Exploring herbal synergies in the management of rheumatoid arthritis: a multifaceted approach to inflammation and joint health.

IF 5.3 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-10-04 DOI:10.1007/s10787-025-01987-5

Shikhar Verma, Mitali Panchpuri, Vagish Dwibedi, Santosh Kumar Rath, Arti Devi

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引用次数: 0

Abstract

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and pain, often leading to severe disability. Conventional treatments, including NSAIDs, DMARDs, and biologics, are expensive and associated with adverse effects, prompting interest in alternative therapies. Herbal synergy, which combines multiple medicinal plants, offers a promising holistic approach to RA management. This review explores the potential of herbal synergy in treating RA, focusing on the anti-inflammatory, immunomodulatory, and antioxidant properties of plants such as Curcuma longa, Boswellia serrata, Withaniasomnifera, Zingiber officinaleetc. These herbs target various RA mechanisms, including inflammatory pathways and oxidative stress, while minimizing side effects. The review highlights these herbal combinations' mechanisms, efficacy, and safety and advocates for their integration into mainstream treatment regimens under expert supervision. The development of standardized formulations, rigorous clinical trials, and robust regulatory frameworks is essential to enhance their therapeutic potential.

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探索类风湿性关节炎管理中的草药协同作用：炎症和关节健康的多方面方法。

类风湿性关节炎（RA）是一种以关节炎症和疼痛为特征的慢性自身免疫性疾病，常导致严重的残疾。传统的治疗方法，包括非甾体抗炎药、dmard和生物制剂，价格昂贵且有副作用，促使人们对替代疗法产生兴趣。草药协同，结合多种药用植物，提供了一个有前途的整体方法来管理类风湿性关节炎。本文综述了草药协同治疗类风湿性关节炎的潜力，重点介绍了姜黄、博斯韦利亚、金银花、生姜等植物的抗炎、免疫调节和抗氧化特性。这些草药针对各种RA机制，包括炎症途径和氧化应激，同时尽量减少副作用。该综述强调了这些草药组合的机制、功效和安全性，并倡导在专家监督下将其纳入主流治疗方案。开发标准化配方、严格的临床试验和健全的监管框架对于提高其治疗潜力至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]