Inflammopharmacology最新文献

{"title":"Berberine as a natural immunomodulator of B lymphocytes.","authors":"Saeed Mohammadian Haftcheshmeh, Maryam Musavi, Shadi Lotfi, Anvar Soleimani, Masoumeh Dodangeh, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni","doi":"10.1007/s10787-025-01852-5","DOIUrl":"https://doi.org/10.1007/s10787-025-01852-5","url":null,"abstract":"<p><p>B lymphocytes play crucial roles in host immune responses by mediating humoral immunity via the production of various types of antibodies and also contribute to the pathogenesis of a wide range of inflammatory, autoimmune, and neoplastic disorders. Recently, considerable literature has grown around the naturally occurring compounds immunomodulatory potential. In this regard, berberine (BBR) is an isoquinoline alkaloid with unique pharmacological actions including anti-inflammatory, anti-oxidant, anti-microbial, and anti-tumor activity, which arises from its polytrophic pharmacological and biochemical properties. Up to now, no previous study has investigated the immunomodulatory actions of BBR on B cells. Herewith, this review attempts to explore the immunomodulatory effects of BBR on B cells by gathering all evidence from research investigations. BBR has high potency to inhibit the activation, proliferation, and differentiation of pathological B cells, which is represented by the reduced number of antibody-producing B cells and the production of IgE (allergies) and IgG/IgA autoantibodies (autoimmune and inflammatory disorders). The molecular mechanisms by which BBR play its modulatory action are interacting with NF-κB, MAPK, JAK/STAT, and PI3K signaling pathways, along with the regulation of transcription factors such as STAT6, GATA3, and Blimp-1. Interestingly, BBR has stimulatory effects on B cells in infection via the augmentation of IgM, IgA, and IgG production. Notably, BBR and its derivatives exerts anti-tumor activities against B cell malignancies by inducing DNA damage, expression of proapoptotic proteins, cell cycle arrest, cell death, dysregulation of mitochondrial metabolism, reactive oxygen species (ROS), which are mainly mediated by modulating c-Myc/CD47 axis, ROS/JNK/DNA damage pathway, PIK3CG signaling cascade, and the expression of CDK4, CDK6, CyclinD1, CD19, CD69, Ki67, and Bcl-2. BBR also shows contradictory effects on the therapeutic efficacy of conventional anti-lymphoma therapies such as rituximab. Together these findings support that BBR could be considered as a promising natural agent for immunomodulation in pathologic conditions by targeting B cells.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Veratric acid and zinc: a synergistic approach to accelerated wound healing in rats.","authors":"Rumila Afzal, Sidra Kaleem, Aslam Khan, Fareeha Anwar, Umair Ilyas, Alaa S Alhegaili, Mansoor Ali, Sajid Ali","doi":"10.1007/s10787-025-01857-0","DOIUrl":"https://doi.org/10.1007/s10787-025-01857-0","url":null,"abstract":"<p><p>Veratric acid, a naturally occurring derivative of benzoic acid present in various plants and fruits, has been reported to possess antioxidant, anti-inflammatory, antimicrobial, and antihypertensive properties. This study was designed to evaluate the effects of veratric acid (VA) and zinc (ZN) on wound healing in rats, assessing their individual (per se) and combined effects to determine the potential for synergistic healing benefits. In an experimental rat model, key variables, including wound closure rate, collagen synthesis, angiogenesis, and inflammation, were assessed in the presence or absence of VA and ZN, both individually and in combination. According to the study's findings, the combination of VA and ZN (10% + 10%) significantly enhances wound healing by promoting collagen synthesis, accelerating angiogenesis (the formation of new blood vessels), and reducing inflammation, thereby facilitating wound closure. The combination of veratric acid and zinc further amplified these effects, indicating a potential synergistic interaction between the two compounds. In the treatment groups, hydroxyproline levels and antioxidant parameters-including catalase, superoxide dismutase, nitric oxide, malondialdehyde, and glutathione-were significantly restored compared to the diseased control group, showing a recovery pattern similar to that of the standard control group. This study aims to provide the therapeutic potential of veratric acid, zinc, and combinations of both. The combination group shows more promising results as compared to their individual effects, indicating synergistic effects. Our data demonstrated a positive effect of the combination group along with the underlying mechanisms, suggesting its clinical potential for wound-healing applications.