Yuan Zhang, Zengxiao Zhang, Chengshuo Wang, Luo Zhang
{"title":"Efficacy and Safety of Combined Pharmacotherapies in Moderate-to-Severe Allergic Rhinitis: A Network Meta-Analysis.","authors":"Yuan Zhang, Zengxiao Zhang, Chengshuo Wang, Luo Zhang","doi":"10.1002/alr.23578","DOIUrl":"https://doi.org/10.1002/alr.23578","url":null,"abstract":"<p><strong>Background: </strong>Combination pharmacotherapies are often selected for moderate-to-severe allergic rhinitis (AR), particularly when monotherapies do not control symptoms effectively. However, few studies have compared the efficacy and safety of different combination regimens. Therefore, we performed this study to investigate the clinical benefits of different combination strategies for moderate-to-severe AR.</p><p><strong>Methods: </strong>Electronic databases were searched (inception-May 31, 2024) for randomized controlled trials involving combination therapies for treating moderate-to-severe AR. The medication classes included intranasal corticosteroids (INCS), intranasal antihistamines (INAH), oral antihistamines (OAH), and oral leukotriene receptor antagonists (LTRA). A network meta-analysis with a random-effects model was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p><p><strong>Results: </strong>Forty-eight eligible studies with 17,188 participants were included. In this meta-analysis, INAH and INCS, OAH and INCS, and INCS were the most effective in improving Total Nasal Symptom Score, and INAH and INCS, INAH, and INCS most effectively enhanced the total ocular symptom score. INCS and LTRA, OAH and INCS, and INAH and INCS showed the greatest benefit in improving the Rhinitis Quality of Life Questionnaire. Although INCS and INAH and INAH increased the risk of overall adverse events, specific adverse events predominantly included a bitter taste.</p><p><strong>Conclusion: </strong>Combination therapies demonstrated superior efficacy compared to monotherapies overall. The INAH and INCS combination provided the greatest advantage in symptom improvement. The combination of OAH and INCS could be a viable alternative treatment option if the bitter taste is unacceptable. Our findings provide novel insights into optimizing personalized combination therapies.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23578"},"PeriodicalIF":7.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A. Gudis, Benjamin S. Bleier, Jean Anderson Eloy, James J. Evans, Juan Carlos Fernandez-Miranda, Paul A. Gardner, Mathew Geltzeiler, Jessica W. Grayson, Richard J. Harvey, Elisa A. Illing, David W. Kennedy, Cristine Klatt-Cromwell, Edward C. Kuan, Jivianne Lee, Michael J. Link, James K. Liu, Patricia Loftus, Nyall R. London, Erin L. McKean, Kibwei A. McKinney, L. Madison Michael, Gurston G. Nyquist, Zara M. Patel, Mindy Rabinowitz, Sanjeet V. Rangarajan, M. Eng, Kenneth D. Rodriguez, Nicholas R. Rowan, Rodney J. Schlosser, Kafui Searyoh, Raymond F. Sekula Jr., Timothy L. Smith, Carl Snyderman, Satyan B. Sreenath, Dennis M. Tang, Brian D. Thorp, Eric W. Wang, Marilene B. Wang, Bradford A. Woodworth, Garret Choby
{"title":"June 4: International Skull Base Surgery Day","authors":"David A. Gudis, Benjamin S. Bleier, Jean Anderson Eloy, James J. Evans, Juan Carlos Fernandez-Miranda, Paul A. Gardner, Mathew Geltzeiler, Jessica W. Grayson, Richard J. Harvey, Elisa A. Illing, David W. Kennedy, Cristine Klatt-Cromwell, Edward C. Kuan, Jivianne Lee, Michael J. Link, James K. Liu, Patricia Loftus, Nyall R. London, Erin L. McKean, Kibwei A. McKinney, L. Madison Michael, Gurston G. Nyquist, Zara M. Patel, Mindy Rabinowitz, Sanjeet V. Rangarajan, M. Eng, Kenneth D. Rodriguez, Nicholas R. Rowan, Rodney J. Schlosser, Kafui Searyoh, Raymond F. Sekula Jr., Timothy L. Smith, Carl Snyderman, Satyan B. Sreenath, Dennis M. Tang, Brian D. Thorp, Eric W. Wang, Marilene B. Wang, Bradford A. Woodworth, Garret Choby","doi":"10.1002/alr.23545","DOIUrl":"10.1002/alr.23545","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 5","pages":"481-482"},"PeriodicalIF":7.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruowu Liu, Jiao Zhou, Jing Zhou, Feng Liu, Yafeng Liu, Juan Meng, Luo Ba, Hengyi Xiao, Shixi Liu, Nan Zhang, Claus Bachert, Jintao Du
