Inflammopharmacology最新文献

Correction: Ropivacaine effect on hemostasis and pain level in patients undergoing orthognathic surgery: a triple-blinded, randomized, clinical trial. 更正：罗哌卡因对正颌手术患者止血和疼痛水平的影响：一项三盲、随机、临床试验。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-09 DOI: 10.1007/s10787-025-01728-8

Majid Hosseini-Abrishami, Mozhgan Kazemian, Mohammad Javad Sedaghati, Mohammad Alipour, Melika Hoseinzade, Alireza Ghaffarian-Hosseini, Vahid Reza Askari

引用次数: 0

Role of guanylate-binding protein 5 in inflammatory diseases, immune diseases, cancers, and its potential therapeutic implications. 鸟苷酸结合蛋白5在炎症性疾病、免疫性疾病、癌症中的作用及其潜在的治疗意义

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-07 DOI: 10.1007/s10787-025-01727-9

Xufan Sun, Guiyuan Jin, Huihui Zhou, Yan Wang, Fengxian Dai, Guangxi Zhou

{"title":"Role of guanylate-binding protein 5 in inflammatory diseases, immune diseases, cancers, and its potential therapeutic implications.","authors":"Xufan Sun, Guiyuan Jin, Huihui Zhou, Yan Wang, Fengxian Dai, Guangxi Zhou","doi":"10.1007/s10787-025-01727-9","DOIUrl":"https://doi.org/10.1007/s10787-025-01727-9","url":null,"abstract":"Guanylate-binding protein 5 (GBP5) is an interferon-γ (IFN-γ)-induced GTPase (Guanosine Triphosphatease) family member. It contains highly conserved guanosine triphosphate (GTP)-binding and hydrolysis domains, particularly within myeloid and T cells. Extensive research has underscored the critical role of GBP5 in various biological processes, including inflammation, cancer cell migration, and viral defence. In addition, GBP5 is involved in a range of physiological processes and is implicated in various pathological conditions, including inflammation and immune-related disorders. Recent studies have revealed the significant role of GBP5 in the initiation and progression of cancer. The impact of GBP5 on cancer varies depending on the specific cancer type and its underlying mechanisms of action. GBP5 can modulate multiple signalling pathways, including those involved in cell proliferation, cell cycle regulation, invasive metastasis, and the maintenance of homeostasis in vivo, all of which contribute to the progression of cancer. Consequently, in addition to functioning as a downstream molecule in the IFN-γ signalling pathway, GBP5 can influence the onset and progression of various diseases. This article examines the role of GBP5 in inflammation, autoimmune disorders, and malignancies while also exploring its potential therapeutic implications. We aim to deepen our understanding of GBP5 and assess its prospective applications in clinical diagnosis and treatment.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: Exploring the therapeutic potential of Anastatica hierochuntica essential oil in DSS-induced colitis. 摘要：探讨青脐草精油对dss性结肠炎的治疗潜力。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-04 DOI: 10.1007/s10787-025-01724-y

Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan, Mohammed Alqudah, Muna Oqal, Rawan Abudalo, Shtaywy S Abdalla

引用次数: 0

Phytochemical studies of Gerbera jamesonii and evaluation of anti-inflammatory potential in formaldehyde-induced arthritis in rats. 非洲菊植物化学研究及对甲醛性关节炎大鼠抗炎作用的评价。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-03 DOI: 10.1007/s10787-025-01720-2

Malik Saad Ullah, Ateeq Amjad, Zunera Chauhdary, Uzma Saleem, Naheed Akhtar

{"title":"Phytochemical studies of Gerbera jamesonii and evaluation of anti-inflammatory potential in formaldehyde-induced arthritis in rats.","authors":"Malik Saad Ullah, Ateeq Amjad, Zunera Chauhdary, Uzma Saleem, Naheed Akhtar","doi":"10.1007/s10787-025-01720-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01720-2","url":null,"abstract":"In plants, numerous intricate and structurally diverse phytochemicals are found naturally. The adoption of traditional herbal medicines for many ailments in recent years has prompted researchers to look into the medicinal properties of numerous plants. Although the Asteraceae family has a wide range of significant pharmacological benefits, its antioxidant and antibacterial properties are the most significant. The goal of this study was to ascertain the phytochemical profiling and investigation of anti-arthritic pursuits of Gerbera jamesonii. GC-MS analysis was performed to screen the fingerprints of bioactive compounds. The efficacy of ethanol extract against formaldehyde-induced inflammation in rats was assessed in an in vivo investigation using oral doses of 250-, 500- and 800 mg/kg. The study lasted for 29 days, Hematological and biochemical evaluations were conducted on blood and serum samples. Gerbera jamesonii ethanolic extract (GJE) extract treatment dose dependently decreased the paw inflammation, paw diameter and arthritic score. GJE treatment downregulated the mRNA and protein expression of inflammatory cytokines. Radiological and histo-pathological assessments revealed that GJE treatment effectively reversed the histological and radiological alterations induced by formaldehyde exposure, demonstrating a significant recovery. In the light of above findings, it is suggested that Gerbera jamesonii might be useful in the treatment of inflammatory diseases.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iota-carrageenan oligosaccharide ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating SCFAs-PI3K-AKT pathway. 卡拉胶寡糖通过介导肠道菌群失调和调节SCFAs-PI3K-AKT通路改善dss诱导的小鼠结肠炎。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-01 DOI: 10.1007/s10787-025-01718-w

