International Forum of Allergy & Rhinology最新文献

{"title":"Comment on \"Effect of Budesonide Nasal Irrigation in Patients With Chronic Rhinosinusitis With Nasal Polyps Without Prior Sinus Surgery: A Randomized, Double-Blind, Placebo-Controlled Study\".","authors":"Maajid Mohi Ud Din Malik, Abhay Saraf","doi":"10.1002/alr.70268","DOIUrl":"10.1002/alr.70268","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"1238-1239"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Sinonasal Complications After Frontal Sinus Setback in Facial Feminization Surgery: A Retrospective Case Series From a Single Tertiary Care Center.","authors":"Omer Baker, Clifford He, Claire Perrin, Vivienne Li, Vanessa Ho, Farhoud Faraji, Carol H Yan, Amanda A Gosman, Adam S DeConde","doi":"10.1002/alr.70242","DOIUrl":"10.1002/alr.70242","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"1229-1234"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Brushing Transcriptomics Reveals Candidate Biomarkers of Glucocorticoid Treatment Response in Allergic Rhinitis.","authors":"Tianjian Xie, Pei Gao, Ziyi Long, Bingyue Huo, Xiangning Cheng, Qianxue Hu, Lijun Du, Bo Liu, Yuzhe Hao, Shan Chen, Yuxuan Liu, Yue Zhou, Jianjun Chen","doi":"10.1002/alr.70251","DOIUrl":"10.1002/alr.70251","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"1225-1228"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Screening for Age-Related Olfactory Dysfunction Using the 4-Item Concise Aging Adults Smell Test.","authors":"Zachary M Soler, Daniel Giles, Mathew J Gregoski, Rodney J Schlosser","doi":"10.1002/alr.70231","DOIUrl":"10.1002/alr.70231","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"1221-1224"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Human Olfactory Epithelium Mirrors Adult Structure and Function in a Human Olfactory Organoid Model.","authors":"Randy Bach, Ankit Chauhan, Michael Xiang, Kang-Hoon Kim, James N Palmer, Nithin D Adappa, Michael A Kohanski, Noam A Cohen, Hong Wang, Jennifer E Douglas","doi":"10.1002/alr.70276","DOIUrl":"https://doi.org/10.1002/alr.70276","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the developmental differences in structure, gene expression, and function of human olfactory epithelium (OE) using pediatric and adult specimens and human olfactory organoids.</p><p><strong>Background: </strong>Olfactory dysfunction (OD) is characterized by loss or alterations in the sense of smell and has an age-related increase in prevalence. Murine models have demonstrated stable expression of olfactory receptors in the OE over time, pointing toward OE cell density as a potential driver of age-related OD. Developmental changes in human OE remain poorly characterized. Herein we assess the structure and function of human OE across the lifespan to better understand normal maturation and age-related degeneration.</p><p><strong>Methods: </strong>Superior turbinate biopsies from pediatric and adult subjects were obtained for the culture of three-dimensional olfactory organoids. Immunofluorescence (IF) and reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) were performed to confirm the structural make-up and gene expression of expected OE cell types. Live-cell calcium imaging was performed to assess organoid response to odorants, a surrogate of function.</p><p><strong>Results: </strong>IF confirmed that pediatric and adult organoids contain major OE cell populations (e.g., horizontal and globose basal cells, sustentacular cells, and immature and mature olfactory sensory neurons). There was no statistical difference in OE cell gene expression between pediatric and adult tissue. Calcium imaging demonstrated no significant difference in odorant-evoked responses (peak amplitude, area under the curve).</p><p><strong>Conclusion: </strong>Human OE appears structurally, transcriptionally, and functionally stable across the lifespan under the conditions assessed in this organoid model. Further research is needed to better understand age-related OD, which may stem from non-OE-derived changes.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of Otolaryngologists on Delayed Epistaxis Following Posterior Nasal Nerve Ablation.","authors":"Jacob Schwartz, Carter Smith, Jose Luis Mattos","doi":"10.1002/alr.70249","DOIUrl":"10.1002/alr.70249","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"1235-1237"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Comment on \"Intranasal Azelastine for Recurrent Acute Rhinosinusitis Prophylaxis: A Multicenter Retrospective Study\".","authors":"Akshay R Prabhakar, Roger Neuberger, Justina R Varghese, Miguel Quintanilla, William Marshall, Utkarsh Singh, Jake Hacker, Yixuan J Zheng, Samuel E Razmi, Ron L Moses, Chadi A Makary, Masayoshi Takashima, Omar G Ahmed","doi":"10.1002/alr.70281","DOIUrl":"https://doi.org/10.1002/alr.70281","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irreversible Electroporation for Inferior Turbinate Reduction Ablation in Adults.","authors":"Narin Nard Carmel Neiderman, Codrut Sarafoleanu, Ionut Tanase, Mihai Alexandru Pascu, Desiderio Passali, Ulugbek Saidakramovich Khasanov, Ulugbek Nuridinovich Vokhidov, Eugenijus Lesinskas, Marius Polianskis, Avraham Abergel","doi":"10.1002/alr.70282","DOIUrl":"https://doi.org/10.1002/alr.70282","url":null,"abstract":"<p><strong>Background: </strong>Inferior turbinate hypertrophy is a common cause of nasal airway obstruction. An optimal surgical approach should provide effective volume reduction while preserving mucosal integrity and minimizing postoperative morbidity.