Infectious Disease Reports最新文献

{"title":"Sex, Age, and COVID-19 Vaccine Characteristics Associated with Adverse Events After Vaccination and Severity: A Retrospective Analysis.","authors":"Edgar P Rodríguez-Vidales, Jesús M Santos-Flores, Mara I Garza-Rodríguez, Ana M Salinas-Martínez, Alejandra G Martínez-Pérez, Roberto Montes de Oca-Luna, Alma R Marroquín-Escamilla","doi":"10.3390/idr17050108","DOIUrl":"10.3390/idr17050108","url":null,"abstract":"<p><strong>Background: </strong>Although the safety of COVID-19 vaccines has been demonstrated in clinical trials, real-world pharmacovigilance remains essential to detect rare or unexpected adverse events following immunization (AEFI). In Mexico, the national AEFI surveillance system is in place, yet there is limited analysis of state-level data.</p><p><strong>Objective: </strong>To characterize AEFI related to five COVID-19 vaccines and identify factors associated with AEFI type and seriousness in Nuevo León, Mexico.</p><p><strong>Methods: </strong>A retrospective analysis of the State of Nuevo León AEFI database was conducted, including all AEFI reports between December 2020 and June 2022 (n = 2213). Data included patient sex, age, vaccine type (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, CanSino), number of doses (1 or ≥2), symptom categories, and AEFI seriousness. Symptoms were classified as local or systemic and grouped by organ systems. Descriptive analysis and binary multivariate logistic regression were used to examine associations between demographic and vaccine-related factors with AEFI type and severity. Odds ratios (OR) with 95% confidence intervals (CI) were estimated.</p><p><strong>Results: </strong>Most AEFI reports involved females aged 19-59 years and occurred after the first vaccine dose. The most frequently reported unexpected adverse events (UAEs) were mild to moderate, including injection-site reactions, headache, chills, fatigue, nausea, fever, dizziness, weakness, myalgia, and tachycardia. The Pfizer/BioNTech vaccine was associated with higher odds of arm pain and lower odds of hemorrhagic events. Receiving ≥2 doses increased the odds of arm pain and systemic symptoms. Less than 3% of AEFIs were classified as serious. Older adults (≥65 years) and second vaccine doses were associated with increased odds of a serious AEFI, while female sex and receiving the Pfizer/BioNTech vaccine were associated with reduced odds.</p><p><strong>Conclusions: </strong>In Nuevo León, most AEFIs related to COVID-19 vaccination were mild to moderate and resolved without complications. Serious AEFIs were uncommon, with older age and second doses associated with higher risk, and female sex and Pfizer/BioNTech vaccination associated with lower risk. These findings provide a local perspective on vaccine safety that complements national and international evidence.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torque Teno Virus as a Biomarker for Infection Risk in Kidney Transplant Recipients: A Machine Learning-Enabled Cohort Study.","authors":"Sara Querido, Luís Ramalhete, Perpétua Gomes, André Weigert","doi":"10.3390/idr17050107","DOIUrl":"10.3390/idr17050107","url":null,"abstract":"<p><strong>Background: </strong>Torque Teno Virus (TTV) viremia has been proposed as a marker for infection risk in kidney transplant (KT) recipients. This study aimed to evaluate the prognostic value of TTV levels for predicting infections post-KT.</p><p><strong>Methods: </strong>A cohort of 82 KT patients was analyzed. TTV loads were measured before KT and at the time of cutoff analysis (mean time since KT: 20.2 ± 10.3 months). Infections were tracked within six months following the time of cutoff analysis. Univariable analyses and a supervised machine learning approach (logistic regression with leave-one-out cross-validation) were conducted to rigorously assess TTV's predictive ability for post-transplant infection.</p><p><strong>Results: </strong>Seventy-two patients (87.8%) had detectable TTV before KT. Of these, 30.5% developed infections, predominantly viral. TTV loads increased significantly from 3.35 ± 1.67 log₁₀ cp/mL before KT to 4.53 ± 1.93 log₁₀ cp/mL at the time of cutoff analysis. Infected patients had significantly higher TTV loads (5.39 ± 1.68 log₁₀ vs. 4.16 ± 1.94 log₁₀ cp/mL, <i>p</i> = 0.0057). The optimal TTV threshold for predicting infection at the time of cutoff analysis was 5.16 log₁₀ cp/mL, with 60% sensitivity and 81% specificity. Machine learning models improved performance, with sensitivity and specificity 0.805 and 0.735, respectively.