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of melatonin-induced mitophagy in the pathogenesis of Alzheimer's disease.","authors":"Pouya Goleij, Mohammad Amin Khazeei Tabari, Mohadeseh Poudineh, Pantea Majma Sanaye, Haroon Khan, Alan Prem Kumar, Danaé S Larsen, Maria Daglia","doi":"10.1007/s10787-025-01859-y","DOIUrl":"https://doi.org/10.1007/s10787-025-01859-y","url":null,"abstract":"<p><p>Neurons rely heavily on functional mitochondria for energy production. Mitochondrial dysfunction is a key player in age-related neurodegenerative diseases like Alzheimer's disease (AD). In AD, damaged mitochondria accumulate early, worsening the disease. This dysfunction disrupts cellular balance in neurons, leading to energy deficiencies, calcium imbalances, and oxidative stress. These issues further aggravate the harmful effects of amyloid beta (Aβ) plaques and tau tangles, ultimately leading to synaptic dysfunction, memory loss, and cognitive decline. While a complex link exists between mitochondrial dysfunction and AD hallmarks like Aβ plaques and tau tangles, the exact cause-and-effect relationship remains unclear. Additionally, recent evidence suggests impaired mechanisms for mitophagy in AD. Mitophagy is crucial for neuronal health, and studies have found changes to proteins involved in this process, mitochondrial dynamics, and mitochondrial production in AD. Impaired mitophagy might also be linked to problems with how cells fuse waste disposal compartments (autophagosomes) with lysosomes, and issues with maintaining proper acidity within lysosomes. Interestingly, melatonin, a hormone known for regulating sleep, has recently emerged as a potential neuroprotective agent. Studies using a mouse model of AD showed that melatonin treatment improved cognitive function by enhancing mitophagy. These findings suggest that melatonin's ability to improve mitophagy may be a promising avenue for future AD therapies. Therefore, in this review, we discuss the therapeutic effect of melatonin on mitochondrial dysfunction, especially mitophagy, in AD.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical modulation of mTOR signaling: emerging nanotechnology-driven therapeutics for rheumatoid arthritis management.","authors":"Deepa Mandlik, Prapti Adgaonkar, Satish Mandlik","doi":"10.1007/s10787-025-01844-5","DOIUrl":"https://doi.org/10.1007/s10787-025-01844-5","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by persistent synovial inflammation, cartilage degradation, and joint destruction. Central to RA pathogenesis is the mammalian target of the rapamycin (mTOR) signaling pathway, which regulates immune responses, cell proliferation, metabolism, and inflammation. Dysregulation of mTOR contributes to synovial hyperplasia, immune cell infiltration, and cytokine release. Although conventional therapies, including disease-modifying anti-rheumatic drugs and biologics, have improved clinical outcomes, their use is limited by cost, toxicity, and drug resistance. Phytochemicals-bioactive compounds derived from plants-have emerged as promising alternatives due to their immunomodulatory and anti-inflammatory properties, and their ability to target key molecular pathways, including mTOR. This review explores the role of phytochemicals such as curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, luteolin, celastrol, astragalus, and others in modulating the mTOR pathway and their therapeutic potential in RA. It provides mechanistic insights into how these compounds affect inflammatory signaling, immune cell activation, and the behavior of fibroblast-like synoviocytes. Challenges associated with poor solubility, low bioavailability, and rapid metabolism are discussed, alongside advances in nanoformulations that enhance targeted delivery and efficacy. Preclinical and emerging clinical evidence supports the role of phytochemicals, alone or in combination with conventional agents, in suppressing RA pathogenesis. Overall, phytochemicals targeting the mTOR pathway offer a safe, cost-effective, and multifunctional therapeutic strategy for RA management.