{"title":"MiR-221-3p Attenuates IL-33-Induced Mast Cell Cytokine Expression by Targeting KIT.","authors":"Ruowu Liu, Jiao Zhou, Jing Zhou, Feng Liu, Yafeng Liu, Juan Meng, Luo Ba, Hengyi Xiao, Shixi Liu, Nan Zhang, Claus Bachert, Jintao Du","doi":"10.1002/alr.23558","DOIUrl":"https://doi.org/10.1002/alr.23558","url":null,"abstract":"<p><strong>Background: </strong>Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)-33 stimulation. MiR-221 is reported to be an important regulator of MCs, and miR-221-3p can be expressed in CRSwNP. However, the role of miR-221-3p in CRSwNP is unclear.</p><p><strong>Methods: </strong>Ethmoid tissues from control subjects (n = 12) and polyps from patients with CRSwNP (n = 40) were collected. The expression of miR-221-3p and cytokines was detected by real-time quantitative polymerase chain reaction (qPCR). The activation of P65 and ERK was determined by western blotting. The localization of miR-221-3p was detected via in situ hybridization combined with immunofluorescence (IF), and its target was identified via a luciferase reporter system. Human MCs were incubated with IL-33 or stem cell factor. MicroRNA mimics/inhibitor and lentiviral plasmids were used to determine the role of miR-221-3p in MCs.</p><p><strong>Results: </strong>We observed increased expression of miR-221-3p in CRSwNP, and localized its expression in MCs. The expression of miR-221-3p was negatively correlated with that of IL-4, IL-5, and IL-13 in CRSwNP. MiR-221-3p can be induced by IL-33 in MCs and plays a negative regulatory role in cytokine expression and signaling pathways in IL-33-induced MC activation. As the direct target of miR-221-3p, the receptor KIT was negatively correlated with miR-221-3p and decreased in CRSwNP. In MCs, KIT is essential for an effective response to IL-33 stimulation. We here demonstrated that miR-221-3p regulates cytokine expression by targeting KIT in IL-33-activated MCs.</p><p><strong>Conclusions: </strong>MiR-221-3p inhibits MC-dependent type 2 inflammatory conditions, rendering it a negative regulator of CRSwNP.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23558"},"PeriodicalIF":7.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hussain Albaharna, Abdulaziz Alrasheed, Abdulaziz AlQahtani, Alkis J Psaltis, Amin Javer, Cem Meco, Christos Georgalas, Eric W Wang, Isam Alobid, Kazuhiro Omura, Luis Fernando Macias-Valle, Marc Tewfik, Narayanan Prepageran, Paolo Battaglia, Paolo Castelnuovo, Ricardo Carrau, Richard Douglas, Richard Harvey, Roy R Casiano, Shahzada Ahmed, Saad Alsaleh
{"title":"A Novel International Endoscopic Sphenoid Surgery Classification (IESSC): A Delphi Consensus.","authors":"Hussain Albaharna, Abdulaziz Alrasheed, Abdulaziz AlQahtani, Alkis J Psaltis, Amin Javer, Cem Meco, Christos Georgalas, Eric W Wang, Isam Alobid, Kazuhiro Omura, Luis Fernando Macias-Valle, Marc Tewfik, Narayanan Prepageran, Paolo Battaglia, Paolo Castelnuovo, Ricardo Carrau, Richard Douglas, Richard Harvey, Roy R Casiano, Shahzada Ahmed, Saad Alsaleh","doi":"10.1002/alr.23572","DOIUrl":"https://doi.org/10.1002/alr.23572","url":null,"abstract":"<p><strong>Background: </strong>Advancements in endoscopic sinus and skull base surgery created a need for standardized terminology to describe sphenoid sinus surgery. Although classification systems exist for other sinuses, one for endoscopic sphenoid sinus surgery is lacking. Developing such a system would standardize procedure descriptions and promote a common language among surgeons. This study aimed to develop a new classification system for endoscopic sphenoid surgery.