Inflammopharmacology最新文献

{"title":"Therapeutic potential of luteolin in neurodegenerative disorders: targeting Nrf2, NFĸB, MAPK, and JAK-STAT pathways to combat neuroinflammation and apoptosis.","authors":"Koleshwar Mahto, Omkar Kumar Kuwar, Aayushi Maloo, Nileshwar Kalia","doi":"10.1007/s10787-025-01846-3","DOIUrl":"https://doi.org/10.1007/s10787-025-01846-3","url":null,"abstract":"<p><p>Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's disease, Multiple sclerosis and Amyotrophic Lateral Sclerosis, are characterized by progressive neuronal loss, oxidative stress, chronic neuroinflammation, mitochondrial dysfunction, and apoptosis. The Nrf2/ARE, IĸB/NFĸB, MAPK/AP-1, and JAK-STAT signaling pathways play a pivotal role in these pathological processes, making them promising therapeutic targets. Luteolin, a naturally occurring flavonoid, has demonstrated potent antioxidant, anti-inflammatory, and neuroprotective properties by modulating these interconnected pathways. Activation of Nrf2/ARE signaling by luteolin enhances cellular antioxidant defences, while its inhibition of NFĸB, MAPK/AP-1, and JAK-STAT pathways suppresses neuroinflammation and apoptotic signalling, thereby mitigating neuronal damage. Emerging evidences suggest that luteolin effectively reduces neurotoxic effects by regulating inflammatory cytokine production, stabilizing mitochondrial function, and maintaining redox homeostasis. Its ability to interfere with crosstalk between these signaling pathways highlights its potential as a multi-targeted neuroprotective agent. Preclinical studies have provided strong evidence supporting luteolin's role in mitigating neurodegeneration, suggesting its applicability in neurodegenerative disease management. These findings underscore the therapeutic potential of luteolin in neurodegenerative diseases by targeting multiple pathological mechanisms. However, further investigations are needed to fully elucidate its molecular mechanisms and optimize its therapeutic benefits.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting psoriatic inflammation with natural compounds: mechanistic insights and therapeutic promise.","authors":"Aya M Mustafa, Ahmed M Atwa, Ali M Elgindy, Mahmoud Abdelrahman Alkabbani, Kawther Magdy Ibrahim, Manar M Esmail, Riham A El-Shiekh, Esraa M Mohamed, Kamel Mahmoud Kamel","doi":"10.1007/s10787-025-01851-6","DOIUrl":"https://doi.org/10.1007/s10787-025-01851-6","url":null,"abstract":"<p><p>Psoriasis is a chronic immune-mediated skin disorder characterized by aberrant keratinocyte proliferation, immune cell dysregulation, and sustained inflammation driven by cytokines, such as TNF-α, IL-17, and IL-23. Despite advancements in biologic therapies, limitations related to cost, safety, and resistance have prompted interest in alternative strategies. This review explores the pharmacological basis of natural products as promising anti-psoriatic agents, focusing on compounds with multi-targeted mechanisms including anti-inflammatory, anti-oxidant, anti-proliferative, and immunomodulatory activities. Key phytochemicals, such as curcumin, thymoquinone, glycyrrhizin, and boswellic acids, are examined for their roles in modulating psoriatic pathways like NF-κB, IL-23/Th17 axis, and oxidative stress. Evidence from preclinical and clinical studies highlights their potential in reducing psoriasis area and severity index (PASI) scores, mitigating immune hyperactivity, and enhancing the safety and efficacy of standard therapies. Despite promising outcomes, translational hurdles persist, including extract standardization, pharmacokinetic limitations, and regulatory barriers. The integration of omics-based research and advanced formulation technologies is essential to support the clinical application of these agents. This review underscores the therapeutic potential of natural compounds as viable complements or alternatives in modern psoriasis management.