</p><p><strong>Conclusions: </strong>TTV viremia may serve as a biomarker for infection risk, particularly when used with other clinical variables. The identified TTV threshold of 5.16 log₁₀ cp/mL offers a practical tool for clinical decision-making, particularly when integrated with a machine learning model. Further studies with larger cohorts are needed to validate these findings and refine clinical applications.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyponatremia Due to VZV-Induced SIADH in an Older Patient: Case Report and Literature Review.","authors":"Zuzanna Żak-Skryśkiewicz, Patrycja Krupińska, Carlo Bieńkowski, Przemysław Witek","doi":"10.3390/idr17050106","DOIUrl":"10.3390/idr17050106","url":null,"abstract":"<p><strong>Introduction: </strong>Hyponatremia is a common finding in hospitalized patients, especially the elderly. Symptoms of hyponatremia can vary depending on the concentration of sodium in serum as well as the dynamics of its escalation. Hyponatremia can have many etiologies, including medication, vomiting, or diarrhea, and central nervous system disorders, including tumors, trauma, and infections.</p><p><strong>Case report: </strong>In this case, we present a 74-year-old patient who was admitted to the Department of Internal Medicine with symptomatic, acute, and severe hyponatremia in the course of the syndrome of inappropriate antidiuretic hormone secretion due to varicella zoster virus meningoencephalitis. Clinical improvement and normalization of natremia occurred after the initiation of causal treatment.</p><p><strong>Conclusion: </strong>Given the complexity of the potential causes of hyponatremia and the variety of treatments available, it is essential to thoroughly consider the possible reasons for electrolyte abnormalities, including uncommon ones such as central nervous system infections.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Disparities in Central Line-Associated Bloodstream Infections: Analysis of the U.S. National Inpatient Sample Database (2016-2022).","authors":"Nicholas Mielke, Ryan W Walters, Faran Ahmad","doi":"10.3390/idr17050105","DOIUrl":"10.3390/idr17050105","url":null,"abstract":"<p><strong>Introduction: </strong>Central line-associated bloodstream infections (CLABSIs) are a major cause of morbidity and mortality, yet health disparities in CLABSI incidence and outcomes remain understudied. This study evaluates these disparities and their impact on CLABSI rates, in-hospital mortality, hospital length of stay (LOS), and costs using the National Inpatient Sample (NIS) from 2016 to 2022.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of adult hospitalizations using the NIS database that included central venous catheter placement and identified CLABSI using AHRQ's Patient Safety Indicator 07. Primary outcomes included CLABSI incidence and in-hospital mortality; secondary outcomes were LOS and inflation-adjusted hospital costs. Outcomes were analyzed using logistic and lognormal regression models, focusing on demographic and clinical variables that included sex, race, socioeconomic status, and insurance type.</p><p><strong>Results: </strong>Among 11.5 million CVCs placed between 2016 and 2022, 6.56 million met CLABSI eligibility criteria, with 1 in 400 (0.25%) complicated by CLABSI. Blacks had 29.8% higher adjusted odds of CLABSI than Whites (<i>p</i> < 0.001), whereas Medicaid beneficiaries had 18.4% higher odds compared to those privately insured (<i>p</i> = 0.002). CLABSI was associated with a 97% increase in LOS and an 82% increase in hospital costs (both <i>p</i> < 0.001). In-hospital mortality was 13.3% and did not differ significantly by CLABSI status after adjustment.</p><p><strong>Discussion: </strong>Racial and socioeconomic disparities persist in CLABSI incidence and healthcare resource utilization, with Blacks and Medicaid beneficiaries at the highest risk. Although CLABSI rates returned to pre-pandemic levels in 2022, associated costs and LOS remained elevated. Further research and targeted prevention strategies are needed to reduce health disparities and improve patient outcomes.