Infectious Disease Reports最新文献_第4页

Legionella pneumophila-Klebsiella pneumoniae Pulmonary Coinfection in a COVID-19 Patient: Case Report. 一名 COVID-19 患者的嗜肺军团菌-肺炎克雷伯菌肺部合并感染：病例报告。

IF 3.4

Infectious Disease Reports Pub Date : 2024-11-11 DOI: 10.3390/idr16060085

Maria Irina Brumboiu, Edina Iuga, Andreea Ivanciuc, Irina Iaru, Alexandru Durla-Pașca, Pavel Șchiopu, Adrian Gabriel Pană

{"title":"Legionella pneumophila-Klebsiella pneumoniae Pulmonary Coinfection in a COVID-19 Patient: Case Report.","authors":"Maria Irina Brumboiu, Edina Iuga, Andreea Ivanciuc, Irina Iaru, Alexandru Durla-Pașca, Pavel Șchiopu, Adrian Gabriel Pană","doi":"10.3390/idr16060085","DOIUrl":"10.3390/idr16060085","url":null,"abstract":"Background. Pulmonary superinfections increase the mortality risk among COVID-19 patients, highlighting the need for enhanced understanding to enable early and accurate diagnosis. Methods. We present the case of a patient, a 76-year-old man, hospitalized for a severe form of COVID-19, with a ground-glass pneumonia, involving 40-45% of lung surfaces. Results. In evolution, the clinical condition worsened, presenting leukocytosis with neutrophilia, imaging towards resorption, and computer tomography images showing the appearance of pulmonary condensations in the right lower lobe, the posterior portion of the left lower lobe and pleural collections. Carbapenemase-producing Klebsiella pneumoniae was isolated from the tracheal aspirate, and the real-time polymerase chain reaction test was positive for Klebsiella pneumoniae and Legionella pneumophila. The investigations that were carried out allowed us to establish the coinfections as a probable case of Legionnaire's disease and a ventilator-associated pneumonia with Klebsiella pneumoniae. Conclusions. The case analysis revealed that rare pneumonias may remain undiagnosed, and coinfections may be conditioned by pathophysiological factors or components of COVID-19 critical form treatment. Enhanced understanding of these aspects in clinical practice may contribute to reducing mortality risk in COVID-19 patients.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 6","pages":"1055-1063"},"PeriodicalIF":3.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary Approach in Rare, Fulminant-Progressing, and Life-Threatening Facial Necrotizing Fasciitis. 多学科方法治疗罕见、进展迅速、危及生命的面部坏死性筋膜炎。

IF 3.4

Infectious Disease Reports Pub Date : 2024-11-01 DOI: 10.3390/idr16060084

Mihaela Pertea, Stefana Luca, Raluca Tatar, Bogdan Huzum, Mihai Ciofu, Vladimir Poroch, Dragos Octavian Palade, Daniela Vrinceanu, Mihail Balan, Oxana Madalina Grosu

{"title":"Multidisciplinary Approach in Rare, Fulminant-Progressing, and Life-Threatening Facial Necrotizing Fasciitis.","authors":"Mihaela Pertea, Stefana Luca, Raluca Tatar, Bogdan Huzum, Mihai Ciofu, Vladimir Poroch, Dragos Octavian Palade, Daniela Vrinceanu, Mihail Balan, Oxana Madalina Grosu","doi":"10.3390/idr16060084","DOIUrl":"10.3390/idr16060084","url":null,"abstract":"(1) Background: Necrotizing fasciitis is known as a severe condition with a high risk of mortality, placing it among the most feared infections. In most cases, it has a polymicrobial etiology (type 1), requiring complex treatment that is continuously adapted to the evolving microbiological status. The facial localization of the disease is rare, fulminant progressing, and is often life-threatening. (2) Methods: We present the case of a patient with multiple comorbidities who, following trauma to the nasal dorsum, developed a wound with a rapid and severe progression to extensive bilateral periorbital necrosis. This was accompanied by a dramatic deterioration in their general condition, a polymicrobial biological status, and fluctuating progression despite instituted treatment (both medical and surgical). (3) Results: The patient required multiple surgical interventions by multidisciplinary teams (plastic surgery; ear, nose, and throat specialist (ENT); maxillofacial surgery; and ophthalmology), experiencing periods of a severe, life-threatening general condition, necessitating prolonged orotracheal intubation. Wounds with fluctuating progression, extensive skin necrosis, and significant post-excisional soft tissue defects required skin graft coverage. The result meant a saved life and functional and aesthetic sequelae at the level of the face. (4) Conclusions: Necrotizing fasciitis of the face is a rare and severe disease that must be recognized early and treated appropriately by a multidisciplinary team to save the patient's life and minimize the resulting functional and aesthetic sequelae.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 6","pages":"1045-1054"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proprotein Convertase Subtilisin Kexin 9 Inhibitor in Severe Sepsis and Septic Shock Patients in a Phase II Prospective Cohort Study-Preliminary Results. 一项 II 期前瞻性队列研究的初步结果：重症脓毒症和脓毒性休克患者的蛋白转化酶亚基酶 Kexin 9 抑制剂。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-24 DOI: 10.3390/idr16060083