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of anti-arthritic potential of pulegone in formaldehyde- and Complete Freund's Adjuvant-induced arthritis in rats.","authors":"Amina Shabeer, Wajiha Manzoor, Waqas Younis, Ambreen Malik Uttra, Alamgeer, Naveed Mushtaq, Mehreen Lateef, Umme Habiba Hasan, Maaz Bin Nasim, Mohd Zaheen Hassan, Jalal Uddin, Sania Aslam, Arisa Namie Higashijima, Francislaine Aparecida Reis Dos Lívero, Arquimedes Gasparotto Junior","doi":"10.1007/s10787-025-01847-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01847-2","url":null,"abstract":"<p><p>Pulegone, a monoterpene phytochemical, was evaluated for its anti-inflammatory and anti-arthritic properties. This study investigated its preventive efficacy against rheumatoid arthritis using in vivo animal models and in vitro assays. The in vitro analysis included the inhibition of egg albumin and bovine serum albumin (BSA) denaturation, as well as the stabilization of red blood cell membranes against hemolysis, across concentrations of 50-6400 μg/mL. For in vivo evaluation, arthritis was induced using formaldehyde and Complete Freund's Adjuvant (CFA) models, with pulegone administered at doses of 20, 40, and 80 mg/kg. The mRNA expression levels of key inflammatory mediators, including interleukin-1 beta (IL-1β), interleukin-17 (IL-17), nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin receptor-associated kinase (IRAK), and interleukin (IL)-10 and IL-17, were also analyzed. Results showed concentration-dependent inhibition of egg albumin and BSA denaturation, with maximum erythrocyte membrane-stabilizing effects observed at 6400 μg/mL. Pulegone exhibited dose-dependent anti-arthritic activity in the formaldehyde model, with the highest efficacy at 80 mg/kg. In the CFA model, pulegone significantly reduced arthritic lesions, mitigated weight loss, reversed hematological and biochemical abnormalities, and improved radiographic and histopathological outcomes. Additionally, pulegone demonstrated potent antioxidant effects in superoxide dismutase and reducing power assays. Treatment with pulegone significantly reduced pro-inflammatory cytokines (IL-1β, TNF-α, IRAK, and NF-κB) while increasing anti-inflammatory cytokines (IL-10 and IL-17) compared to the control group. In conclusion, pulegone effectively suppressed inflammatory responses in rheumatoid arthritis by modulating cytokine levels and enhancing antioxidant activity, making it a promising candidate for therapeutic development.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of inflammatory regulatory effects of probiotics as adjuvants in cancer development management with considering possible challenges: a comprehensive review.","authors":"Mehran Mahooti, Fatemeh Safaei, Faezeh Firuzpour, Elahe Abdolalipour, Davood Zare, Samira Sanami, Maliheh Safavi, Saeed Mirdamadi","doi":"10.1007/s10787-025-01855-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01855-2","url":null,"abstract":"<p><p>Probiotics have gained significant interest due to their versatile therapeutic and preventive potential. These beneficial microorganisms have primarily been studied in gastrointestinal disorders and, due to their inflammatory regulatory effects, have then been investigated for their effects on a wide range of conditions, from acute illnesses and chronic diseases to inflammation-related diseases, including cancer. Probiotics can not only restore microbiome balance following different treatments, from antibiotic therapy to some cancer treatments, but also, with their immunomodulatory and inflammatory regulation effects, they can induce potent immune responses in different conditions with minor side effects. Moreover, as they can secrete anti-inflammatory cytokines as well as reduce pro-inflammatory cytokines as well as chemokine, they can be applied to prevent the development of many inflammation disorders. Therefore, studies have been directed to survey probiotic adjuvant effects, especially regarding their potential in the reduction of inflammation to become chronic. Probiotics, as an adjuvant, can increase the antigens displayed to related cells and thus activate different immune response compartments. Moreover, probiotic adjuvant can modulate inflammation in cancer development, making them strong candidates for regulating inflammation. With the increase and improvement in our knowledge about the adjuvant role of probiotics in the inflammatory processes underlying cancer development, it is pivotal to review current studies in this field. Therefore, the current study strives to provide a review of the latest studies regarding the probiotic's adjuvant effect in the field of immunology and oncology research to benefit the scientific community.