International Forum of Allergy & Rhinology最新文献

{"title":"Correction to “Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites”","authors":"","doi":"10.1002/alr.23465","DOIUrl":"10.1002/alr.23465","url":null,"abstract":"<p>Murao T, Kouzaki H, Arai H, et al. Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites. <i>Int Forum Allergy Rhinol</i>. 2024;14:57−67. doi:10.1002/alr.23221</p><p>In the article cited above, the authors have determined that the legends for Figures 3 and 5 had incorrect parts, some methods were omitted in the online supplementary materials, and one reference was cited incorrectly.</p><p>The corrected figure legends appear below; the online supplementary materials have been revised and published online.</p><p>DISCUSSION</p><p>Page 64, right column, second paragraph, line 6: Yao et al.<sup>18</sup> reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.<sup>21</sup></p><p>Should be changed to: Yao et al.<sup>21</sup> reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.<sup>21</sup></p><p>Page 64, right column, second paragraph, line 14: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.<sup>18</sup></p><p>Should be changed to: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.<sup>21</sup></p><p><b>Figure legend 3</b></p><p>Serum concentrations of house dust mite (HDM)–specific IgA, IgE, and IgG4 antibodies. (A) Prior to treatment, the serum concentrations of HDM-specific IgE were significantly higher in patients with allergic rhinitis (AR) than in healthy controls (HCs; HC: 0.08 ± 0.01 optimal density [OD] value, AR: 0.99 ± 0.08 OD value), while no significant difference was detected in serum concentrations of HDM-specific IgA (HC: 0.68 ± 0.05 OD value, AR: 0.69 ± 0.04 OD value) and HDM-specific IgG4 (HC: 1.17 ± 0.14 OD value, AR: 1.31 ± 0.15 OD value). (B) Changes in serum concentrations of HDM-specific IgA, IgE, and IgG4 in patients with AR before and after sublingual immunotherapy (SLIT). Serum concentrations of HDM-specific IgA and IgG4 were significantly increased after 1 year of SLIT; those of HDM-specific IgE did not change significantly after SLIT. Comparisons of data from two independent groups were performed using a two-tailed Mann–Whitney <i>U-</i>test. Paired data were analyzed by the Wilcoxon signed rank test. **<i>p </i>< 0.01, *<i>p </i>< 0.05; ns, not significant. Where indicated, values are provided as mean ± standard error of the mean.</p><p><b>Figure legend 5</b></p><p>(A) Total nasal ocular symptom score (TNOSS) and visual analog scale (VAS) scores in patients with allergic rhinitis (AR) before and after sublingual immunotherapy (SLIT). Both symptom scores were significantly improved after 1 year of SLIT. (B) Correlation between the improvements in TNOSS and VAS scores, and the prevalence of cluster of differentiation 4 (CD4)+ T-cell subse","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 11","pages":"1838-1839"},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-derived organoid model of olfactory ensheathing cell tumor.","authors":"John B Finlay, Ralph Abi Hachem, Patrick Codd, Bradley J Goldstein","doi":"10.1002/alr.23464","DOIUrl":"https://doi.org/10.1002/alr.23464","url":null,"abstract":"<p><strong>Key points: </strong>We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of allergen immunotherapy in patients with central compartment atopic disease post-surgery.","authors":"Christian M Meerwein, Peta-Lee Sacks, Jacqueline Ho, Christine Choy, Larry Kalish, Raewyn G Campbell, Ray R Sacks, Richard J Harvey","doi":"10.1002/alr.23459","DOIUrl":"https://doi.org/10.1002/alr.23459","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effect of allergen immunotherapy (AIT) on patients with central compartment atopic disease (CCAD) and house dust mite (HDM) sensitization post-surgery.</p><p><strong>Methods: </strong>A retrospective cohort of surgically treated, HDM-sensitized CRSwNP patients phenotyped as CCAD was assessed. Patients were divided into two groups based on whether they had AIT commenced as part of their surgical care. All AIT patients started immunotherapy prior to their surgery. The primary endpoint was reformation of middle turbinate (MT) edema 12 months postsurgery. Secondary endpoints were corticosteroid irrigation use (<4 times/week vs. ≥4 times/week, %) and the rhinologic domain of the 22-item sino-nasal outcome test (SNOT-22). Demographic characteristics, concomitant asthma, smoking status, history of aspirin-exacerbated respiratory disease, conjunctival symptoms, polysensitization, serum eosinophils (cell × 10⁹/L), tissue eosinophilia (% > 100/HPF), and serum IgE (kU/L) were also recorded.</p><p><strong>Results: </strong>Eighty-six CCAD patients were assessed (41 ± 14 yrs, 64% female). AIT was applied in 37% (n = 32). Baseline features were similar apart from greater conjunctival symptoms (72 vs. 45%, p = 0.02) in the AIT group. At 12 months post-surgery, the AIT group has less MT edema (% ≥ diffuse 15.6 vs. 52.9, p < 0.01). Patients on AIT also had less pharmacotherapy requirements at 12 months (% ≥ 4/week, 37.5 vs. 79.6%, p < 0.01). The rhinologic symptoms were similar (21.1 ± 17.1 vs. 20.1 ± 21.6, p = 0.83).