International Forum of Allergy & Rhinology最新文献

{"title":"Identification of Serum Inflammatory Markers in House Dust Mite-Induced Allergic Rhinitis Using the Olink Proteomics.","authors":"Xiaoxue Gong, Xinliang Zheng, Jiaqi Shen, Mohan Yan, Qianmin Feng, Chan Ding, Shuanghua Xie, Huadong Xu","doi":"10.1002/alr.23605","DOIUrl":"https://doi.org/10.1002/alr.23605","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23605"},"PeriodicalIF":7.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence Supports Single Intraoperative Application of Hyaluronic Acid-Containing Gel or Nasal Pack After Endoscopic Sinus Surgery","authors":"Esther Yanxin Gao, Benjamin Kye Jyn Tan, Andy Jian Kai Chua","doi":"10.1002/alr.23609","DOIUrl":"10.1002/alr.23609","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":"669-670"},"PeriodicalIF":7.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgeon Case Volume Impacts Revision Rate of Endoscopic Sinus Surgery.","authors":"Daniel J Lee, Chungah Kim, Mauz Asghar, John M Lee, Jasmin Kantarevic, Lyn M Sibley, Yvonne Chan","doi":"10.1002/alr.23602","DOIUrl":"https://doi.org/10.1002/alr.23602","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have demonstrated a positive relationship between surgeon volume and patient outcomes. While this relationship has been established in oncologic, bariatric, and orthopedic surgeries, little is known in the realm of endoscopic sinus surgery (ESS). The objective was to assess the association between a surgeon's ESS annual volume and rates of revision surgery within 5 years as well as 30-day complications for patients with chronic rhinosinusitis (CRS).</p><p><strong>Methods: </strong>We identified CRS patients in Ontario, Canada, who underwent primary ESS, using surgeon-level administrative data between 2014 and 2018 (N = 13,562). Surgeon volume was calculated based on the number of procedures performed in the previous year by the surgeon and was divided into quartiles. We identified those who underwent revision ESS within the subsequent 5-year period. Complications were defined as unplanned hospital admission or emergency department visit within the first 30 days following the operation. A multivariate regression model was used to estimate the effect of surgeon volume on revision rate.</p><p><strong>Results: </strong>An unadjusted model demonstrated that high surgeon volume quartile (> 63/year) was associated with lower rates of revision surgery and 30-day hospitalization (p < 0.05 for both) along with a higher rate of complete ESS (p < 0.001). After controlling for patient/surgeon covariates and extent of ESS, low-volume surgeons (1-17/year) remained an independent statistically significant predictor of revision surgery (hazard ratios [HR]: 1.60, 95% confidence interval [CI]: 1.17-2.19).</p><p><strong>Conclusion: </strong>Our study is the first to demonstrate a surgeon volume-outcome relationship in ESS. Being a high-volume surgeon is predictive of a lower revision rate in CRS patients undergoing ESS.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e3602"},"PeriodicalIF":7.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop","authors":"Lauren T. Roland,&nbsp;Cecelia Damask,&nbsp;Amber U. Luong,&nbsp;Antoine Azar,&nbsp;Charles S. Ebert Jr.,&nbsp;Thomas Edwards,&nbsp;Katherine N. Cahill,&nbsp;Do-Yeon Cho,&nbsp;David Corry,&nbsp;Tara L. Croston,&nbsp;Alexandra F. Freeman,&nbsp;Amin Javer,&nbsp;Paneez Khoury,&nbsp;Jean Kim,&nbsp;Michael Koval,&nbsp;Edward D. McCoul,&nbsp;James W. Mims,&nbsp;Anju Peters,&nbsp;Jay F. Piccirillo,&nbsp;Richard P. Ramonell,&nbsp;Amali Samarasinghe,&nbsp;Robert P. Schleimer,&nbsp;Prestina Smith-Davidson,&nbsp;Andrej Spec,&nbsp;Michael E. Wechsler,&nbsp;Sarah K. Wise,&nbsp;Joshua M. Levy","doi":"10.1002/alr.23582","DOIUrl":"10.1002/alr.23582","url":null,"abstract":"<div>\u0000 \u0000 <p>Allergic fungal rhinosinusitis (AFRS) is a unique endotype of chronic rhinosinusitis with nasal polyps (CRSwNP). Despite high recurrence rates and often more severe presenting signs compared with other subtypes of CRSwNP, research dedicated to AFRS has been lacking. Diagnostic criteria are outdated, the mechanistic relationship of AFRS to other associated diseases is unclear, and the pathophysiology of disease and risk factors for recurrence have not been well studied. In December 2023, a multidisciplinary group of rhinologists, otolaryngologists, pulmonologists, allergists, immunologists, scientists, and infectious disease experts met at the National Institute of Health to discuss unmet needs for future AFRS research and care, including patient management, diagnostic criteria, severity, pathophysiology, and related conditions. A summary of these clinical and associated research discussions is included below.</p>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":"626-641"},"PeriodicalIF":7.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of the LOEM Classification in Chronic Rhinosinusitis Management: A Retrospective Analysis of Surgical Outcomes.","authors":"Daniel Martin-Jimenez, Meritxell Clari-Comes, Miriam Gonzalez-Garcia, Juan Maza-Solano, Jaime Gonzalez-Garcia, Alfonso Del Cuvillo, Ramon Moreno-Luna, Serafin Sanchez-Gomez","doi":"10.1002/alr.23594","DOIUrl":"https://doi.org/10.1002/alr.23594","url":null,"abstract":"<p><strong>Background: </strong>The lack of a standardized framework for defining endoscopic sinus surgery (ESS) in chronic rhinosinusitis (CRS) has led to ambiguity and inconsistency in surgical descriptions. This study evaluates the recently described lamella ostium extent mucosa (LOEM) classification's usefulness, aiming to solidify its role in enhancing clinical decision-making and the reproducibility of surgical studies.