Integrated Environmental Assessment and Management最新文献

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Development and application of human health risk-based screening levels for crude oil affected soils and sediments in the Niger Delta. 尼日尔三角洲原油影响土壤和沉积物人类健康风险筛选水平的开发和应用。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf052
George E DeVaull, Matthijs Bonte, Erich R Gundlach, Ogonnaya I Iroakasi
{"title":"Development and application of human health risk-based screening levels for crude oil affected soils and sediments in the Niger Delta.","authors":"George E DeVaull, Matthijs Bonte, Erich R Gundlach, Ogonnaya I Iroakasi","doi":"10.1093/inteam/vjaf052","DOIUrl":"10.1093/inteam/vjaf052","url":null,"abstract":"<p><p>Management of oil-affected sites in Nigeria is regulated through the Environmental Guidelines and Standards for the Petroleum Industry in Nigeria (EGASPIN). This includes an intervention value for total petroleum hydrocarbons (TPHs) of 5,000 mg/kg as a trigger for remedial action. This single intervention value does not differentiate between varied land uses or the specific chemical composition of spilled oil. The EGASPIN does allow development of refined screening levels based on human health risk assessment methods. Following these requirements, we applied the ASTM risk-based corrective action process to define Tier 1 risk-based screening levels (RBSLs) and Tier 2 site-specific target levels (SSTLs). Both are derived using USEPA guidance supplemented by equations correcting for the properties of chemical mixtures, presence of a residual oil phase, and preferential depletion of volatile oil components. The RBSLs were calculated for five Nigerian crude oils and six exposure scenarios specific to the Niger Delta, and SSTLs were calculated using sediment sampling results and four exposure scenarios from the Bodo oil spill area located in the eastern Niger Delta mangrove swamp area. Derived TPH RBSLs range between a factor of 2.5 lower (more stringent) for residential land use to >10 times higher for \"commercial and industrial workers,\" when compared with the Nigerian EGASPIN intervention value. Derived SSTLs for TPH ranged between a value just above the intervention value for shoreline areas near Bodo Town to values approximately six times higher than the intervention value for most uninhabited mangrove areas. The derived RBSLs and SSTLs are protective of human health, but other criteria (aesthetic, ecological) may be more stringent. Additional criteria were introduced, including oil mobility (potential spreading of existing impacts) and criteria for ensuring the viability of the mangrove environment.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1173-1185"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in soil ecotoxicology in climate change scenarios. 气候变化情景下土壤生态毒理学的挑战。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf069
Fernanda Oliveira Reis, Lisiane Martins Volcão, Yuri Dornelles Zebral, Flavio Manoel Rodrigues da Silva Júnior
{"title":"Challenges in soil ecotoxicology in climate change scenarios.","authors":"Fernanda Oliveira Reis, Lisiane Martins Volcão, Yuri Dornelles Zebral, Flavio Manoel Rodrigues da Silva Júnior","doi":"10.1093/inteam/vjaf069","DOIUrl":"https://doi.org/10.1093/inteam/vjaf069","url":null,"abstract":"","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":"21 5","pages":"977-978"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling of dimethylsilanediol fate and transport in soil. 二甲基硅二醇(DMSD)在土壤中的宿命和迁移模拟。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf072
Jaeshin Kim, Shihe Xu, Marc-André Courtemanche
{"title":"Modeling of dimethylsilanediol fate and transport in soil.","authors":"Jaeshin Kim, Shihe Xu, Marc-André Courtemanche","doi":"10.1093/inteam/vjaf072","DOIUrl":"10.1093/inteam/vjaf072","url":null,"abstract":"<p><p>Produced on a scale of over two billion tons per year, methylsiloxanes are ubiquitous in our daily lives. Dimethylsilanediol (DMSD), while not sold commercially, has been demonstrated to be a degradation product of methylsiloxane polymers and volatile methylsiloxanes (VMS) in the environment. Polydimethylsiloxanes and VMS enter the soil compartment when biosolids from wastewater treatment are applied for soil amendment. Understanding the fate and transport of DMSD in soil is important for understanding the ultimate fate of