Inflammopharmacology最新文献_第2页

Immunomodulatory properties of a methanolic extract of Ficus lyrata mitigate inflammation in Complete Freund's Adjuvant-induced arthritis.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-26 DOI: 10.1007/s10787-025-01700-6

Anam Iftikhar, Mohammad Saleem, Syed Atif Raza, Adrian Achuthan, Rodney Luwor, Taha Muhammad, Umair Majeed

{"title":"Immunomodulatory properties of a methanolic extract of Ficus lyrata mitigate inflammation in Complete Freund's Adjuvant-induced arthritis.","authors":"Anam Iftikhar, Mohammad Saleem, Syed Atif Raza, Adrian Achuthan, Rodney Luwor, Taha Muhammad, Umair Majeed","doi":"10.1007/s10787-025-01700-6","DOIUrl":"https://doi.org/10.1007/s10787-025-01700-6","url":null,"abstract":"Ficus lyrata, renowned for its traditional use in alleviating rheumatic pain and inflammation, was validated for its purported anti-arthritic and antiinflammatory properties using InvivoandInvitromodels. In the in-vivo studies, carrageenan-induced acute oedema and a chronic arthritis induced by complete Freund's adjuvant (CFA) were employed. Oral dosing of methanolic extract from Ficus lyrata (m-FL) was administered at (250,500 and 750 mg/kg) as well as methotrexate at 1 mg/kg, significantly (p < 0.0001) demonstrated a dose dependent decrease in percent oedema/inflammation and notably reduced arthritis development in the CFA model, indicating strong anti-inflammatory effects over time. Further analysis revealed m-FL extract inhibited protein denaturation across all evaluated concentrations(1600,800,400,200,100,50 µg/ml) suggesting potential mechanisms for their anti-inflammatory action. Phytochemical analysis identified flavonoids and phenolic compounds in the extract. Gene expression analysis of m-FL extract treatment group using qPCR showed a significant (p < 0.0001) downregulation of various inflammatory markers (IL1,COX2,IL1β, NFκB, TNF,STAT-3,IL6) with simultaneous upregulation in the expression of antiinflammatory markers (IL4,10). The m-FL extract targets TNF-mediated decrease in interleukins specifically IL-1, IL1β and IL-6. Histopathological assessments and radiographic evaluations conducted subsequently demonstrated a significant decline in joint inflammation, bone erosion, and pannus formation, along with improved bone integrity and reduced inflammation in the m-FL extract-treated groups (p < 0.0001). Although the m-FL extract exhibited relatively stronger antioxidant activity compared to ascorbic acid in-vitro, the primary efficacy lies in the potent immunomodulatory and anti-arthritic effects. The m-FL extract showed potential as an adjunct therapy for managing inflammatory conditions.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the neuroprotective potential of Jatropha humboldtiana leaves and its metabolic profiling by UPLC-MS/MS.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-23 DOI: 10.1007/s10787-025-01707-z

Paul Alan Arkin Alvarado-García, Marilú Roxana Soto-Vásquez, Ricardo D D G de Albuquerque, Fadia S Youssef, Reem M Diri, Mohamed L Ashour

{"title":"Unveiling the neuroprotective potential of Jatropha humboldtiana leaves and its metabolic profiling by UPLC-MS/MS.","authors":"Paul Alan Arkin Alvarado-García, Marilú Roxana Soto-Vásquez, Ricardo D D G de Albuquerque, Fadia S Youssef, Reem M Diri, Mohamed L Ashour","doi":"10.1007/s10787-025-01707-z","DOIUrl":"https://doi.org/10.1007/s10787-025-01707-z","url":null,"abstract":"This study aims to determine the phytochemical profile of Jatropha humboldtiana ethyl acetate fraction (EAFHJ) using UPLC-MS/MS and evaluate its neuroprotective potential via in vivo model. In vivo behavioral assays including elevated plus maze (EPM), forced swim test (FST), tail suspension test, and pentylenetetrazol (PTZ) assay were conducted in mice to evaluate the anxiolytic, antidepressant, and anticonvulsant effects. Pro- and anti-inflammatory cytokines were measured, and acute toxicity studies were performed to determine LD50. Thirty-three compounds were identified in EAFHJ, including phenolic acids, flavonoids, and coumarins. In the FST, EAFHJ reduced the immobility time to 131.50 ± 3.46 s at 100 mg/kg compared to 139.88 ± 4.58 s in the control group (p < 0.01). In the EPM, the group treated with 200 mg/kg of EAFJH spent 48.14% of the time in the open arms, compared to 31.30% of the control group (p < 0.05). In the PTZ trial, the latency to myoclonic seizures was 3.0 ± 0.5 min at 200 mg/kg of EAFHJ compared with 1.01 ± 0.5 min in the control group (p < 0.05). The LD50 of the EAFJH was greater than 5000 mg/kg, indicating low toxicity. Furthermore, a significant reduction in pro-inflammatory cytokine levels (IL-6, TNF-α, IL-1β) and an increase in anti-inflammatory cytokines (IL-10, IL-4) were observed. Thus, it was concluded that Jatropha humboldtiana exhibits a diverse phytochemical profile and promising anxiolytic, antidepressant, and anticonvulsant effects, likely mediated by a combination of neurotransmitter modulation and anti-inflammatory mechanisms. Further studies are required to elucidate the precise molecular pathways involved and explore its clinical potential.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative nanocarriers in arthritis therapy: the role of herbal cubosomes.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-23 DOI: 10.1007/s10787-025-01714-0

