Inflammopharmacology最新文献

{"title":"A thioridazine-derived molecule exhibits potential anti-inflammatory activity through IKK inhibition.","authors":"Shivmuni Sarup, Rajat Atre, Alexander G Obukhov, Shams Tabrez, Priyanka Yadav, Aravind Singh Kshatri, M Hassan Sk, Abdulaziz Alamri, Mohd Shahnawaz Khan, Mirza S Baig","doi":"10.1007/s10787-025-01786-y","DOIUrl":"https://doi.org/10.1007/s10787-025-01786-y","url":null,"abstract":"<p><p>Chronic inflammatory diseases are leading causes of morbidity and mortality, necessitating the development of targeted therapeutics with improved safety. Many drugs have been withdrawn from the market because of their off-target effects, particularly hERG inhibition, which leads to severe cardiotoxicity. The NF-κB pathway plays a critical role in inflammation and immune response, making IKKβ an attractive therapeutic target. Thioridazine, a known inhibitor of IKKβ, has demonstrated potential anti-inflammatory effects. However, its clinical utility is severely limited by the strong inhibition of the hERG potassium channel, which increases the risk of cardiac arrhythmias. Therefore, it is necessary to develop safer IKKβ inhibitors using rational drug design approaches. By leveraging a similar compound library and in silico techniques, we aimed to retain the original therapeutic potential of thioridazine, while minimising its drawbacks. A library of thioridazine derivatives was computationally designed and screened by molecular docking and simulations. The selected compounds were subjected to patch-clamp analysis, confocal microscopy, western blotting, and qRT-PCR to evaluate their anti-inflammatory potential and hERG affinity, respectively. TDZ-D2{10-(2-oxo-2-pyrrolidin-1-ylethyl)acridin-9-one}, a thioridazine derivative, displayed significantly lower hERG binding while maintaining strong IKKβ inhibition, preserving IκBα stability, reducing NF-κB p65 translocation, and suppressing pro-inflammatory cytokine expression. This study highlights the potential of ligand-based lead optimisation techniques for mitigating off-target effects, thereby offering a safer anti-inflammatory therapeutic candidate. By overcoming the cardiotoxicity associated with thioridazine, TDZ-D2 presents a promising avenue for drug development for inflammatory diseases.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the gut-skin axis: the role of gut microbiota in pathogenesis and management of psoriasis.","authors":"Arun Pachauri, Shweta Sharma","doi":"10.1007/s10787-025-01813-y","DOIUrl":"https://doi.org/10.1007/s10787-025-01813-y","url":null,"abstract":"<p><p>Psoriasis is a chronic, multifactorial, inflammatory skin disease, increasingly recognized as a systemic disorder influenced by the gut-skin axis, which is a dynamic bidirectional communication between intestinal microbiome and cutaneous immune response. This narrative review explores the understanding of the gut-skin axis with the latest evidence on how gut dysbiosis occurs in psoriasis, characterized by reduced microbial diversity and its shifts, and how it contributes to pathogenesis and exacerbation of psoriasis. Notably, recent scientific literature evidence suggests that the alteration of gut microbiome in psoriasis includes a decreased level of beneficial species like Faecalibacterium prausnitzii and a rise in the level of proinflammatory bacterial species like Prevotella copri. Mechanistic insights reveal that gut-derived metabolites, impaired barrier functions, and immune signaling, particularly involving IL-23 and Th17 cells, play a pivotal role in this axis, linking intestinal health to cutaneous manifestations. Both animal and human trials underscore the therapeutic potential of interventions targeting the gut microbiota, including prebiotics, probiotics, dietary modifications, and FMT, demonstrating some promising but variable effects on disease severity and systemic inflammation. Despite these advances, translating the gut-skin axis into clinical practice presents a notable challenge due to limited scientific evidence, a lack of standardised microbiome profiling, and the absence of universally accepted biomarkers to monitor and stratify therapeutic outcomes. These limitations hinder the development of personalised care approaches and the integration of the gut-skin axis as a promising frontier in many autoimmune diseases, where the gut-skin axis and the intestinal microbiome play a crucial role.