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Tetramethylpyrazine alleviates hepatic fibrosis induced by experimental mansonic schistosomiasis.","authors":"Ana Carolina Campos Dos Santos, Daniel Figueiredo-Vanzan, Josiane Bentes, Juliana Maria Motta, Hilton Antônio Mata-Santos, Alexandre Dos Santos Pyrrho, Morgana Teixeira Lima Castelo-Branco","doi":"10.1007/s10787-025-01814-x","DOIUrl":"https://doi.org/10.1007/s10787-025-01814-x","url":null,"abstract":"","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroinflammatory crosstalk in migraine: consolidated activity of rizatriptan and meloxicam in suppressing CGRP-induced nociception and COX-mediated inflammation.","authors":"Vandana Bhatia, Vir Vikram, Aditya Rattan, Anjali Chandel, M S Ashawat","doi":"10.1007/s10787-025-01848-1","DOIUrl":"https://doi.org/10.1007/s10787-025-01848-1","url":null,"abstract":"<p><p>Migraine is among the most frequently observed neurovascular malady affecting almost 1 billion people globally and is defined by frequent episodes of headache, accompanying neurological problems, and a markedly reduced standard of health. Migraine pathogenesis is directly linked to the CGRP (Calcitonin-gene-related-peptide), a strong vasodilating protein entangled in the exchange of nociceptor signals, and the cyclo-oxygenase (COX) enzymes, influencing inflammatory responses which aggravate migraine manifestations. Although COX inhibiting drugs as well as CGRP receptor blockers have therapeutical advantages when administered independently, however, they also have drawbacks, such as insufficient effectiveness or side effects, highlighting the necessity of synergistic approaches. In this regard, SYMBRAVO is a unique combinatorial pharmacological approach that aims to combine the advantages of COX-2 suppression and CGRP regulation. We have explored the molecular basis, pharmacological interaction, and clinical effectiveness of SYMBRAVO in this study, with a focus on how it can improve effectiveness, reduce adverse reactions and overcome barriers to single drug therapy. The results support a paradigm change towards integrated migraine therapy strategies that emphasize controlled, multi-pathway regulation.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alphonsea elliptica (Hook.f. and Thomson) methanol leaves extract obliterates inflammatory processes in LPS-induced human plasma.","authors":"Ali Attiq, Juriyati Jalil, Sheryar Afzal, Waqas Ahmad","doi":"10.1007/s10787-025-01843-6","DOIUrl":"https://doi.org/10.1007/s10787-025-01843-6","url":null,"abstract":"<p><p>In our previous findings, the methanol extract of A. elliptica (MEL) exhibited platelet-activating factor inhibition, indicating possible anti-inflammatory properties. Despite its ethnopharmacological significance, no studies have thoroughly investigated its anti-inflammatory potential. Based on our preliminary findings, we hypothesised that MEL might exert anti-inflammatory effects by modulating key inflammatory mediators, such as prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines (IL-1β and IL-6). The cytotoxicity of MEL was assessed on peripheral blood mononuclear cells (PBMCs) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In vitro, anti-inflammatory activity was investigated in lipopolysaccharide (LPS)-induced human plasma through an enzyme-linked immunosorbent assay (ELISA) and a radioimmunoassay. In addition, the phytochemical profile of MEL was characterised using LC-ESI-MS/MS spectrometry. The extract demonstrated no cytotoxic effects at 20 μg/mL concentrations. MEL exhibited significant anti-inflammatory activity, with notable inhibition of PGE2 (76.18%) and COX-2 (80.12%), as well as pronounced reductions in IL-1β and IL-6 levels, corresponding to 11.6-fold and ninefold decreases at 10 μg/mL, respectively. Concentration-dependent effects were observed, with IC₅₀ values of 4.09, 5.81, 2.12, and 1.97 μg/mL for PGE2, COX-2, IL-1β, and IL-6, respectively. LC-ESI-MS/MS analysis revealed the presence of 30 bioactive compounds, including Gramine, Eruberin B, and Grossamide, which likely contributed to the extract's anti-inflammatory effects. In conclusion, MEL abrogated LPS-induced inflammatory responses in human plasma at non-cytotoxic concentrations, demonstrating its potential as a natural anti-inflammatory agent. Furthermore, this study is the first to report the phytochemical composition of A. elliptica leaves, providing insights into its bioactive constituents and therapeutic potential.