Kajal Chaudhary, Lubhan Singh, Pallavi Dinanath Rai

{"title":"Innovative nanocarriers in arthritis therapy: the role of herbal cubosomes.","authors":"Kajal Chaudhary, Lubhan Singh, Pallavi Dinanath Rai","doi":"10.1007/s10787-025-01714-0","DOIUrl":"https://doi.org/10.1007/s10787-025-01714-0","url":null,"abstract":"Background: Both osteoarthritis (OA) and rheumatoid arthritis (RA) are long-lasting inflammatory disorders that impact the joints. While conventional treatments like NSAIDs and DMARDs are effective, they often have adverse side effects.Objective: The aim of this review is to explore the possibilities of using herbal treatments in treating the symptoms of arthritis, their stability and bioavailability. Traditional therapies often lead to adverse side effects, prompting a search for safer alternatives, particularly in herbal medicines. This review explores the innovative use of herbal cubosomes as advanced nanocarriers for arthritis therapy. Cubosomes, a type of self-assembled lipid nanoparticle, exhibit unique structural characteristics that enhance the delivery and bioavailability of encapsulated herbal compounds.Method: Access was gained to PubMed, Scopus database, Google Scholar and Web of Science for the literature search. The results were later screened according to the titles, abstracts, and availability of full texts.Results: The expository evaluation of the literature revealed that Key herbal components, such as Withania somnifera (Ashwagandha), Curcuma longa (Turmeric) and Boswellia serrata (Frankincense) are emphasized for their anti-inflammatory characteristics and possible advantages in managing arthritis. The herbal cubosomes enhance drug absorption, retention, and release kinetics in arthritic conditions. The difficulties in delivering and maintaining herbal substances are also discussed, with a focus on how nanotechnology can help get over these obstacles.Conclusion: Overall, the integration of herbal cubosomes in arthritis therapy presents a promising approach that could result in safer and more efficient treatment alternatives, warranting further research and clinical exploration.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between anti-inflammatory therapies and renal outcomes in patients with established cardiovascular disease or high cardiovascular risks: a meta-analysis of randomised controlled trials.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-19 DOI: 10.1007/s10787-025-01711-3

