International Forum of Allergy & Rhinology最新文献

{"title":"Ectopic olfactory neuroblastoma is associated with increased frequency of syndrome of inappropriate antidiuretic hormone secretion and reduced disease control: Case series with systematic review and pooled analysis.","authors":"Antonio Daloiso, Piergiorgio Gaudioso, Alessandro Vinciguerra, Mario Turri-Zanoni, Gabriele Testa, Diego Cazzador, Alessia Lambertoni, Alberto Daniele Arosio, Giacomo Contro, Stefano Taboni, Vittorio Rampinelli, Cesare Piazza, Maurizio Bignami, Enzo Emanuelli, Paolo Battaglia, Paolo Bossi, Philippe Herman, Paolo Castelnuovo, Ehab Y Hanna, Piero Nicolai, Davide Mattavelli, Marco Ferrari","doi":"10.1002/alr.23502","DOIUrl":"10.1002/alr.23502","url":null,"abstract":"<p><strong>Introduction: </strong>Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as \"ectopic\" (eONB), in contrast to \"orthotopic\" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This study investigate the association between eONB and SIADH and compared the prognosis of eONB to oONB.</p><p><strong>Methods: </strong>A systematic literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted, focusing on studies reporting eONB and oONB associated with SIADH. Data from four newly identified eONB cases were reported and a pooled analysis was performed. Statistical analyses were conducted to evaluate the prevalence of SIADH in eONB and oONB and to compare clinical outcomes in the two groups.</p><p><strong>Results: </strong>eONB had a significantly higher prevalence of SIADH (18.3%) compared to oONB (2.0%; p < 0.0001). Patients with eONB were younger, with a slight predominance of females. Recurrence-free survival and time-to-recurrence of eONB were worse than oONB, independently of other prognosticators.</p><p><strong>Conclusions: </strong>eONB is associated with a significantly higher incidence of SIADH than oONB, suggesting distinct biological characteristics. Moreover, patients with eONB had worse prognostic outcomes. Further research is needed to understand the underlying mechanisms and improve management strategies for eONB.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"45-67"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidance for the evaluation by payors of claims submitted using Current Procedural Terminology codes 95165, 95115, and 95117.","authors":"J Allen Meadows, Gary N Gross, Anita N Wasan, Dole P Baker, Amber Patterson, Robert Puchalski, Anil Nanda, Jami Lucas, J Wesley Sublett, Paul V Williams","doi":"10.1002/alr.23480","DOIUrl":"10.1002/alr.23480","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"5-8"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"To the editor: Ambient particulate matter and frequency of outpatient visits for chronic rhinosinusitis in the United States\".","authors":"Hong-Ho Yang, David Grimm, Esther Velasquez, Peter H Hwang","doi":"10.1002/alr.23490","DOIUrl":"10.1002/alr.23490","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"102-103"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the Editor: Ambient particulate matter and frequency of outpatient visits for chronic rhinosinusitis in the United States.","authors":"Yiheng Liu, Weiran Dai","doi":"10.1002/alr.23499","DOIUrl":"10.1002/alr.23499","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"97-98"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of disseminated amebiasis in a patient on biologic therapy for chronic rhinosinusitis.","authors":"Ariel Omiunu, Lindsey Brown, Darpan Kayastha, R Peter Manes","doi":"10.1002/alr.23473","DOIUrl":"10.1002/alr.23473","url":null,"abstract":"<p><strong>Key points: </strong>Dupilumab targets Th2-associated inflammatory mediators to reduce disease burden in CRSwNP. While rare, potential sequelae include viral, helminth, and potentially amebic infections.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"86-88"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Letter to the Editor\"; Liao and Kern.","authors":"Audrey Pelletier, Leandra Mfuna Endam, Emmanuel Gonzalez, Sheherazade Jannat, Thea Irani, Martin Desrosiers","doi":"10.1002/alr.23518","DOIUrl":"https://doi.org/10.1002/alr.23518","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Autologous versus Synthetic Inlay Grafts After Skull Base Reconstruction for High-Flow Defects: A Multicenter Case-Control Analysis.","authors":"Theodore V Nguyen, Arash Abiri, Victoria Idowu, Saawan Patel, Thomas Truong, David K Lerner, Alan D Workman, Pete S Batra, Raewyn G Campbell, John R Craig, Dana L Crosby, Jennifer E Douglas, Jacob G Eide, Michael A Kohanski, Rijul S Kshirsagar, Tran B Locke, Peter Papagiannopoulos, Bobby A Tajudeen, Charles C L Tong, Nithin D Adappa, James N Palmer, Edward C Kuan","doi":"10.1002/alr.23509","DOIUrl":"https://doi.org/10.1002/alr.23509","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 biomarkers in olfactory cleft mucus correlate with SNOT-22 in chronic rhinosinusitis independent of nasal polyp status.","authors":"Nikita Chapurin, Zachary M Soler, Sofia Khan, Jennifer K Mulligan, Vijay R Ramakrishnan, Jess C Mace, Timothy L Smith, Jeremiah A Alt, Jose L Mattos, Vinay K Rathi, Rodney J Schlosser","doi":"10.1002/alr.23503","DOIUrl":"https://doi.org/10.1002/alr.23503","url":null,"abstract":"<p><strong>Background: </strong>Quantitative mucus cytokine analysis to examine the sinonasal microenvironment may bridge the gap between patient-reported outcome measures (PROMs) and empirical measures of inflammation in patients with chronic rhinosinusitis (CRS).