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress on the mechanism of natural polysaccharides in the treatment of arthritis.","authors":"Lili Yuan, Michael Adu-Frimpong, Hong Chen, Yaping Yang, Jiangnan Yu, Huiya Wang, Yuxiang He, Elmurat Toreniyazov, Xia Cao, Qilong Wang, Ximing Xu","doi":"10.1007/s10787-025-01772-4","DOIUrl":"https://doi.org/10.1007/s10787-025-01772-4","url":null,"abstract":"<p><p>Arthritis is a common joint-injury disease, and because its exact etiology and pathogenesis remain incompletely understood, current treatment options for it are highly limited. Conventional treatments focus on anti-inflammatory drugs to alleviate the disease. However, long-term use of these medications can cause increasingly serious side effects. Therefore, there is an urgent need to develop safe and effective anti-arthritis drugs with fewer side effects. Polysaccharides derived from natural products have received a lot of attention because of their safety and multiple active effects, wherein they have shown strong potential especially in the treatment of arthritis. However, a systematic presentation of polysaccharides against arthritis is still lacking. In this paper, we summarize the recent studies on natural polysaccharides for arthritis treatment mainly in terms of isolation, structure-anti-arthritic relationship, pharmacokinetics, mechanisms, and association of polysaccharides with other substances. It is helpful for researchers to fully understand the anti-arthritic effects of polysaccharides and provide some references for the development and application of polysaccharides in arthritis treatment.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical studies of Veitchia arecina Becc. leaves with evaluation of in-vitro, in-vivo anti-inflammatory, and wound healing properties in rats.","authors":"Radwa S Emad, Rasha A Attia, Mona Fekry, Nesreen M I M Elkomy, Tarek M Ibrahim, Amal A Al-Gendy","doi":"10.1007/s10787-025-01802-1","DOIUrl":"https://doi.org/10.1007/s10787-025-01802-1","url":null,"abstract":"<p><p>Veitchia arecina Becc. (Arecaceae family), a palm species known for its antioxidant and anti-inflammatory properties, attributed to bioactive constituents that may facilitate wound healing and enhance dermatological health. However, the wound-healing efficacy of Veitchia arecina remains uninvestigated. This study is the first to evaluate the chemical composition, antioxidant and anti-inflammatory activities, dermal safety, and wound-healing potential of Veitchia arecina leaf fractions in a rat model. The study aimed to elucidate their mechanism of action in tissue regeneration. The chemical composition of light petroleum ether and n-butanol soluble fractions of Veitchia arecina was analyzed via gas-liquid chromatography-mass spectrometry (GLC-MS) and liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS), respectively. In-vitro antioxidant (DPPH), anti-inflammatory (COX-1), and MTT assays were performed utilizing a 5% gel formulation, with povidone-iodine serving as the standard. The phytochemical analysis of the tested fractions using GLC-MS and LC-ESI-MS/MS revealed the presence of sterols, terpenes, vitamin E isomers, and fatty acids in light petroleum ether soluble fraction as well as flavonoid glycosides and phenolics in n-butanol soluble fraction. Both fractions showed significant antioxidant and COX-1 inhibitory activities comparable to Trolox and ibuprofen. The topical gel formulations exhibited no dermal toxicity while improving healing by attenuating inflammation and oxidative stress, enhancing blood vessel formation, re-epithelization, formation of collagen, and restoring skin architecture. Notably, the n-butanol fraction demonstrated superior efficacy in facilitating granulation tissue maturation. This study demonstrates the dermal safety, antioxidant, anti-inflammatory, and wound-healing properties of Veitchia arecina leaf fractions, particularly flavonoid-rich variants, suggesting their potential therapeutic applications in dermatological conditions.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bee venom modulates human neutrophil inflammatory functions in Vitro and exerts an anti- inflammatory effect in Vivo in rats.","authors":"Meriem-Dehbia Chabane, Samia Bedouhene, Sahra-Amel Belambri, Nassima Senani, Tinhinane Rekeb, Kahina Ladj, Riadh Ksouri, Pham My-Chan Dang, Jamel El-Benna","doi":"10.1007/s10787-025-01797-9","DOIUrl":"https://doi.org/10.1007/s10787-025-01797-9","url":null,"abstract":"<p><p>Bee venom (BV) is a complex bioactive mixture known for its paradoxical ability to exert both pro-inflammatory and anti-inflammatory effects, making it a compelling modulator of inflammatory responses. In this study, we investigated the effect of BV on human neutrophil inflammatory functions in vitro and its effect on inflammation in vivo in rats. Results revealed that BV exhibited a dose-dependent inhibitory effect on formyl-Met-Leu-Phe (fMLF)-induced superoxide production by neutrophils, without affecting PMA-induced superoxide production or superoxide production by the xanthine-xanthine oxidase system. BV was not toxic to neutrophils and did not affect neutrophil adhesion, however, and surprisingly it induced myeloperoxidase release from neutrophils. Interestingly, in vivo BV effectively suppressed xylene-induced ear edema and significantly reduced carrageenan-induced peritonitis by limiting neutrophil recruitment to the peritoneum. These findings suggest that although bee venom can either inhibit or stimulate neutrophil functions in vitro, it still exerts an anti-inflammatory effect in vivo. This dual action highlights the complexity of BV's bioactive components and the importance of targeted therapeutic modulation in inflammatory conditions.