Infectious Disease Reports最新文献

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Gut Microbiome in Pulmonary Arterial Hypertension-An Emerging Frontier. 肺动脉高压的肠道微生物组——一个新兴的前沿。
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-09 DOI: 10.3390/idr17030066
Sasha Z Prisco, Suellen D Oliveira, E Kenneth Weir, Thenappan Thenappan, Imad Al Ghouleh
{"title":"Gut Microbiome in Pulmonary Arterial Hypertension-An Emerging Frontier.","authors":"Sasha Z Prisco, Suellen D Oliveira, E Kenneth Weir, Thenappan Thenappan, Imad Al Ghouleh","doi":"10.3390/idr17030066","DOIUrl":"10.3390/idr17030066","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) is an irreversible disease characterized by vascular and systemic inflammation, ultimately leading to right ventricular failure. There is a great need for adjunctive therapies to extend survival for PAH patients. The gut microbiome influences the host immune system and is a potential novel target for PAH treatment. We review the emerging preclinical and clinical evidence which strongly suggests that there is gut dysbiosis in PAH and that alterations in the gut microbiome may either initiate or facilitate the progression of PAH by modifying systemic immune responses. We also outline approaches to modify the intestinal microbiome and delineate some practical challenges that may impact efforts to translate preclinical microbiome findings to PAH patients. Finally, we briefly describe studies that demonstrate contributions of infections to PAH pathogenesis. We hope that this review will propel further investigations into the mechanisms by which gut dysbiosis impacts PAH and/or right ventricular function, approaches to modify the gut microbiome, and the impact of infections on PAH development or progression.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction. 人类免疫缺陷病毒Nef变异对肺血管内皮细胞功能障碍的不同影响。
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-06 DOI: 10.3390/idr17030065
Amanda K Garcia, Noelia C Lujea, Javaria Baig, Eli Heath, Minh T Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar
{"title":"Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction.","authors":"Amanda K Garcia, Noelia C Lujea, Javaria Baig, Eli Heath, Minh T Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar","doi":"10.3390/idr17030065","DOIUrl":"10.3390/idr17030065","url":null,"abstract":"<p><p><b>Background:</b> Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy. Still to this day, pulmonary hypertension (PH) severely affects the prognosis in this patient population. The persistent expression of HIV proteins, even during viral suppression, has been implicated in vascular dysfunction; however, little is known about the specific effects of these proteins on the pulmonary vasculature. This study investigates the impact of Nef variants derived from HIV-positive pulmonary hypertensive and normotensive donors on pulmonary vascular cells in vitro. <b>Methods:</b> We utilized well-characterized Nef molecular constructs to examine their effects on cell adhesion molecule gene expression (<i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>), pro-apoptotic gene expression (<i>BAX</i>, <i>BAK</i>), and vasoconstrictive endothelin-1 (<i>EDN1</i>) gene expression in endothelial nitric oxide synthase (eNOS) nitric oxide and the production and secretion of pro-inflammatory cytokines over 24, 48, and 72 h post-transfections with Nef variants. <b>Results:</b> HIV Nef variants SF2, NA7, and PH-associated Fr17 and 3236 induced a significant increase in adhesion molecule gene expression of <i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>. Pulmonary normotensive Nef 1138 decreased <i>ICAM1</i> gene expression, but had increased <i>VCAM1</i>. PH Nef ItVR showed a consistent decrease in <i>ICAM1</i> and no changes in <i>SELE</i> and <i>VCAM1</i> expression. Further gene expression analyses of pro-apoptotic genes <i>BAX</i> and <i>BAK</i> demonstrated that Nef NA7, SF2, normotensive Nef 1138, and PH Nef Fr8, Fr9, Fr17, and 3236 variants significantly increased gene expression for apoptosis. Normotensive Nef 1138, as well as PH Nef Fr9 and ItVR, all displayed a statistically significant decrease in <i>BAX</i> expression. The expression of <i>EDN1</i> had a statistically significant increase in samples treated with Nef NA7, SF2, normotensive Nef 2044 and PH Nef 3236, Fr17, and Fr8. Notably, PH-associated Nef variants sustained pro-inflammatory cytokine production, including IL-2, IL-4, and TNFα, while anti-inflammatory cytokine levels remained insufficient. Furthermore, eNOS was transiently upregulated by all Nef variants except for normotensive Nef 2044. <b>Conclusions:</b> The distinct effects of Nef variants on pulmonary vascular cell biology highlight the complex interplay between Nef, host factors, and vascular pathogenesis according to the variants.