International Forum of Allergy & Rhinology最新文献

{"title":"Molecular Profiling and Tumor Microenvironment in Sinonasal Mucosal Melanoma as Biomarkers for Enhanced Prognostic Stratification.","authors":"Manuel Molina-Garcia, Maria Jesus Rojas-Lechuga, Cristobal Langdon, Judit Mateu, Jaume Bague, Teresa Torres, Vinicius G de Souza, Manuel Bernal-Sprekelsen, Isam Alobid, Rui Milton Patricio da Silva-Júnior, Susana Puig","doi":"10.1002/alr.23606","DOIUrl":"https://doi.org/10.1002/alr.23606","url":null,"abstract":"<p><strong>Background: </strong>Sinonasal mucosal melanoma (SNMM) is a rare and aggressive melanoma subtype with a notably poor prognosis. Despite molecular characterization advances, SNMM remains clinically challenging, highlighting the need for detailed molecular profiling. This study aimed to identify the molecular features of SNMM, elucidate its prognostic implications, and provide insights for improved therapies.</p><p><strong>Methods: </strong>Sixteen SNMM tumors were retrospectively analyzed at the Hospital Clinic of Barcelona. Next-generation sequencing targeted 1392 immuno-oncology-related probes. Log-rank test, hierarchical clustering analysis (HCA), Cox regression, differentially expressed genes, gene set enrichment analysis, and the xCell algorithm were performed. Statistical analyses comprised descriptive statistics, clinical variable associations, and survival analyses.</p><p><strong>Results: </strong>Among 16 tumors, 107 genes significantly correlated with melanoma-specific survival (MSS) (p < 0.05). HCA based on these genes revealed two clusters: Cluster B showed poorer prognosis (median MSS: 11.73 months; Q1: 8.74, Q3: 30.78) compared to Cluster A (median MSS: 81.74 months; Q1: 32.82, Q3: 92.44; p = 0.0051). Cox regression identified staging and molecular clustering as independent MSS predictors, with Cluster B exhibiting a hazard ratio of 13.23 (95% confidence intervals [CI]: 1.503-116.48, p = 0.02). Cluster B tumors displayed upregulated cell cycle genes and reduced infiltration of CD4+, CD8+, Th1, and B cells.</p><p><strong>Conclusions: </strong>Molecular profiling in SNMM provides prognostic information beyond standard clinical parameters. Cell cycle and immune-related gene expression patterns, together with decreased infiltration of CD4+, CD8+, Th1, and B cells, correlate with poorer MSS. Integrating molecular profiling with clinical staging could improve risk assessment and help identify high-risk patients for tailored therapeutic approaches.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23606"},"PeriodicalIF":7.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Epidemiology, Outcomes, and Testing for HPV-Associated Sinonasal Squamous Cell Carcinoma: Should Routine HPV Testing Be Encouraged?","authors":"Avraham Adelman, Young Lee, Eunice Im, Brian C Lobo, Jeb M Justice, Nikita Chapurin","doi":"10.1002/alr.23611","DOIUrl":"https://doi.org/10.1002/alr.23611","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23611"},"PeriodicalIF":7.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Strategies: Skull Base Reconstruction-Global Perspectives, Insights, and Algorithms through a Mixed Methods Approach.","authors":"Edward C Kuan, Vidit Talati, Jagatkumar A Patel, Theodore V Nguyen, Arash Abiri, Jonathan C Pang, Khodayar Goshtasbi, Lauren Liu, John R Craig, Peter Papagiannopoulos, Katie M Phillips, Bobby A Tajudeen, Nithin D Adappa, James N Palmer, Ahmad R Sedaghat, Eric W Wang, Vijay Anand, Pete S Batra, Marvin Bergsneider, Manuel Bernal-Sprekelsen, Benjamin S Bleier, Paolo Cappabianca, Ricardo L Carrau, Roy R Casiano, Paolo Castelnuovo, Luigi M Cavallo, Marc A Cohen, Iacopo Dallan, Jean Anderson Eloy, Ivan H El-Sayed, James J Evans, Juan C Fernandez-Miranda, Marco Ferrari, Sebastien Froelich, Paul A Gardner, Christos Georgalas, Stacey T Gray, Ehab Y Hanna, Richard J Harvey, Sang Duk Hong, Peter H Hwang, Daniel F Kelly, Doo-Sik Kong, Ming-Ying Lan, John Y K Lee, Corinna G Levine, James K Liu, Davide Locatelli, Cem Meço, Erin L McKean, Piero Nicolai, Gurston G Nyquist, Kazuhiro Omura, Thibault Passeri, Zara M Patel, Maria Peris Celda, Carlos Pinheiro Neto, Danny M. Prevedello, Mindy R Rabinowitz, Shaan