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the neuroprotective potential of Jatropha humboldtiana leaves and its metabolic profiling by UPLC-MS/MS.","authors":"Paul Alan Arkin Alvarado-García, Marilú Roxana Soto-Vásquez, Ricardo D D G de Albuquerque, Fadia S Youssef, Reem M Diri, Mohamed L Ashour","doi":"10.1007/s10787-025-01707-z","DOIUrl":"10.1007/s10787-025-01707-z","url":null,"abstract":"<p><p>This study aims to determine the phytochemical profile of Jatropha humboldtiana ethyl acetate fraction (EAFHJ) using UPLC-MS/MS and evaluate its neuroprotective potential via in vivo model. In vivo behavioral assays including elevated plus maze (EPM), forced swim test (FST), tail suspension test, and pentylenetetrazol (PTZ) assay were conducted in mice to evaluate the anxiolytic, antidepressant, and anticonvulsant effects. Pro- and anti-inflammatory cytokines were measured, and acute toxicity studies were performed to determine LD50. Thirty-three compounds were identified in EAFHJ, including phenolic acids, flavonoids, and coumarins. In the FST, EAFHJ reduced the immobility time to 131.50 ± 3.46 s at 100 mg/kg compared to 139.88 ± 4.58 s in the control group (p < 0.01). In the EPM, the group treated with 200 mg/kg of EAFJH spent 48.14% of the time in the open arms, compared to 31.30% of the control group (p < 0.05). In the PTZ trial, the latency to myoclonic seizures was 3.0 ± 0.5 min at 200 mg/kg of EAFHJ compared with 1.01 ± 0.5 min in the control group (p < 0.05). The LD50 of the EAFJH was greater than 5000 mg/kg, indicating low toxicity. Furthermore, a significant reduction in pro-inflammatory cytokine levels (IL-6, TNF-α, IL-1β) and an increase in anti-inflammatory cytokines (IL-10, IL-4) were observed. Thus, it was concluded that Jatropha humboldtiana exhibits a diverse phytochemical profile and promising anxiolytic, antidepressant, and anticonvulsant effects, likely mediated by a combination of neurotransmitter modulation and anti-inflammatory mechanisms. Further studies are required to elucidate the precise molecular pathways involved and explore its clinical potential.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"3411-3426"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iota-carrageenan oligosaccharide ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating SCFAs-PI3K-AKT pathway.","authors":"Meixian Xiang, Songtao Wu, Minxin Liu, Bin Zhang, Xiankun Xia, Wenjing Tan, Shijian Xiang","doi":"10.1007/s10787-025-01718-w","DOIUrl":"10.1007/s10787-025-01718-w","url":null,"abstract":"<p><p>Iota-carrageenan oligosaccharides (iCOs), derived from marine red algae, are traditionally used as antithrombotic and anti-inflammatory agents in folk medicinal practice. Despite the prevailing emphasis on these aspects in their applications, the potential of iCOs as a prebiotic agent for gut health and its subsequent impact on intestinal disorders such as colitis remains largely unexplored. A DSS-induced colitis model was employed in C57BL/6 male mice to analyze the gut microbiota via 16S rRNA sequencing. Fecal microbiota transplantation (FMT) was used to assess the therapeutic effects of iCOs on colitis. RNA sequencing (RNA-Seq) identified pathways and genes affected by iCOs. ELISA measured inflammatory cytokines, while western blot and RT-qPCR evaluated protein and gene expressions, respectively. The iCOs increased beneficial bacteria, such as Lactobacillus, Bifidobacterium, and Akkermansia. They enhanced short-chain fatty acid production and upregulated GPR41, GPR43, and GPR109A mRNA, influencing cytokine secretion. The iCOs reduced mRNA of SPHK1, BDKRB1, LCN2, and so on, potentially through PI3K-Akt pathway inhibition, and promoted tight junction protein expression. Our findings highlight the novel therapeutic potential of iCOs in colitis, indicating a multifaceted approach to treatment that includes gut microbiota modulation, intestinal barrier restoration, and the suppression of inflammatory responses.