International Forum of Allergy & Rhinology最新文献

{"title":"Letter to the Editor Regarding “Ambient Particulate Matter and Frequency of Outpatient Visits for Chronic Rhinosinusitis in the United States”","authors":"Hyun Jin Min","doi":"10.1002/alr.23600","DOIUrl":"10.1002/alr.23600","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":"666-667"},"PeriodicalIF":7.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Administered Taste Testing Without Water: Normative Data for the 53-Item Waterless Empirical Taste Test (WETT^®).","authors":"Richard L Doty, Ryan Sharetts, Shima T Moein","doi":"10.1002/alr.23587","DOIUrl":"https://doi.org/10.1002/alr.23587","url":null,"abstract":"<p><strong>Background: </strong>According to the National Health and Nutrition Examination Survey (NHANES), more than 20 million Americans suffer from chronic taste problems. Unfortunately, quantitative testing is rarely performed, self-reports are inaccurate, and \"taste\" is often confused with olfaction-dependent flavors. Clearly, a reliable, practical, and norm-based clinical taste test is sorely needed.</p><p><strong>Methods: </strong>The recently developed 53-item Waterless Empirical Taste Test (WETT^®) was self-administered by 1392 healthy subjects (493 men and 899 women) spanning the ages of 10-94. Normative percentile ranks were developed, and the influences of sex, age, COVID-19 infection history, and smoking behavior were evaluated using general linear models.</p><p><strong>Results: </strong>On average, WETT^® scores declined with age beginning in the 30s and were lower in men than in women (ps < 0.0001), with the sex difference most apparent between 40 and 70 years of age. Subtest scores for the five basic taste qualities followed similar age- and sex-related patterns. No influences of COVID-19 history were evident. Smokers had lower salty (NaCl) and bitter (caffeine) WETT^® scores than nonsmokers. The developed normative tables make it possible to determine a patient's absolute dysfunction score as well as a relative score based on age- and sex-related percentiles.</p><p><strong>Conclusion: </strong>This study provides normative data based on 1392 healthy subjects for interpreting a patient's performance on a reliable self-administered taste test that requires no liquid stimuli or rinses. Its findings support the view that both sex and age are significant determinants of taste function in the general population.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23587"},"PeriodicalIF":7.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Particulate Matter Exposure May Increase Risk of Chronic Rhinosinusitis WIth Nasal Polyposis: Results from an Exposure-Matched Study.","authors":"Rory J Lubner, Mason Krysinski, Ping Li, Rakesh K Chandra, Justin H Turner, Naweed I Chowdhury","doi":"10.1002/alr.23589","DOIUrl":"https://doi.org/10.1002/alr.23589","url":null,"abstract":"<p><strong>Background: </strong>Particulate matter ⩽2.5 µm in diameter (PM_2.5) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM_2.5 exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway. However, there are limited data comparing cytokine changes in CRS sinonasal tissue to non-CRS patients as it relates to PM_2.5 exposure. We hypothesized that long-term exposure preferentially increases the risk of manifesting CRS with nasal polyposis (CRSwNP).</p><p><strong>Methods: </strong>We performed a retrospective analysis of 376 patients (308 CRS, 68 controls) who underwent endoscopic sinus or skull base surgery. A spatiotemporal machine-learning model estimated daily PM_2.5 levels for 1 year prior to each patient's surgery date. Cytokines were quantified using a multiplex flow cytometric bead assay and compared to estimated PM_2.5 exposure using Spearman correlation and multivariate regression. Patients with high and low 12-month PM_2.5 exposures were matched across age, sex, income, and rurality using a nearest neighbor algorithm. Multivariate adjusted logistic regression was used to estimate the odds of CRS based on PM_2.5 exposure.</p><p><strong>Results: </strong>Reduced IL-10 levels were associated with higher PM_2.5 exposures in control patients (β = -0.735, p = 0.0196). In exposure-matched logistic regression analysis, high 12-month PM_2.5 exposure was an independent predictor of CRSwNP (β = 1.97, OR: 7.22, p = 0.0001) after adjustment for age, income, rurality, and comorbid asthma/allergic rhinitis. A similar relationship was not identified for CRSsNP.