M Raza, Pablo F Recinos, Marc R Rosen, Zoukaa B Sargi, Rodney J Schlosser, Theodore H Schwartz, Raj Sindwani, Carl H Snyderman, Aldo C Stamm, Brian D Thorp, Mario Turri-Zanoni, Marilene B Wang, Wei-Hsin Wang, Ian J Witterick, Tae-Bin Won, Bradford A Woodworth, Peter-John Wormald, Gabriel Zada, Shirley Y Su","doi":"10.1002/alr.23596","DOIUrl":"10.1002/alr.23596","url":null,"abstract":"<p><strong>Objective: </strong>There is limited consensus on endoscopic skull base surgery (ESBS) reconstruction principles. This study aims to generate comprehensive themes regarding ESBS reconstruction by pooling the experiences of ESBS experts, with comparison to a literature review of current published evidence.</p><p><strong>Methods: </strong>Structured qualitative interviews of ESBS experts regarding postoperative management and reconstruction of various defect locations were conducted.</p><p><strong>Results: </strong>A total of 68 experts comprising 40 academic teams across 13 countries with an average of 18 years of ESBS experience were included. We propose 10 stepwise algorithms for common skull base reconstruction scenarios based on these expert interviews. When available, the nasoseptal flap is used for all high_flow cerebrospinal leak defects. Multilayered reconstruction is favored at all anatomical subsites with increasing number of layers for increasing defect size and complexity. Heterogeneity exists in terms of inlay technique and materials, free grafting versus various pedicled flap options for low-flow defects or in the absence of a nasal septum, nasal packing, tissue sealant, lumbar drain use, and postoperative management. Commonalities and discrepancies between experts were summarized.</p><p><strong>Conclusion: </strong>Skull base reconstruction and post-ESBS management is highly complex with a wide variety of practice patterns and expert strategies. Further research of higher quality evidence is warranted to identify optimal management patterns, though the current work aims to inform surgeons on these controversial areas by drawing from numerous experiences.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23596"},"PeriodicalIF":7.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Quality of YouTube Videos on Chronic Rhinosinusitis","authors":"Simon Høj,&nbsp;Vibeke Backer,&nbsp;Laura Høj,&nbsp;Torben Sigsgaard,&nbsp;Howraman Meteran","doi":"10.1002/alr.23610","DOIUrl":"10.1002/alr.23610","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 8","pages":"873-875"},"PeriodicalIF":6.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab Decreases Local Galectin-10 Expression in Eosinophilic Chronic Rhinosinusitis","authors":"Isao Suzaki,&nbsp;Keisuke Ito,&nbsp;Shigeharu Ueki,&nbsp;Mineyo Fukuchi,&nbsp;Tomomi Mizuyoshi,&nbsp;Yurie Otani,&nbsp;Tatsuya Kitajima,&nbsp;Mio Takeuchi,&nbsp;Taisuke Hamasaki,&nbsp;Kojiro Hirano,&nbsp;Toshikazu Shimane","doi":"10.1002/alr.23614","DOIUrl":"10.1002/alr.23614","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 8","pages":"876-880"},"PeriodicalIF":6.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People With Cystic Fibrosis: Limiting Survey Burden","authors":"Haidee Chen,&nbsp;Jakob L. Fischer,&nbsp;Tristan D. Tibbe,&nbsp;Ahmad R. Sedaghat,&nbsp;Ethan J. Han,&nbsp;Jess C. Mace,&nbsp;Jeremiah A. Alt,&nbsp;Todd E. Bodner,&nbsp;Naweed I. Chowdhury,&nbsp;Yuqing A. Gao,&nbsp;Peter H. Hwang,&nbsp;Ashoke Khanwalkar,&nbsp;Adam J. Kimple,&nbsp;Jivianne T. Lee,&nbsp;Douglas A. Li,&nbsp;Meghan Norris,&nbsp;Jayakar V. Nayak,&nbsp;Cameran Collins,&nbsp;Zara M. Patel,&nbsp;Katie Phillips,&nbsp;Katie Poch,&nbsp;Rodney J. Schlosser,&nbsp;Kristine A. Smith,&nbsp;Zachary M. Soler,&nbsp;Jeffrey D. Suh,&nbsp;Grant A. Turner,&nbsp;Marilene B. Wang,&nbsp;Anne Getz,&nbsp;Ashleigh Halderman,&nbsp;Sei Chung,&nbsp;Jeremy P. Tervo,&nbsp;Jonathan B. Overdevest,&nbsp;Ryan A. Cotter,&nbsp;Milene T. Saavedra,&nbsp;Jennifer L. Taylor-Cousar,&nbsp;Myung-Shin Sim,&nbsp;Daniel M. Beswick","doi":"10.1002/alr.23591","DOIUrl":"10.1002/alr.23591","url":null,"abstract":"&lt;p&gt;Chronic rhinosinusitis (CRS) affects quality-of-life (QoL) in people with cystic fibrosis (PwCF), despite the reduction in symptoms and symptom