</p><p><strong>Conclusions: </strong>Surgery and pharmacotherapy are effective in managing CCAD, but the addition of AIT improved allergic phenomenon and allowed de-escalation of topical therapy. Longer term studies are required to demonstrate further immunomodulation.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time is money: An analysis of cost drivers in ambulatory sinus surgery.","authors":"David K Lerner, Chau Phung, Alan D Workman, Saawan Patel, Glenn Pennington, Robert Stetson, Jennifer E Douglas, Michael A Kohanski, James N Palmer, Nithin D Adappa","doi":"10.1002/alr.23455","DOIUrl":"https://doi.org/10.1002/alr.23455","url":null,"abstract":"<p><strong>Background: </strong>Functional endoscopic sinus surgery (FESS) is one of the most commonly performed otolaryngologic procedures and is associated with significant cost variability.</p><p><strong>Methods: </strong>We performed a retrospective analysis of all inflammatory sinus surgeries at a single tertiary care medical center from July 2021 to July 2023. The electronic medical record was reviewed for patient factors and cost variables for each procedure, and multivariable analysis was performed.</p><p><strong>Results: </strong>A total of 221 patients were included in analysis with a mean age of 48.2 years. There was a 44.8% incidence (n = 99) of nasal polyps and 31.2% (n = 69) of cases were revision surgeries. The average total cost for the surgical encounter was $8960.31 (standard deviation $1967.97). Operating room time represented $4912.46 (54.8% of all costs), while average operating room supply costs were $1296.06 (14.5%) and recovery room costs were $919.48 (10.3%). Total costs were significantly associated with length of surgery ($7.83/min, p = 0.04), in addition to presence of nasal polyps ($531.96, p = 0.04). There was no significant association between total costs and the remaining clinical and demographic factors.</p><p><strong>Conclusions: </strong>Costs associated with ambulatory FESS for inflammatory sinus disease vary across patients and this cost variability is predominantly driven by time efficiency within the operating room, as well as supply utilization and nasal polyposis to a lesser degree. As a result, operating room efficiency represents a primary target for cost-related interventions. Additionally, our data provide a framework for surgeons and hospitals to make evidence-based decisions on intraoperative equipment in a tradeoff between efficiency and supply costs. Our findings indicate that an approach focused on streamlining efficiency across the entire ambulatory surgery encounter will have the greatest impact on reducing healthcare expenses for both the patient and the health system.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time augmentation of diagnostic nasal endoscopy video using AI-enabled edge computing.","authors":"Jonathan Bidwell, Dipesh Gyawali, Jonathan Morse, Vinayak Ganeshan, Thinh Nguyen, Edward D McCoul","doi":"10.1002/alr.23458","DOIUrl":"https://doi.org/10.1002/alr.23458","url":null,"abstract":"<p><strong>Key points: </strong>AI-enabled augmentation of nasal endoscopy video images is feasible in the clinical setting. Edge computing hardware can interface with existing nasal endoscopy equipment. Real-time AI performance can achieve an acceptable balance of accuracy and efficiency.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence for article titled “The relationship between survey-based subjective olfactory awareness and objective olfactory function”","authors":"Hyun Jin Min MD,PhD","doi":"10.1002/alr.23456","DOIUrl":"10.1002/alr.23456","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 10","pages":"1673-1674"},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cost utility analysis for the management of acute exacerbations of chronic rhinosinusitis.","authors":"Matthew M Chu, Jack T Garcia, Ahmad R Sedaghat, George A Scangas, Katie M Phillips","doi":"10.1002/alr.23452","DOIUrl":"https://doi.org/10.1002/alr.23452","url":null,"abstract":"<p><strong>Background: </strong>The management of acute exacerbations of chronic rhinosinusitis (AECRS) is understudied and the most cost-effective management of AECRS has not been previously investigated. The aim of this study is to determine the most cost-effective strategy for the initial management of AECRS.</p><p><strong>Methods: </strong>The study design consisted of a decision-tree economic model comparing three different initial strategies for managing a patient perceived AECRS: observation, upfront rescue medications, or clinic visit with diagnostic nasal endoscopy (DNE). The primary study outcome was the disease burden of a single AECRS, which was determined by the health utility value and the duration of symptoms. Strategies with an incremental cost-effectiveness ratio < $50,000/quality-adjusted life year (QALY) or equivalently < $137/quality-adjusted life day (QALD) were considered cost-effective.