methylsiloxanes. Recently published experimental studies in bare soil and plant-soil systems have significantly advanced the understanding of the fate of DMSD. The results supported the upward transport of DMSD to top surface soil along with pore water during dry periods, its volatilization into the air phase at the soil surface, and its phytovolatilization via transpiration through plants. However, a more systematic understanding was needed to interpret the data using mechanistic models. Thus, the objectives of this study were to: (a) develop mathematical models for DMSD movement in soil systems, (b) optimize the model parameters using recent experimental data, and (c) test the models with varying parameters under different environmental conditions to evaluate DMSD movement in soils. Our models predicted DMSD concentrations and movements that were in good agreement with the experimental results from previously reported column studies in bare soil and soil-plant systems. Sensitivity analyses reveal the key factors governing hydraulic conductivity, DMSD vs water transport, and rate of DMSD transfer to air are soil texture, KOC and KOA, respectively. The impact of plants on DMSD removal to air is also discussed. In the future, we hope to use this model in combination with experimental data to better understand the fate of DMSD in the environment.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1134-1147"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socioeconomic benefits of indigenous agroforestry in enhancing climate adaptation in the Gedeo Zone, Southeastern Ethiopia. 埃塞俄比亚东南部Gedeo地区土著农林业在加强气候适应方面的社会经济效益。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf061
Tigistu Gezahegn, Mesele Negash, Eshetu Yirsaw
{"title":"Socioeconomic benefits of indigenous agroforestry in enhancing climate adaptation in the Gedeo Zone, Southeastern Ethiopia.","authors":"Tigistu Gezahegn, Mesele Negash, Eshetu Yirsaw","doi":"10.1093/inteam/vjaf061","DOIUrl":"10.1093/inteam/vjaf061","url":null,"abstract":"<p><p>Agroforestry, which integrates trees and shrubs into agricultural landscapes, presents a promising solution for enhancing the resilience of smallholder farmers against climate variability and socioeconomic challenges. In the Gedeo Zone of Ethiopia, specifically in Kochere, Wonago, and Yirgachefe districts, farmers are increasingly adapting agroforestry to improve their livelihoods and manage natural resources sustainably. This research investigates the socioeconomic benefits of agroforestry, focusing on its role in enhancing farmers' adaptive capacity. Using an explanatory research design, the study used both quantitative and qualitative approaches. Respondents were selected through multistage stratified sampling, with quantitative data collected from 384 farm households via structured questionnaires. The survey assessed the socioeconomic benefits of agroforestry adaptations. Additionally, focus group discussions and key informant interviews provided qualitative insights. Data analysis included descriptive statistics and a multivariate probit regression model. The findings indicate a predominant engagement in coffee-based agroforestry systems, especially in Yirgachefe, where 77.17% of farmers participate, reflecting a tradition that supports economic stability and environmental sustainability. Moreover, the presence of enset-based agroforestry practices highlights the diversity of applications tailored to local needs. The results highlight the multifaceted benefits of agroforestry, including improved food security, increased income, and enhanced community resilience. Consequently, targeted support programs are recommended to promote sustainable practices and address the challenges faced by farmers, particularly in highland areas, through collaborative efforts among stakeholders to foster resilience and productivity across agroecological zones.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1098-1109"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI may exacerbate the energy trilemma. 人工智能可能会加剧能源三难困境。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf070
Shiyu Sheng, Zebin Zhao