</p><p><strong>Objective: </strong>To evaluate the safety and efficacy of irreversible electroporation (IRE) for non-thermal ablation of inferior turbinate hypertrophy.</p><p><strong>Methods: </strong>This prospective, multi-center, single-arm study included adult patients with symptomatic nasal obstruction due to inferior turbinate hypertrophy refractory to medical therapy. All patients underwent IRE turbinate reduction using the ENTire system. Outcomes were assessed using the Nasal Obstruction Symptom Evaluation (NOSE), Nasal Obstruction Visual Analog Scale (NO-VAS), and the 22-item Sino-Nasal Outcome Test (SNOT-22) at baseline and at 1 week, 1 month, and 3 months. Postoperative pain and clinical healing were also evaluated.</p><p><strong>Results: </strong>Forty-eight patients completed the study. Significant improvement was observed across all outcome measures. The mean NOSE score decreased from 74.38 ± 13.39 to 11.25 ± 9.20, the NO-VAS score from 69.55 ± 19.48 to 12.51 ± 11.81, and the SNOT-22 score from 33.06 ± 24.18 to 7.48 ± 10.37 at 3 months (all p < 0.0001). Improvement was evident at 1 week and progressed through follow-up. Postoperative pain was low. No major complications occurred, and transient mucosal changes resolved by 3 months.</p><p><strong>Conclusion: </strong>IRE is a promising non-thermal, minimally invasive technique for inferior turbinate reduction, providing significant symptom improvement with low postoperative morbidity. Larger studies with longer follow-up are needed to confirm durability.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Intranasal Azelastine for Recurrent Acute Rhinosinusitis Prophylaxis: A Multicenter Retrospective Study\".","authors":"Ercan Yılmaz, Nezihe Köker Özer","doi":"10.1002/alr.70280","DOIUrl":"https://doi.org/10.1002/alr.70280","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory Function in Cystic Fibrosis: Outcome Measures, Olfactory Dysfunction Prevalence and the Impact of Management-A Systematic Review and Meta-Analysis.","authors":"Luca Cox, Kofi Cox, Katherine Whitcroft, Susanne Weise, Sonal Kansra, Eishaan Bhargava","doi":"10.1002/alr.70275","DOIUrl":"https://doi.org/10.1002/alr.70275","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Olfactory dysfunction (OD) is an increasingly recognized but under-investigated comorbidity of cystic fibrosis (CF). Its prevalence, assessment methods, and response to CF-directed treatment, including highly effective modulator therapy (HEMT) remains incompletely characterized.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a PRISMA 2020-compliant systematic review (PROSPERO: CRD420251060317) with a database search from inception to December 2025. Studies were eligible if they included participants with confirmed CF and reported an explicit olfactory outcome. Two reviewers independently screened titles and abstracts; full-text screening and Joanna Briggs Institute critical appraisal were initially completed by one reviewer, with a second-reviewer re-check of a random subset. Narrative synthesis was the primary method. An exploratory random-effects prevalence meta-analysis was pre-specified. Sensitivity analyses and exploratory meta-regression by OD case definition and assessment method, and adult/pediatric subgroup analysis were performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Twenty-nine publications representing 21 unique study populations were included, and 15 distinct assessment instruments were identified. Exploratory meta-analysis pooled OD prevalence (all assessment methods) was 51.9% (95% CI: 29.1-74.3%; PI 0.0%-100%; I&lt;sup&gt;2&lt;/sup&gt; = 98.2%). In the psychophysical-only sensitivity analysis, pooled prevalence was 58.6% (95% CI: 41.6-74.6%; I&lt;sup&gt;2&lt;/sup&gt; = 92.0%), with it being significantly higher (p &lt; 0.0001) in adults 76.4% (95% CI: 66.5-85.1%; n = 319) than in children (27.3% (95% CI: 9.8-48.7% n = 118). The pooled Sniffin' Sticks Test score was 26.5 (95% CI: 22.0-31.0; 95% PI: 17.7-35.4; n = 127), placing the cohort within the hyposmic range. The pooled total SNOT-22 score was 35.8 (95% CI: 27.6-44.1; 95% PI: 10.2-61.4), reflecting substantial overall sinonasal and HRQoL burden. The pooled Lund-Mackay score was 13.5 (95% CI: 11.1-15.9), indicating moderate-to-severe radiological sinonasal disease burden. HEMT consistently improved radiological markers of sinonasal disease, but patient-reported HRQoL improvement was variable and did not reach statistical significance in most studies. No included study demonstrated a statistically significant improvement in psychophysical olfactory performance after HEMT, and olfactory minimum clinically important difference was not reached where reported.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;OD is an important comorbidity of CF affecting an estimated 51.9% of people with CF overall, with higher rates in adults than children. Pooled prevalence varies materially by OD case definition and assessment method. Multidimensional psychophysical testing should be considered the reference functional assessment, complemented by olfaction-specific patient-reported outcome measures. HEMT does not appear to restore psychophysical olfactory function in the available studies, supporting continued ","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}