Ziv Rosman, Yasmin Maor, Iris Zohar, Gingy Ronen Balmor, Miri Schamroth Pravda, Adam Lee Goldstein, Milena Tocut, Arie Soroksky

{"title":"Proprotein Convertase Subtilisin Kexin 9 Inhibitor in Severe Sepsis and Septic Shock Patients in a Phase II Prospective Cohort Study-Preliminary Results.","authors":"Ziv Rosman, Yasmin Maor, Iris Zohar, Gingy Ronen Balmor, Miri Schamroth Pravda, Adam Lee Goldstein, Milena Tocut, Arie Soroksky","doi":"10.3390/idr16060083","DOIUrl":"10.3390/idr16060083","url":null,"abstract":"Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection that has a high mortality rate. Proprotein convertase subtilisin kexin 9 (PCSK9) is a serine protease secreted by the liver. Its binding to the low-density lipoprotein (LDL) receptor enhances its degradation, causing an increase in LDL levels in the blood. Objectives: Administering a PCSK9 inhibitor leading to an increase in lipid uptake by the liver may positively affect septic patients due to the increased removal of endotoxins. Methods: This preliminary study aimed to examine the safety of PCSK9 inhibitor use in septic and septic shock patients. We treated five septic patients in the intensive care unit with 300 mg of alirocumab following serious adverse events for 28 days. Results: Four of our patients did not experience any adverse events, and all of them survived. One patient died after discharge from the intensive care unit, and this death was presumably not related to the study drug. The patients rapidly recovered from the inflammatory stage of sepsis. Conclusions: Alirocumab appears safe in severe sepsis and septic shock patients. The outcome data are promising. Only a basic safety profile can be assessed based on this pilot study. Further study with a PCSK-9 inhibitor in septic or septic shock patients is required to further determine its benefit in ICU patients.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 6","pages":"1036-1044"},"PeriodicalIF":3.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consideration of Antifungal Coverage in Treating Infections Related to Delayed Esophageal Perforation from Anterior Cervical Spine Hardware. 在治疗与颈椎前路硬件延迟性食管穿孔相关的感染时考虑使用抗真菌药物。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-23 DOI: 10.3390/idr16060082

Kavita Prasad, John Ceremsak, Jean-Nicolas Gallant, Hannah G Kay, Erin B Gettler, Benjamin R Campbell, Catherine R Carlile, Byron F Stephens, Sarah L Rohde, Patty W Wright, Christina T Fiske