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review of Progress in Preventing Urinary Infections Associated with the Use of Urinary Catheters: A Dual Analysis of Publications and Patents. 导尿管相关尿路感染预防进展综述:文献和专利的双重分析。
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-04 DOI: 10.3390/idr17030064
Brunella Corrado, Aniello Cammarano, Stefania Dello Iacono, Emilia Renzi, Rosalba Moretta, Maria Emilia Mercurio, Laura Ascione, Annunziata Cummaro, Caterina Meglio, Luigi Nicolais
{"title":"A Comprehensive Review of Progress in Preventing Urinary Infections Associated with the Use of Urinary Catheters: A Dual Analysis of Publications and Patents.","authors":"Brunella Corrado, Aniello Cammarano, Stefania Dello Iacono, Emilia Renzi, Rosalba Moretta, Maria Emilia Mercurio, Laura Ascione, Annunziata Cummaro, Caterina Meglio, Luigi Nicolais","doi":"10.3390/idr17030064","DOIUrl":"10.3390/idr17030064","url":null,"abstract":"<p><p>Catheter-associated urinary tract infections (CAUTIs), caused by microbial colonization of catheter surfaces, are among the most common healthcare-associated infections and significantly strain healthcare systems worldwide. This review aimed to provide a comprehensive analysis of the current scientific literature and the patent landscape from 2014 to 2024 on strategies for preventing CAUTIs. A systematic search was conducted using the PRISMA method, which involved searching the Scopus database for scientific evidence and analyzing patent search results on The Lens.org platform. Co-authorship and co-occurrence analysis unveiled key contributors and emerging themes within the scientific community. Simultaneously, an in-depth inspection of patents filed elucidated top origins, applicants, and classifications. Additionally, network analysis based on keywords from papers and patents revealed the scientific scenario and the innovation trends, enriching the understanding of technological advancements. It highlights emerging technologies, key actors, and potential gaps, providing valuable insights for researchers, clinicians, and industry stakeholders, thereby contributing to overcoming barriers to treating CAUTIs.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canine Leptospirosis in Flood-Affected Areas of Southern Brazil: Molecular Assessment and Public Health Implications. 巴西南部受洪水影响地区的犬钩端螺旋体病:分子评估和公共卫生影响。
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-03 DOI: 10.3390/idr17030063
Gabriela Merker Breyer, Nathasha Noronha Arechavaleta, Bruna Corrêa da Silva, Maria Eduarda Rocha Jacques da Silva, Mariana Costa Torres, Laura Cadó Nemitz, Rafaela da Rosa Marques, Fernando Borges Meurer, Gabriela Amanda Linden, Tainara Soares Weyh, Franciele Maboni Siqueira
{"title":"Canine Leptospirosis in Flood-Affected Areas of Southern Brazil: Molecular Assessment and Public Health Implications.","authors":"Gabriela Merker Breyer, Nathasha Noronha Arechavaleta, Bruna Corrêa da Silva, Maria Eduarda Rocha Jacques da Silva, Mariana Costa Torres, Laura Cadó Nemitz, Rafaela da Rosa Marques, Fernando Borges Meurer, Gabriela Amanda Linden, Tainara Soares Weyh, Franciele Maboni Siqueira","doi":"10.3390/idr17030063","DOIUrl":"10.3390/idr17030063","url":null,"abstract":"<p><strong>Background: </strong>Southern Brazil faced massive rains and floods in May 2024, which led to social, infrastructural, and One Health issues affecting over 478 municipalities and 2.3 million people. Exposure to floodwater increased the risk of bacterial infections, including leptospirosis. Despite the zoonotic nature of leptospiral infections, only human leptospirosis is subject to mandatory reporting, while canine cases are less closely monitored. Considering the extent of this climatic event, many emergency shelters were created for rescued dogs, highlighting the need to monitor infectious diseases to mitigate the spread of hazardous pathogens.