</p><p><strong>Methods: </strong>Consensus on a novel endoscopic sphenoid surgery classification system by running the Delphi procedure with 16 rhinology experts from around the world.</p><p><strong>Results: </strong>Four Delphi rounds were required to reach a consensus on all stages of the classification. The average percentage of agreement on the stages of classification progressively increased from 70.83% in the first round to 87.68% in the last round. The rejection rates continuously decreased from 8.81% in the first round to 4.44% in the last round. The classification system was developed as follows: stage 1, presphenoid surgery; stage 2A, partial sphenoidotomy; stage 2B, complete sphenoidotomy; stage 2C, transpterygoid sphenoidotomy; stage 3A, Rostral sphenoidectomy; and stage 3B, extended sphenoid drill-out.</p><p><strong>Conclusions: </strong>This novel endoscopic sphenoid surgery classification system facilitates the description of different sphenoid sinus procedures, providing surgeons with better opportunities for discussion and communication.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e3572"},"PeriodicalIF":7.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakob L Fischer, Nikitha Kosaraju, Katherine M Lucarelli, Christine R Wells, Connie M Sears, Reem Karmouta, Ashley S Shirriff, Maxwell Weng, Jeffrey D Suh, Jivianne T Lee, Daniel M Beswick, Daniel B Rootman, Marilene B Wang
{"title":"Outcomes of Acute Invasive Fungal Rhinosinusitis Patients Treated with Retrobulbar Amphotericin B Injections versus Orbital Exenteration.","authors":"Jakob L Fischer, Nikitha Kosaraju, Katherine M Lucarelli, Christine R Wells, Connie M Sears, Reem Karmouta, Ashley S Shirriff, Maxwell Weng, Jeffrey D Suh, Jivianne T Lee, Daniel M Beswick, Daniel B Rootman, Marilene B Wang","doi":"10.1002/alr.23573","DOIUrl":"https://doi.org/10.1002/alr.23573","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e3573"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Access to Care for the Management of Chronic Rhinosinusitis with Nasal Polyps","authors":"David A. Gudis","doi":"10.1002/alr.23569","DOIUrl":"10.1002/alr.23569","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"468"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Xu, WenJie Zheng, JiaLin Feng, QinYi Zhou, Jun Chen
{"title":"Letter to the Editor Regarding “Tissue Eosinophils Threshold and Its Association With Adult-Onset Asthma in Chronic Rhinosinusitis”","authors":"Le Xu, WenJie Zheng, JiaLin Feng, QinYi Zhou, Jun Chen","doi":"10.1002/alr.23575","DOIUrl":"10.1002/alr.23575","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"469-470"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Forrest W Fearington, Lazaro R Peraza, Aja Leatherwood, Alexis K Grover, Jacob K Dey, Andrea A Tooley, Janalee K Stokken
{"title":"Measuring the Visibility of Thyroid Eye Disease: What Severity Draws Attention?","authors":"Forrest W Fearington, Lazaro R Peraza, Aja Leatherwood, Alexis K Grover, Jacob K Dey, Andrea A Tooley, Janalee K Stokken","doi":"10.1002/alr.23574","DOIUrl":"https://doi.org/10.1002/alr.23574","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23574"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to: Correspondence for “Developing a Virtual Endoscopic Surgery Planning System to Optimize Surgical Outcomes”","authors":"Kai Zhao, Bradley A. Otto, Gregory J. Wiet","doi":"10.1002/alr.23570","DOIUrl":"10.1002/alr.23570","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 4","pages":"471-472"},"PeriodicalIF":7.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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