Wenfeng Yang, Zonglin Li, Chu Lin, Xiaoling Cai, Fang Lv, Wenjia Yang, Linong Ji

{"title":"The association between anti-inflammatory therapies and renal outcomes in patients with established cardiovascular disease or high cardiovascular risks: a meta-analysis of randomised controlled trials.","authors":"Wenfeng Yang, Zonglin Li, Chu Lin, Xiaoling Cai, Fang Lv, Wenjia Yang, Linong Ji","doi":"10.1007/s10787-025-01711-3","DOIUrl":"https://doi.org/10.1007/s10787-025-01711-3","url":null,"abstract":"Background: To assess the relationship between anti-inflammatory therapy and renal events risk in participants with cardiovascular risks or diagnosed cardiovascular disease (CVD).Methods: Literature searches were carried out in PubMed, Embase, clinicaltrial.gov and the Cochrane Central Register of Controlled Trials. Randomised controlled trials that were published from January 1995 to July 2024, compared anti-inflammatory therapy and placebo in participants at cardiovascular risks or with diagnosed CVD and with reports of renal outcomes were included. The results were shown as risk ratio (RR) and 95% confidence interval (CI).Results: In comparison to placebo, therapies targeting inflammation did not exhibit a significant association with the risk of composite renal outcomes (worsening of renal function, death due to kidney disease and end-stage renal disease) (RR = 0.89, 95% CI 0.40 to 1.99, I2 = 0%). The risk of worsening of renal function (RR = 0.81, 95% CI 0.21 to 3.07, I2 = NA), end-stage renal disease (RR = 0.94, 95% CI 0.31 to 2.85, I2 = 0%), death due to kidney disease (RR = 3.00, 95% CI 0.12 to 73.56, I2 = NA), chronic kidney disease (RR = 1.77, 95% CI 0.74 to 4.23, I2 = 0%), chronic renal failure (RR = 1.70, 95% CI 0.56 to 5.15, I2 = 61%) and acute kidney injury (RR = 1.16, 95% CI 0.95 to 1.42, I2 = 0%) showed no significant difference between patients receiving anti-inflammatory therapy and placebo.Conclusion: Current evidence did not indicate associations between anti-inflammatory therapies and adverse renal events risks in patients with cardiovascular risks or established CVD. Future researches are needed to explore the renal effects of anti-inflammatory therapy.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the anti-anaphylaxis potential of natural products: A Review.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-19 DOI: 10.1007/s10787-025-01685-2

Aya H Eid, Eman S Zaki, Miral O Sabry, Riham A El-Shiekh, Samar S Khalaf

{"title":"Exploring the anti-anaphylaxis potential of natural products: A Review.","authors":"Aya H Eid, Eman S Zaki, Miral O Sabry, Riham A El-Shiekh, Samar S Khalaf","doi":"10.1007/s10787-025-01685-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01685-2","url":null,"abstract":"Allergies are a common health issue affecting many people around the world, especially in developed countries. They occur when the immune system overreacts to substances that are usually harmless. Some common allergic conditions include asthma, sinus infections, skin rashes, food allergies, hay fever, severe allergic reactions, eczema, swelling, and reactions to medications or insect stings. The causes of these allergies are complex and often linked to genetics, which can lead to heightened immune responses known as atopy. Throughout history, plant extracts have been used for various purposes, including medicine and food. In addition, their bioactive compounds show a wide range of beneficial effects, such as reducing allergic reactions, fighting oxidative stress, mast cell stabilizers, and lowering inflammation, highlighting their potential for treating various health conditions. Flavonoids and phenolic compounds are commonly used in anaphylaxis for their potent anti-inflammatory action. This review aims to promote the use of natural products as potential treatments for anaphylaxis. In addition, the discovery of new drugs derived from natural sources holds significant promise for the management of anaphylaxis.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of the cognitive impairment associated with Alzheimer's disease by valproic acid: possible drug repurposing.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-19 DOI: 10.1007/s10787-025-01695-0

Mirna Ezzat Sedrak Sorial, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed

{"title":"Modulation of the cognitive impairment associated with Alzheimer's disease by valproic acid: possible drug repurposing.","authors":"Mirna Ezzat Sedrak Sorial, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed","doi":"10.1007/s10787-025-01695-0","DOIUrl":"https://doi.org/10.1007/s10787-025-01695-0","url":null,"abstract":"Sporadic Alzheimer's disease is a progressive neurodegenerative disorder affecting the central nervous system. Its main two hallmarks are extracellular deposition of aggregated amyloid beta resulting in senile plaques and intracellular hyperphosphorylated tau proteins forming neuro-fibrillary tangles. As those processes are promoted by the glycogen synthase kinase-3 enzyme, GSK3 inhibitors may be of therapeutic value in SAD. GSK3 is also inhibited by the action of insulin on insulin signaling. Insulin receptor desensitization in the brain is hypothesized to cause inhibition of insulin signaling pathway that ultimately causes cognitive deficits seen in SAD. In extant research, induction of cognitive impairment is achieved by intracerebroventricular injection of streptozotocin-a diabetogenic compound that causes desensitization to insulin receptors in the brain leading to the appearance of most of the SAD signs and symptoms. Valproic acid -a histone deacetylase inhibitor and anti-epileptic drug-has been recently studied in the management of SAD as a possible GSK3 inhibitor. Accordingly, the aim of the present study is to explore the role of multiple VPA doses on the downstream effects of the insulin signaling pathway in ICV STZ-injected mice and suggest a possible mechanism of VPA action. ICV STZ-injected mice showed deficiency in short- and long-term memory as well as increased anxiety, as established by open field test, Modified Y-maze, Morris water maze, and elevated plus maze neurobehavioral tests.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted therapeutic potentials of catalpol, an iridoid glycoside: an updated comprehensive review.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-17 DOI: 10.1007/s10787-025-01694-1

