Infectious diseases now最新文献

{"title":"Recommended gentamicin peak plasma levels rarely reached, even with recommended dosages","authors":"Quentin Perrier ,&nbsp;Anne-Flore Dumas ,&nbsp;Hélène Pluchart ,&nbsp;Mireille Bartoli ,&nbsp;Elodie Gautier ,&nbsp;Pierrick Bedouch ,&nbsp;Olivier Epaulard","doi":"10.1016/j.idnow.2025.105076","DOIUrl":"10.1016/j.idnow.2025.105076","url":null,"abstract":"<div><h3>Introduction</h3><div>The recommended gentamicin peak plasma concentration range is 32–40 mg/L; we aimed to determine how frequently it was reached, and for which gentamicin doses.</div></div><div><h3>Patients and methods</h3><div>We retrospectively reviewed 601 gentamicin peak plasma concentrations in 501 patients aged ≥15 in our institution between 2013 and 2023.</div></div><div><h3>Results</h3><div>Median gentamicin dose was 5.9 mg/kg [IQR 4.1–7.9]. Median peak plasma concentration was 16.5 mg/L [IQR 10.8–22.8] and was strongly correlated with dose (p &lt; 0.0001). Only 5.7 % of values were ≥32 mg/L, including 22.8 % for dose ≥10 mg/kg.</div></div><div><h3>Conclusion</h3><div>This suggests that existing recommendations regarding either dose or target concentration for gentamicin should be modified.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105076"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and clinical utility of [18F] FDG PET/CT in management of Staphylococcus aureus bacteremia","authors":"Yui Okamura ,&nbsp;Chisato Numa ,&nbsp;Kota Tokunaga ,&nbsp;Tomonari M. Shimoda ,&nbsp;Hiroshi Ito","doi":"10.1016/j.idnow.2025.105075","DOIUrl":"10.1016/j.idnow.2025.105075","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105075"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, clinical Presentation and risk factors for Trichomonas Vaginalis in Reunion Island between 2020 and 2022","authors":"Pauline Caillau ,&nbsp;Maud Lekieffre ,&nbsp;Nicolas Traversier ,&nbsp;Marie-Christine Jaffar-Bandjee ,&nbsp;Fanny Andry ,&nbsp;Malik Boukerrou ,&nbsp;Kevin Diallo ,&nbsp;Roland Rodet ,&nbsp;Yves-Marie Diarra ,&nbsp;Antoine Bertolotti","doi":"10.1016/j.idnow.2025.105078","DOIUrl":"10.1016/j.idnow.2025.105078","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Trichomonas vaginalis</em> (TV) is a little known sexually transmitted infection (STI) that presents complications for infected individuals. In the absence of data in Reunion Island, our aim was to estimate the prevalence of TV and to study the risk factors and clinical signs associated with this infection.</div></div><div><h3>Method</h3><div>Between January 2020 and December 2022, all persons tested for TV at the University Hospital (UH) and STI centres (CeGIDDs) of Reunion Island were included in this study. TV prevalence was estimated based on the results of the multiplex PCR tests on samples collected from genital, anal or oropharyngeal sites.</div></div><div><h3>Results</h3><div>Out of the 17,261 samples (from 13,847 patients) included, 310 were positive for TV (30 from CeGIDDs and 280 from UH), representing overall TV prevalence of 2.20 % (95 % CI: 1.99–2.49). The prevalence of TV was 0.80 % (95 % CI: 0.52–1.10) in CeGIDDs (n = 3,733) and 2.80 % (95 % CI: 2.45–3.09) in UH (n = 10,114). In the CeGIDD population, prevalence of TV was 1.15 % (95 % CI: 0.71–1.8) for women, compared with 0.47 % (95 % CI: 0.22–0.90) for men. TV was statistically significantly associated with precariousness (aOR 3.13, 95 % CI: 1.46–6.46), and 23.3 % (7/30, 95 % CI: 8.20–38.47) of TV-positive patients had symptoms.</div></div><div><h3>Conclusion</h3><div>Compared to other countries, Reunion Island is one of the lower-risk areas for TV. Its presence is associated with poor living conditions and a paucity of clinical signs.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105078"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an antibiotic stewardship programme in the emergency department of a secondary hospital","authors":"Martínez-de la Cruz Paula ,&nbsp;Moreno-Núñez Leonor ,&nbsp;Valverde-Canovas José Francisco ,&nbsp;Sanz-Márquez Sira ,&nbsp;Velasco-Arribas Maria ,&nbsp;Martín-Segarra Oriol ,&nbsp;Hervás-Gómez Rafael ,&nbsp;Vegas-Serrano Ana ,&nbsp;Losa-García Juan Emilio","doi":"10.1016/j.idnow.2025.105063","DOIUrl":"10.1016/j.idnow.2025.105063","url":null,"abstract":"<div><h3>Introduction</h3><div>Emergency Departments (ED) are usually the first point of contact between patients and hospitals. There is no solid evidence evaluating the activity of antibiotic stewardship programs (ASP) in EDs. We aimed to assess antibiotic prescription appropriateness after the implementation of an ASP in an ED in May 2019 and to determine the risk factors associated with inappropriate antibiotic prescription.