</p><p><strong>Methods: </strong>We performed a molecular assessment of canine leptospirosis in Porto Alegre and its metropolitan region. A total of 246 dogs rescued from the flooded areas underwent molecular diagnosis targeting <i>lipL32.</i> In addition, positive samples were identified by sequencing of the partial <i>secY</i> gene.</p><p><strong>Results: </strong>A total of 9 (4%) dogs were positive for <i>Leptospira</i> spp. Molecular and phylogenetic analyses of <i>secY</i> from the positive samples determined that the circulating strains belonged to <i>L. interrogans</i> (<i>n</i> = 8)-Icterohaemorrhagiae and Pomona as the suggested serogroups-and <i>L. kirschneri</i> (<i>n</i> = 1).</p><p><strong>Conclusions: </strong>Our findings point out the challenges in diagnosing and controlling leptospirosis during severe climatic events and reinforce the need for preventive sanitary measures to mitigate the dissemination of <i>Leptospira</i> spp., including the adoption of a mandatory notification system for canine leptospirosis.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Underestimated Threat-Mycobacterium Genavense Infection: A Case Report. 被低估的威胁——Genavense分枝杆菌感染1例报告。
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-01 DOI: 10.3390/idr17030060
Jannik Sonnenberg, Gert Gabriels, Ioana Diana Olaru, Sebastian Mühl, Julia Fischer, Hermann Pavenstädt, Jonel Trebicka, Kai-Henrik Peiffer, Phil-Robin Tepasse
{"title":"The Underestimated Threat-Mycobacterium Genavense Infection: A Case Report.","authors":"Jannik Sonnenberg, Gert Gabriels, Ioana Diana Olaru, Sebastian Mühl, Julia Fischer, Hermann Pavenstädt, Jonel Trebicka, Kai-Henrik Peiffer, Phil-Robin Tepasse","doi":"10.3390/idr17030060","DOIUrl":"10.3390/idr17030060","url":null,"abstract":"<p><strong>Background/objectives: </strong>Nontuberculous mycobacteria (NTM) represent a heterogeneous group of pathogens with increasing global prevalence and significant geographical variation in species distribution. NTM infections, often affecting immunocompromised individuals, are difficult to diagnose due to nonspecific clinical presentations and laboratory findings. This case study presents a rare extrapulmonary NTM infection in a 73-year-old man, initially misdiagnosed as sarcoidosis, highlighting the diagnostic and therapeutic challenges posed by such infections.</p><p><strong>Methods: </strong>The patient, a pigeon fancier, presented with recurrent fever and pancytopenia. Extensive diagnostics included blood cultures, bone marrow aspiration, and histopathology. Initial cultures and serological tests remained negative.</p><p><strong>Results: </strong>Bone marrow aspiration revealed epithelioid granulomas, initially leading to the provisional diagnosis of sarcoidosis. However, after six weeks, <i>M. genavense</i> was isolated from mycobacterial blood cultures from bone marrow aspirant. Antimicrobial therapy with azithromycin, rifampicin, and ethambutol was initiated. Following the initiation of appropriate antimycobacterial therapy, the patient developed immune reconstitution inflammatory syndrome (IRIS), which was managed with supportive care. The patient's condition improved, and no further febrile episodes occurred post-treatment, marking the successful conclusion of NTM therapy.</p><p><strong>Conclusions: </strong>This case underscores the diagnostic complexity of extrapulmonary NTM infections, particularly in immunocompromised patients. Misdiagnosis can delay appropriate treatment. <i>M. genavense</i>, though rare, should be considered in patients with a fever of unknown origin, especially with a background of immunosuppression. Prompt mycobacterial testing and tailored antibiotic therapy are crucial to improving outcomes in NTM infections.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tropheryma whipplei and Giardia intestinalis Co-Infection: Metagenomic Analysis During Infection and the Recovery Follow-Up. 鞭虫和肠贾第虫合并感染:感染期间宏基因组分析及恢复随访。
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-01 DOI: 10.3390/idr17030062
Anna Anselmo, Fabiana Rizzo, Elena Gervasi, Luca Corrent, Andrea Ciammaruconi, Silvia Fillo, Antonella Fortunato, Anna Maria Marella, Silvia Costantini, Luca Baldassari, Florigio Lista, Alessandra Ciervo