severity associated with cystic fibrosis transmembrane conductance regulator (CFTR) modulators [&lt;span&gt;1&lt;/span&gt;]. To precisely assess sinus symptoms and treatment needs in the post-modulator period, patient-related QOL instruments should be revisited. The 22-item SinoNasal Outcome Test (SNOT-22) measures CRS burden and QoL. Abbreviated surveys can lessen respondent fatigue. Item response theory (IRT) can help refine surveys by identifying the most informative survey items while maintaining reliability [&lt;span&gt;2-4&lt;/span&gt;]. IRT assesses item discrimination (ɑ), the ability to differentiate trait levels, and difficulty (β), which defines thresholds for response categories [&lt;span&gt;2-4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Liu et al. refined the SNOT-22 using IRT with strong reliability and validity [&lt;span&gt;5&lt;/span&gt;]. Given PwCF's unique CRS burden, this study used IRT to create abbreviated SNOT-22 versions by selecting the most informative items. A secondary aim explored SNOT-22 differences by modulator therapy history.&lt;/p&gt;&lt;p&gt;This cross-sectional study, approved by local Institutional Review Boards, analyzed 185 adults (age 18 and over) with cystic fibrosis (CF) and CRS from 12 academic centers between 2018 and 2023, primarily from an ongoing trial (NCT04469439). Baseline SNOT-22 scores were analyzed, with full information maximum likelihood used to handle missingness in the graded response IRT models assessing item discrimination and difficulty. Demographic and clinical data were collected.&lt;/p&gt;&lt;p&gt;Shortened surveys were developed by first retaining items contributing above-average information within subdomains (nasal, otologic/facial pain, sleep, emotional), whereupon we applied a stricter rule ensuring at least 30% of the test information was retained from each subdomain to produce a further shortened survey, as implemented by Feng et al. [&lt;span&gt;6&lt;/span&gt;]. Internal consistency (Cronbach's &lt;i&gt;α&lt;/i&gt; &gt; 0.7) and convergent validity (Pearson's &lt;i&gt;r&lt;/i&gt; &gt;0.8) confirmed reliability and efficacy of shortened surveys. Statistical analyses were conducted using R with the “mirt” and “psych” packages [&lt;span&gt;7, 8&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The study included 185 PwCF with CRS, predominantly male (60%), with history of modulator therapy use (77%), and with F508del variants (59%) (Table 1).&lt;/p&gt;&lt;p&gt;The mean total SNOT-22 score was 39.3 [±19.8]. Subdomain mean scores were 13.0 [±8.3] for nasal, 4.8 [±3.8] for otologic/facial pain, 13.0 [±9.7] for sleep, and 1.5 [±2.0] for emotional. Responses ranged from 0 (“No problem”) to 5 (“Severe problem”) across most subdomains, except for the emotional subdomain, which lacked the most extreme responses.&lt;/p&gt;&lt;p&gt;Initial IRT analysis for all PwCF retained above-average information items across subdomains, preserving 55%–63% of subdomain information and yielding an 11-item survey. A stricter 30% threshold retained six i","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 8","pages":"865-868"},"PeriodicalIF":6.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tertiary Lymphoid Organs Are Associated With Bacterial Dysbiosis in Chronic Rhinosinusitis","authors":"Sathish Paramasivan,&nbsp;Ahmed Bassiouni,&nbsp;Nicholas A. Bokulich,&nbsp;Mahnaz Ramezanpour,&nbsp;Clare Cooksley,&nbsp;J. Gregory Caporasso,&nbsp;Shaun R. McColl,&nbsp;Peter-John Wormald,&nbsp;Alkis J. Psaltis,&nbsp;Sarah Vreugde","doi":"10.1002/alr.23608","DOIUrl":"10.1002/alr.23608","url":null,"abstract":"&lt;p&gt;Tertiary lymphoid organs (TLOs) are increasingly recognized as significant entities in many inflammatory processes [&lt;span&gt;1&lt;/span&gt;]. The phenomenon of de novo and organized lymphocytosis in normally immunodeplete tissue allows effector cells to be aggregated within the vicinity of antigenic sources, thereby heightening the inflammatory response [&lt;span&gt;2&lt;/span&gt;]. Chronic bacterial infections have been shown to induce TLO formation. Recently the presence of TLOs has been described within the mucosa of chronic rhinosinusitis (CRS) patients [&lt;span&gt;3&lt;/span&gt;]. This subset of patients demonstrated severe, treatment-resistant disease necessitating multiple surgical interventions [&lt;span&gt;4&lt;/span&gt;]. Unlike the distinct disease processes listed above, no single causative mechanism for CRS and subsequent TLO development has been delineated [&lt;span&gt;5&lt;/span&gt;]. One potential mechanism is the interaction between the sinonasal microbiome and the underlying immune response, which appears to be central to the CRS paradigm.