International Forum of Allergy & Rhinology最新文献

{"title":"Correspondence Regarding 'Evaluating the Quality of YouTube Videos on Chronic Rhinosinusitis'.","authors":"Hyun Jin Min","doi":"10.1002/alr.23634","DOIUrl":"https://doi.org/10.1002/alr.23634","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23634"},"PeriodicalIF":7.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Anti-IgE Therapy for Chronic Rhinosinusitis With Nasal Polyps and Asthma: Efficacy and Prognostic Factors.","authors":"Xiaomei Yang, Menghan Ye, Minghao Pan, Jiashu Zhao, Yang Liu, Xuelan Zeng, Wendong Liu, Yueqi Sun, Yi Wei, Fenghong Chen, Rui Xu","doi":"10.1002/alr.23626","DOIUrl":"https://doi.org/10.1002/alr.23626","url":null,"abstract":"<p><strong>Background: </strong>Omalizumab has demonstrated efficacy in treating chronic rhinosinusitis (CRS) with nasal polyps and comorbid asthma (NPwAS) in preoperative settings. However, real-world evidence regarding its postoperative application remains limited. This study aimed to assess the effectiveness and safety of omalizumab in managing NPwAS following endoscopic sinus surgery (ESS), and to identify predictors for treatment response.</p><p><strong>Methods: </strong>This prospective observational study enrolled 60 NPwAS patients who underwent ESS between January 2020 and March 2023. Participants were divided into two groups: Control group (receiving standard care: nasal saline lavage and budesonide nasal spray) and Omalizumab group (receiving omalizumab in addition to standard care). Disease assessments, including total nasal symptom score (TNSS), visual analog scale (VAS) score, asthma control test (ACT), and sino-nasal outcome test-22 (SNOT-22), were conducted at baseline and 6 months post-treatment. Blood and nasal polyp tissue samples were collected to explore potential predictors. CRS disease control was categorized as controlled, partly controlled, or uncontrolled based on the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS).</p><p><strong>Results: </strong>Thirty patients in the Omalizumab group and 28 in the Control group completed the treatment and follow-up. At 6 months, CRS control was significantly better in the Omalizumab group compared to the Control group, with response rates of 40% and 14.3%, respectively (p = 0.009). The Omalizumab group also demonstrated greater mean improvements from baseline in TNSS, loss of smell score, and SNOT-22 score compared to the Control group. The treatment exhibited a favorable safety profile.</p><p><strong>Conclusions: </strong>Omalizumab significantly improved clinical outcomes in NPwAS patients 6 months post-surgery, underscoring its potential as an effective adjunctive therapy in the postoperative management of NPwAS.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23626"},"PeriodicalIF":7.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of YouTube Videos on Chronic Rhinosinusitis.","authors":"Simon Høj, Vibeke Backer, Laura Høj, Torben Sigsgaard, Howraman Meteran","doi":"10.1002/alr.23633","DOIUrl":"https://doi.org/10.1002/alr.23633","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23633"},"PeriodicalIF":7.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Stem Cell Characterization in Olfactory Neuroblastoma Tissue.","authors":"Shivani Ramolia, Riley Larkin, Yvette Robbins, Diana C Lopez, Wiem Lassoued, Sreenivasulu Gunti, James L Gulley, Gary Gallia, Clint Allen, Nyall R London","doi":"10.1002/alr.23620","DOIUrl":"https://doi.org/10.1002/alr.23620","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23620"},"PeriodicalIF":7.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate Detection of Cerebrospinal Fluid by DNA Aptamers Derived by Clinical Samples.","authors":"Xinlei Chen, Arash Abiri, Dana Kadifa, Brandon Latifi, Yana Khetiya, Frank P K Hsu, Mehmet Senel, Andrej Luptak, Michelle Khine, Edward C Kuan","doi":"10.1002/alr.23624","DOIUrl":"https://doi.org/10.1002/alr.23624","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23624"},"PeriodicalIF":7.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Abundance of Caution: Insights From Negative Re-Explorations for Postoperative Cerebrospinal Fluid Leaks","authors":"Edward C. Kuan,&nbsp;Nithin D. Adappa,&nbsp;Eric W. Wang","doi":"10.1002/alr.23627","DOIUrl":"10.1002/alr.23627","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 7","pages":"677-679"},"PeriodicalIF":7.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective Sleep Gains in Empty Nose Syndrome: A Cautionary Note on the Need for Objective Validation","authors":"Xiao Yu,&nbsp;Yidan Zhang,&nbsp;Hui Wang","doi":"10.1002/alr.23631","DOIUrl":"10.1002/alr.23631","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 7","pages":"761-762"},"PeriodicalIF":7.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Skin Prick Tests Predict Nasal Provocation Test Outcomes in Allergic Rhinitis Patients?","authors":"Yunhyung Lee, Gyu Tae Kim, Seo Jun Kang, Marn Joon Park","doi":"10.1002/alr.23622","DOIUrl":"https://doi.org/10.1002/alr.23622","url":null,"abstract":"<p><strong>Background: </strong>In diagnosing allergic rhinitis (AR), conventional skin prick tests (SPTs) often fail to reflect allergen-induced nasal symptoms. Conversely, nasal provocation tests (NPTs) provide more definitive assessments but are less accessible. Therefore, we aimed to evaluate the correlation between SPT and NPT outcomes to assess SPT's predictive reliability for NPT results.</p><p><strong>Methods: </strong>A retrospective review was performed on 106 patients who underwent simultaneous SPT and NPT for suspected perennial AR. The SPT was assessed by measuring the mean wheal diameter of Dermatophagoides pteronyssinus (Dp). The NPT was performed by administering 100 µL of a 1000 AU/mL Dp solution into both nostrils, with responses assessed by changes in the five AR-related symptoms (total nasal symptom score, TNSS) at 15 min. Correlation and linear regression analyses were conducted to evaluate the relationship between SPT and NPT outcomes.</p><p><strong>Results: </strong>TNSS changes at 15 min following intranasal Dp challenge showed a significant, moderately positive correlation with SPT Dp wheal diameter for all 106 subjects (ρ = 0.640, p < 0.001). In patients positive for both SPT and NPT (n = 24, ρ = 0.510, p = 0.011) and those with monosensitization (n = 30, ρ = 0.644, p < 0.001), a stronger and significant correlation was observed compared to the polysensitized group (n = 35, ρ = 0.372, p = 0.028), while no significant correlation was noted in patients negative for either test. Linear regression confirmed a significant linear relationship (R² = 0.423, Y = 2.65X - 0.59, p < 0.001) between SPT wheal size and 15-min TNSS changes in NPT among all the subjects.</p><p><strong>Conclusion: </strong>Significant correlations and linear associations between SPT and NPT outcomes support SPT's predictive capability for NPT responses.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23622"},"PeriodicalIF":7.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Variability in Sinonasal Measurements Relevant for Nasoseptal Flap Harvest: Is There an Opportunity to Preserve More Anterior Septal Mucosa?","authors":"Beatrice M Katsnelson, R Peter Manes, Ryan A Rimmer","doi":"10.1002/alr.23616","DOIUrl":"https://doi.org/10.1002/alr.23616","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23616"},"PeriodicalIF":7.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal-Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitisto Total IgE Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitis.","authors":"Dong Liu, Yuan Zhang, Jingyun Li, Xu Zhang, Luo Zhang, Chengshuo Wang","doi":"10.1002/alr.23621","DOIUrl":"https://doi.org/10.1002/alr.23621","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23621"},"PeriodicalIF":7.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}