</p><p><strong>Conclusions: </strong>PM_2.5 exposure is associated with reduced IL-10 in control patients compared to CRS and may increase odds of CRSwNP development.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23589"},"PeriodicalIF":7.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silastic Septal Splints in the Management of Refractory Epistaxis in Hereditary Hemorrhagic Telangiectasia.","authors":"Avraham Adelman, Eunice Im, Brett Labella, Anil Patel, Nikita Chapurin, Christina Eagan, Ali Ataya, Marc Zumberg, Jennifer K Mulligan, Carl Atkinson, Brian C Lobo, Jeb M Justice","doi":"10.1002/alr.23584","DOIUrl":"https://doi.org/10.1002/alr.23584","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23584"},"PeriodicalIF":7.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Rhinosinusitis and Recalcitrant Disease in Liver Transplantation: What Have We Learned from This?","authors":"Hanwen Yang,&nbsp;Simeng Lei,&nbsp;Zhili JI","doi":"10.1002/alr.23592","DOIUrl":"10.1002/alr.23592","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 5","pages":"570-571"},"PeriodicalIF":7.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Discrepancy Between Skin Prick Test and Serum-Specific Immunoglobulin E Test Results.","authors":"Jayoung Oh, Jae-Chul Ahn, Yunhee Choi, Heung-Woo Park, Dong-Young Kim, Chae-Seo Rhee, Doo Hee Han","doi":"10.1002/alr.23588","DOIUrl":"https://doi.org/10.1002/alr.23588","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e3588"},"PeriodicalIF":7.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Mediator Profiles in the Unchallenged Sinonasal Mucus of Allergic Rhinitis Patients Set to Begin Allergen Immunotherapy.","authors":"Cameron P Worden, Adam M Speen, Meghan E Rebuli, Ilona Jaspers, Brian D Thorp, Cristine N Klatt-Cromwell, Brent A Senior, Adam J Kimple, Charles S Ebert","doi":"10.1002/alr.23583","DOIUrl":"https://doi.org/10.1002/alr.23583","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23583"},"PeriodicalIF":7.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency Ablation of Inferior Turbinates With Laser Posterior Nasal Nerve Neurolysis for the Treatment of Chronic Rhinitis","authors":"Yi-Li Hwang,&nbsp;Jyun-Yi Liao,&nbsp;Ying-Shuo Hsu,&nbsp;Ming-Shao Tsai,&nbsp;Ting-Yu Shih,&nbsp;Han-Lo Teng,&nbsp;Bor-Hwang Kang,&nbsp;Chien-Yu Huang","doi":"10.1002/alr.23580","DOIUrl":"10.1002/alr.23580","url":null,"abstract":"&lt;p&gt;Posterior nasal nerve neurolysis (PNNN) is a potential approach for treating chronic rhinitis among patients unresponsive to pharmacological therapy [&lt;span&gt;1&lt;/span&gt;]. However, the treatment response was not immediate. Studies by Lee and Takashima found a response rate of 67.5%–76.2% at 3 months and varied up to 80.6%–85.5% at 12 months [&lt;span&gt;2, 3&lt;/span&gt;]. These radiofrequency (RF) PNNN devices have also been patented and can only be legally used in the US; hence, other countries have been left with no effective modality to support the use of PNNN. Other modalities to perform PNNN include Krespi et al., who proposed using a diode laser to perform PNNN [&lt;span&gt;4&lt;/span&gt;], and Samy et al., who used RF ablation of the posterior end of the inferior turbinate to treat the peripheral branches of the posterior nasal nerve [&lt;span&gt;5&lt;/span&gt;] showed significant improvement in chronic rhinitis symptoms.&lt;/p&gt;&lt;p&gt;With this background, we hypothesized that combining radiofrequency ablation of inferior turbinates and intraturbinate segments of the posterior nasal nerve (RAPN) with laser PNNN (collectively abbreviated as RPN3) may improve short-term response rates and enhance symptom control.&lt;/p&gt;&lt;p&gt;The inclusion criteria were: age 18–65 years, chronic rhinitis refractory to medical treatment for &gt;6 months with at least 4 weeks of medical treatments, rTNSS ≥ 5, rhinorrhea ≥2, and congestion ≥2. The exclusion criteria were rhinosinusitis, difficult posterior nasal passage, concurrent other or previous nasal surgery in the nasal and oral area, and rhinitis medicamentosa.