Curcumin: multifaceted biological actions and therapeutic implications-a narrative review.

IF 5.3 2区 医学 Q2 IMMUNOLOGY
Behnam Ghorbani-Nejad, Matin Baghani, Sajad Amiri, Nasim Agaei Delche, Mohammad Hossein Darijani, Motahareh Soltani, Alireza Nezami, Milad Rahimzadegan
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Abstract

Curcumin, a bioactive polyphenol extracted from the rhizome of Curcuma longa, has garnered considerable attention for its wide-ranging pharmacological properties and potential therapeutic applications. This narrative review critically synthesizes current evidence on curcumin's multifaceted biological actions, encompassing its antioxidant, anti-inflammatory, anti-cancer, and metabolic regulatory effects. Extensive preclinical and clinical studies have demonstrated that curcumin exerts beneficial effects by modulating key cellular signaling pathways and mitigating oxidative stress and inflammatory responses. Despite its promising profile, clinical translation has been hampered by issues related to low bioavailability and rapid metabolism. Recent advances in novel formulation strategies and combination therapies, however, have shown potential in overcoming these limitations. This review uniquely consolidates recent mechanistic insights with clinical translation challenges, identifying specific gaps in bioavailability research and proposing novel combination therapy approaches that distinguish it from existing curcumin reviews, ultimately facilitating evidence-based therapeutic development.

姜黄素:多方面的生物学作用和治疗意义。
姜黄素是一种从姜黄根茎中提取的生物活性多酚,因其广泛的药理特性和潜在的治疗应用而受到广泛关注。本文综述了姜黄素多方面生物学作用的最新证据,包括其抗氧化、抗炎、抗癌和代谢调节作用。广泛的临床前和临床研究表明,姜黄素通过调节关键的细胞信号通路和减轻氧化应激和炎症反应发挥有益的作用。尽管其前景光明,但临床翻译一直受到与低生物利用度和快速代谢相关的问题的阻碍。然而,新配方策略和联合疗法的最新进展显示出克服这些限制的潜力。这篇综述独特地整合了最近的机制见解和临床翻译挑战,确定了生物利用度研究中的具体差距,并提出了新的联合治疗方法,将其与现有的姜黄素综述区分开来,最终促进了循证治疗的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Inflammopharmacology
Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY
CiteScore
8.00
自引率
3.40%
发文量
200
期刊介绍: Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]
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