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted with patients admitted to the ED of the University Hospital Fundación Alcorcón, a second-level university hospital in Spain. All patients admitted to the ED in May 2019, March 2021, and between October and November 2022 were included. We analyzed demographic data, epidemiological variables, comorbidities, empirical antibiotic treatment, previous isolations, and treatment duration. A 30-day follow-up was implemented.</div></div><div><h3>Results</h3><div>A total of 402 patients were included. No significant improvement in antibiotic appropriateness was observed between the first and second periods (50 % vs. 57.3 %; OR = 1.3, 95 % CI: 0.65–2.76, <em>p</em> = 0.424), while antibiotic appropriateness increased between the first and third periods (50 % vs. 71.2 %; OR = 2.47, 95 % CI: 1.28–4.79, <em>p</em> = 0.007). Factors associated with antibiotic inadequacy were having a urinary catheter (33 % vs. 56 %, <em>p</em> = 0.008, OR: 2.62, 95 % CI: 1.29–5.33), a history of infection/colonization by multidrug-resistant microorganisms (32 % vs. 57 %, <em>p</em> = 0.007), and coming from a retirement home or medium-stay hospital (32 % vs. 47 % vs. 53 %, <em>p</em> = 0.015).The overall use of carbapenems was 9 % (n = 36), showing a decrease in consumption between the first and third periods (26.2 % vs. 7 % vs. 7 %, <em>p</em> &lt; 0.01).</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105063"},"PeriodicalIF":2.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety profile of fluoroquinolones","authors":"Annie-Pierre Jonville-Béra ,&nbsp;Bérenger Largeau ,&nbsp;Ferderico di Meglio ,&nbsp;Antoine Pariente","doi":"10.1016/j.idnow.2025.105064","DOIUrl":"10.1016/j.idnow.2025.105064","url":null,"abstract":"<div><div>While they are very useful agents, fluoroquinolones (FQs) are associated with a number of serious adverse effects (AEs). The objective of this paper is to describe the characteristics of frequent serious AEs related to FQs along with their risk factors, their safety in specific populations, and the main drug-drug interactions that may occur. Serious AEs commonly associated with FQs include tendon disorders (particularly tendinopathy and tendon rupture), CNS toxicity (seizure and encephalopathy), peripheral neuropathy (including small fiber neuropathy), cardiovascular toxicity (QT interval prolongation, dissection, and aneurysm rupture), disrupted glucose metabolism, phototoxicity, C. difficile infections, acute renal failure, and hepatic toxicity. Most of these AEs are common to all FQs, but some, such as acute kidney failure on crystallization with ciprofloxacin or norfloxacin, are more specific. Unlike the AEs associated with most other antibiotics, some of these AEs (e.g. tendinopathy or neuropathy) may occur after FQ discontinuation, and others may subsequently progress (e.g. FQ-associated disability). The risk of serious AE is heightened by factors having to do with patient age and comorbidities, the characteristics of the FQ treatment (dose and/or duration) and associated drug intake. To conclude, FQs appear to be associated with a higher risk of serious AEs than most of the other antibiotics available for the same indications, however some AEs can be avoided by bearing in mind the predisposing risk factors.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105064"},"PeriodicalIF":2.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fragility of public health expertise and the challenges to overcome","authors":"François Bourdillon","doi":"10.1016/j.idnow.2025.105074","DOIUrl":"10.1016/j.idnow.2025.105074","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105074"},"PeriodicalIF":2.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The latest updates on the proper use of fluoroquinolones – Actualisation 2025 update by the SPILF and the GPIP","authors":"F. Vuotto ,&nbsp;J.P. Bru ,&nbsp;E. Canoui ,&nbsp;M. Caseris ,&nbsp;M.C.C. Chopin ,&nbsp;R. Cohen ,&nbsp;S. Diamantis ,&nbsp;A. Dinh ,&nbsp;P. Fillatre ,&nbsp;R. Gauzit ,&nbsp;Y. Gillet ,&nbsp;A.P. Jonville-Bera ,&nbsp;M. Lafaurie ,&nbsp;P. Lesprit ,&nbsp;M. Lorrot ,&nbsp;J. Lourtet ,&nbsp;L. Maulin ,&nbsp;D. Poitrenaud ,&nbsp;A. Pariente ,&nbsp;J. Raymond ,&nbsp;E. Bonnet","doi":"10.1016/j.idnow.2025.105062","DOIUrl":"10.1016/j.idnow.2025.105062","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105062"},"PeriodicalIF":2.