International Forum of Allergy & Rhinology最新文献

{"title":"Reply to \"Comments on Clinical Longitudinal Evaluation After Regimen Stop (CLEAR) of Dupilumab in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)\".","authors":"Patrick Huber, Moritz Gröger","doi":"10.1002/alr.70278","DOIUrl":"https://doi.org/10.1002/alr.70278","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom Characteristics of Patients With Gastroesophageal Reflux Disease Presenting With Sinonasal Complaints.","authors":"Ryan S Ziltzer, Shane V Perelman, Chadi A Makary","doi":"10.1002/alr.70294","DOIUrl":"https://doi.org/10.1002/alr.70294","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Exposures, Chronic Sinusitis, and Olfaction in People With Cystic Fibrosis.","authors":"Benton Tullis, Larissa Nicolas, Jeremiah A Alt, Todd E Bodner, Michael Chang, Naweed I Chowdhury, Sei Chung, Patricia Eshaghian, Yuqing A Gao, Anne Getz, Amarbir S Gill, Peter H Hwang, Ashoke Khanwalkar, Adam J Kimple, Todd Kingdom, Jivianne T Lee, Douglas A Li, Jess C Mace, Jayakar V Nayak, Meghan Norris, Jonathan B Overdevest, Zara M Patel, Katie Poch, Rodney J Schlosser, Kristine A Smith, Zachary M Soler, Jeffrey D Suh, Grant A Turner, Marilene B Wang, Milene T Saavedra, Jennifer L Taylor, Daniel M Beswick","doi":"10.1002/alr.70204","DOIUrl":"https://doi.org/10.1002/alr.70204","url":null,"abstract":"<p><strong>Background: </strong>Environmental air pollutants may contribute to chronic rhinosinusitis (CRS), but their relationship with upper airway disease in people with cystic fibrosis (CF) remains poorly understood. This study evaluated associations between long-term ambient air pollutant exposure and CRS severity and olfactory dysfunction in adults with CF and CRS.</p><p><strong>Methods: </strong>80 adults with CF and comorbid CRS were prospectively enrolled from 2019 to 2023 at multiple U.S. academic rhinology centers. Long-term exposure to PM_2.5, PM₁₀, CO, SO₂, NO₂, and ozone was estimated using the nearest U.S. Environmental Protection Agency monitor linked to each participant's residential ZIP code, with 3-year mean exposure calculated before enrollment. CRS severity and olfaction were assessed using Lund-Kennedy endoscopy scores, Lund-Mackay CT scores, SNOT-22, Questionnaire of Olfactory Disorders-Negative Statements, and 40-item Smell Identification Test. Analyses used Spearman correlations and nonparametric group comparisons.</p><p><strong>Results: </strong>Higher ozone exposure was associated with worse total SNOT-22 scores (R_s = 0.34 p = 0.002), including ear/facial, psychological, and sleep dysfunction domains, as well as worse olfactory-specific outcomes, including higher QOD-NS scores (R_s = 0.30, p = 0.007) and lower Smell Identification Test scores (R_s = -0.30, p = 0.018). Other pollutants did not show significant associations with CRS or olfactory outcomes.</p><p><strong>Conclusions: </strong>In adults with CF and CRS, higher long-term ambient ozone exposure was associated with greater sinonasal symptom burden and worse olfactory function. These findings suggest that ozone may be an environmental contributor to upper airway disease severity in this population and support further study in larger, adjusted analyses.</p><p><strong>Key points: </strong>Increased ozone pollution correlates with more severe CRS in people with CF. Among people with CF and CRS, higher ozone exposure is associated with worse olfactory function.