Meixian Xiang, Songtao Wu, Minxin Liu, Bin Zhang, Xiankun Xia, Wenjing Tan, Shijian Xiang

{"title":"Iota-carrageenan oligosaccharide ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating SCFAs-PI3K-AKT pathway.","authors":"Meixian Xiang, Songtao Wu, Minxin Liu, Bin Zhang, Xiankun Xia, Wenjing Tan, Shijian Xiang","doi":"10.1007/s10787-025-01718-w","DOIUrl":"https://doi.org/10.1007/s10787-025-01718-w","url":null,"abstract":"Iota-carrageenan oligosaccharides (iCOs), derived from marine red algae, are traditionally used as antithrombotic and anti-inflammatory agents in folk medicinal practice. Despite the prevailing emphasis on these aspects in their applications, the potential of iCOs as a prebiotic agent for gut health and its subsequent impact on intestinal disorders such as colitis remains largely unexplored. A DSS-induced colitis model was employed in C57BL/6 male mice to analyze the gut microbiota via 16S rRNA sequencing. Fecal microbiota transplantation (FMT) was used to assess the therapeutic effects of iCOs on colitis. RNA sequencing (RNA-Seq) identified pathways and genes affected by iCOs. ELISA measured inflammatory cytokines, while western blot and RT-qPCR evaluated protein and gene expressions, respectively. The iCOs increased beneficial bacteria, such as Lactobacillus, Bifidobacterium, and Akkermansia. They enhanced short-chain fatty acid production and upregulated GPR41, GPR43, and GPR109A mRNA, influencing cytokine secretion. The iCOs reduced mRNA of SPHK1, BDKRB1, LCN2, and so on, potentially through PI3K-Akt pathway inhibition, and promoted tight junction protein expression. Our findings highlight the novel therapeutic potential of iCOs in colitis, indicating a multifaceted approach to treatment that includes gut microbiota modulation, intestinal barrier restoration, and the suppression of inflammatory responses.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amelioration of Freund's adjuvant-induced polyarthritis by Diosmin-loaded nanoparticles in Wistar rats; a mechanistic study. 载薯蓣皂苷纳米颗粒对Wistar大鼠Freund佐剂性多关节炎的改善作用机械的研究。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-31 DOI: 10.1007/s10787-025-01654-9

Hamna Mehmood, Ammara Saleem, Muhammad Furqan Akhtar, Aisha Mobashar

{"title":"Amelioration of Freund's adjuvant-induced polyarthritis by Diosmin-loaded nanoparticles in Wistar rats; a mechanistic study.","authors":"Hamna Mehmood, Ammara Saleem, Muhammad Furqan Akhtar, Aisha Mobashar","doi":"10.1007/s10787-025-01654-9","DOIUrl":"https://doi.org/10.1007/s10787-025-01654-9","url":null,"abstract":"The current study aims to synthesize diosmin-loaded nanoparticles (DNPs) to make available an alternative safe treatment for adjuvant-induced polyarthritis. DNPs were formulated using chitosan biopolymer and characterized. Acute toxicity study was also performed and acute anti-inflammatory potential was accessed using phologistic agents. For anti-arthritic potential, disease was inoculated by injecting 0.15-ml Freund's adjuvant at day 1 to all groups except normal control in left hind paw. Therapy using DNPs at 5-20 mg/kg and diosmin 20 mg/kg and methotrexate was started from day 8-28 orally. The DNPs of size 223 nm, potential 2.9 Mv, polydisparity index > 0.7 and spherical shape particles as revealed by scanning electron microscopy and amorphous nature were revealed by X-ray diffraction. DNPs dose dependently ameliorated arthritic scoring, pain, paw swelling and body weight in contrary to disease control. DNPs and free drug restored significantly altered blood parameters, oxidation status and neurotransmitters level in treated animals as evident by histologic examination of tissues. Treatment with DNPs and free drug profoundly downregulated the expression of cyclooxygenase-2, interleukin (IL)-6, TNF-α, NF-κβ and increased IL-4 and IL-10 in arthritic animals. DNP 20 mg/kg revealed noteworthy anti-arthritic, anti-inflammatory and anti-nociceptive potential in counter to diosmin and methotrexate treated animals.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPLC-HRMS/MS and anti-inflammatory effects of bunya pine resin through multifaceted pathway modulation: NUMB/NOTCH1/HES1/mTOR/ PI3K/HMGB1 signaling cascades. HPLC-HRMS/MS与松脂抗炎作用的多途径调控：NUMB/NOTCH1/HES1/mTOR/ PI3K/HMGB1信号级联。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-31 DOI: 10.1007/s10787-025-01660-x

