;i&gt;p &lt;/i&gt;&lt; 0.01, *&lt;i&gt;p &lt;/i&gt;&lt; 0.05; ns, not significant. Where indicated, values are provided as mean ± standard error of the mean.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Figure legend 5&lt;/b&gt;&lt;/p&gt;&lt;p&gt;(A) Total nasal ocular symptom score (TNOSS) and visual analog scale (VAS) scores in patients with allergic rhinitis (AR) before and after sublingual immunotherapy (SLIT). Both symptom scores were significantly improved after 1 year of SLIT. (B) Correlation between the improvements in TNOSS and VAS scores, and the prevalence of cluster of differentiation 4 (CD4)+ T-cell subse","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 11","pages":"1838-1839"},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-derived organoid model of olfactory ensheathing cell tumor","authors":"John B. Finlay MPhil,&nbsp;Ralph Abi Hachem MD,&nbsp;Patrick Codd MD,&nbsp;Bradley J. Goldstein MD, PhD","doi":"10.1002/alr.23464","DOIUrl":"10.1002/alr.23464","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>\u0000 <p>We developed a culture model of a human olfactory ensheathing cell tumor.</p>\u0000 </li>\u0000 \u0000 <li>\u0000 <p>Cultured organoids resemble normal ensheathing cells.</p>\u0000 </li>\u0000 \u0000 <li>\u0000 <p>Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.</p>\u0000 </li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"195-199"},"PeriodicalIF":7.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of allergen immunotherapy in patients with central compartment atopic disease post-surgery","authors":"Christian M. Meerwein MD,&nbsp;Peta-Lee Sacks MD,&nbsp;Jacqueline Ho MD, PhD,&nbsp;Christine Choy,&nbsp;Larry Kalish MD,&nbsp;Raewyn G Campbell MD,&nbsp;Ray R. Sacks MD,&nbsp;Richard J Harvey MD, PhD","doi":"10.1002/alr.23459","DOIUrl":"10.1002/alr.23459","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the effect of allergen immunotherapy (AIT) on patients with central compartment atopic disease (CCAD) and house dust mite (HDM) sensitization post-surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective cohort of surgically treated, HDM-sensitized CRSwNP patients phenotyped as CCAD was assessed. Patients were divided into two groups based on whether they had AIT commenced as part of their surgical care. All AIT patients started immunotherapy prior to their surgery. The primary endpoint was reformation of middle turbinate (MT) edema 12 months postsurgery. Secondary endpoints were corticosteroid irrigation use (&lt;4 times/week vs. ≥4 times/week, %) and the rhinologic domain of the 22-item sino-nasal outcome test (SNOT-22). Demographic characteristics, concomitant asthma, smoking status, history of aspirin-exacerbated respiratory disease, conjunctival symptoms, polysensitization, serum eosinophils (cell × 10⁹/L), tissue eosinophilia (% &gt; 100/HPF), and serum IgE (kU/L) were also recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-six CCAD patients were assessed (41 ± 14 yrs, 64% female). AIT was applied in 37% (<i>n</i> = 32). Baseline features were similar apart from greater conjunctival symptoms (72 vs. 45%, <i>p</i> = 0.02) in the AIT group. At 12 months post-surgery, the AIT group has less MT edema (% ≥ diffuse 15.6 vs. 52.9, <i>p</i> &lt; 0.01). Patients on AIT also had less pharmacotherapy requirements at 12 months (% ≥ 4/week, 37.5 vs. 79.6%, <i>p</i> &lt; 0.01). The rhinologic symptoms were similar (21.1 ± 17.1 vs. 20.1 ± 21.6, <i>p</i> = 0.83).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Surgery and pharmacotherapy are effective in managing CCAD, but the addition of AIT improved allergic phenomenon and allowed de-escalation of topical therapy. Longer term studies are required to demonstrate further immunomodulation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"128-134"},"PeriodicalIF":7.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time is money: An analysis of cost drivers in ambulatory sinus surgery","authors":"David K. Lerner MD,&nbsp;Chau Phung BA,&nbsp;Alan D. Workman MD, MPH,&nbsp;Saawan Patel BBA,&nbsp;Glenn Pennington MHA,&nbsp;Robert Stetson MHA,&nbsp;Jennifer E. Douglas MD,&nbsp;Michael A. Kohanski MD, PhD,&nbsp;James N. Palmer MD,&nbsp;Nithin D. Adappa MD","doi":"10.1002/alr.23455","DOIUrl":"10.1002/alr.23455","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Functional endoscopic sinus surgery (FESS) is one of the most commonly performed otolaryngologic procedures and is associated with significant cost variability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a retrospective analysis of all inflammatory sinus surgeries at a single tertiary care medical center from July 2021 to July 2023. The electronic medical record was reviewed for patient factors and cost variables for each procedure, and multivariable analysis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 221 patients were included in analysis with a mean age of 48.2 years. There was a 44.8% incidence (<i>n</i> = 99) of nasal polyps and 