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Immunization with Yeast-Surface Display of SARS-CoV-2 Antigens in <i>Pichia pastoris</i> Induces Humoral Responses in BALB/C Mice.","authors":"Larissa Silva de Macêdo, Benigno Cristofer Flores Espinoza, Maria da Conceição Viana Invenção, Samara Sousa de Pinho, Lígia Rosa Sales Leal, Micaela Evellin Dos Santos Silva, Beatriz Mendonça Alves Bandeira, Pedro Vinícius Silva Novis, Tiago Henrique Dos Santos Souza, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Antonio Carlos de Freitas, Anna Jéssica Duarte Silva","doi":"10.3390/idr17050104","DOIUrl":"10.3390/idr17050104","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The pandemic caused by SARS-CoV-2 boosted the development of different vaccine models. In parallel, yeasts stand out as a vaccine platform in healthcare biotechnology. Species such as <i>Saccharomyces cerevisiae</i> and <i>Pichia pastoris</i> can express heterologous proteins, which are capable of inducing specific antibodies and can perform as an attractive vaccine vehicle with immunomodulating properties due to their cell wall composition. Furthermore, the yeast surface display system facilitates antigen presentation to immune cells. We developed an oral vaccine based on <i>P. pastoris</i> displaying a synthetic antigen composed of <i>Spike</i> and <i>Nucleocapsid</i> epitopes. <b>Methods:</b> The vaccine was administered to BALB/c mice. Systemic immune response was measured through antibody detection in blood samples, and mucosal immunity was assessed via IgA levels in feces. Histopathological analysis of intestinal and gastric tissues was also conducted. <b>Results:</b> The yeast-based vaccine elicited a humoral immune response, reflected in the production of neutralizing antibodies and elevated levels of IgG2a and IgG2. No structural alterations or pathological changes were observed in gastrointestinal tissues. <b>Conclusions:</b> This study demonstrates the feasibility of using <i>P. pastoris</i> as an oral vaccine delivery system, supporting previous findings with other yeast species such as <i>Saccharomyces cerevisiae</i>, and highlighting its potential in developing effective mucosal vaccines.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Neck and Lung Masses Post Dental Procedure-A Potential Novel Presentation of the <i>Cellulosimicrobium</i> Species in Humans.","authors":"Kevin M Sheehan, Geraldine Moloney, Olive Murphy, Paul Ryan, Triona Hayes, Madeleine R Harney, Michael Harney, Oisin O'Connell","doi":"10.3390/idr17050103","DOIUrl":"10.3390/idr17050103","url":null,"abstract":"<p><p><b>Background:</b> <i>Cellulosimicrobium</i>, formerly known as the <i>Oerskovia</i> genus, is a Gram-positive organism known for its characteristic bright yellow colonies. While abundant in nature, it is very rarely linked to pathogenesis in humans. While there is no classical presentation for <i>Cellulosimicrobium</i>-associated infections, cases tend to be foreign body-related or involve immunocompromised patients. Rates of <i>Cellulosimicrobium</i>-associated infections have been hypothesised to rise in the future, due to rising numbers of immunocompromised patients in the community and increasing usage of foreign bodies such as prostheses and long-term catheters. Existing technical difficulties regarding misidentifying cultures as other species (often other coryneforms) may also play a significant role in the low number of documented cases, and this may change in the near future with diagnostic advancements such as whole genomic sequencing. <b>Case Presentation:</b> A 57-year-old immunocompetent Irish male presented with concomitant neck and lung masses. Notably, this was found to be directly following a recent dental procedure. During extensive investigations, <i>Cellulosimicrobium</i> was isolated from biopsied lung tissue using 16S ribosomal ribonucleic acid gene-sequencing analysis. The patient was treated with long-term oral amoxicillin and safely discharged, with both masses showing measurable reductions in size on subsequent imaging. <b>Conclusions:</b> Should <i>Cellulosimicrobium</i> represent the causative pathological organism in this case, then we believe this to represent a potential novel documented presentation of the organism's pathogenesis in humans. We provide detailed discussion surrounding the successful management of this patient and the evaluation of the evolving differential diagnosis throughout this case.