Evgenia Chaideftou, Shiva Sabzevari, Mazen Ismael, Richard Hůlek, Anke Huss, Daniel Martins Figueiredo, Jakub Hofman
{"title":"National registers of authorized plant protection products in Europe-the data treasury needed for the sustainable use of pesticides.","authors":"Evgenia Chaideftou, Shiva Sabzevari, Mazen Ismael, Richard Hůlek, Anke Huss, Daniel Martins Figueiredo, Jakub Hofman","doi":"10.1093/inteam/vjag054","DOIUrl":"10.1093/inteam/vjag054","url":null,"abstract":"<p><p>Data from the Plant Protection Product (PPP) authorization process in Europe are stored by national institutions and comprise comprehensive datasets on permitted application schemes over time. These datasets provide enormous potential to inform policy and governance. The aim of our study was to inventorize the data from the national PPP-registers across Europe and to appraise the quality of PPP-register data in terms of availability, accessibility, resolution in content, and harmonization. To our knowledge, this is the first attempt to appraise systematically the quality of such PPP-related data. Our analyses show that data quality was better in terms of resolution and availability than in terms of accessibility and harmonization. Accessibility was quite variable, and, in general, harmonization was lacking. Four PPP-registers representing different European pedoclimatic conditions and regulatory zones were selected following a decision-tree approach. The database from Czechia was used as a prototype showcasing what valuable tools can be derived from the PPP-register data that are of high quality. Then, the Austrian, Portuguese, and Estonian databases were processed in a similar way. The data processing revealed limitations associated with a lack of harmonization across databases and resources. The selected data were extracted and converted into Generalized Application Patterns of PPPs in each country, i.e., databases containing all possible authorized uses (substance-specific and crop-specific application rates, time, and number of applications per year). Using existing large data of high quality, new tools can be derived to assist PPP-related assessments and decision making. This contributes to achieving the pesticide sustainable use goals embedded in the European Farm to Fork Strategy.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1413-1433"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonnie B Dunne, Hendrik Rathjens, Michael Winchell, Max Feken, Richard Brain
{"title":"Advances in probabilistic co-occurrence assessment: New features and capabilities in APCOAT version 3.0.","authors":"Jonnie B Dunne, Hendrik Rathjens, Michael Winchell, Max Feken, Richard Brain","doi":"10.1093/inteam/vjag087","DOIUrl":"https://doi.org/10.1093/inteam/vjag087","url":null,"abstract":"","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":"22 5","pages":"1352-1353"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leah M Oliver, Amanda A Brennan, Kimberly Salinas, Kelly R McCaffrey, Jill A Awkerman, Mark Jankowski, Brittany E Cunningham, Kristin Jones, Sandy Raimondo
{"title":"Toxicity of chlorpyrifos, diazinon, malathion, carbaryl, and acrolein alone and in mixtures on the fairy shrimp Thamnocephalus platyurus.","authors":"Leah M Oliver, Amanda A Brennan, Kimberly Salinas, Kelly R McCaffrey, Jill A Awkerman, Mark Jankowski, Brittany E Cunningham, Kristin Jones, Sandy Raimondo","doi":"10.1093/inteam/vjag044","DOIUrl":"10.1093/inteam/vjag044","url":null,"abstract":"<p><p>Assessments of potential risk to nontarget organisms from pesticide exposure are required for federal actions, including registering pesticides and setting water quality criteria. Where threatened or endangered (listed) species are potentially impacted, pesticide-related assessments should include environmentally relevant exposure scenarios, and yet experimental toxicity data for surrogate species often focuse on single-chemical laboratory exposures. Vernal pools in California, USA are home to several ecologically important listed species, including the vernal pool fairy shrimp (Branchinecta lynchi), and coincide with areas of intense agricultural pesticide use. We tested individual and combined toxicity of pesticides chlorpyrifos, malathion, diazinon, carbaryl, and acrolein in 24-hr acute bioassays to Thamnocephalus platyurus, a surrogate fairy shrimp species to endangered B. lynchi. Acrolein, an herbicide, was the most toxic and was associated with the highest percent lethality of total effect, which included death and morbidity. Chlorpyrifos was the most toxic of the remaining acetylcholinesterase-inhibiting pesticides. For pesticide mixture