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenolic protection: the role of mangiferin in mitigating neurodegeneration and neuroinflammation.","authors":"Aya M Mustafa, Ghadir A Bastawesy, Shymaa Hatem, Roxane Abdel-Gawad Moussa, Dina M Hal, Mariam H Fawzy, Mahmoud A Mansour, Mohamed S Abd El Hafeez","doi":"10.1007/s10787-025-01854-3","DOIUrl":"https://doi.org/10.1007/s10787-025-01854-3","url":null,"abstract":"<p><p>Mangiferin, a polyphenol of natural occurrence predominantly present in Mangifera indica, has attracted significant interest because of its multiplicity of pharmacological activities, of which its neuroprotective activity is of particular interest. Herein, the review delves into the biosynthetic mechanisms, structural properties, and action mechanisms responsible for the therapeutic value of mangiferin in neurological disorders. Of special note is that mangiferin has antioxidative, anti-inflammatory, and anti-apoptotic activities, which are responsible for its effectiveness in reducing cognitive impairments and neuronal damage in disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, epilepsy, depression, anxiety, and general cognitive decline. Though being of low bioavailability, more recent approaches such as chemical derivatization, nanoparticle-mediated drug delivery, and intranasal delivery have the promise to enhance its central nervous system (CNS) delivery. By combining preclinical and mechanistic studies, the review herein highlights the potential of mangiferin as a multitherapeutic neuroprotectant and addresses new approaches to facilitate its clinical application.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macroscopic and microscopic evaluation of the therapeutic effects of fosfomycin on surgical wound healing in a rat model.","authors":"Ali Darabniya, Mahdi Darabniya, Shahrzad Jalilpour Rezaei, AmirReza Davoodi, Elham Azarmehr, Sara Shokrpoor, Sakineh Khanamani Falahatipour","doi":"10.1007/s10787-025-01863-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01863-2","url":null,"abstract":"<p><p>This study evaluated the therapeutic potential of fosfomycin on surgical wound healing in a sterile rat model, emphasizing its immunomodulatory and regenerative effects beyond antimicrobial activity. Thirty male Sprague Dawley rats were randomly assigned to five groups: negative control, positive control (dexamethasone 1 mg/kg), and three fosfomycin-treated groups (75, 150, and 300 mg/kg, intraperitoneally). A standardized full-thickness dorsal wound was surgically induced, and treatments were administered over a 14-day period. Macroscopic healing was assessed using a validated Wound Healing Score (WHS) on days 1, 3, 5, 7, 9, 12, and 14. Histological analyses using H&E and Masson's trichrome staining were performed on days 7 and 14. Additionally, ELISA was used to quantify pro- and anti-inflammatory cytokines (TNF-α, IL-6, IL-10) and VEGF levels, while western blotting assessed the expression of NF-κB, p-NF-κB, NLRP3, and caspase-3 proteins. Fosfomycin at 150 mg/kg significantly accelerated wound closure, enhanced collagen deposition, improved re-epithelialization, and increased neovascularization compared to control groups. ELISA results showed reduced TNF-α and IL-6 levels and elevated IL-10 and VEGF levels, indicating an anti-inflammatory and a pro-angiogenic profile. Western blot analyses confirmed the downregulation of NF-κB, p-NF-κB, caspase-3, and NLRP3, suggesting suppressed inflammatory signaling and apoptosis. These results support the hypothesis that fosfomycin facilitates wound healing through modulation of immune responses and tissue regeneration pathways. 150 mg/kg dose emerged as the most effective, highlighting a potential therapeutic window. Collectively, the findings suggest that fosfomycin may serve as a dual-function agent in surgical wound care, warranting further investigations in clinical and infected wound models.