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"3443-3460"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neuroprotective potential of Gerbera Jamesonii in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α.","authors":"Shazia Anwer Bukhari, Haleema Sadia, Zunera Chauhdary","doi":"10.1007/s10787-025-01742-w","DOIUrl":"10.1007/s10787-025-01742-w","url":null,"abstract":"<p><p>Multiple sclerosis is characterized by the demyelination of neurons, which is a chronic inflammatory disease of the central nervous system. This autoimmune disorder occurs due to an imbalance in the body's immune system as a result of uncontrolled oxidative stress. The B and T lymphocytes cross the blood-brain barrier and destroy the myelin sheath. Multiple sclerosis is one of the most common causes of disability in young adults affecting approximately 3 million individuals worldwide. Among them, females are considered at higher risk than males. It disrupts the normal functioning of life badly and major symptoms include loss of sensation, poor vision, impaired hearing, and cognitive abnormalities. Several treatments and drugs have been used to treat this medical condition, but they pose serious side effects also. So, the need of the hour is to explore such natural bioactive compounds that have neuroprotective properties, thus leading to the treatment of neurodegenerative disorders. Among various plants with medicinal properties, Gerbera jamesonii is a plant that exhibits antioxidant, anti-inflammatory, and neuroprotective properties. To enhance its therapeutic potential, this study aimed to load its ethanolic extract into solid-lipid nanoparticle formulations (SLNs), which is an innovative approach for treatment because nanoparticles provide effective targeted drug delivery due to their extremely small size. Solid-lipid nanoparticles were prepared using the emulsification-solvent evaporation method. For experimental design, 30 Wistar rats were randomly divided into seven groups (n = 10): normal, demyelination disease model, standard drugs, dimethyl fumarate and fingolimod (FTY 720) 15 mg/kg, and three treatment groups: GJ-NPs 250 mg/kg, 500 mg/kg, and 750 mg/kg. Prior to treatment, 0.2% cuprizone solution was prepared for the induction of multiple sclerosis in all groups except the normal group for 42 days. Biochemical analyses such as determination of inflammatory biomarkers and antioxidant enzymes were performed. The plant extract was subjected to HPLC to examine its phenolic compounds which are active in healing neurodegeneration. Physiological changes in rats were observed such as motor dysfunction and anxiety-like behavior caused by cuprizone. Behavioral tests showed significant improvement of motor function, muscular coordination, and enhanced cognitive abilities in the treatment groups as compared to the demyelination disease model. Histopathology of the rat brain regions showed significant differences in the normal and demyelinated areas. The results showed that GJ-NPs treated demyelination, modulating oxidative stress manifested by pro-inflammatory cytokines TNF-α, IL-6, AβPP, α-synuclein, NF-_KB, etc., thus restoring the levels of antioxidant enzymes to normal range.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"3329-3347"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The impact of tocilizumab treatment on the severity of inflammation and survival rates in sepsis is significantly influence by the timing of administration.","authors":"Taha Tavaci, Zekai Halici, Elif Cadirci, Mustafa Ozkaraca, Kamber Kasali","doi":"10.1007/s10787-025-01748-4","DOIUrl":"10.1007/s10787-025-01748-4","url":null,"abstract":"","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"3515"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farnesol alleviates inflammatory responses and oxidative stress in Freund's complete adjuvant induced arthritic rat model and associated risk factors of atherosclerosis.","authors":"Isma Anwar, Ali Sharif, Mushtaq Ahmad, Maryam Shabbir, Bushra Akhtar","doi":"10.1007/s10787-025-01787-x","DOIUrl":"10.1007/s10787-025-01787-x","url":null,"abstract":"<p><p>This preclinical study aims to evaluate the antiarthritic and therapeutic efficacy of farnesol in a model of Freund's complete adjuvant (FCA)-induced arthritis. Farnesol was administered orally once daily for 15 days at doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg in 5% DMSO. Methotrexate (MTX) at 0.75 mg/kg was used as a standard treatment, both alone and in combination with 200 mg/kg farnesol. Hematological tests, paw thickness, body weight, and antioxidative status were measured to assess the protective effects of farnesol. Farnesol significantly increased the enzymatic activity of catalase (CAT) and superoxide dismutase (SOD), as well as the non-enzymatic activity of glutathione (GSH). In addition, farnesol reduced tissue lipid peroxidation and nitric oxide (NO) synthetase activity, which was evident by the reduced levels of oxidative stress markers malondialdehyde (MDA), asymmetric dimethylarginine (ADMA), and nitrite. Farnesol downregulated inflammatory markers, including dimethylarginine dimethylaminohydrolase 1 (DDAH 1), cortistatin (CST), interleukin-6 (IL-6), IL-1β, and tumor necrosis factor (TNF-α), in a dose-dependent manner. These findings suggest that oral administration of farnesol, particularly in combination with MTX, effectively suppresses FCA-induced arthritis by ameliorating oxidative stress and inflammatory markers.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"3085-3098"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}