experiments in which proportions of acetylcholinesterase inhibitors varied, the expected additive effective concentrations affecting half of the population (EC50s) overestimated the observed effect. Malathion and diazinon mixtures with relatively high percent diazinon were closer to expected effects than high malathion mixtures, whereas in mixtures with carbaryl, treatments with higher diazinon percentage had less than additive effects. Variation within treatments was high, and overall deviations from expected values were moderate, supporting a general additive approach for evaluating risks from these pesticides where they may co-occur. Pesticide EC50s to T. platyurus are further compared with other aquatic invertebrates, to modeled concentrations in vernal pools, and with environmental concentrations from a paucity of in situ field-collected data from vernal pool habitats in the Western United States. Our results can be applied to ecological risk assessments of pesticide impact to B. lynchi or its critical habitat, and to those involving the wider vernal pool habitat range for T. platyurus.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1635-1649"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Devecchi, Efstathios Reppas-Chrysovitsinos, Anna Lia S Tromer Dragsdahl, Lisa Pizzol, Elena Semenzin, Alex Zabeo, Danail Hristozov, Tomas Rydberg
{"title":"Planetary Boundaries and Absolute Sustainability in Life Cycle Assessment - past, present, and future.","authors":"Sarah Devecchi, Efstathios Reppas-Chrysovitsinos, Anna Lia S Tromer Dragsdahl, Lisa Pizzol, Elena Semenzin, Alex Zabeo, Danail Hristozov, Tomas Rydberg","doi":"10.1093/inteam/vjag150","DOIUrl":"https://doi.org/10.1093/inteam/vjag150","url":null,"abstract":"<p><p>Efforts to steer the social metabolism (i.e., how human societies interact with nature) towards sustainability are pulling assessment practice in two directions: \"relative\" product-to-product comparisons and \"absolute\" product-to-limit benchmarking, where the limit works as benchmark for the assessment. Within approaches such as Safe and Sustainable by Design, inherently threshold-based \"absolute\" chemical Risk Assessment is coupled to Life Cycle Assessment, which has traditionally been used as a tool for comparing alternatives. This coupling is driving the development of methodologies for comparative assessment of (eco)toxicological impact potentials (e.g., chemical footprinting). In parallel, the emergence of the Planetary Boundaries framework has renewed the interest in shifting from comparative assessments towards absolute benchmarking against global environmental limits, leading to Absolute Environmental Sustainability Assessment. This paper reviews how environmental limits are incorporated into Life Cycle Assessment through early distance to target methods (such as Ecological Scarcity, Environmental Themes, Eco-Indicator 95) to support business-driven eco-efficiency decisions and how impacts were anchored in national or regional targets and critical loads. We then discuss how the Planetary Boundaries framework reorganizes limits around Earth-system processes and how Planetary Boundaries based Life Cycle Assessment translates global boundaries into Life Cycle Assessment indicators and Planetary Boundaries based \"budgets\" for products and sectors. Across these developments, we show that setting and allocating thresholds reflects conflicting notions of \"weak\" and \"strong\" sustainability and is unavoidably value-laden and argue that making this \"valuesphere\" explicit is crucial if Planetary Boundaries based Life Cycle Assessment is to inform credible, product-level Safe and Sustainable by Design decisions on absolute sustainability.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Porush Kumar, Paras Kumar, Mahendra Pratap Choudhary
{"title":"Assessing the nexus between human health and air pollutants through spatiotemporal analysis of particulate matters.","authors":"Porush Kumar, Paras Kumar, Mahendra Pratap Choudhary","doi":"10.1093/inteam/vjag046","DOIUrl":"10.1093/inteam/vjag046","url":null,"abstract":"<p><p>This study evaluates spatiotemporal variation of particulate pollution and associated health impacts in Jodhpur, an arid Indian city among the most polluted in the country. Data from nine monitoring stations (2019-2024) were analyzed for PM2.5 and PM10 using meteorological parameters, geospatial mapping, and the Air Quality Index (AQI). Health risks were quantified with the WHO-recommended AirQ+ model for both long-term (LTEs) and short-term exposures (STEs). Results indicate that city-averaged PM2.5 concentrations declined from 100.9 