{"title":"Consideration of Antifungal Coverage in Treating Infections Related to Delayed Esophageal Perforation from Anterior Cervical Spine Hardware.","authors":"Kavita Prasad, John Ceremsak, Jean-Nicolas Gallant, Hannah G Kay, Erin B Gettler, Benjamin R Campbell, Catherine R Carlile, Byron F Stephens, Sarah L Rohde, Patty W Wright, Christina T Fiske","doi":"10.3390/idr16060082","DOIUrl":"https://doi.org/10.3390/idr16060082","url":null,"abstract":"(1) Background/Objectives: Delayed esophageal perforation following anterior cervical (spine) discectomy and fusion (ACDF) is rare but can lead to serious infectious complications. The treatment usually involves hardware explanation and prolonged intravenous antibiotics; however, there are scarce reports about the microbiology of these infections and corresponding targeted therapy. (2) Methods: Patients diagnosed or treated for delayed esophageal perforation after anterior cervical fusion between 2000-2020 at a tertiary medical center were studied. (3) Results: Seven patients with delayed esophageal perforation following ACDF were identified. The most common bacteria isolated included Streptococcus, Haemophilus, and Mycobacterium species. The cultures from five patients grew fungal species, including Candida albicans and C. glabrata. All the patients received several weeks of broad-spectrum antibiotics, and, notably, 5/7 patients received antifungal therapy targeting Candida. (4) Conclusions: Although the incidence of delayed esophageal perforation following ACDF is low, providers should remain aware of this entity due to the serious infectious complications. Most infections are polymicrobial in nature, and providers should consider empiric antifungal coverage specifically targeting Candida species when treating patients with this complication.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 6","pages":"1030-1035"},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cumulative Variations of Respiratory Syncytial Virus Fusion Protein (F) in Ten Consecutive Years in China. 中国呼吸道合胞病毒融合蛋白（F）连续十年的累积变化。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-17 DOI: 10.3390/idr16050081

Fengjie Wang, Mingli Jiang, Zhenzhi Han, Yanpeng Xu, Yu Sun, Runan Zhu, Dongmei Chen, Qi Guo, Yutong Zhou, Yao Yao, Ling Cao, Dong Qu, Muya Li, Linqing Zhao

{"title":"The Cumulative Variations of Respiratory Syncytial Virus Fusion Protein (F) in Ten Consecutive Years in China.","authors":"Fengjie Wang, Mingli Jiang, Zhenzhi Han, Yanpeng Xu, Yu Sun, Runan Zhu, Dongmei Chen, Qi Guo, Yutong Zhou, Yao Yao, Ling Cao, Dong Qu, Muya Li, Linqing Zhao","doi":"10.3390/idr16050081","DOIUrl":"https://doi.org/10.3390/idr16050081","url":null,"abstract":"Background: Variations in the fusion (F) protein of respiratory syncytial virus (RSV) with main antigenic sites I-V and Ø may affect the development of RSV vaccines and therapies.Methods: In the study, 30 respiratory specimens positive for RSV were randomly selected from children with acute lower respiratory infections (ALRI) in Beijing every year from 2012 to 2021 for F gene sequencing. Then, 300 F gene sequences and 508 uploaded to GenBank from China were subjected to phylogenetic analysis.Results: The results indicated the nucleotide identities were 95.4-100% among 446 sequences of RSV A, and 96.3-100% among 362 of RSV B. The most common variant loci were N80K (100.00%) and R213S (97.76%) for site Ø, and V384I/T (98.43%) for site I among sequences of RSV A, and M152I (100.00%), I185V (100.00%), and L172Q/H (94.48%) for site V, and R202Q (99.45%) for site Ø among sequences of RSV B. N276S appears in 95.29% sequences of RSV A, while S276N and N262 I/S appear in 1.38% and 0.55% sequences of RSV B, respectively. No variation was found in all sequences at the binding sites of 14N4 and motavizumab.Conclusions: There were cumulative variations of the RSV F gene, especially at some binding sites of antigenic sites.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 5","pages":"1017-1029"},"PeriodicalIF":3.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive Thoracolumbar Tuberculosis in a Young Male: Diagnostic, Therapeutic, and Surgical Insights. 一名年轻男性的进行性胸腰椎结核病：诊断、治疗和手术的启示。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-12 DOI: 10.3390/idr16050080

Dana-Georgiana Nedelea, Diana Elena Vulpe, George Viscopoleanu, Alexandru Constantin Radulescu, Alexandra Ana Mihailescu, Sebastian Gradinaru, Mihnea Orghidan, Cristian Scheau, Romica Cergan, Serban Dragosloveanu