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of luteolin in neurodegenerative disorders: targeting Nrf2, NFĸB, MAPK, and JAK-STAT pathways to combat neuroinflammation and apoptosis.","authors":"Koleshwar Mahto, Omkar Kumar Kuwar, Aayushi Maloo, Nileshwar Kalia","doi":"10.1007/s10787-025-01846-3","DOIUrl":"https://doi.org/10.1007/s10787-025-01846-3","url":null,"abstract":"<p><p>Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's disease, Multiple sclerosis and Amyotrophic Lateral Sclerosis, are characterized by progressive neuronal loss, oxidative stress, chronic neuroinflammation, mitochondrial dysfunction, and apoptosis. The Nrf2/ARE, IĸB/NFĸB, MAPK/AP-1, and JAK-STAT signaling pathways play a pivotal role in these pathological processes, making them promising therapeutic targets. Luteolin, a naturally occurring flavonoid, has demonstrated potent antioxidant, anti-inflammatory, and neuroprotective properties by modulating these interconnected pathways. Activation of Nrf2/ARE signaling by luteolin enhances cellular antioxidant defences, while its inhibition of NFĸB, MAPK/AP-1, and JAK-STAT pathways suppresses neuroinflammation and apoptotic signalling, thereby mitigating neuronal damage. Emerging evidences suggest that luteolin effectively reduces neurotoxic effects by regulating inflammatory cytokine production, stabilizing mitochondrial function, and maintaining redox homeostasis. Its ability to interfere with crosstalk between these signaling pathways highlights its potential as a multi-targeted neuroprotective agent. Preclinical studies have provided strong evidence supporting luteolin's role in mitigating neurodegeneration, suggesting its applicability in neurodegenerative disease management. These findings underscore the therapeutic potential of luteolin in neurodegenerative diseases by targeting multiple pathological mechanisms. However, further investigations are needed to fully elucidate its molecular mechanisms and optimize its therapeutic benefits.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting psoriatic inflammation with natural compounds: mechanistic insights and therapeutic promise.","authors":"Aya M Mustafa, Ahmed M Atwa, Ali M Elgindy, Mahmoud Abdelrahman Alkabbani, Kawther Magdy Ibrahim, Manar M Esmail, Riham A El-Shiekh, Esraa M Mohamed, Kamel Mahmoud Kamel","doi":"10.1007/s10787-025-01851-6","DOIUrl":"https://doi.org/10.1007/s10787-025-01851-6","url":null,"abstract":"<p><p>Psoriasis is a chronic immune-mediated skin disorder characterized by aberrant keratinocyte proliferation, immune cell dysregulation, and sustained inflammation driven by cytokines, such as TNF-α, IL-17, and IL-23. Despite advancements in biologic therapies, limitations related to cost, safety, and resistance have prompted interest in alternative strategies. This review explores the pharmacological basis of natural products as promising anti-psoriatic agents, focusing on compounds with multi-targeted mechanisms including anti-inflammatory, anti-oxidant, anti-proliferative, and immunomodulatory activities. Key phytochemicals, such as curcumin, thymoquinone, glycyrrhizin, and boswellic acids, are examined for their roles in modulating psoriatic pathways like NF-κB, IL-23/Th17 axis, and oxidative stress. Evidence from preclinical and clinical studies highlights their potential in reducing psoriasis area and severity index (PASI) scores, mitigating immune hyperactivity, and enhancing the safety and efficacy of standard therapies. Despite promising outcomes, translational hurdles persist, including extract standardization, pharmacokinetic limitations, and regulatory barriers. The integration of omics-based research and advanced formulation technologies is essential to support the clinical application of these agents. This review underscores the therapeutic potential of natural compounds as viable complements or alternatives in modern psoriasis management.