Quinic acid alleviates inflammatory responses and oxidative stress in Freund's complete adjuvant-induced arthritic rat model and associated risk factors of atherosclerosis.

IF 5.3 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-10-03 DOI:10.1007/s10787-025-01930-8

Iqra, Ali Sharif, Bushra Akhtar, Chuxiao Shao, Shuanghu Wang, Ayesha Younas

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引用次数: 0

Abstract

Background: Arthritis is an inflammatory disease which causes inflammation, damages joint, and increases the risk of cardiovascular disorders like atherosclerosis. Quinic acid, a naturally occurring compound, exhibits anti-inflammatory and antioxidant potential.

Method: The current study was aimed to estimate the pharmacological effects of quinic acid in Freund complete adjuvant-induced arthritis and its possible impact on associated predisposing biomarkers of atherosclerosis development. Quinic acid at various doses (25, 50, and 100 mg/kg) and methotrexate as reference drug were administered, with one group receiving combination treatment. Body weight changes, paw size, arthritic and joint stiffness score, hematological parameters, lipid profile, asymmetric dimethylarginine, homocysteine, oxidative stress, inflammatory biomarkers, and histopathological evaluation of ankle joint and heart tissues were performed to ascertain the severity of arthritis and predisposing biomarkers of atherosclerosis.

Results: The findings indicated that combination treatment significantly improved (p < 0.001) body weight, hematological parameters, high density lipoprotein levels, antioxidant enzyme concentrations, and expressions of dimethyl arginine dimethyl amino hydrolase and cortistatin. Simultaneously, it substantially reduces (p < 0.001) paw size, joint stiffness, arthritic score, platelets and leucocyte count, lipid markers, asymmetric dimethylarginine, homocysteine, malondialdehyde, and nitrite levels, whereas downregulation of mRNA expression of inflammatory markers (interleukin-6, interleukin-1β, tumor necrosis factor-α) was observed. It also significantly (p < 0.001) improves the histopathological parameters of ankle joint and heart tissue.

Conclusion: It was concluded that quinic acid possessed hypolipidemic, anti-inflammatory, and antioxidant properties and may be an effective therapeutic substance for the management of polyarthritis and predisposing markers of atherosclerosis.

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奎宁酸减轻Freund完全佐剂诱导的关节炎大鼠模型的炎症反应和氧化应激以及动脉粥样硬化的相关危险因素。

背景：关节炎是一种炎症性疾病，可引起炎症，损害关节，并增加动脉粥样硬化等心血管疾病的风险。奎宁酸是一种天然化合物，具有抗炎和抗氧化的潜力。方法：本研究旨在评估奎宁酸在Freund完全性佐剂性关节炎中的药理作用及其对动脉粥样硬化发展相关易感生物标志物的可能影响。采用不同剂量（25、50、100 mg/kg）的奎宁酸和甲氨蝶呤作为对照药物，其中一组采用联合治疗。通过体重变化、爪子大小、关节炎和关节僵硬评分、血液学参数、血脂、不对称二甲基精氨酸、同型半胱氨酸、氧化应激、炎症生物标志物以及踝关节和心脏组织的组织病理学评估来确定关节炎的严重程度和动脉粥样硬化的易感生物标志物。结论：奎宁酸具有降血脂、抗炎和抗氧化的作用，可能是治疗多发性关节炎和动脉粥样硬化易感标志物的有效药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]