International Forum of Allergy & Rhinology最新文献

{"title":"Letter to the Editor Regarding \"Do Skin Prick Tests Predict Nasal Provocation Test Outcomes in Allergic Rhinitis Patients?\"","authors":"Xu Li, Mingxia Gao, Tingting Gao, Peng Jin, Lili Zhi","doi":"10.1002/alr.70030","DOIUrl":"https://doi.org/10.1002/alr.70030","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Li et al.'s Letter to the Editor Regarding \"Do Skin Prick Tests Predict Nasal Provocation Test Outcomes in Allergic Rhinitis Patients?\"","authors":"Yunhyung Lee, Marn Joon Park","doi":"10.1002/alr.70029","DOIUrl":"10.1002/alr.70029","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Venous Sinus Stenosis in Spontaneous Cerebrospinal Fluid Leak and the Role for Venous Sinus Stenting: A Systematic Review and Meta-Analysis","authors":"Jenny B. Xiao,&nbsp;Carlos Khalil,&nbsp;Helen Hsiao,&nbsp;Janiss Skulsampaopol,&nbsp;Daniel J. Lee,&nbsp;Michael D. Cusimano,&nbsp;John M. Lee","doi":"10.1002/alr.70026","DOIUrl":"10.1002/alr.70026","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Given the association between spontaneous cerebrospinal fluid (sCSF) leak and idiopathic intracranial hypertension (IIH), and the association of IIH and venous sinus stenosis (VSS), we sought to determine the prevalence of VSS in sCSF leak and the role of venous sinus stenting for sCSF leak.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A protocol was registered in PROSPERO [CRD42024568270]. A search was conducted in four electronic databases: Medline (Ovid), Embase, CINAHL, Web of Science, and Cochrane CENTRAL. Two reviewers independently screened citations and extracted data. Methodological quality was assessed using the Joanna Briggs Institute's critical appraisal tool. Data were pooled using a random effects model to calculate overall prevalence and relative risk (RR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifteen studies met the final inclusion criteria, with a total of 372 patients presenting with sCSF leak. The pooled prevalence of VSS in patients with sCSF leak was 0.71 (95% CI: 0.56–0.83, <i>I</i>² = 74%). VSS was three-fold greater in patients with sCSF leak compared to those without, although this was not statistically significant (RR = 3.11; 95% CI: 0.64–15.27, <i>I</i>² = 87%). Ninety percent of patients with VSS who underwent venous sinus stenting as adjunctive therapy to surgical repair of sCSF leak or for medically refractive IIH demonstrated resolution of symptoms without sCSF leak recurrence at last follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>VSS is common in patients with sCSF leak, and adjunctive venous sinus stenting after surgical leak repair may benefit a subset of patients. Further studies are needed to clarify the role of venous sinus stenting in conjunction with surgical repair of leaks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 10","pages":"1136-1151"},"PeriodicalIF":6.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Nasal Septal Deviation and Recurrent Epistaxis in Adults.","authors":"Sairisheel Gabbi Reddy, Ruifeng Cui, Armen Aprahamian, Andrew Seman, Camron Latterner, Hassan H Ramadan, Chadi A Makary","doi":"10.1002/alr.70025","DOIUrl":"https://doi.org/10.1002/alr.70025","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6-Month Trial\".","authors":"Yi Deng, Ping Lv","doi":"10.1002/alr.70023","DOIUrl":"https://doi.org/10.1002/alr.70023","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor Regarding: \"Assessing Adequacy of Surgical Extent in CRSwNP: The Completion of Surgery Index (CoSI)\".","authors":"Alan Workman, James N Palmer","doi":"10.1002/alr.23601","DOIUrl":"https://doi.org/10.1002/alr.23601","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23601"},"PeriodicalIF":6.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle Turbinate Resection May Lead to Nasal Septal Polyp Formation in Allergic Patients","authors":"John M. DelGaudio","doi":"10.1002/alr.70016","DOIUrl":"10.1002/alr.70016","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 10","pages":"1178-1180"},"PeriodicalIF":6.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision-Guided Surgical Navigation Using Computer Vision for Dynamic Intraoperative Imaging Updates.","authors":"Jeremy Ruthberg, Nicole Gunderson, Pengcheng Chen, Graham Harris, Hannah Case, Randall Bly, Eric J Seibel, Waleed M Abuzeid","doi":"10.1002/alr.70000","DOIUrl":"https://doi.org/10.1002/alr.70000","url":null,"abstract":"<p><strong>Background: </strong>Residual disease after endoscopic sinus surgery (ESS) contributes to poor outcomes and revision surgery. Image-guided surgery systems cannot dynamically reflect intraoperative changes. We propose a sensorless, video-based method for intraoperative CT updating using neural radiance fields (NeRF), a deep learning algorithm used to create 3D surgical field reconstructions.</p><p><strong>Methods: </strong>Bilateral ESS was performed on three 3D-printed models (n = 6 sides). Postoperative endoscopic videos were processed through a custom NeRF pipeline to generate 3D reconstructions, which were co-registered to preoperative CT scans. Digitally updated CT models were created through algorithmic subtraction of resected regions, then volumetrically segmented, and compared to ground-truth postoperative CT. Accuracy was assessed using Hausdorff distance (surface alignment), Dice similarity coefficient (DSC) (volumetric overlap), and Bland‒Altman analysis (BAA) (statistical agreement).