</p><p><strong>Results: </strong>Observation was the most cost-effective strategy at a willingness to pay of $137 per QALD. One-way sensitivity analysis demonstrated that observation was more effective than upfront rescue medications when the probability of bacterial infection as the cause of AECRS was <24.0%. Upfront rescue medications wer more cost effective than observation when the probability of bacterial infection exceeded 49.0%. Clinic visit with DNE was the most effective strategy to manage an AECRS, but it was not considered cost-effective.</p><p><strong>Conclusion: </strong>Observation is the most cost-effective strategy for the initial management of AECRS when there is a low likelihood of bacterial infection. When the probability of bacterial etiology of AECRS exceeds 49.0%, upfront rescue medications proved to be the most cost-effective strategy.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative characterization of eosinophilia in nasal polyps with AI-based single cell classification.","authors":"Martin Stampe, Ida Skovgaard Christiansen, Vibeke Backer, Kasper Aanæs, Anne-Sophie Homøe, Jens Tidemandsen, Emilie Neumann Nielsen, Sigrid Louise Hjorth Rasmussen, Rasmus Hartvig, Katalin Kiss, Thomas Hartvig Lindkær Jensen","doi":"10.1002/alr.23454","DOIUrl":"https://doi.org/10.1002/alr.23454","url":null,"abstract":"<p><strong>Key points: </strong>Eosinophilic granulocytes have characteristic morphological features. This makes them prime candidates for utilization of a single cell binary classification network. Single cell binary classification networks can reliably help quantify eosinophils in nasal polyps.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to correspondence regarding the article “The relationship between survey-based subjective olfactory awareness and objective olfactory function”","authors":"Aurelia S. Monk BA,&nbsp;Shreyas Pyati BS,&nbsp;Meredith Lamb DO,&nbsp;Nicholas Melott MS,&nbsp;Ezer H. Benaim MD,&nbsp;Christopher Wiesen PhD,&nbsp;Cristine Klatt-Cromwell MD,&nbsp;Brian D. Thorp MD,&nbsp;Charles S. Ebert Jr. MD,&nbsp;Adam J. Kimple MD, PhD,&nbsp;Brent A. Senior MD","doi":"10.1002/alr.23457","DOIUrl":"10.1002/alr.23457","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 10","pages":"1676-1677"},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatic adverse events associated with biologic therapy for chronic rhinosinusitis: A systematic review and meta-analysis","authors":"Jenny B. Xiao HBSc, MSc,&nbsp;Helen Hsiao BSc,&nbsp;Carlos Khalil MD,&nbsp;John M. Lee MD, FRCSC, MSc","doi":"10.1002/alr.23453","DOIUrl":"10.1002/alr.23453","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Biologic therapies approved for treating chronic rhinosinusitis with nasal polyps (CRSwNP) have well-established safety profiles but reports of rheumatic adverse events (AEs) are increasing and not well defined. This review aims to assess the risk and incidence of rheumatic AEs associated with biologic therapy in CRSwNP and summarize current reported management strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A protocol was registered in PROSPERO [CRD42024525663]. A search was conducted in four electronic databases: Medline (Ovid), Embase, Scopus, and Cochrane CENTRAL from inception until January 4, 2024. Two reviewers independently screened citations and extracted data. Methodological quality was assessed using the Joanna Briggs Institute's critical appraisal tool. Data were pooled using a random effects model to calculate overall incidence and relative risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-one studies met the final inclusion criteria, totaling 3434 patients of which 2763 (80%) received either dupilumab (<i>n</i> = 2257; 82%), mepolizumab (<i>n</i> = 372; 13%), or omalizumab (<i>n</i> = 134; 5%) for treatment of CRSwNP. The overall incidence rate for any on-treatment rheumatic AE was 0.05 per person–year (95% CI, 0.03–0.09, <i>I</i>²= 75%). Biologic therapy increased the risk of developing a rheumatic AE (RR = 2.53; 95% CI, 1.29–4.94) compared with placebo. The most frequently reported rheumatic AE was arthralgia or joint pain (<i>n</i> = 94; 95%), followed by lupus-like syndrome or lupus erythematosus-like reaction (<i>n</i> = 2; 2.5%). Discontinuation of treatment was the most common intervention (<i>n</i> = 21, 39%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Biologic therapy increases the risk of rheumatic AEs in CRSwNP patients by over twofold. Healthcare providers should remain vigilant in monitoring rheumatic AEs and apply appropriate management strategies on a case-by-case basis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 10","pages":"1618-1633"},"PeriodicalIF":7.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}