31.2% (<i>n</i> = 69) of cases were revision surgeries. The average total cost for the surgical encounter was $8960.31 (standard deviation $1967.97). Operating room time represented $4912.46 (54.8% of all costs), while average operating room supply costs were $1296.06 (14.5%) and recovery room costs were $919.48 (10.3%). Total costs were significantly associated with length of surgery ($7.83/min, <i>p</i> = 0.04), in addition to presence of nasal polyps ($531.96, <i>p</i> = 0.04). There was no significant association between total costs and the remaining clinical and demographic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Costs associated with ambulatory FESS for inflammatory sinus disease vary across patients and this cost variability is predominantly driven by time efficiency within the operating room, as well as supply utilization and nasal polyposis to a lesser degree. As a result, operating room efficiency represents a primary target for cost-related interventions. Additionally, our data provide a framework for surgeons and hospitals to make evidence-based decisions on intraoperative equipment in a tradeoff between efficiency and supply costs. Our findings indicate that an approach focused on streamlining efficiency across the entire ambulatory surgery encounter will have the greatest impact on reducing healthcare expenses for both the patient and the health system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"120-127"},"PeriodicalIF":7.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time augmentation of diagnostic nasal endoscopy video using AI-enabled edge computing","authors":"Jonathan Bidwell PhD,&nbsp;Dipesh Gyawali MS,&nbsp;Jonathan Morse,&nbsp;Vinayak Ganeshan MD,&nbsp;Thinh Nguyen MD,&nbsp;Edward D. McCoul MD, MPH","doi":"10.1002/alr.23458","DOIUrl":"10.1002/alr.23458","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>\u0000 <p>AI-enabled augmentation of nasal endoscopy video images is feasible in the clinical setting.</p>\u0000 </li>\u0000 \u0000 <li>\u0000 <p>Edge computing hardware can interface with existing nasal endoscopy equipment.</p>\u0000 </li>\u0000 \u0000 <li>\u0000 <p>Real-time AI performance can achieve an acceptable balance of accuracy and efficiency.</p>\u0000 </li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"191-194"},"PeriodicalIF":7.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence for article titled “The relationship between survey-based subjective olfactory awareness and objective olfactory function”","authors":"Hyun Jin Min MD,PhD","doi":"10.1002/alr.23456","DOIUrl":"10.1002/alr.23456","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 10","pages":"1673-1674"},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cost utility analysis for the management of acute exacerbations of chronic rhinosinusitis","authors":"Matthew M. Chu MD,&nbsp;Jack T. Garcia BS,&nbsp;Ahmad R. Sedaghat MD, PhD,&nbsp;George A. Scangas MD,&nbsp;Katie M. Phillips MD","doi":"10.1002/alr.23452","DOIUrl":"10.1002/alr.23452","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The management of acute exacerbations of chronic rhinosinusitis (AECRS) is understudied and the most cost-effective management of AECRS has not been previously investigated. The aim of this study is to determine the most cost-effective strategy for the initial management of AECRS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study design consisted of a decision-tree economic model comparing three different initial strategies for managing a patient perceived AECRS: observation, upfront rescue medications, or clinic visit with diagnostic nasal endoscopy (DNE). The primary study outcome was the disease burden of a single AECRS, which was determined by the health utility value and the duration of symptoms. Strategies with an incremental cost-effectiveness ratio &lt; $50,000/quality-adjusted life year (QALY) or equivalently &lt; $137/quality-adjusted life day (QALD) were considered cost-effective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Observation was the most cost-effective strategy at a willingness to pay of $137 per QALD. One-way sensitivity analysis demonstrated that observation was more effective than upfront rescue medications when the probability of bacterial infection as the cause of AECRS was &lt;24.0%. Upfront rescue medications wer more cost effective than observation when the probability of bacterial infection exceeded 49.0%. Clinic visit with DNE was the most effective strategy to manage an AECRS, but it was not considered cost-effective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Observation is the most cost-effective strategy for the initial management of AECRS when there is a low likelihood of bacterial infection. When the probability of bacterial etiology of AECRS exceeds 49.0%, upfront rescue medications proved to be the most cost-effective strategy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 2","pages":"109-119"},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}