&lt;/p&gt;&lt;p&gt;Research involving human tissue was approved by the Human Research Ethics Committees from both The Queen Elizabeth Hospital and The University of Adelaide. Microbiome swabs and sinonasal tissue were harvested intraoperatively. Samples were collected in a standardized fashion prior to any surgical alteration. Endoscopically guided microbial swabs, nasal polyps and mucosal tissue were taken from the middle meatus. TLOs were confirmed via immunofluorescence using a previous protocol described by Lau et al. [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In total, 117 consecutive patients were recruited. Characteristics of the cohort are described in Supporting Information Table S1. TLOs were identified in 35 diseased patients, with six (35%) in the CRSsNP group and 29 (45%) in the CRSwNP group. No TLOs were observed in the control group (Supporting Information Table S1).&lt;/p&gt;&lt;p&gt;To our knowledge this represents the first investigation into TLO-related microbiomes in any human disease process. Our results demonstrate that, in the presence of TLOs, there is a significant depletion of &lt;i&gt;Corynebacterium&lt;/i&gt; species within the sinonasal cavity among CRS patients. The reduction in &lt;i&gt;Corynebacterium&lt;/i&gt; relative abundance occurs simultaneously with an increase in &lt;i&gt;Staphylococcal&lt;/i&gt; representation. This is the first time that a distinct microbiome dysbiosis has been demonstrated in association with TLOs in any disease model. The significantly reduced microbial diversity results in a reduction of genetic potential in the mucosa-microbe organ. If a number of these microbially provided genes were critical for immunological balance within the sinuses, it could account for the particularly severe disease seen within this subset of patient.&lt;/p&gt;&lt;p&gt;To further characterize the inflammatory consequences of TLOs in CRS, a global transcriptomic analysis was performed. When comparing TLO-positive and -negative CRS cohorts, an increase in leukocyte chemotaxis genes was observed in the","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 8","pages":"869-872"},"PeriodicalIF":6.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDA Recalls of Image Guidance Systems for Sinus and Skull Base Surgery, 2003-2024.","authors":"Thriaksh Rajan, Rodney J Schlosser, Zachary M Soler, Patrick Walz, Kyle C Wu, Ralph B Metson, Stacey T Gray, Alan D Workman, Vinay K Rathi","doi":"10.1002/alr.23590","DOIUrl":"https://doi.org/10.1002/alr.23590","url":null,"abstract":"<p><strong>Background: </strong>Surgeons use stereotactic image guidance systems (IGS) to help navigate complex anatomy. However, the FDA has received reports of IGS malfunction linked to operative delays and complications. We investigated FDA recalls of IGS between 2003 and 2024.</p><p><strong>Methods: </strong>We performed a cross-sectional analysis of IGS recalls occurring between January 1, 2003, and December 1, 2024 (analytical cut-off date) using the FDA Medical Device Recalls database. For each recall, we extracted FDA-designated characteristics: disease area (otolaryngologic/neurosurgical), hazard classification (Class I-most severe/Class II-moderately severe/Class III-least severe), manufacturer, recalled units, FDA-determined cause. We calculated recall duration as the difference between initiation date and termination date (for completed recalls) or analytical cut-off date (for ongoing recalls).