µg/m3 in 2019 to 53.5 µg/m3 in 2024 (47%), while PM10 decreased from 213.0 to 135.6 µg/m3 (36%). Seasonal patterns remained distinct, with premonsoon and winter peaks influenced by boundary-layer dynamics, wind regimes, and monsoonal washout. Spatial analysis identified persistent hotspots in residential (S-2) and traffic-dense (S-9) zones, while S-6 showed the largest relative improvement. The AQI improved from poor (273) in April 2019 to good (50) in August 2024. PM2.5-attributable all-cause and lung cancer mortality declined by 47% and 44%, respectively, alongside 69% reductions in asthma and cardiovascular hospitalizations. Despite these gains, persistent hotspots necessitate stricter emission control and seasonally adaptive strategies for sustainable urban air quality management in arid regions.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1663-1681"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baile Xu, Bing Zhang, Xiaojing Li, Ying Chen, Yang Yu, Geoff Hodges, Bruno Campos, Juliet Hodges, Jin Li, Guang-Guo Ying, Jianguo Liu, Wei Shi, Yiping Xu, Yanbin Zhao, Changsheng Guo, Zi-Feng Zhang, Liguo Xing, Amelie Ott, Qinqin Liu, Jie-Bing Zhu, Lili Shi, Zhongyu Wang, Lei Wang
{"title":"Moving toward next-generation environmental risk assessment of chemicals in China.","authors":"Baile Xu, Bing Zhang, Xiaojing Li, Ying Chen, Yang Yu, Geoff Hodges, Bruno Campos, Juliet Hodges, Jin Li, Guang-Guo Ying, Jianguo Liu, Wei Shi, Yiping Xu, Yanbin Zhao, Changsheng Guo, Zi-Feng Zhang, Liguo Xing, Amelie Ott, Qinqin Liu, Jie-Bing Zhu, Lili Shi, Zhongyu Wang, Lei Wang","doi":"10.1093/inteam/vjag084","DOIUrl":"10.1093/inteam/vjag084","url":null,"abstract":"<p><p>Rapid industrial development and its inherent use of chemicals raise environmental concerns in China, and their risk assessment and management remain challenging. Next-generation environmental risk assessment (environmental NGRA), as an exposure-led, hypothesis-driven approach, is a promising framework to address this challenge and better protect human and environmental health. This brief communication stems from the recent, first multistakeholder workshop on environmental NGRA in China, which brought together regulators, academia, and industry. We reviewed current progress and identified challenges for implementation of environmental NGRA in China, focusing on scientific advancements and regulatory application of spatially explicit exposure modeling and new approach methodologies (NAMs). More importantly, we identified future opportunities and key prioritized actions to advance its implementation in China. Four key recommendations were identified to accelerate implementation, including: (i) create a multipartite discussion forum (e.g., a working group) to support and guide the development and application of environmental NGRA; (ii) develop an environmental NGRA framework and roadmap in China; (iii) develop case studies integrating human and environmental safety; and (iv) foster international collaboration for the co-development of best practice in environmental NGRA ensuring global alignment where possible. Overall, we provide a forward-looking perspective on its scientific, regulatory, and technical dimensions, marking a critical milestone for advancing next-generation safety science in China.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1365-1375"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From sources to solutions: An integrated framework for industrial risk assessment, subsurface contaminant dynamics, and nature-based remediation from RemTech Europe 2024.","authors":"Paola Grenni, Marco Falconi","doi":"10.1093/inteam/vjag108","DOIUrl":"10.1093/inteam/vjag108","url":null,"abstract":"<p><p>Effective territorial preservation and contaminated site management require an integrated multiscale framework that bridges macroeconomic tracking with site-specific physics, chemical forensics, and biotechnology. Within this framework, this brief communication synthesizes seven key advancements discussed at RemTech Europe 2024. Environmental assessments presented during the meeting span the macroregional level with soil pollution inventories in the Western Balkans to localized atmospheric natural hazard-triggered technological accident risk modeling for industrial facilities. At the subsurface scale, the dynamic interplay of groundwater table fluctuations controls light nonaqueous phase liquid migration, while hydrogeological fingerprinting isolates distinct anthropogenic per- and polyfluoroalkyl substance sources. Addressing these complex matrices, biotechnological assessments elucidate how emerging graphene-related