{"title":"Progressive Thoracolumbar Tuberculosis in a Young Male: Diagnostic, Therapeutic, and Surgical Insights.","authors":"Dana-Georgiana Nedelea, Diana Elena Vulpe, George Viscopoleanu, Alexandru Constantin Radulescu, Alexandra Ana Mihailescu, Sebastian Gradinaru, Mihnea Orghidan, Cristian Scheau, Romica Cergan, Serban Dragosloveanu","doi":"10.3390/idr16050080","DOIUrl":"https://doi.org/10.3390/idr16050080","url":null,"abstract":"Objective: We present the case of a 26-year-old male with severe spinal tuberculosis of the thoracolumbar region. The patient suffered from worsening back pain over five years, initially responding to over-the-counter analgesics. Despite being proposed surgery in 2019, the patient refused the intervention and subsequently experienced significant disease progression.Methods: Upon re-presentation in 2022, mild involvement of the T12-L1 vertebrae was recorded by imaging, leading to a percutaneous needle biopsy which confirmed tuberculosis. Despite undergoing anti-tuberculous therapy for one year, the follow-up in 2024 revealed extensive infection from T10 to S1, with large psoas abscesses and a pseudo-tumoral mass of the right thigh. The patient was ultimately submitted to a two-stage surgical intervention: anterior resection and reconstruction of T11-L1 with an expandable cage, followed by posterior stabilization from T8-S1.Results: Postoperative recovery was uneventful, with significant pain relief and no neurological deficits. The patient was discharged on a continued anti-tuberculous regimen and remains under close surveillance.Conclusions: This paper presents details on the challenges of diagnosis and management of severe spinal tuberculosis, with emphasis on the importance of timely intervention and multidisciplinary care.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 5","pages":"1005-1016"},"PeriodicalIF":3.4,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Effect of the COVID-19 Pandemic Period on Respiratory Tract Viruses at Istanbul Medical Faculty Hospital, Turkey. 调查 COVID-19 大流行期间对土耳其伊斯坦布尔医学院附属医院呼吸道病毒的影响。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-10 DOI: 10.3390/idr16050079

Sevim Mese, Aytaj Allahverdiyeva, Mustafa Onel, Hayriye Kırkoyun Uysal, Ali Agacfidan

{"title":"Investigation of the Effect of the COVID-19 Pandemic Period on Respiratory Tract Viruses at Istanbul Medical Faculty Hospital, Turkey.","authors":"Sevim Mese, Aytaj Allahverdiyeva, Mustafa Onel, Hayriye Kırkoyun Uysal, Ali Agacfidan","doi":"10.3390/idr16050079","DOIUrl":"https://doi.org/10.3390/idr16050079","url":null,"abstract":"Aim: Respiratory viruses significantly impact public health, contributing to high morbidity and mortality rates in both children and adults. This study evaluates the distribution and incidence of respiratory tract viruses in our hospital from 2019 to 2022, focusing on changes post-COVID-19 pandemic. Material and Methods: Utilizing molecular methods, we analyzed nasopharyngeal swabs with the FTD Respiratory Pathogens 21 kit and the QIAStat Dx Respiratory Panel kit at Istanbul Faculty of Medicine. A total of 1186 viruses were detected in 2488 samples (47.6% of the total) examined with the FTD Respiratory Pathogens 21 kit between 2019 and 2022. Results: It was determined that the detection rates were 52.8% in 2019, 44.3% in 2020, 50.0% in 2021, and 40.0% in 2022. Notable changes in prevalence were observed for pandemic influenza A (IAV-H1N1pdm2009), parainfluenza virus (PIV)-3, rhinovirus (RV), and respiratory syncytial virus (RSV)-A/B (p < 0.05). RV consistently showed the highest detection rates across all years (17.6% to 7.9%). Additionally, 1276 viruses were detected in 1496 samples using the QIAStat DX kit, with 91.3% positivity in 2021 and 78.6% in 2022, highlighting the kit's effectiveness in rapid diagnosis. Conclusions: This study enhances understanding of respiratory virus epidemiology during and after the pandemic, emphasizing the need for ongoing surveillance and strategic public health measures to address the evolving landscape of respiratory infections.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 5","pages":"992-1004"},"PeriodicalIF":3.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallbladder Burkitt's Lymphoma: A Literature Review Including a Case Report in a Child Living with HIV. 胆囊伯基特淋巴瘤：文献综述，包括一名艾滋病病毒感染儿童的病例报告。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-10 DOI: 10.3390/idr16050078