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dressing Impregnated with Chlorhexidine and Vancomycin for the Prophylaxis of Central Venous Catheter-Related Infections-A Randomized Trial.","authors":"Giovanna Cerri Lessa, Carolina Comitti Zanella, Gustavo Pessatto Krause, Alexandre Moreira Senter, Paula Hansen Suss, Gabriel Burato Ortis, Thyago Proenca de Moraes, Felipe Francisco Tuon","doi":"10.3390/idr17040102","DOIUrl":"10.3390/idr17040102","url":null,"abstract":"<p><p><b>Background:</b> Central venous catheters (CVCs) are essential in intensive care units (ICUs) for monitoring and administering treatments; however, catheter-related bloodstream infections (CRBSIs) are significant complications, leading to severe outcomes and increased healthcare costs. The objective of this study was to evaluate the effectiveness of a simple and inexpensive impregnated dressing (intervention) compared to a non-impregnated dressing in reducing catheter-related infections among critically ill patients using vancomycin and chlorhexidine. <b>Methods</b>: This was a randomized, double-blind, controlled clinical trial in a university hospital in Brazil with 207 beds from June 2022 to October 2023. Patients over 18 years old admitted to the ICU and needing a CVC for a period exceeding 72 h were included. A CVC inserted outside the ICU and the need for two CVCs in the same patient simultaneously were exclusion criteria. One group received an impregnated dressing (intervention) compared to the other group, which received a standard dressing (comparator). The incidence of CRBSIs and the microbiological outcomes were evaluated. The primary endpoint was CRBSI. <b>Results</b>: The clinical trial included 516 patients randomized to receive either the new antimicrobial dressing or a control dressing. The dressing significantly reduced CVC colonization but not CRBSI rates. <b>Conclusions</b>: This new dressing provides enhanced antimicrobial protection but does not decrease CRBSI incidence. Future studies should further explore the cost-effectiveness and long-term benefits of this approach.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Nutritional Environment in <i>Cryptococcus gattii</i> Titan Cells' Ultrastructure, Biophysical Properties, Molecular Features, and Virulence in Cryptococcosis.","authors":"Igor Avellar-Moura, Glauber R de S Araujo, Juliana Godoy, Vinicius Alves, Iara Bastos de Andrade, Juliana Soares, Bruno Pontes, Susana Frases","doi":"10.3390/idr17040101","DOIUrl":"10.3390/idr17040101","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>Cryptococcus gattii</i> presents a significant threat to healthy individuals. Titan cell formation, a key virulence factor, is influenced by the nutritional environment and plays a critical role in immune evasion and stress resistance. This study investigates the molecular and biophysical changes in titanized <i>C. gattii</i> cells grown in nutrient-rich Neurobasal™ medium, a potent inducer of titan cells.</p><p><strong>Methods: </strong>An integrative approach was used, combining scanning electron microscopy, optical tweezers, fluorescence microscopy, and physicochemical methods to analyze <i>C. gattii</i> cells grown in Neurobasal™ medium and minimal media.</p><p><strong>Results: </strong>Cells grown in Neurobasal™ medium exhibited significant differences compared to those grown in minimal media. These included a thicker and more defined polysaccharide capsule, enhanced capsule elasticity, and the secretion of more elastic polysaccharides. Furthermore, cells grown in the enriched medium showed reduced susceptibility to antifungals and delayed mortality in infection models.</p><p><strong>Conclusions: </strong><i>C. gattii</i> adapts to nutritional cues by forming titan cells, thereby enhancing its pathogenicity. Targeting nutritional sensing pathways may offer novel therapeutic strategies against cryptococcal infections.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr Virus Detection in Lymphoproliferative Disorders: Epidemiological Characterization in Western Mexico.","authors":"Karel Cesar Licona-Lasteros, Eduardo Navarrete-Medina, Karina Franco-Topete, Sergio Yair Rodriguez-Preciado, Jaime Palomares-Marin, Gerardo Cazarez-Navarro, Ramón Antonio Franco-Topete, Iván Isidro Hernández-Cañaveral","doi":"10.3390/idr17040100","DOIUrl":"10.3390/idr17040100","url":null,"abstract":"<p><strong>Background/objectives: </strong>Epstein-Barr virus (EBV) detection patterns in lymphoproliferative disorders (LPDs) show significant geographical variation worldwide. Regional epidemiological data are essential for understanding viral distribution patterns and developing appropriate clinical surveillance strategies. This study aimed to determine EBV detection frequency in LPDs using available molecular and immunohistochemical methods in Western Mexico.