{"title":"<i>Tropheryma whipplei</i> and <i>Giardia intestinalis</i> Co-Infection: Metagenomic Analysis During Infection and the Recovery Follow-Up.","authors":"Anna Anselmo, Fabiana Rizzo, Elena Gervasi, Luca Corrent, Andrea Ciammaruconi, Silvia Fillo, Antonella Fortunato, Anna Maria Marella, Silvia Costantini, Luca Baldassari, Florigio Lista, Alessandra Ciervo","doi":"10.3390/idr17030062","DOIUrl":"10.3390/idr17030062","url":null,"abstract":"<p><strong>Background: </strong>Whipple's disease (WD) is a rare infection caused by <i>Tropheryma whipplei</i>. Diagnosis is challenging and requires a combination of several data sets, such as patient history, clinical and laboratory investigations, and endoscopy with histology analyses. While persistent diarrhea is a common symptom, WD can affect multiple organs.</p><p><strong>Case description: </strong>We present the case of a 66-year-old immunocompetent patient with WD and a history of <i>Helicobacter pylori</i> infection who developed chronic diarrhea. Colonoscopy and histopathological analysis revealed the presence of foamy macrophages with periodic acid-Schiff-positive particles. Subsequently, molecular methods confirmed the clinical WD diagnosis and metagenomic analyses further identified a co-infection with <i>Giardia intestinalis</i>. The patient fully recovered after 14 months of antibiotic therapy. During pharmacological treatment, clinical and laboratory follow-ups were conducted at 6 and 12 months, and microbiome profiles were also analyzed to identify the most abundant species in the samples.</p><p><strong>Conclusion: </strong>The metagenomic analyses showed the eradication of the two pathogens and a progressive restoration to a healthy/balanced status after antibiotic therapy.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Treatment of Enterovirus-D68 and Rhinovirus Respiratory Infections. 肠病毒- d68和鼻病毒呼吸道感染的治疗进展
IF 3.4
Infectious Disease Reports Pub Date : 2025-06-01 DOI: 10.3390/idr17030061
Vonintsoa L Rahajamanana, Mathieu Thériault, Henintsoa Rabezanahary, Yesmine G Sahnoun, Maria Christina Mallet, Sandra Isabel, Sylvie Trottier, Mariana Baz
{"title":"Advances in the Treatment of Enterovirus-D68 and Rhinovirus Respiratory Infections.","authors":"Vonintsoa L Rahajamanana, Mathieu Thériault, Henintsoa Rabezanahary, Yesmine G Sahnoun, Maria Christina Mallet, Sandra Isabel, Sylvie Trottier, Mariana Baz","doi":"10.3390/idr17030061","DOIUrl":"10.3390/idr17030061","url":null,"abstract":"<p><strong>Background/objectives: </strong>Enterovirus-D68 (EV-D68) and rhinoviruses are major contributors to respiratory illnesses in children, presenting a spectrum of clinical manifestations ranging from asymptomatic cases to severe lower respiratory tract infections. No specific antiviral treatments are currently approved for these viruses.</p><p><strong>Method: </strong>We conducted a comprehensive literature review of antiviral agents investigated for EV-D68 and rhinovirus infections.</p><p><strong>Results: </strong>Several antiviral candidates are under investigation, each targeting distinct stages of the viral replicative cycle. Capsid-binding agents and monoclonal antibodies prevent viral attachment by blocking receptor-virus interactions. Inhibitors of viral replication proteins disrupt polyprotein processing and replication organelle biogenesis by targeting non-structural viral proteins. Host factor inhibitors impair viral attachment, replication organelle formation, or RNA replication by interfering with critical host pathways.</p><p><strong>Conclusions: </strong>While no specific antivirals are yet approved for EV-D68 and rhinovirus infections, emerging therapeutic candidates offer potential avenues for treatment. Continued preclinical and clinical investigation will be essential to validate these approaches and expand the available options for affected patients.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Retrospective Study of the Effects of COVID-19 Non-Pharmaceutical Interventions on Influenza in Canada. 加拿大COVID-19非药物干预措施对流感影响的回顾性研究
IF 3.4
Infectious Disease Reports Pub Date : 2025-05-26 DOI: 10.3390/idr17030059
Heather MacTavish, Kenzie MacIntyre, Paniz Zadeh, Matthew Betti