Nathalia Lopez Duarte, Ana Paula Silva Bueno, Bárbara Sarni Sanches, Gabriella Alves Ramos, Layanara Albino Batista, Thalita Fernandes de Abreu, Marcelo Gerardin Poirot Land, Cristiane Bedran Milito

{"title":"Gallbladder Burkitt's Lymphoma: A Literature Review Including a Case Report in a Child Living with HIV.","authors":"Nathalia Lopez Duarte, Ana Paula Silva Bueno, Bárbara Sarni Sanches, Gabriella Alves Ramos, Layanara Albino Batista, Thalita Fernandes de Abreu, Marcelo Gerardin Poirot Land, Cristiane Bedran Milito","doi":"10.3390/idr16050078","DOIUrl":"https://doi.org/10.3390/idr16050078","url":null,"abstract":"Malignant lymphoma is an unusual form of gallbladder neoplasm. Almost all these tumors are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas. Herein, we present a literature review of gallbladder Burkitt's lymphoma (BL) cases that includes also an unpublished case in an HIV-infected child, observed by our center. The patient (a five-year-old black female child) attended the Federal Hospital of Lagoa, Rio de Janeiro, Brazil, underwent cholecystectomy, and the postoperative pathological analysis of the gallbladder revealed a diagnosis of BL (EBV-positive). Also, HIV serology was performed and returned positive. She was transferred to the Martagão Gesteira Institute of Pediatrics and Childcare for oncological treatment, dying from sepsis and disease progression about 18 months later. The patient did not undergo ART/cART. Previous cases of gallbladder BL were herein described and analyzed to characterize the clinicopathological features and possible similarities. BL can occur in the gallbladder both in the context of HIV infection and in the pediatric population. A biopsy is mandatory in cases with suggestive findings of lymphoma, and an early diagnosis can change the course of the disease. Furthermore, the case highlights the importance of an early initiation of ART/cART in people living with HIV (PLWH), especially in children.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 5","pages":"981-991"},"PeriodicalIF":3.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Battle beyond the Battlefield: War's Influence on Antibiotic Resistance. 战场之外的战斗：战争对抗生素耐药性的影响。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-09 DOI: 10.3390/idr16050077

Guido Granata, Stefania Cicalini, Nicola Petrosillo

引用次数: 0

Emerging Fungal Infections of the Central Nervous System in the Past Decade: A Literature Review. 过去十年中新出现的中枢神经系统真菌感染：文献综述。

IF 3.4

Infectious Disease Reports Pub Date : 2024-10-09 DOI: 10.3390/idr16050076

Rita Lino, André Rodrigues Guimarães, Estela Sousa, Mariana Azevedo, Lurdes Santos

{"title":"Emerging Fungal Infections of the Central Nervous System in the Past Decade: A Literature Review.","authors":"Rita Lino, André Rodrigues Guimarães, Estela Sousa, Mariana Azevedo, Lurdes Santos","doi":"10.3390/idr16050076","DOIUrl":"https://doi.org/10.3390/idr16050076","url":null,"abstract":"Introduction: Invasive fungal infections affecting the central nervous system (CNS) are a major health concern worldwide associated with high mortality rates. Their increased incidence is largely due to an increase in the vulnerable immunocompromised population, changing environmental factors, and development of more accurate diagnostic methods. The aim of this article is to identify fungal causes of CNS infections that are recently emerging or have the potential to become emerging pathogens in the near future, as well as their clinical characteristics, including: Candida auris, Trichosporon spp., Blastomyces spp., Sporothrix spp., Talaromyces marneffei, Lomentospora prolificans, and Scedosporium spp.Methods: A review of the literature in PubMed in the last ten years was conducted to identify central nervous system infections caused by each of these fungi.Results: The review identified 10 cases caused by C. auris, 5 cases by Trichosporon spp., 82 cases by Blastomyces spp., 36 cases by Sporothrix spp., 21 cases by T. marneffei, 22 cases by Lomentospora prolificans, and 42 cases by Scedosporium spp.Discussion: The exact burden of these diseases remains difficult to ascertain, but their apparent rise underscores the urgent need for improved diagnostic, treatment, and management strategies against CNS fungal pathogens to improve outcomes against these life-threatening infections.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 5","pages":"952-976"},"PeriodicalIF":3.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0