Progress on the mechanism of natural polysaccharides in the treatment of arthritis.

IF 5.3 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-06-11 DOI:10.1007/s10787-025-01772-4

Lili Yuan, Michael Adu-Frimpong, Hong Chen, Yaping Yang, Jiangnan Yu, Huiya Wang, Yuxiang He, Elmurat Toreniyazov, Xia Cao, Qilong Wang, Ximing Xu

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Abstract

Arthritis is a common joint-injury disease, and because its exact etiology and pathogenesis remain incompletely understood, current treatment options for it are highly limited. Conventional treatments focus on anti-inflammatory drugs to alleviate the disease. However, long-term use of these medications can cause increasingly serious side effects. Therefore, there is an urgent need to develop safe and effective anti-arthritis drugs with fewer side effects. Polysaccharides derived from natural products have received a lot of attention because of their safety and multiple active effects, wherein they have shown strong potential especially in the treatment of arthritis. However, a systematic presentation of polysaccharides against arthritis is still lacking. In this paper, we summarize the recent studies on natural polysaccharides for arthritis treatment mainly in terms of isolation, structure-anti-arthritic relationship, pharmacokinetics, mechanisms, and association of polysaccharides with other substances. It is helpful for researchers to fully understand the anti-arthritic effects of polysaccharides and provide some references for the development and application of polysaccharides in arthritis treatment.

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天然多糖治疗关节炎的作用机制研究进展。

关节炎是一种常见的关节损伤疾病，由于其确切的病因和发病机制尚不完全清楚，目前的治疗方案非常有限。传统的治疗方法主要是用消炎药来缓解这种疾病。然而，长期使用这些药物会导致越来越严重的副作用。因此，迫切需要开发出安全有效、副作用少的抗关节炎药物。从天然产物中提取的多糖因其安全性和多重活性作用而受到广泛关注，其中在治疗关节炎方面显示出强大的潜力。然而，多糖抗关节炎的系统介绍仍然缺乏。本文主要从天然多糖的分离、结构-抗关节炎关系、药代动力学、作用机制以及多糖与其他物质的关联等方面综述了近年来天然多糖治疗关节炎的研究进展。这有助于研究人员全面了解多糖的抗关节炎作用，并为多糖在关节炎治疗中的开发和应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]