{"title":"A Retrospective Study of the Effects of COVID-19 Non-Pharmaceutical Interventions on Influenza in Canada.","authors":"Heather MacTavish, Kenzie MacIntyre, Paniz Zadeh, Matthew Betti","doi":"10.3390/idr17030059","DOIUrl":"10.3390/idr17030059","url":null,"abstract":"<p><p><b>Background/Objectives</b>: COVID-19 pandemic had a significant impact on endemic respiratory illnesses. Through behavioral changes in populations and government policy, mainly through non-pharmaceutical interventions (NPIs), Canada saw historic lows in the number of influenza A cases from 2020 through 2022. In this study, we use historical influenza A data for Canada and three provincial jurisdictions within Canada-Ontario, Quebec, and Alberta-to quantify the effects of these NPIs on influenza A. <b>Methods</b>: We aim to see which base parameters and derived parameters of an SIR model are most affected by NPIs. We fit a simple SIR model to historical influenza data to get average paramters for seasonal influenza. We then compare these parameters to those predicted by fitting influenza cases during the COVID-19 pandemic. <b>Results</b>: We find substantial differences in the effective population size and basic reproduction number during the COVID-19 pandemic. We also see the effects of fatigue and relaxation of NPIs when comparing the years 2020, 2021, and 2022. <b>Conclusions</b>: We find that the effective population size is the main driver of change to disease spread and discuss how these retrospective estimates can be used for future forecasting.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasculonecrotic Reaction Caused by Mycobacterium Lepromatosis Infection-A Case Report of an HIV/Leprosy-Coinfected Patient. 麻风分枝杆菌感染引起的血管坏死反应——1例HIV/麻风合并感染患者报告。
IF 3.4
Infectious Disease Reports Pub Date : 2025-05-23 DOI: 10.3390/idr17030058
Fernando Amador-Lara, Jorge L Mayorga-Garibaldi, Felipe J Bustos-Rodríguez, Luz A González-Hernández, Pedro Martínez-Ayala, Jaime F Andrade-Villanueva
{"title":"Vasculonecrotic Reaction Caused by Mycobacterium Lepromatosis Infection-A Case Report of an HIV/Leprosy-Coinfected Patient.","authors":"Fernando Amador-Lara, Jorge L Mayorga-Garibaldi, Felipe J Bustos-Rodríguez, Luz A González-Hernández, Pedro Martínez-Ayala, Jaime F Andrade-Villanueva","doi":"10.3390/idr17030058","DOIUrl":"10.3390/idr17030058","url":null,"abstract":"<p><strong>Background: </strong>Vasculonecrotic reactions in leprosy are typically associated with type 2 reactions. Differentiating between necrotizing erythema nodosum leprosum (nENL) and Lucio's phenomenon (LP) can be difficult, as overlapping clinical and histopathological features have been reported. <i>Mycobacterium lepromatosis</i>, a recently identified species causing leprosy, has been sporadically linked to LP. While type 1 reactions are more commonly observed in HIV-coinfected individuals, reports of LP or ENL occurring outside the context of immune reconstitution inflammatory syndrome (IRIS) remain rare.</p><p><strong>Methods: </strong>We report a case of a vasculonecrotic leprosy reaction due to <i>M. lepromatosis</i> in an antiretroviral-naive patient with advanced HIV infection.</p><p><strong>Results: </strong>The patient presented with a two-month history of papules and nodules that progressed to painful necrotic ulcers, accompanied by systemic symptoms. Clinically, the presentation was consistent with nENL; however, histopathological analysis supported a diagnosis of LP. The patient rapidly deteriorated, developing septic shock and dying shortly thereafter. To our knowledge, this is the first reported case of a leprosy-associated vasculonecrotic reaction caused by <i>M. lepromatosis</i> in an HIV-infected individual not associated with IRIS.</p><p><strong>Conclusions: </strong>Vasculonecrotic reactions in leprosy are life-threatening emergencies due to their potential for rapid clinical deterioration and sepsis. In individuals with advanced HIV infection, recognition of these reactions may be challenging, as they can mimic other opportunistic infections, including fungal diseases, malignant syphilis, and disseminated mycobacterial infections. Early identification and prompt treatment are critical to improving outcomes.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial, Social and Serological Factors in the Prevalence and Risk of Leprosy in Areas of High Endemicity: An Integrative Review. 空间、社会和血清学因素在麻风病高流行地区的流行和风险:综合评价。
IF 3.4
Infectious Disease Reports Pub Date : 2025-05-22 DOI: 10.3390/idr17030057
Daniele Dos Santos Lages, Isabela Cristina Lana Maciel, Sarah Lamas Vidal, Francisco Carlos Félix Lana
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