</p><p><strong>Methods: </strong>A nonrandomized retrospective study compared CRS patients who underwent ESS, categorized into four groups based on LOEM. Baseline characteristics, disease severity, and QoL were compared at baseline and 2 years postsurgery. Predictors of clinically meaningful improvements in QoL were assessed using linear and logistic regression models, analyzing changes in the Sinonasal Outcome Test (SNOT)-22. Additionally, a subgroup analysis evaluated QoL outcomes specific to different clinical phenotypes and the ESS type (t) performed.</p><p><strong>Results: </strong>305 patients were analyzed, with significant baseline differences across ESS groups, showing increasing disease severity and comorbidities from t1 to t4 surgeries. The t4 ESS showed the greatest postoperative improvements in SNOT-22, nasal polyp score, and Lund Mackay scale. Multivariate regression confirmed t4 ESS as a significant predictor of greater QoL improvements and higher responder rates (OR = 8.49, p = 0.036). Subgroup analyses found that prior ESS negatively impacted outcomes, while t4 ESS was more effective across CRS phenotypes, except in exclusive atopy, where t3 ESS proved superior.</p><p><strong>Conclusions: </strong>The LOEM classification correlates surgical complexity with disease burden. The t4 ESS demonstrated superior clinical outcomes, particularly in CRS patients with poorly controlled asthma, severe N-ERD, or several prior ESS. These findings underscore the importance of personalized surgical planning and the potential utility of the LOEM system in optimizing patient outcomes.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23594"},"PeriodicalIF":7.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Fungal Rhinosinusitis and Eosinophilic Chronic Rhinosinusitis Have Different Phenotypes in Japan.","authors":"Tsuguhisa Nakayama, Natsuki Inoue, Makoto Akutsu, Yasuhiro Tsunemi, Takashi Kashiwagi, Yoshinori Matsuwaki, Mamoru Yoshikawa","doi":"10.1002/alr.23597","DOIUrl":"https://doi.org/10.1002/alr.23597","url":null,"abstract":"<p><strong>Background: </strong>Allergic fungal rhinosinusitis (AFRS) is a subtype of chronic rhinosinusitis driven by Types 1 and 3 allergies to fungi. In Japan, it is relatively rare and characterized by prominent eosinophilic infiltration of the sinonasal mucosa, together with eosinophilic mucin containing scattered fungi in the sinus cavity. Eosinophilic chronic rhinosinusitis (eCRS) involves similar eosinophilic infiltration and shares some clinical features with AFRS. However, the clinical differences between eCRS and AFRS remain to be fully elucidated. The aim of this study was to clarify the phenotypes of eCRS and AFRS.</p><p><strong>Methods: </strong>This multicenter retrospective study enrolled patients with AFRS and eCRS and compared their clinical parameters. A cluster analysis was conducted to determine the phenotypes of the two diseases.</p><p><strong>Results: </strong>AFRS patients had a younger age of onset and exhibited milder computed tomography and nasal polyp scores than eCRS patients. Total IgE was significantly higher in AFRS patients than in eCRS patients, while mucosal eosinophil counts were similar. Olfactory disturbances were significantly less severe in AFRS patients compared with eCRS patients. The cluster analysis revealed three phenotypes for AFRS: one that was distinct and independent from eCRS, representing the more classically described AFRS patients, and more the other two that shared characteristics with eCRS.</p><p><strong>Conclusions: </strong>AFRS exhibits unique clinical features compared with eCRS. Cluster analysis identified three distinct AFRS phenotypes characterized by CT findings, eosinophilic inflammation, and specific IgE levels against inhaled antigens. These findings underscore the importance of differential diagnosis and personalized treatment strategies for AFRS and eCRS.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23597"},"PeriodicalIF":7.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital Decompression in the Biologic Era: Is There Still a Need for Surgery?","authors":"Daniel Gorelik, Zain Mehdi, Najm S Khan, Heli Majeethia, Masayoshi Takashima, Tracy Lu, Amina Malik, Omar G Ahmed","doi":"10.1002/alr.23603","DOIUrl":"https://doi.org/10.1002/alr.23603","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e3603"},"PeriodicalIF":7.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding “S100A9 Induces Tissue Remodeling of Human Nasal Epithelium in Chronic Rhinosinusitis With Nasal Polyp”","authors":"Yuqing Jiang,&nbsp;Chi Zhang,&nbsp;Xiande Ma,&nbsp;Hui Leng","doi":"10.1002/alr.23581","DOIUrl":"10.1002/alr.23581","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":"662-663"},"PeriodicalIF":7.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding: “Assessing Adequacy of Surgical Extent in CRSwNP: The Completion of Surgery Index (CoSI)”","authors":"Daniel Spielman","doi":"10.1002/alr.23598","DOIUrl":"10.1002/alr.23598","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":"664-665"},"PeriodicalIF":7.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding “Ambient Particulate Matter and Frequency of Outpatient Visits for Chronic Rhinosinusitis in the United States”","authors":"Hyun Jin Min","doi":"10.1002/alr.23600","DOIUrl":"10.1002/alr.23600","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":"666-667"},"PeriodicalIF":7.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}