&lt;/p&gt;&lt;p&gt;RPN3 surgery was performed as day surgery under local anesthesia in the operating room. Septoplasty was not performed in all cases. First, RAPN was performed using an Olympus Celon Elite ESG-400 (Olympus Europa, Hamburg, Germany) at 15 W with a needle RF probe. RF was applied to the turbinate and ablated the head, middle and posterior aspect of the inferior turbinate, including the mulberry, and the superior, medial and inferior aspect of the posterior end of the turbinates, aiming to reduce the intraturbinate segment of the posterior nasal nerves, with 15–20 punctures on each turbinate. Second, laser PNNN was performed using a 2-W continuous wave laser with the AcuPulse CO&lt;sub&gt;2&lt;/sub&gt; laser (Lumenis Ltd., Yokne'am Illit, Israel) transmitted via a nasal probe with a straight-tip 90°mirror. Each side takes 2–3 min to complete the ablation. After the procedure, the inferior turbinate head was covered with Hemopatch (Baxter International, Deerfield, US) to prevent bleeding, which could be removed within 1 week and keeps the inferior meatus patent after removal.&lt;/p&gt;&lt;p&gt;Of the 54 enrolled in the study, 50 completed the 6-month follow-ups. The enrolled patient's characteristics, procedure information, and baseline rhinitis data are reported in Table 1.&lt;/p&gt;&lt;p&gt;Both rTNSS and NOSE scores showed significant post-surgical improvement. From baseline scores of 8.7 (95% CI, 8.2–9.2) and 61.6 (95% CI, 56.8–","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 5","pages":"565-567"},"PeriodicalIF":7.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Year Outcomes of Temperature-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve in Patients With Chronic Rhinitis.","authors":"J Pablo Stolovitzky, Randall A Ow, Stacey L Silvers, Bobby A Tajudeen, Chad M McDuffie, Marc Dean, Ahmad R Sedaghat, Katie Phillips, Masayoshi Takashima","doi":"10.1002/alr.23577","DOIUrl":"https://doi.org/10.1002/alr.23577","url":null,"abstract":"<p><strong>Background: </strong>Temperature-controlled radiofrequency (TCRF) ablation of the posterior nasal nerve has been shown to improve chronic rhinitis (CR) symptoms and quality of life (QoL). This study assesses the durability of TCRF's effectiveness and safety 3 years post-procedure in patients with perennial allergic CR and nonallergic CR.</p><p><strong>Methodology: </strong>This prospective, multicenter, single-blinded, randomized controlled trial included a sham control arm and long-term follow-up. Analysis combined patients from the active treatment and control crossover arms. Outcomes include reflective total nasal symptom score (rTNSS), postnasal drip (PND), and cough scores, as well as QoL measured by the Mini Rhinoconjunctivitis Quality-of-Life Questionnaire (MiniRQLQ).</p><p><strong>Results: </strong>Of 104 patients who underwent TCRF, 59 participated in the 3-year follow-up. The baseline mean rTNSS was 8.2 (95% confidence interval [95% CI, 7.9-8.6]), reduced to 3.5 (95% CI, 2.9-4.1) at 3 years, a 57.3% reduction and mean change of -4.7 (95% CI, -5.3 to -4.1; p < 0.0001). Most patients (79.7%) were responders. Cough scores decreased from a mean baseline of 1.5 (95% CI, 1.3-1.7) to 0.7 (95% CI, 0.5-0.9; mean change, -0.8; p < 0.0001). PND symptoms were also reduced from 2.5 (95% CI, 2.4 - 2.7) to 1.4 (95% CI, 1.2-1.7; mean change, -1.1; p < 0.0001). No severe adverse events were reported throughout the study, and no adverse events were reported between 24 months and 36 months of follow-up.</p><p><strong>Conclusion: </strong>TCRF ablation of the posterior nasal nerve provided sustained safety and improvement in CR symptoms, cough, postnasal drip, and patient-reported QoL at 3 years, supporting its long-term safety and efficacy in CR.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23577"},"PeriodicalIF":7.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor Regarding “Readability of Rhinology-Related Patient Education Materials Generated by Artificial Intelligence-Based Chatbots”","authors":"Amani Kais,&nbsp;John Nguyen,&nbsp;Hassan H Ramadan,&nbsp;Ruifeng Cui,&nbsp;Chadi A. Makary","doi":"10.1002/alr.23586","DOIUrl":"10.1002/alr.23586","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 5","pages":"572"},"PeriodicalIF":7.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}