Mennat-Allah M Hassan, Mohamed I Fahmy, Hany N Azzam, Yasmina M Ebrahim, Riham A El-Shiekh, Yara M Aboulmagd

{"title":"Multifaceted therapeutic potentials of catalpol, an iridoid glycoside: an updated comprehensive review.","authors":"Mennat-Allah M Hassan, Mohamed I Fahmy, Hany N Azzam, Yasmina M Ebrahim, Riham A El-Shiekh, Yara M Aboulmagd","doi":"10.1007/s10787-025-01694-1","DOIUrl":"https://doi.org/10.1007/s10787-025-01694-1","url":null,"abstract":"Catalpol, classified as an iridoid glucoside, is recognized for its significant role in medicine, particularly in the treatment of various conditions such as diabetes mellitus, neuronal disorders, and inflammatory diseases. This review aims to evaluate the biological implications of catalpol and the mechanisms underlying its diverse pharmacological effects. A thorough exploration of existing literature was conducted utilizing the keyword \"Catalpol\" across prominent public domains like Google Scholar, PubMed, and EKB. Catalpol has demonstrated a diverse array of pharmacological effects in experimental models, showcasing its anti-diabetic, cardiovascular-protective, neuroprotective, anticancer, hepatoprotective, anti-inflammatory, and antioxidant properties. In summary, catalpol manifests a spectrum of biological effects through a myriad of mechanisms, prominently featuring its anti-inflammatory and antioxidant capabilities. Its diverse pharmacological profile underscores its potential for therapeutic applications across a range of conditions. Further research is warranted to fully elucidate the clinical implications of catalpol and optimize its use in medical practice.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallic acid enhances memory, learning and reduces neuroinflammation in a rat model of scopolamine-induced cholinergic dysfunction.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-16 DOI: 10.1007/s10787-025-01699-w

Mahbobe Alikhanzade, Maryam Khosravi, Mahmoud Hosseini, Arezoo Rajabian

{"title":"Gallic acid enhances memory, learning and reduces neuroinflammation in a rat model of scopolamine-induced cholinergic dysfunction.","authors":"Mahbobe Alikhanzade, Maryam Khosravi, Mahmoud Hosseini, Arezoo Rajabian","doi":"10.1007/s10787-025-01699-w","DOIUrl":"https://doi.org/10.1007/s10787-025-01699-w","url":null,"abstract":"Gallic acid (GA), a potent polyphenol antioxidant, has demonstrated beneficial effects on the nervous system. This study aimed to investigate the neuroprotective potential of GA on learning and memory in a rat model of scopolamine-induced cholinergic dysfunction. Additionally, the roles of oxidative stress and neuroinflammation were examined. Rats were divided into six groups: Control, scopolamine (2 mg/kg/day), scopolamine plus 25, 50, or 100 mg/kg of GA, and scopolamine plus 2 mg/kg of donepezil (DN, administered once daily). Behavioral performance was evaluated using the Morris Water Maze (MWM) and Passive Avoidance Test. Biochemical parameters were assessed to determine oxidative stress, and gene expression analyses were conducted to explore neuroinflammation in the hippocampus. The behavioral tests revealed that both GA and DN treatments improved the rats' performance in the MWM, as evidenced by their ability to locate the platform and spend more time in the target area. Additionally, GA administration increased the latency of entering the dark compartment and extended the time spent in the light compartment while reducing the frequency of dark compartment entries in the Passive Avoidance Test. Furthermore, GA exhibited antioxidant, anti-acetylcholinesterase, and anti-inflammatory effects, as indicated by the modulation of malondialdehyde levels, thiol content, superoxide dismutase activity, acetylcholinesterase activity, and the expression of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6. In conclusion, this study provides evidence for the potential therapeutic benefits of GA in Alzheimer's disease, highlighting its ability to enhance memory function and mitigate oxidative stress, acetylcholinesterase activity, and inflammation.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effect of formononetin in 6-OHDA induced Parkinson disease in rats. 福莫西汀对 6-OHDA 诱发的帕金森病大鼠的治疗作用

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-16 DOI: 10.1007/s10787-025-01709-x