</p><p><strong>Results: </strong>Between 2003 and 2024, there were 75 FDA recalls involving IGS authorized for sinus or skull base surgery. The majority were for neurosurgical devices (n = 59; 78.7%) and categorized as Class II (n = 69; 92.0%). Median recall duration was 121 days (IQR: 41-380 days), with 20 (26.7%) recalls extending beyond 365 days. Recalls were initiated by Medtronic (54.7%), Stryker (26.7%), Integra (13.3%), and Brainlab (5.3%); no Karl Storz (0.0%) or Fiagon (0.0%) devices were recalled. Median number of recalled units was 271 (IQR: 27-2528). The most common reason for recall was software malfunction (n = 27; 36.0%), including all 6 (100.0%) Class I (most severe) recalls.</p><p><strong>Conclusions: </strong>IGS have been subject to FDA recalls. Surgeons should avoid overreliance on IGS when planning and performing procedures. Manufacturers and FDA should resolve recalls in a timely manner to support safe surgery.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23590"},"PeriodicalIF":7.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Development and Validation of the Smell-Qx Questionnaire, Based on a Systematic Review of the Literature and the COMET Initiative on the Development of Core Outcome Sets for Clinical Trials in Olfactory Disorders.","authors":"Matt Lechner, Alexander Fjaeldstad, Umar Rehman, Jacklyn Liu, David Boniface, Jim Boardman, Duncan Boak, Aytug Altundag, Johannes Frasnelli, Simon Gane, Eric Holbrook, Julien Hsieh, Caroline Huart, Iordanis Konstantinidis, Basile N Landis, Valerie J Lund, Alberto Macchi, Eri Mori, Christian Mueller, Joaquim Mullol, Simona Negoias, Zara M Patel, Jayant M Pinto, Sophia Poletti, Vijay Ramakrishnan, Philippe Rombaux, Jan Vodicka, Antje Welge-Luessen, Katherine L Whitcroft, Carol Yan, Carl Philpott, Thomas Hummel","doi":"10.1002/alr.23604","DOIUrl":"https://doi.org/10.1002/alr.23604","url":null,"abstract":"<p><strong>Background: </strong>Olfactory dysfunction affects up to 22% of the population. Accurate assessment is vital for diagnosis and tracking outcomes, often using patient-reported outcome measures (PROMs).</p><p><strong>Aims: </strong>We aimed to develop and validate a novel questionnaire for assessing olfactory and gustatory dysfunction.</p><p><strong>Methods: </strong>A systematic review identified existing smell and taste questionnaires, followed by item generation and selection. After two Delphi cycles and consultation with a large panel of smell and taste experts, the Smell-Qx questionnaire was developed. A validation study recruited patients from smell and taste clinics (cases) and general ENT clinics (controls) to complete the Smell-Qx. Additionally, patients with smell and taste disorders underwent psychophysical testing using Sniffin' Stick Threshold, Discrimination, and Identification (TDI) tests.</p><p><strong>Results: </strong>The Smell-Qx is an 11-domain instrument, with five core domains used for total score calculation and six history/quality-of-life domains for obtaining a comprehensive history. The validation study recruited 60 participants (32 patients with smell/taste disorders and 28 controls). Items showed acceptable to significant internal consistency (Cronbach's α: 0.64-0.97) and test-retest reliability (ICC: 0.65-0.99, p < 0.001). The Smell-Qx was effective at distinguishing patients with smell and taste disorders from controls (t = 9.99, df = 58, p < 0.0001). Concurrent criterion validity was good with overall SATD-related quality of life (r = 0.43, p = 0.015), as well as with the smell loss domain and overall smell TDI scores (r = -0.54, p = 0.011).</p><p><strong>Conclusion: </strong>The Smell-Qx is a reliable and valid PROM for assessing olfactory and self-reported gustatory disorders, capturing symptom severity and quality-of-life impact. It can integrate into a multi-modal assessment approach alongside psychophysical testing.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23604"},"PeriodicalIF":7.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Letter to the Editor Regarding Ambient Particulate Matter and Frequency of Outpatient Visits for Chronic Rhinosinusitis in the United States”","authors":"Hong-Ho Yang,&nbsp;David Grimm,&nbsp;Esther Velasquez,&nbsp;Peter H. Hwang","doi":"10.1002/alr.23599","DOIUrl":"10.1002/alr.23599","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 6","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}