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor Regarding \"Dosing Interval Extension of Dupilumab in CRSwNP: Five Year Real World Outcomes\" by Meulmeester et al.","authors":"Nicholas J Campion, Dioni-Pinelopi Petsiou, Florian C Fally, Karina Berbalk, Noah F Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl-Dorna, Sven Schneider","doi":"10.1002/alr.70293","DOIUrl":"https://doi.org/10.1002/alr.70293","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Peripheral Immune Cell Subsets Following Endoscopic Sinus Surgery Differ Between CRSwNP and AERD.","authors":"Kathleen R Bartemes, Danielle E Hunter, Marisa D Griesel, Elina Jerschow, Rohit D Divekar, Erin K O'Brien","doi":"10.1002/alr.70289","DOIUrl":"https://doi.org/10.1002/alr.70289","url":null,"abstract":"<p><strong>Introduction: </strong>Changes in peripheral eosinophils follow endoscopic sinus surgery (ESS) in chronic rhinosinusitis with nasal polyps (CRSwNP), with and without aspirin sensitivity. Cytometry by time-of-flight (CyTOF) identifies more immune cell subsets than conventional assays or clinical testing. We hypothesized that ESS-associated changes in peripheral immune cell subsets differ between aspirin-tolerant (AT)-CRSwNP and aspirin-exacerbated respiratory disease (AERD) as measured by CyTOF.</p><p><strong>Methods: </strong>Pre- and post-ESS peripheral blood from patients with CRSwNP (n = 13) or with AERD (n = 15) was analyzed for immune cell populations using a 37-marker CyTOF panel. CITRUS analysis identified cell clusters most predictive of patient group or sample timepoint.</p><p><strong>Results: </strong>In the combined cohort of 28 patients, circulating CD4⁺ naïve T cells and CD194⁺ neutrophils increased after ESS, while eosinophils decreased. When stratified by disease, CD4⁺ naïve T cells increased in both AERD and CRSwNP post-ESS; however, eosinophils decreased after ESS only in CRSwNP. Neutrophil subsets showed a mixed response in both patient groups after ESS. Dendritic cells increased in CRSwNP but not in AERD after ESS. Individual timepoint analyses showed more CD141⁺ monocyte-derived DCs (moDCs) in CRSwNP than in AERD pre- and post-ESS. Pre-ESS, both CD185⁺ and CD194⁺ neutrophils were higher in AERD compared to CRSwNP.</p><p><strong>Conclusion: </strong>CD141⁺ moDCs were more prevalent in CRSwNP versus AERD, both before and after ESS. Naïve CD4⁺ T cells increased, and neutrophil subsets changed in all groups after ESS, but eosinophils decreased only in CRSwNP. Our study points to possible systemic immune effects of ESS and candidate immune signatures in CRSwNP and AERD.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding \"Dosing Interval Extension of Dupilumab in CRSwNP: Five-Year Real World Outcomes\".","authors":"Fleur L Meulmeester, Camiel J M Marijnissen, Jacob K Sont","doi":"10.1002/alr.70291","DOIUrl":"https://doi.org/10.1002/alr.70291","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis.","authors":"Jeffanie W Gayoso, Li-Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K Chandra, Justin H Turner, Naweed Chowdhury","doi":"10.1002/alr.70284","DOIUrl":"https://doi.org/10.1002/alr.70284","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common underlying etiology. Obesity is known to create a proinflammatory state in similar chronic inflammatory conditions such as asthma. However, the potential impact of obesity in CRS has not been investigated.</p><p><strong>Methods: </strong>Samples were collected from 512 patients with CRS (235 CRSsNP, 277 CRSwNP) and 100 control patients undergoing surgery in a prospective longitudinal study. Mucus inflammatory cytokines were measured using a multiplex cytometric bead assay targeting IL-1a, IL-1b, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-17, IL-18, IL-21, TNF-⍺, IFN-𝛾, eotaxin, RANTES, and GM-CSF. Cytokine levels were then compared between obese and non-obese patients using categorical and continuous measures of BMI.</p><p><strong>Results: </strong>In patients with CRSwNP, there were significant elevations in multiple pro-inflammatory cytokines. Levels of IL-2 (185 pg/mL vs. 39 pg/mL, p = 0.02), IL-4 (17.7 pg/mL vs. 6.3 pg/mL, p = 0.04), TNF-⍺ (58 pg/mL vs. 45 pg/mL, p = 0.04), IFN-ɣ (18.5 pg/mL vs. 17.3 pg/mL, p = 0.009), and GM-CSF (8.5 pg/mL vs. 2.5 pg/mL, p = 0.007) were elevated in obese CRSwNP patients. Continuous regression analysis did not confirm these results, potentially due to non-linear effects of obesity on sinonasal inflammation.