nanomaterials interact with biodegradative enzymes to evaluate targeted biodegradation pathways. Finally, the scale transitions to nature-based engineering solutions, utilizing urban green gutters for stormwater retention and quantifying the long-term recovery of ecosystem services through spontaneous quarry revegetation. The integration of modeling, forensic analysis, biotechnologies, and nature-based solutions provides actionable insights for environmental risk management and sustainable land use planning. Ultimately, this collective evidence offers regulators and stakeholders an operational roadmap to accelerate the transition from hazard identification to scale-appropriate, climate-resilient remediation strategies.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":"1441-1445"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Minolfi, Fabio Rosada, Elisa Giubilato, Alex Zabeo, Stephane Belbèze, Virginie Derycke, Timo Tarvainen, Isadora Antoniano-Villalobos, Elena Semenzin, Lisa Pizzol
{"title":"Regional risk assessment Part II: identification of diffuse soil contamination hotspots.","authors":"Giulia Minolfi, Fabio Rosada, Elisa Giubilato, Alex Zabeo, Stephane Belbèze, Virginie Derycke, Timo Tarvainen, Isadora Antoniano-Villalobos, Elena Semenzin, Lisa Pizzol","doi":"10.1093/inteam/vjag148","DOIUrl":"https://doi.org/10.1093/inteam/vjag148","url":null,"abstract":"<p><p>Diffuse soil contamination represents a widespread environmental issue, resulting from multiple low-intensity and spatially dispersed sources, including atmospheric deposition, agricultural practices, traffic emissions, and legacy industrial activities. Unlike point-source pollution, diffuse contamination lacks a clear spatial origin, requiring methodologies that can integrate measured data with environmental processes. In this case concentration-based mapping alone is often insufficient to support risk-informed management decisions. This study presents a regional-scale environmental risk assessment framework for diffuse soil contamination, building on the methodological advances introduced in the companion paper (Part I) and extending them to spatially distributed pressures. The assessment is expanded to a multi-contaminant context, including both inorganic and organic compounds, and contaminant concentrations are evaluated against land-use-specific regulatory threshold values. Hazard maps are normalised according to the established criterion whereby soils are considered hazardous when concentrations exceed threshold values by one order of magnitude, enabling consistent comparison and aggregation across contaminants. Exposure is modelled through four exposure pathways (groundwater, surface water, direct contact, and air dispersion) and receptor vulnerability is further articulated for groundwater resources, surface waters, protected areas and human health. The resulting framework supports a transition from a predominantly regional human-health-oriented assessment towards a more comprehensive environmental risk assessment, producing spatially explicit prioritisation maps for individual contaminants and aggregated diffuse-contamination risk. Application to the Toulouse Metropolitan Area (France), demonstrates the ability to move beyond concentration exceedances by identifying areas of higher management priority where diffuse pressures, transport processes and receptor vulnerability converge. Implemented within a GIS-based Model Builder environment, the methodology is reproducible and transferable to other regions where soil data are available but site-specific information is limited, offering a scientifically grounded basis for supporting decision-makers in land-use planning, monitoring prioritization and early-stage risk-based management actions, in line with the new EU Soil Monitoring and Resilience Directive.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anja Gladbach, Christoph J Mayer, Aaron Stoler, Sian Ellis, Marta Baccaro, David A Bohan, Franziska Enzmann, Emily Garman, Jutta Hellstern, Sarah A Hughes, Philippe Lemaire, Jan-Dieter Ludwigs, Lorraine Maltby, Anna-Maija Nyman, Hans Sanderson, Simran Sandhu, Marco Thines, Johannes Tolls, Lucy Wilmot, Nika Galic