{"title":"AI may exacerbate the energy trilemma.","authors":"Shiyu Sheng, Zebin Zhao","doi":"10.1093/inteam/vjaf070","DOIUrl":"https://doi.org/10.1093/inteam/vjaf070","url":null,"abstract":"<p><p>The rapid expansion of artificial intelligence (AI) is intensifying the global energy trilemma, threatening security, equity, and sustainability. Its soaring electricity demand-projected to rival Japan's entire annual consumption by 2030-is the primary driver. This surge poses a direct threat to energy security, as demand growth dramatically outpaces grid infrastructure development and provokes regional power crises. This trend also undermines energy equity: locally, it drives up electricity prices, unfairly burdening consumers, while globally, it creates a stark imbalance wherein developed nations reap the benefits of AI while developing regions disproportionately bear the environmental costs of raw material extraction. Finally, this dynamic challenges energy sustainability, as short-term, AI-driven productivity gains are often eclipsed by unsustainable energy consumption. While AI holds immense long-term potential to advance a green transition, realizing this is contingent upon embedding the technology within an inclusive governance framework that aligns its trajectory with the overarching goals of sustainable development.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":"21 5","pages":"1223-1224"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of mango (Mangifera indica L.) plantations in carbon detention and ecosystem services. 芒果人工林在碳滞留和生态系统服务中的潜力
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf045
Ajaya Kumar Trivedi, Ghanshyam Pandey, Sushil Kumar Shukla, Jay Narayan Tiwari, Achal Singh
{"title":"Potential of mango (Mangifera indica L.) plantations in carbon detention and ecosystem services.","authors":"Ajaya Kumar Trivedi, Ghanshyam Pandey, Sushil Kumar Shukla, Jay Narayan Tiwari, Achal Singh","doi":"10.1093/inteam/vjaf045","DOIUrl":"10.1093/inteam/vjaf045","url":null,"abstract":"<p><p>Fruit tree plantations have a pivotal role in regulating the microclimate and physical environment of a region. Contribution of forestry species in carbon sequestration and as carbon sinks has been well documented. However, meager attention has been paid to reveal the contribution of fruit tree species. Mango (Mangifera indica L.) is an important fruit tree crop of tropical and subtropical regions of the world, grown in more than 100 countries. With an annual production of 20,946 thousand metric tons (MT), a 2,371 thousand ha area is under mango cultivation in India alone. To assess the carbon detention potential of mango trees, 35-year-old, uniform trees were selected. The circumference of trees in the study was found to vary from 1.43 to 1.96 m, diameter below graft union varied from 0.44 to 0.68 m, tree height varied from 9.45 to 11.13 m, above-ground weight of trees ranged from 1,489.44 to 3,788.56 kg/tree, total weight of trees varied from 1,787.32 to 4,546.27 kg/tree, and total dry weight of trees varied from 1,295.81 to 3,296.05 kg/tree. Magnitude of carbon dioxide sequestered by mango trees was estimated to be 660.98-3,838.96 kg/tree. Annual carbon sequestration potential of an individual mango tree was found to vary from 30.78 to 78.30 kg/tree with an average of 50.55 kg/tree. Mango plantations are crucial for fruit production, ecosystem services, and sustainability of the region. Hence, monitoring and estimation of carbon detention and interaction with the farmers was done simultaneously. The study signifies the fundamental role of mango trees in the mitigation of adverse impact of climate change through carbon detention and vital impact on ecosystem services.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1076-1087"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated probabilistic spatial co-occurrence assessments for aquatic endangered species. 水生濒危物种空间共现概率自动评估。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-09-01 DOI: 10.1093/inteam/vjaf042
Jonnie B Dunne, Hendrik Rathjens, Michael Winchell, Scott Teed, Max Feken, Tony Burd, Richard Brain