</p><p><strong>Conclusions: </strong>Obese CRSwNP patients have elevations in Type 1 and 2 cytokines compared to non-obese patients, potentially indicative of a pro-inflammatory bias in the sinonasal mucosa of obese patients. As such, there may be a role for weight loss and medical weight management in the treatment of CRSwNP, although further research is needed.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil Peroxidase Activity is a Reliable and Resilient Biomarker for Eosinophilic Chronic Rhinosinusitis.","authors":"Christian Caceres, Evan D Marsh, Kristine A Smith, Chelsea E Pollard, Fok Vun Chan, Fatemeh Zarei Haji Abadi, Prince A B Minkah, Paul O Neilsen, Justin R Savage, Bryan R McRae, Benjamin L Witt, Jeremiah A Alt, Gretchen M Oakley, Richard R Orlandi, Abigail Pulsipher","doi":"10.1002/alr.70286","DOIUrl":"https://doi.org/10.1002/alr.70286","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Rhinologic Society Expert Practice Statement: Indications and Recommendations for Posterior Nasal Nerve Ablation.","authors":"Dara R Adams, Meha G Fox, Peter H Hwang, Christopher R Roxbury, Mas Takashima, Arthur W Wu, David M Yen, Omar G Ahmed","doi":"10.1002/alr.70279","DOIUrl":"https://doi.org/10.1002/alr.70279","url":null,"abstract":"<p><p>The goal of this American Rhinologic Society expert practice statement (EPS) is to provide an evidence-based evaluation of the current literature on posterior nasal nerve ablation. Subtopics reviewed include the evidence for specific indications such as nonallergic rhinitis, allergic rhinitis, and postnasal drip and chronic cough; the durability of response; the safety profile of posterior nasal nerve ablation; the ability of ipratropium bromide response to predict procedural success; and recommendations regarding surgical technique. This EPS was developed following the previously published methodology and approval process. Following a modified Delphi approach, eight statements were developed, five of which reached consensus and three of which did not reach consensus. These statements and accompanying evidence are summarized along with an assessment of future needs.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Tuft Cell Markers Are Predictive of Overall Survival in Sinonasal Neuroendocrine and Sinonasal Undifferentiated Carcinomas.","authors":"Nikolina Dioufa, Ricardo V Bruneto, Jennifer E Douglas, Nithin D Adappa, James N Palmer, Noam A Cohen, Michael A Kohanski","doi":"10.1002/alr.70283","DOIUrl":"https://doi.org/10.1002/alr.70283","url":null,"abstract":"<p><strong>Background: </strong>Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and KIT, a tuft-progenitor marker, to determine whether SNECs/SNUCs exhibit a tuft cell lineage.</p><p><strong>Methods: </strong>We retrospectively studied patients with rare sinonasal malignancies treated between 2010 and 2025 at the University of Pennsylvania. Archived specimens underwent immunohistochemistry for KIT, POU2F3, SOX9, TRPM5, ASCL1, and IDH2 R172 mutations. Clinical, radiological, and treatment data were collected. Associations with overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier and Cox regression analyses.</p><p><strong>Results: </strong>KIT was expressed in 90.2% of SNECs (N = 11) and 54.6% of SNUCs (N = 11), with the KIT⁺POU2F3⁺ phenotype in 72.7% and 18.2%, respectively. KIT/POU2F3 expression correlated with SOX9 and TRPM5, and KIT/POU2F3 phenotypes correlated with IDH2 R172 mutation status (p = 0.015). KIT⁺POU2F3⁺ tumors had significantly improved OS (p = 0.004) and DFS (p = 0.001). Univariable analysis showed that lack of double positive KIT/POU2F3 phenotype predicted decreased OS (HR: 12.24; 95% CI: 2.29-226.78; p = 0.001) and DFS (p < 0.001). In multivariable analyses, this association persisted for OS in models including histologic subtype or IDH2 mutation status.</p><p><strong>Conclusions: </strong>Results indicate that a subgroup of SNECs and SNUCs expresses a tuft cell-associated marker profile. KIT⁺POU2F3⁺ SNECS and SNUCs have markedly improved OS and DFS suggesting these markers have diagnostic, prognostic and potentially therapeutic utility.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}