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144617408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel in vivo adjuvant activity of hydrocarbon isolated from Hippophae rhamnoides.","authors":"Himanshi Tanwar, Shruti Shukla, Lilly Ganju","doi":"10.1007/s10787-025-01825-8","DOIUrl":"https://doi.org/10.1007/s10787-025-01825-8","url":null,"abstract":"<p><p>The new generation vaccines containing purified antigens are safer to use but generally induce weaker immune responses. Therefore, purified subunit vaccines require the addition of an exogenous adjuvant to enhance the immune response to the antigens following immunization. In the present study, a molecule has been isolated and characterized from 70% ethanolic extract of the medicinal plant Hippophaerhamnoides L. (Elaeagnaceae), commonly known as seabuckthorn (SBT). In this study, we have fractionated SBT leaf extract using solvents to identify the bioactive compound(s) and evaluated its adjuvant efficacy with weak antigen ovalbumin in balb/c mice. The identified bioactive compound was found to have a hydrocarbon moiety and was identified as alkane (named SSFa1), which in combination with ovalbumin boost humoral response in terms of high antibody titers, cell-mediated immune response such as T cell activation marker (CD27), and increased nitric oxide and proinflammatory cytokines (TNF-a and IL-6) production by peritoneal macrophages.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144617407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Effects of Chrysophyllum albidum fruit pulp on haemodynamic parameters, pro-inflammatory markers, antioxidant parameters and critical biomolecules associated with hypertension-in vivo.","authors":"Folake Lucy Oyetayo, Seun Funmilola Akomolafe, Gbemisola Beulah Balogun","doi":"10.1007/s10787-025-01838-3","DOIUrl":"https://doi.org/10.1007/s10787-025-01838-3","url":null,"abstract":"","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating programmed cell death in diabetic retinal microangionopathy and neurodegeneration: unraveling molecular mechanisms and therapeutic actions of natural products.","authors":"Lianyuan Tang, Chunni Zhao, Yuan Ren, Huan Liang, Mei Zhang","doi":"10.1007/s10787-025-01840-9","DOIUrl":"https://doi.org/10.1007/s10787-025-01840-9","url":null,"abstract":"<p><p>Diabetic retinopathy (DR) is a common diabetes condition that contributes significantly to vision impairment and blindness in working-age people. The classical theory contends that DR is solely a retinal microvascular disorder. Nevertheless, a growing body of research has demonstrated that the pathological variations of DR consist of retinal microangiopathy and retinal neurodegeneration triggered by hyperglycemia. When these two pathological alterations arise, they are commonly accompanied by programmed cell death (PCD) in the retina. With the intensification of research on retinal pathology, PCD has emerged as a matter of concern in the study of DR. Programmed cell death includes apoptosis, pyroptosis, autophagy and ferroptosis. These four approaches can deal with DR by mediating the death of blood vessels and nerve cells to preserve the homeostasis of the internal environment within the retina. Notably, numerous natural products have been demonstrated to influence PCD, resulting in vascular and neuroprotective effects. This study offers a thorough analysis of the molecular processes that underlie different types of PCDs and clarifies how they affect the development of neurodegeneration and retinal microangiopathy. Additionally, this review systematically outlines the regulatory effects of natural products on PCD, highlighting their potential mechanisms and clinical applications in two pathological stages of treatment. This targeted approach not only enhances the relevance of this paper in the study of diabetic retinal microangiopathy and neurodegeneration but also provides new insights into the development of drug treatments for different stages of DR.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}