{"title":"Biodiversity and chemical regulation: Status quo, data gaps, and recommendations for future action.","authors":"Anja Gladbach, Christoph J Mayer, Aaron Stoler, Sian Ellis, Marta Baccaro, David A Bohan, Franziska Enzmann, Emily Garman, Jutta Hellstern, Sarah A Hughes, Philippe Lemaire, Jan-Dieter Ludwigs, Lorraine Maltby, Anna-Maija Nyman, Hans Sanderson, Simran Sandhu, Marco Thines, Johannes Tolls, Lucy Wilmot, Nika Galic","doi":"10.1093/inteam/vjag145","DOIUrl":"https://doi.org/10.1093/inteam/vjag145","url":null,"abstract":"<p><p>Global biodiversity is declining, driven by multiple, interacting pressures including the 5 most prominent of resource use, habitat loss, invasive species, climate change, and chemical pollution. While chemical exposure is recognised as a potential driver of biodiversity loss, quantitative links and its relative impact compared to other stressors remains poorly understood. The European Union (EU) has intensified efforts to reduce pollution and restore biodiversity through strategic frameworks such as the Biodiversity Strategy, Farm to Fork Strategy, Zero Pollution Action Plan, and Chemical Strategy for Sustainability. Key chemicals regulations like REACH and the Plant Protection Products Regulation aim to protect ecosystems, however, due to the complexity of ecosystems and the range of impacting stressors it is difficult to measure their direct impact on maintaining or improving biodiversity objectives. This review, conducted by a multidisciplinary Task Force brought together by ECETOC, evaluates the current state of biodiversity research efforts and its integration within EU chemical regulation. We examined EU legislation, strategy documents, EU-funded research, and peer-reviewed literature to identify biodiversity definitions, metrics, and methodologies, and to highlight gaps in linking chemical exposure to biodiversity outcomes. Findings indicate that: current chemical regulations reference biodiversity mainly qualitatively, biodiversity research often lacks a focus on chemical impacts, and research outcomes are not clearly linked to regulatory frameworks. The relationship between biodiversity and chemical impacts is further complicated by diverse definitions and metrics of biodiversity in the academic literature, with limited consistency across biomes and minimal alignment with chemical risk assessment practices. To strengthen biodiversity considerations in chemical regulation, we recommend: developing operational definitions of biodiversity applicable across regulatory contexts; standardising metrics and indicators; establishing a centralised data platform for biodiversity research; and leveraging existing data, methodologies, tools and new technologies (e.g. machine learning). Bridging knowledge gaps between policy objectives and available approaches, whilst aligning biodiversity considerations across both chemical regulation and other regulations which can impact biodiversity such as habitat loss, will promote coherence and cooperation. Continued multistakeholder engagement and alignment is critical in achieving these recommendations.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From \"wish-list\" to successful delivery: Opportunities for multidisciplinary and multisectoral engagement in implementation of strategies to phase out animal testing.","authors":"Paris Jeffcoat, Steven Maguire, Gordon M Hickey","doi":"10.1093/inteam/vjag146","DOIUrl":"https://doi.org/10.1093/inteam/vjag146","url":null,"abstract":"<p><p>Regulatory agencies worldwide are calling for New Approach Methods (NAMs) that reduce reliance on vertebrate animal testing in toxicological risk assessment and related regulatory decision-making. In this Brief Communication, we consider three recent examples of holistic strategies that support the development, validation, and uptake of NAMs in regulatory settings, namely the 'Strategy to replace, reduce or refine vertebrate animal testing under the Canadian Environmental Protection Act, 1999 (CEPA)', the 'Replacing animals in science: A strategy to support the development, validation and uptake of alternative methods' in the United Kingdom, and the 'Roadmap towards phasing out animal testing for chemical safety assessments' from the European Union. The development, consultation on, and publication of these strategies represent an important step forward in the regulatory adoption of NAMs. We aim to interpret and highlight commonalities and differences between these strategies to identify the themes and actions being proposed to eliminate NAM obstacles and enhance NAM drivers in different regulatory settings. Further, we consider some of the challenges that may lay ahead in the effective implementation and delivery of these strategies, including 1) Sustaining commitment to delivery of aspirational plans, 2) Increasing engagement in regulatory processes by NAM developers, and 3) Increasing the regulatory relevance of NAM data.</p>","PeriodicalId":13557,"journal":{"name":"Integrated Environmental Assessment and Management","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}