Dalia E Ali, Sherouk Hussein Sweilam, Ahmed M Atwa, Ali M Elgindy, Aya M Mustafa, Manar M Esmail, Mahmoud Abdelrahman Alkabbani, Mohamed Magdy Senna, Riham A El-Shiekh

{"title":"HPLC-HRMS/MS and anti-inflammatory effects of bunya pine resin through multifaceted pathway modulation: NUMB/NOTCH1/HES1/mTOR/ PI3K/HMGB1 signaling cascades.","authors":"Dalia E Ali, Sherouk Hussein Sweilam, Ahmed M Atwa, Ali M Elgindy, Aya M Mustafa, Manar M Esmail, Mahmoud Abdelrahman Alkabbani, Mohamed Magdy Senna, Riham A El-Shiekh","doi":"10.1007/s10787-025-01660-x","DOIUrl":"https://doi.org/10.1007/s10787-025-01660-x","url":null,"abstract":"The oleoresins of the Araucaria bidwillii Hook. (A.B.) are commonly used for the treatment of several conditions. However, the full phytochemical profile of its active compounds and its mechanism of action to protect the liver from toxicity remain unclear. The purpose of this research was to investigate the complete set of data relating to the A.B. active metabolites and explore the hepatoprotective properties of AB ethanolic extract on MTX-induced liver injury mainly due to its anti-inflammatory role. Hepatic markers, oxidative stress, inflammatory mediators, the NOTCH/NICD signaling cascade, HES1 expression, HMGB1/TLR4, and the PI3K/mTOR axis were assessed. HPLC-HRMS/MS analysis of A.B. led to the annotation of fifteen compounds from different classes, where diterpenes are the dominant class. Additionally, A.B. (100 and 200 mg/kg) significantly decreased hepatic markers, oxidative stress, and inflammatory mediators. Moreover, the extract significantly increased NOTCH pathway stimulation and HES1 expression, accompanied by a significant decline in the NUMB and HMGB1/TLR4 axes. In addition, it significantly inhibited the PI3K/mTOR pathway, with a prominent effect at the higher dose. This study presents A.B. as a promising hepatoprotective agent through stimulation of the NOTCH pathway and inhibition of the HMGB1/TLR4 pathway, as well as the PI3K/mTOR/NF-κB axis, besides its antioxidant and anti-inflammatory effects.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal remedies and traditional treatments for hirsutism and hypertrichosis. 多毛症和多毛症的草药疗法和传统疗法。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-29 DOI: 10.1007/s10787-025-01691-4

Hebatollah E Eitah, Sally E Khaled, Enaam M AbouZeid, Riham A El-Shiekh, Wesam Taher Almagharbeh, Noha M Gamil

{"title":"Herbal remedies and traditional treatments for hirsutism and hypertrichosis.","authors":"Hebatollah E Eitah, Sally E Khaled, Enaam M AbouZeid, Riham A El-Shiekh, Wesam Taher Almagharbeh, Noha M Gamil","doi":"10.1007/s10787-025-01691-4","DOIUrl":"https://doi.org/10.1007/s10787-025-01691-4","url":null,"abstract":"Hypertrichosis and hirsutism are two distinct conditions characterized by abnormal hair growth, but they differ significantly in their underlying mechanisms and implications for patient care. Hypertrichosis, which is characterized by increased hair growth in non-androgen-dependent locations, does not require hormone level monitoring, whereas hirsutism, which is characterized by increased hair growth in androgen-dependent parts of the female genitals, requires. Hirsutism is relatively common among women. Depending on societal and ethnic standards, it might cause severe mental suffering. Importantly, hirsutism may be linked to underlying conditions and co-morbidities. Hirsutism should not be viewed solely as a cosmetic concern. Patients require appropriate examination to identify and manage underlying causes and associated consequences. The article emphasizes the need for comprehensive assessment strategies for both hypertrichosis and hirsutism. While hypertrichosis may primarily be an aesthetic concern, hirsutism requires careful evaluation due to its potential links with significant health issues. However, drugs used to treat hirsutism can cause adverse effects ranging from minor symptoms like nausea and headaches to more significant consequences like vascular clots, heart attacks, hepatotoxicity, osteoporosis, and effeminization of a male fetus. As a result, the purpose of this study is to look at the possible benefits of medicinal plants as a supplemental treatment for hirsutism, specifically whether they can be employed as adjuvants to cosmetic procedures.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoids and flavonoid-based nanoparticles for the treatment of arthritis. 类黄酮和基于类黄酮的纳米颗粒治疗关节炎。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-29 DOI: 10.1007/s10787-025-01722-0