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Update of guidelines for management of community acquired pneumonia in adults by the French infectious disease society (SPILF) and the French-speaking society of respiratory diseases (SPLF). Endorsed by the French intensive care society (SRLF), the French microbiology society (SFM), the French radiology society (SFR) and the French emergency society (SFMU)” [IDNOW 55/2 (2025) 105034]","authors":"A. Dinh ,&nbsp;F. Barbier ,&nbsp;J.-P. Bedos ,&nbsp;M. Blot ,&nbsp;V. Cattoir ,&nbsp;Y.-E. Claessens ,&nbsp;X. Duval ,&nbsp;P. Fillâtre ,&nbsp;M. Gautier ,&nbsp;Y. Guegan ,&nbsp;S. Jarraud ,&nbsp;A. Le Monnier ,&nbsp;D. Lebeaux ,&nbsp;P. Loubet ,&nbsp;C. de Margerie ,&nbsp;P. Serayet ,&nbsp;Y. Tandjaoui-Lambotte ,&nbsp;E. Varon ,&nbsp;Y. Welker ,&nbsp;D. Basille","doi":"10.1016/j.idnow.2025.105060","DOIUrl":"10.1016/j.idnow.2025.105060","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 3","pages":"Article 105060"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of the GeneXpert MTB/RIF Ct for predicting tuberculosis infectiousness","authors":"F. Méchaï ,&nbsp;E. Beugre ,&nbsp;T. Billard-Pomares ,&nbsp;F. Mougari ,&nbsp;B. Wyplosz ,&nbsp;E. Cambau ,&nbsp;N. Vignier","doi":"10.1016/j.idnow.2025.105061","DOIUrl":"10.1016/j.idnow.2025.105061","url":null,"abstract":"<div><h3>Introduction</h3><div>The GeneXpert® MTB/RIF test is faster and more sensitive than smear microscopy (SM) for the diagnosis of pulmonary tuberculosis (pTB). We evaluated the contribution of the Ct (“Cycle threshold”) of the GeneXpert MTB/RIF test to estimate infectiousness.</div></div><div><h3>Methods</h3><div>We performed a multicenter retrospective analysis of patients with pTB confirmed by positivity of culture and GeneXpert. The median Ct was calculated on Day 0 (D0). We studied the following correlations: between the Ct and SM on D0, Ct and Time-To-Detection (TTD) of the culture in liquid medium on D0 and then the correlation between the Ct on D0 and the culture on D15, Month 1 (M1), and M2.</div></div><div><h3>Results</h3><div>A total of 426 patients were included. SM was negative for 130 (30.6 %) patients. The global median Ct was 20.1. The Ct was significantly correlated with the SM grade at diagnosis (Xpert MTB/RIF or Xpert MTB/RIF Ultra, r = -0.77, <em>p</em> &lt; 0.001 and r = -0.69, <em>p</em> &lt; 0.0001, respectively). D0 Ct was significantly correlated with TTD (r = 0.71, <em>p</em> &lt; 0.0001 and r = 0.71, <em>p</em> &lt; 0.0001, respectively) and with a positive culture only on D15 (<em>p</em> &lt; 0.0001 and <em>p</em> &lt; 0.0001, respectively).</div></div><div><h3>Conclusion</h3><div>The Ct value correlated well with the smear grade and with the bacillary load at diagnosis. Smear microscopy is less sensitive for estimating the risk of transmission. The GeneXpert test (and its Ct) could therefore replace smear microscopy for diagnosis but also for estimating the infectiousness of patients, particularly in low-resource countries where smear and culture are poorly available.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105061"},"PeriodicalIF":2.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of nosocomial Trichosporon asahii in urine: A retrospective cohort study","authors":"Bruno Ali Lopez Luis,&nbsp;Karla alhelí León-Palacios,&nbsp;Araceli Acosta-Ruiz,&nbsp;Ana Maria Gonzalez-Cardel,&nbsp;Graciela Rodriguez-Zuñiga","doi":"10.1016/j.idnow.2025.105059","DOIUrl":"10.1016/j.idnow.2025.105059","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the clinical characteristics and outcomes of patients with urine cultures positive for <em>Trichosporon</em> sp with nosocomial acquisition.</div></div><div><h3>Methods</h3><div>Retrospective cohort study between 2019 and 2023 that included all patients with urinary isolates of <em>Trichosporon</em> sp; their clinical data and outcomes were drawn from medical records.</div></div><div><h3>Results</h3><div>Twenty-six patients had urinary Trichosporon asahii. Length of hospital stay before urinary culture with T. asahii averaged 25 days. Seventy percent stayed in the intensive care unit. All patients had an additional bacterial infection and were receiving antibiotic therapy. During the first 30 days, only 57 % were alive. There were no factors significantly associated with mortality.</div></div><div><h3>Conclusions</h3><div>The isolation of T. asahii in urine cultures of patients with extended hospital stay does not suggest invasive disease. T. asahii in urine may be a marker of critically ill patients with a high risk of mortality.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105059"},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}