Tanvi Dayanand Pingale, Girdhari Lal Gupta

{"title":"Therapeutic effect of formononetin in 6-OHDA induced Parkinson disease in rats.","authors":"Tanvi Dayanand Pingale, Girdhari Lal Gupta","doi":"10.1007/s10787-025-01709-x","DOIUrl":"https://doi.org/10.1007/s10787-025-01709-x","url":null,"abstract":"Preclinical models of Parkinson's disease (PD) have been developed using intracerebroventricular (i.c.v.) injection of 6-hydroxydopamine (6-OHDA) to induce neurodegeneration and motor dysfunction. Formononetin, a phytoestrogen with known anti-aging and anti-apoptotic properties, was investigated for its potential neuroprotective effects against 6-OHDA-induced toxicity. In this study, the rats received a single i.c.v. injection of 6-OHDA and were then treated with formononetin at doses of 25, 50, and 100 mg/kg orally for 21 days. Motor coordination, grip strength, and gait were evaluated using the rotarod test, gait analysis, and pole test. Biochemical assessments measured oxidative stress markers [superoxide dismutase (SOD), catalase, and glutathione (GSH)], proinflammatory cytokines (TNFα, IL-6, and IL-1β), and brain monoamines [dopamine (DA) and acetylcholine (ACh)]. Immunohistochemistry was performed to assess α-synuclein and B-cell lymphoma 2 (BCl2) protein expression. The results showed that formononetin significantly improved motor coordination, gait, and grip strength. It also enhanced antioxidant defenses by increasing SOD, catalase, and GSH activities, while reducing neuroinflammation by lowering IL-1β, TNFα, and IL-6 levels. Furthermore, formononetin alleviated DA depletion and reduced ACh levels, indicating its protective effect on dopaminergic neurons. The immunohistochemical analysis revealed that formononetin decreased α-synuclein aggregation and upregulated BCl2 expression, highlighting its neuroprotective and antioxidative properties. In conclusion, formononetin, at doses of 25, 50, and 100 mg/kg, exhibited significant neuroprotective effects in the 6-OHDA-induced PD rat model. By improving motor function, reducing oxidative stress, and attenuating neuroinflammation, formononetin holds promise as a potential therapeutic agent for PD.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ropivacaine effect on hemostasis and pain level in patients undergoing orthognathic surgery: a triple-blinded, randomized, clinical trial.

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-15 DOI: 10.1007/s10787-025-01716-y

Majid Hosseini-Abrishami, Mozhgan Kazemian, Mohammad Javad Sedaghati, Mohammad Alipour, Melika Hoseinzade, Alireza Ghaffarian-Hosseini, Vahid Reza Askari

{"title":"Ropivacaine effect on hemostasis and pain level in patients undergoing orthognathic surgery: a triple-blinded, randomized, clinical trial.","authors":"Majid Hosseini-Abrishami, Mozhgan Kazemian, Mohammad Javad Sedaghati, Mohammad Alipour, Melika Hoseinzade, Alireza Ghaffarian-Hosseini, Vahid Reza Askari","doi":"10.1007/s10787-025-01716-y","DOIUrl":"https://doi.org/10.1007/s10787-025-01716-y","url":null,"abstract":"Objective: This triple-blind, controlled clinical trial aimed to assess the effects of ropivacaine and lidocaine on hemodynamic factors, blood loss, opioid consumption, and postoperative pain in patients undergoing orthognathic surgery.Methods: Thirty-two patients with Class III malocclusion scheduled for orthognathic surgery were included. The participants were randomly assigned to receive 0.5% ropivacaine or 2% lidocaine with 1:80,000 epinephrine for local anesthesia (n = 16). Hemodynamic parameters were recorded at various time intervals, which included heart rate (HR), systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation (SpO2), intraoperative bleeding, opioid consumption, and postoperative pain intensity.Results: The participants' mean age was 23.67 ± 4.56 years, and 75% were female. The groups were comparable in most measured outcomes. HR was significantly higher in the ropivacaine group at 30 and 60 min post-injection (P < 0.05). SpO2 percentages were comparable between the groups, except at 15 min post-anesthesia, where the lidocaine group demonstrated a significantly higher SpO2 (P = 0.029). Blood pressure, postoperative opioid consumption, intraoperative bleeding, and postoperative pain levels showed no statistically significant differences between the two groups.Conclusion: Within the limitations of this study, both 0.5% ropivacaine and lidocaine with epinephrine demonstrated comparable effects on hemodynamic stability, intraoperative blood loss, postoperative pain levels, and opioid consumption in patients undergoing orthognathic surgery. These findings suggest that ropivacaine may serve as a safe and effective alternative to lidocaine for local anesthesia in orthognathic procedures.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0