Sanchit Dhankhar, Jatin Kumar, Samrat Chauhan, Ishrat Zahoor, Shahid Nazir Wani, Monika Saini, Jamila Akter Borsha, Sabina Yasmin, Mohammad Yousuf Ansari

{"title":"Flavonoids and flavonoid-based nanoparticles for the treatment of arthritis.","authors":"Sanchit Dhankhar, Jatin Kumar, Samrat Chauhan, Ishrat Zahoor, Shahid Nazir Wani, Monika Saini, Jamila Akter Borsha, Sabina Yasmin, Mohammad Yousuf Ansari","doi":"10.1007/s10787-025-01722-0","DOIUrl":"https://doi.org/10.1007/s10787-025-01722-0","url":null,"abstract":"Arthritis is an autoimmune disorder that predominantly causes inflammation and impacts peripheral joints. Even though immunosuppressive and NSAIDs or non-steroidal anti-inflammatory medicines are implemented for the management of this disorder, sbut they carry some severe side effects along with them. Therefore, society requires treatment with fewer side effects and powerful anti-arthritic properties, such as flavonoids. These are the most prevalent phenolic compounds found in nature that have potent antioxidant, and immunomodulatory activity and there are several bioactive flavonoids that carry potent anti-inflammatory properties. Nevertheless, only a handful has reached their clinical use. Still, in both clinical and preclinical models of arthritis, flavonoids found in the diet have been shown to reduce swelling in joints and arthritis symptoms. There are only a few scientific studies regarding their mechanisms of action in arthritis. However, the arthritic potential of dietary flavonoids is insufficient because of their limited solubility, absorption, and fast metabolism. Nanocarriers may enhance the bioavailability of flavonoids. This review examines the therapeutic effects of the most prevalent and abundant flavonoid groups on arthritis. Specifically, the modes of action of the most important flavonoids on the chemical messengers in the body that contribute to the signalling of joint inflammation-related indicators of arthritis are discussed in more detail.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy of pharmacologic interventions in ulcerative colitis: a network meta analysis. 药物干预治疗溃疡性结肠炎的比较疗效：网络荟萃分析。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-03-29 DOI: 10.1007/s10787-025-01723-z

Atta Ullah Khan, Maria Ali, Muhammad Aamir Wahab

{"title":"Comparative efficacy of pharmacologic interventions in ulcerative colitis: a network meta analysis.","authors":"Atta Ullah Khan, Maria Ali, Muhammad Aamir Wahab","doi":"10.1007/s10787-025-01723-z","DOIUrl":"https://doi.org/10.1007/s10787-025-01723-z","url":null,"abstract":"Introduction: Ulcerative colitis is chronic inflammatory condition affecting the colon, necessitating remission inducing therapeutic interventions. With the emergence of newer more advanced options, their relative effectiveness remains unclear. This network meta-analysis (NMA) will compare the effectiveness of presently available biologics and small molecules in achieving and maintaining remission among patients of moderate-to-severe ulcerative colitis as part of induction and maintenance therapy.Methods: A systematic search was conducted up to 21st February 2025, including only phase 2b/3 or 3 randomized controlled trials. The primary outcome was induction and maintenance of clinical remission (Full Mayo Score (FMS) ≤ 2, with no individual subscore > 1). Secondary outcomes assessed were clinical response, endoscopic improvement (Mayo Endoscopic Score (MES) ≤ 1 either with or without friability) and steroid free remission.Results: Across 22 studies (7,683 patients), upadacitinib had the highest likelihood of inducing clinical remission (99.08%), clinical response (97.44%) and endoscopic improvement (99.32%), followed by Infliximab and guselkumab following close by for specific outcomes. In maintenance of clinical remission and endoscopic improvement upadacitinib again ranked highest (95.60%) and (99.46%). Tofacitinib (92.43%) has the highest probability with upadacitinib (87.73%) following behind in achieving steroid free remission.Conclusion: Upadacitinib displayed high efficacy across multiple outcomes in both induction and maintenance therapy with Infliximab, guselkumab, and filgotinib following closely behind. For achieving steroid free remission tofacitinib has the highest probability of doing so. Overall small molecules and selective IL-23 inhibitors seems promising alternative to older biologics though additional head-to-head trial are warranted along with more real-world data.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0