{"title":"Automated probabilistic spatial co-occurrence assessments for aquatic endangered species.","authors":"Jonnie B Dunne, Hendrik Rathjens, Michael Winchell, Scott Teed, Max Feken, Tony Burd, Richard Brain","doi":"10.1093/inteam/vjaf042","DOIUrl":"10.1093/inteam/vjaf042","url":null,"abstract":"<p><p>The U.S. Environmental Protection Agency must evaluate potential impacts on federally listed threatened and endangered species during the course of pesticide registration. However, current deterministic methods for analyzing geospatial co-occurrence between listed species and pesticide applications do not account for spatial and temporal variability. To address this challenge, we developed the Automated Probabilistic Co-Occurrence Assessment Tool (APCOAT). Using APCOAT, we modeled potential co-occurrence between atrazine applied to corn and aquatic habitats across the continental United States by developing habitat models for 375 species in flowing waters and 130 species in static waters. The species habitat models showed high predictive power (70%-99% accuracy, median 98%) while maintaining parsimony (median 9 environmental variables). Analysis of both local watershed and upstream pesticide transport revealed that 70% of habitat-pesticide combinations had < 5% co-occurrence probability, 25% showed 5%-10%, and 5% exceeded 10%. The probabilistic approach provides more refined estimates of both species habitat extent and pesticide usage patterns compared with deterministic methods. These spatially explicit models of species distributions and pesticide application patterns provide valuable tools individually, whereas their combination enables nuanced probabilistic co-occurrence assessment. The methods and results demonstrate how incorporating probability and uncertainty can improve both species conservation planning and regulatory decision-making.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1160-1172"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Biotic Ligand Model for The Development of Benthic Toxicity Thresholds and Remedial Goals for Metals at Sediment Management Sites. 生物配体模型对底栖生物毒性阈值和沉积物管理地点金属补救目标的发展的评价。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-08-28 DOI: 10.1093/inteam/vjaf118
Robert W Gensemer, Bjorn Bjorkman, Robert C Santore, Aaron D Redman, Steven S Brown
{"title":"Evaluation of the Biotic Ligand Model for The Development of Benthic Toxicity Thresholds and Remedial Goals for Metals at Sediment Management Sites.","authors":"Robert W Gensemer, Bjorn Bjorkman, Robert C Santore, Aaron D Redman, Steven S Brown","doi":"10.1093/inteam/vjaf118","DOIUrl":"https://doi.org/10.1093/inteam/vjaf118","url":null,"abstract":"<p><p>A combined risk assessment and risk management framework is proposed for application of a multimetal Biotic Ligand Model (mBLM) to develop bulk sediment remedial goals for metals in sediments. Sediment chemistry and toxicity data from five freshwater sediment study areas were compiled to illustrate how this framework could be applied. Based on these data, the mBLM accurately predicted Hyalella azteca toxicity in 85.3% of the samples with respect to H. azteca 20% effect concentrations (EC20s), and in 75.1% of the samples with respect to derived final chronic values (FCVs). The sum of porewater toxic units derived using the mBLM were converted to a bulk sediment remedial goal concentration (CBSRG) using empirical partitioning relationships between metals in sediments and porewater. A median of the CBSRG values in samples with mBLM-FCV ∑ toxic units (TU) > 1 was used as a first approximation of an overall bulk sediment remedial action level (RAL) to identify sediments most in need for remedial action based on the presence of bioavailable metals in porewater in each study area. Bulk sediment RALs ultimately reflected the relative bioavailability of metals in porewater. Where metal porewater bioavailability was relatively low, RALs were higher than bulk sediment remedial goals. Conversely, where metal porewater bioavailability was relatively high, RALs were lower than bulk sediment remedial goals. There is more uncertainty where porewater metal bioavailability was not the primary driver of toxicity as evidenced by low mBLM TU, and a high % of false negative toxicity predictions. We conclude that for sediments in which porewater metal bioavailability is the primary contributor to benthic toxicity, porewater-based remedial goals derived using the mBLM can be used to derive bulk sediment remedial goals that are practical for making site remediation decisions yet still reflect metal bioavailability in porewater.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quaternary ammonium compounds: a standardized nomenclature approach to enhance understanding of an under-studied class of compounds. 季铵化合物:一种标准化的命名方法,以提高对未充分研究的一类化合物的理解。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-08-21 DOI: 10.1093/inteam/vjaf117