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of anti-arthritic potential of pulegone in formaldehyde- and Complete Freund's Adjuvant-induced arthritis in rats.","authors":"Amina Shabeer, Wajiha Manzoor, Waqas Younis, Ambreen Malik Uttra, Alamgeer, Naveed Mushtaq, Mehreen Lateef, Umme Habiba Hasan, Maaz Bin Nasim, Mohd Zaheen Hassan, Jalal Uddin, Sania Aslam, Arisa Namie Higashijima, Francislaine Aparecida Reis Dos Lívero, Arquimedes Gasparotto Junior","doi":"10.1007/s10787-025-01847-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01847-2","url":null,"abstract":"<p><p>Pulegone, a monoterpene phytochemical, was evaluated for its anti-inflammatory and anti-arthritic properties. This study investigated its preventive efficacy against rheumatoid arthritis using in vivo animal models and in vitro assays. The in vitro analysis included the inhibition of egg albumin and bovine serum albumin (BSA) denaturation, as well as the stabilization of red blood cell membranes against hemolysis, across concentrations of 50-6400 μg/mL. For in vivo evaluation, arthritis was induced using formaldehyde and Complete Freund's Adjuvant (CFA) models, with pulegone administered at doses of 20, 40, and 80 mg/kg. The mRNA expression levels of key inflammatory mediators, including interleukin-1 beta (IL-1β), interleukin-17 (IL-17), nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin receptor-associated kinase (IRAK), and interleukin (IL)-10 and IL-17, were also analyzed. Results showed concentration-dependent inhibition of egg albumin and BSA denaturation, with maximum erythrocyte membrane-stabilizing effects observed at 6400 μg/mL. Pulegone exhibited dose-dependent anti-arthritic activity in the formaldehyde model, with the highest efficacy at 80 mg/kg. In the CFA model, pulegone significantly reduced arthritic lesions, mitigated weight loss, reversed hematological and biochemical abnormalities, and improved radiographic and histopathological outcomes. Additionally, pulegone demonstrated potent antioxidant effects in superoxide dismutase and reducing power assays. Treatment with pulegone significantly reduced pro-inflammatory cytokines (IL-1β, TNF-α, IRAK, and NF-κB) while increasing anti-inflammatory cytokines (IL-10 and IL-17) compared to the control group. In conclusion, pulegone effectively suppressed inflammatory responses in rheumatoid arthritis by modulating cytokine levels and enhancing antioxidant activity, making it a promising candidate for therapeutic development.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of inflammatory regulatory effects of probiotics as adjuvants in cancer development management with considering possible challenges: a comprehensive review.","authors":"Mehran Mahooti, Fatemeh Safaei, Faezeh Firuzpour, Elahe Abdolalipour, Davood Zare, Samira Sanami, Maliheh Safavi, Saeed Mirdamadi","doi":"10.1007/s10787-025-01855-2","DOIUrl":"https://doi.org/10.1007/s10787-025-01855-2","url":null,"abstract":"<p><p>Probiotics have gained significant interest due to their versatile therapeutic and preventive potential. These beneficial microorganisms have primarily been studied in gastrointestinal disorders and, due to their inflammatory regulatory effects, have then been investigated for their effects on a wide range of conditions, from acute illnesses and chronic diseases to inflammation-related diseases, including cancer. Probiotics can not only restore microbiome balance following different treatments, from antibiotic therapy to some cancer treatments, but also, with their immunomodulatory and inflammatory regulation effects, they can induce potent immune responses in different conditions with minor side effects. Moreover, as they can secrete anti-inflammatory cytokines as well as reduce pro-inflammatory cytokines as well as chemokine, they can be applied to prevent the development of many inflammation disorders. Therefore, studies have been directed to survey probiotic adjuvant effects, especially regarding their potential in the reduction of inflammation to become chronic. Probiotics, as an adjuvant, can increase the antigens displayed to related cells and thus activate different immune response compartments. Moreover, probiotic adjuvant can modulate inflammation in cancer development, making them strong candidates for regulating inflammation. With the increase and improvement in our knowledge about the adjuvant role of probiotics in the inflammatory processes underlying cancer development, it is pivotal to review current studies in this field. Therefore, the current study strives to provide a review of the latest studies regarding the probiotic's adjuvant effect in the field of immunology and oncology research to benefit the scientific community.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}