</p><p><strong>Objective: </strong>Investigate the correlation between mucus cytokine levels and Sino-Nasal Outcome Test (SNOT-22) scores, including individual subdomains.</p><p><strong>Methods: </strong>Patients with CRS were prospectively recruited between 2016 and 2021 into a multi-institutional observational study. Mucus was collected from the olfactory cleft and evaluated for mucus cytokine biomarkers. Spearman correlations (ρ) between cytokine levels and SNOT-22 scores, including individual subdomains, Lund-Mackay (LM) CT and Lund-Kennedy (LK) endoscopy scores were assessed. Subgroup analysis based on nasal polyp status (CRSsNP-without nasal polyps; CRSwNP-with nasal polyps) was also performed. Linear regression was employed to identify multivariate associations between cytokine expression levels, clinical covariates, and SNOT-22 total and domain scores.</p><p><strong>Results: </strong>A total of 127 patients were included in the study (CRSsNP = 53, CRSwNP = 74). IL-9 (ρ = 0.196, p < 0.05) was the only biomarker that correlated with the SNOT-22 total score. CRSwNP patients had a higher absolute expression level of Type 2 biomarkers (IgE, IL-5, and IL-13), compared to CRSsNP patients. IgE, IL-5, IL-9, and IL-13 significantly correlated with the SNOT-22 rhinologic subdomain scores (p < 0.001), LM scores, and patient reported sense of smell (Question 21). Notably, subgroup analysis showed that CRSsNP patients also demonstrated significant correlations between Type 2 markers (IL-4, IL-5, IL-9, and IL-13) and SNOT-22 rhinologic subdomain scores.</p><p><strong>Conclusion: </strong>Type 2 mucus cytokine levels, especially IL-9, correlate with SNOT-22, and the rhinologic SNOT-22 subdomain scores for both CRSsNP and CRSwNP patients.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Outcomes of PRP Injections for Post-viral Olfactory Loss: A Prospective Cohort Study.","authors":"Maxime Fieux, Bruna R Castro, Sophie S Jang, Carol H Yan, Zara M Patel","doi":"10.1002/alr.23505","DOIUrl":"https://doi.org/10.1002/alr.23505","url":null,"abstract":"<p><strong>Background: </strong>Platelet-rich plasma (PRP) injections have previously been shown to benefit coronavirus disease 2019 (COVID-19)-induced smell loss. It is unknown if that benefit is stable over time. The aim of this study was to assess outcomes at 1-year post-intervention.</p><p><strong>Methods: </strong>Prospective cohort study. Sixteen patients (10 PRP and six placebo) from the original PRP randomized placebo-controlled clinical trial, and a further 16 patients from smell clinic who were a year out from initial treatment (six PRP patients and 10 non-PRP) were enrolled. University of Pennsylvania Smell Identification Tests (UPSITs) and visual analog scale (VAS) subjective scores were compared to initial scores.</p><p><strong>Results: </strong>There was no difference between groups with respect to age, gender, race, duration of smell loss prior to intervention, smoking or diabetes status, Charlson comorbidity index, presence of phantosmia or parosmia, or baseline UPSIT score. The PRP group had a significantly higher change in UPSIT score at 1 year (p = 0.001), a higher number of patients who met the minimal clinically important difference for the UPSIT (87.5% vs. 31.2%, p = 0.004), and a significantly greater change in VAS at 1 year (p = 0.001), compared to those who did not receive injections. On multivariate logistic regression analysis, no factors appeared to have a significant effect on these findings.</p><p><strong>Conclusion: </strong>PRP injections into the olfactory cleft now have long-term data suggesting benefit in both subjective and psychophysical measures of smell, and improvements in both realms at 1 year are significantly higher than in those who do not receive the injections.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinus Microbial Communities in Patients With Chronic Rhinosinusitis are Unpredictable Over Time.","authors":"Tary Yin, Brett Wagner Mackenzie, Fiona Radcliff, David Broderick, Kristi Biswas, Richard Douglas","doi":"10.1002/alr.23506","DOIUrl":"https://doi.org/10.1002/alr.23506","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}