Brian N T Chung, Thomas A Bruton, Vicente Samano, Charles N Lowe, Antony J Williams, Anne-Cooper Doherty
{"title":"Quaternary ammonium compounds: a standardized nomenclature approach to enhance understanding of an under-studied class of compounds.","authors":"Brian N T Chung, Thomas A Bruton, Vicente Samano, Charles N Lowe, Antony J Williams, Anne-Cooper Doherty","doi":"10.1093/inteam/vjaf117","DOIUrl":"https://doi.org/10.1093/inteam/vjaf117","url":null,"abstract":"<p><p>Quaternary ammonium compounds, often referred to as QACs or quats, are a class of frequently used chemicals that have received increasing attention due to their increased use during the COVID-19 pandemic and association with a variety of hazard traits. The lack of a standardized nomenclature for this class compromises our ability to understand the use of individual QACs within and across products and product categories, which in turn makes it challenging to accurately assess the potential for human and environmental exposures. This paper presents a clear, descriptive, and consistent nomenclature for QACs. This nomenclature was developed with a focus on QACs used as surfactants and antimicrobials in personal care and cleaning products. By harmonizing the names and abbreviations used to communicate about QACs by the scientific, regulatory, and industrial communities, we hope to improve the ease and accuracy of that communication.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A bioinformatic ecological risk assessment framework for externally applied dsRNA-based biopesticides. 外用dsrna生物农药的生物信息学生态风险评估框架。
IF 8.4 4区 环境科学与生态学
Integrated Environmental Assessment and Management Pub Date : 2025-08-20 DOI: 10.1093/inteam/vjaf116
Emma De Neef, Valeria Velásquez-Zapata, Eric R L Gordon, Kenneth Narva, Peter Mc Cahon, Laurent Mézin, Philip J Lester, Jörg Romeis, Stephen Fletcher, Neena Mitter, Upendra K Devisetty, Krishnakumar Sridharan
{"title":"A bioinformatic ecological risk assessment framework for externally applied dsRNA-based biopesticides.","authors":"Emma De Neef, Valeria Velásquez-Zapata, Eric R L Gordon, Kenneth Narva, Peter Mc Cahon, Laurent Mézin, Philip J Lester, Jörg Romeis, Stephen Fletcher, Neena Mitter, Upendra K Devisetty, Krishnakumar Sridharan","doi":"10.1093/inteam/vjaf116","DOIUrl":"https://doi.org/10.1093/inteam/vjaf116","url":null,"abstract":"<p><p>Double-stranded RNA (dsRNA)-based biopesticides are a promising new method of pest management. These biopesticides leverage the endogenous RNA interference (RNAi) pathway to selectively regulate expression of key genes involved in growth and development in pests, providing the potential to minimize harmful environmental effects by highly specific targeting. As dsRNA-based biopesticides are presented for regulatory review, evaluating potential off-target effects on Non-Target Organisms (NTOs) in a manner that may be unique to this novel sequence-specific mode of action (MoA) is crucial. To address this, we propose here a bioinformatics framework for consideration of sequence-specific off-target effects in NTOs. This framework includes the careful consideration of NTOs based on potential exposure and susceptibility and recommends standardizing analyses to search for 21 nucleotide (nt) long stretches of perfect identity and 80% overall identity between the dsRNA and off-target transcripts. We recommend a three-pronged approach to ensure a comprehensive risk assessment which includes 1) phylogenetic analysis of gene orthologs that defines the taxonomic scope of sequence similarity, 2) broad searches of large databases to identify potential unexpected similarity in distantly related species, and 3) full transcriptome analyses in NTO species of particular concern for a thorough understanding of all potential hazards. Finally, we recommend considering the results of bioinformatic analyses in the context of risk characterization, which means considering likely exposure to the dsRNA-based pesticide and potential susceptibility or barriers to dsRNA uptake. This approach enables a robust ecological risk assessment for dsRNA-based biopesticides and a regulatory path forward for this promising new pest management tool.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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