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 200 formalin-fixed paraffin-embedded tissue samples from patients diagnosed with LPDs (2015-2019) at Hospital Civil de Guadalajara. EBV detection combined with real-time PCR targeting the BNTp143 gene and immunohistochemistry for LMP-1 protein. Cases were classified following current WHO criteria. Statistical analysis included multivariate logistic regression, diagnostic concordance assessment, and age-stratified analysis.</p><p><strong>Results: </strong>EBV detection frequency reached 35.5% overall, with marked differences between neoplastic (53.9%) and reactive LPDs (24.2%) (OR: 3.515; 95% CI: 1.859-6.645, <i>p</i> < 0.001). Hodgkin lymphoma showed the highest detection rate (80.6%), significantly exceeding non-Hodgkin lymphoma (39.3%) (OR: 6.43; 95% CI: 2.08-19.41, <i>p</i> = 0.001). Age-stratified analysis revealed predominant adult involvement (49.1% vs. 22.0% in young adults, <i>p</i> = 0.025). We identified three epidemiological categories based on detection probability patterns.</p><p><strong>Conclusions: </strong>This study represents the first comprehensive molecular and immunohistochemical characterization of Epstein-Barr virus in lymphoproliferative disorders from Western Mexico, establishing distinct epidemiological patterns that align with Latin American regional characteristics. The validated methodology provides a reproducible framework for multi-center studies, while the epidemiological data serve as an essential baseline for future longitudinal research and resource optimization in similar healthcare settings.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Dynamics of Dengue in the State of Pará and the Socio-Environmental Determinants in Eastern Brazilian Amazon.","authors":"Brenda Caroline Sampaio da Silva, Ricardo José de Paula Souza E Guimarães, Bruno Spacek Godoy, Andressa Tavares Parente, Bergson Cavalcanti de Moraes, Marcia Aparecida da Silva Pimentel, Douglas Batista da Silva Ferreira, Emilene Monteiro Furtado Serra, João de Athaydes Silva Junior, Luciano Jorge Serejo Dos Anjos, Everaldo Barreiros de Souza","doi":"10.3390/idr17040099","DOIUrl":"10.3390/idr17040099","url":null,"abstract":"<p><strong>Background: </strong>The Amazon biome exhibits complex arboviral transmission dynamics influenced by accelerating deforestation, climate change, and socioeconomic inequities.</p><p><strong>Objectives/methods: </strong>This study integrates official epidemiological records with socioeconomic, environmental, and climate variables by applying advanced geostatistical methods (Moran's I, SaTScan, kernel density estimation) combined with principal component analysis and negative binomial regression to assess the spatiotemporal dynamics of dengue incidence and its association with socio-environmental determinants across municipalities in Pará state (eastern Brazilian Amazon) from 2010 to 2024.</p><p><strong>Results: </strong>Dengue incidence showed an overall decline but with marked epidemic peaks in 2010-2012, 2016, and 2024. The spatial analysis revealed significant clustering (Moran's I = 0.221, <i>p</i> < 0.01), with persistent high-risk hotspots across most of Pará. Of 144 municipalities, 104 exhibited significant dengue risk, while 58 maintained sustained transmission. Negative binomial regression model identified key determinants: illiteracy, low urbanization, reduced GDP, and climate variables.</p><p><strong>Conclusions: </strong>Dengue transmission in the Amazon is driven by synergistic socio-environmental disruptions, necessitating intersectoral policies that bridge public health surveillance, sustainable land-use governance, and poverty alleviation. Priority actions include targeted vector control in high-risk clusters, coupled with integrated deforestation and climate monitoring to predict outbreak risks. The findings emphasize the urgency of implementing multisectoral interventions tailored to the territorial and socio-environmental complexities of vulnerable Amazonian regions for effective dengue control.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}