</p><p><strong>Results: </strong>Comparison of the updated CT and the ground-truth postoperative CT indicated an average Hausdorff distance of 0.27 ± 0.076 mm and a 95th percentile Hausdorff distance of 0.82 ± 0.165 mm, indicating sub-millimeter surface alignment. The DSC was 0.93 ± 0.012 with values >0.9 suggestive of excellent spatial overlap. BAA indicated modest underestimation of volume on the updated CT versus ground-truth CT with a mean difference in volumes of 0.40 cm³ with 95% limits of agreement of 0.04‒0.76 cm³ indicating that all samples fell within acceptable bounds of variability.</p><p><strong>Conclusions: </strong>Computer vision can enable dynamic intraoperative imaging by generating highly accurate CT updates from monocular endoscopic video without external tracking. By directly visualizing resection progress, this software-driven tool has the potential to enhance surgical completeness in ESS for next-generation navigation platforms.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation of a Multivariable Diagnostic Prediction Model for Acute Invasive Fungal Rhinosinusitis in Tertiary Care Settings.","authors":"Aviv Spillinger, Johanna Ellefson, Qiuyu Yang, Linda X Yin, Janalee K Stokken, Thomas Pasic, Ian J Koszewski, Sandra Y Lin","doi":"10.1002/alr.70024","DOIUrl":"https://doi.org/10.1002/alr.70024","url":null,"abstract":"<p><strong>Background: </strong>Prompt detection and intervention are crucial for improving outcomes in acute invasive fungal rhinosinusitis (AIFS). Diagnostic prediction models assist in risk-stratification, but their accuracy requires testing through external validation. This study aims to validate a previously published diagnostic prediction model for AIFS in an independent cohort.</p><p><strong>Methods: </strong>A retrospective chart review was conducted at a tertiary care center (2008-2023) to identify patients with an otolaryngology consult for suspected AIFS. Of 65 patients identified, 11 (16.9%) were diagnosed with AIFS based on histopathology. Risk was calculated using Yin et al.'s predictive model. Predictive performance was assessed by calibration and discrimination.</p><p><strong>Results: </strong>Patients had significantly higher rates of diabetes (46.2% vs. 26.1%, p = 0.002), long-term steroid use (60% vs. 28.2%, p < 0.0001), and solid organ transplantation (38.5% vs. 8.5%, p < 0.001), compared with the development cohort, with conversely lower rates of hematologic malignancy (29.2% vs. 58.7, p < 0.001) and neutropenia (19.4% vs. 41%, p = 0.001). Despite these differences, both the three-variable (C-index: 0.844; 95% CI, 0.736-0.952) and four-variable models (C-index: 0.963; 95% CI, 0.919-1) showed adequate discrimination. Both models exhibited slight overprediction of risk, with a calibration-in-the-large predicted risk of 24.1% (95% CI, 13.68-34.46) for the three-variable model and 24.2% (95% CI, 13.76-34.57) for the four-variable model. Calibration plots confirmed overprediction.</p><p><strong>Conclusion: </strong>The AIFS diagnostic model demonstrates acceptable discrimination and calibration on external validation, with generalizability to patients with different comorbidities. Larger studies are recommended to further test the model's predictive performance and clinical applicability.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Compartment Atopic Disease: Analysis of Current Literature and Proposal of Diagnostic Criteria","authors":"Emily M. Barrow,&nbsp;Sarah K. Wise,&nbsp;Anthony Botros,&nbsp;Richard J. Harvey,&nbsp;Thomas S. Edwards,&nbsp;John DelGaudio","doi":"10.1002/alr.70012","DOIUrl":"10.1002/alr.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Central compartment atopic disease (CCAD) is a nasal inflammatory condition associated with allergy and categorized as type 2 dominant chronic rhinosinusitis with nasal polyps (CRSwNP). Sinus opacification in this condition is secondary to obstruction from central tissue remodeling. Although the literature supports a unique phenotype of CCAD, controversy persists due to variations in published studies. Standardized diagnostic criteria for CCAD are lacking. The current literature was systematically evaluated to propose a set of diagnostic criteria for CCAD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature review on CCAD was performed. Using current knowledge as the foundation, diagnostic criteria for CCAD are proposed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Tissue remodeling of the central part of the nasal and sinus cavity in a patient with features of an IgE mediated allergic process is the cornerstone of CCAD. It is a type 2 dominant endotype with an eosinophilic inflammatory profile. While CCAD is represented by unique phenotypic and endotypic features, there are likely geographic variations in CCAD presentation, especially when comparing CCAD to other subtypes of CRS. Previous lack of clear diagnostic criteria for CCAD has likely contributed to conflicting findings in the published literature on CCAD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Endoscopic confirmation of polypoid changes of central compartment structures (middle/superior turbinate, and/or posterosuperior nasal septum) is critical to the diagnosis of CCAD. Allergic history strongly supports CCAD diagnosis. While CCAD may display some unique radiologic features, radiology alone is insufficient to diagnose CCAD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 10","pages":"1113-1135"},"PeriodicalIF":6.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}