Infectious diseases now最新文献

{"title":"Measuring the prevalence of aspiration pneumonia in view of improving the relevance of antibiotic prescription of antibiotics: A retrospective, observational study","authors":"Rodrigue Wankap ,&nbsp;Lyasmine Azzoug ,&nbsp;Florent Rossi ,&nbsp;Adrien Chan Sui Ko ,&nbsp;Jean-Philippe Lanoix","doi":"10.1016/j.idnow.2024.104885","DOIUrl":"10.1016/j.idnow.2024.104885","url":null,"abstract":"<div><h3>Purpose</h3><p>Aspiration pneumonia (AP) has significant incidence and impact on mortality. However, data about clinical diagnosis criteria are scarce. We aimed to evaluate according to predefined criteria the prevalence of true AP and its impact on antibiotic stewardship.</p></div><div><h3>Methods</h3><p>Retrospective study of patients whose main diagnosis was AP hospitalized at Amiens University Hospital in 2018. We first defined diagnostic criteria of certainty for pneumonia and aspiration. AP was then classified according to degree of certainty.</p></div><div><h3>Results</h3><p>Among 862 cases of AP, its diagnosis was certain, likely, probably in excess, certainly in excess or absent in 2 % (n = 17), 3 % (n = 26), 50.5 % (n = 433), 23.1 % (n = 198) and 21.4 % (n = 183) respectively. Irrelevant use of amoxicillin-clavulanic acid and metronidazole was found in 27 % and 13 % of cases, respectively.</p></div><div><h3>Conclusions</h3><p>The diagnosis of AP is frequently excessive, and diagnostic tools are urgently needed to improve antibiotic stewardship.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104885"},"PeriodicalIF":3.5,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266699192400040X/pdfft?md5=7062bb7230926aa7d267d9ce24d327b6&pid=1-s2.0-S266699192400040X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140127785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating ChatGPT ability to answer urinary tract Infection-Related questions","authors":"Hakan Cakir ,&nbsp;Ufuk Caglar ,&nbsp;Sami Sekkeli ,&nbsp;Esra Zerdali ,&nbsp;Omer Sarilar ,&nbsp;Oguzhan Yildiz ,&nbsp;Faruk Ozgor","doi":"10.1016/j.idnow.2024.104884","DOIUrl":"10.1016/j.idnow.2024.104884","url":null,"abstract":"<div><h3>Introduction</h3><p>For the first time, the accuracy and proficiency of ChatGPT answers on urogenital tract infection (UTIs) were evaluated.</p></div><div><h3>Methods</h3><p>The study aimed to create two lists of questions: frequently asked questions (FAQs, public-based inquiries) on relevant topics, and questions based on guideline information (guideline-based inquiries). ChatGPT responses to FAQs and scientific questions were scored by two urologists and an infectious disease specialist. Quality and reliability of all ChatGPT answers were checked using the Global Quality Score (GQS). The reproducibility of ChatGPT answers was analyzed by asking each question twice.</p></div><div><h3>Results</h3><p>All in all, 96.2 % of FAQs (75/78 inquiries) related to UTIs were correctly and adequately answered by ChatGPT, and scored GQS 5. None of the ChatGPT answers were classified as GQS 2 and GQS 1. Moreover, FAQs about cystitis, urethritis, and epididymo-orchitis were answered by ChatGPT with 100 % accuracy (GQS 5). ChatGPT answers for EAU urological infections guidelines showed that 61 (89.7 %), 5 (7.4 %), and 2 (2.9 %) ChatGPT responses were scored GQS 5, GQS 4, and GQS 3, respectively. None of the ChatGPT responses for EAU urological infections guidelines were categorized as GQS 2 and GQS 1. Comparison of mean GQS values of ChatGPT answers for FAQs and EAU urological guideline questions showed that ChatGPT was similarly able to respond to both question groups (p = 0.168). The ChatGPT response reproducibility rate was highest for the FAQ subgroups of cystitis, urethritis, and epididymo-orchitis (100 % for each subgroup).</p></div><div><h3>Conclusion</h3><p>The present study showed that ChatGPT gave accurate and satisfactory answers for both public-based inquiries, and EAU urological infection guideline-based questions. Reproducibility of ChatGPT answers exceeded 90% for both FAQs and scientific questions.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104884"},"PeriodicalIF":3.5,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000393/pdfft?md5=c75d26b339be033e68ccd551c6111988&pid=1-s2.0-S2666991924000393-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CV2 : Editorial Board","authors":"","doi":"10.1016/S2666-9919(24)00026-5","DOIUrl":"https://doi.org/10.1016/S2666-9919(24)00026-5","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104871"},"PeriodicalIF":3.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000265/pdfft?md5=0d7a3ad7797dfd3c792465954ebadac4&pid=1-s2.0-S2666991924000265-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139986755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A malaria elimination milestone reached on Mayotte Island","authors":"Jean-François Lepère,&nbsp;Louis Collet,&nbsp;Ambdoul-Bar Idaroussi,&nbsp;Hassani Youssouf,&nbsp;Marion Soler,&nbsp;Bruno Pradines","doi":"10.1016/j.idnow.2024.104868","DOIUrl":"10.1016/j.idnow.2024.104868","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104868"},"PeriodicalIF":3.5,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266699192400023X/pdfft?md5=c5a3d1e860022172412022e676b95474&pid=1-s2.0-S266699192400023X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics, management, and outcome of tuberculosis after liver transplant: A case series and literature review","authors":"Rémi Nguyen Van ,&nbsp;Pauline Houssel-Debry ,&nbsp;Domitille Erard ,&nbsp;Jérôme Dumortier ,&nbsp;Anne Pouvaret ,&nbsp;Guillaume Bergez ,&nbsp;François Danion ,&nbsp;Laure Surgers ,&nbsp;Vincent Le Moing ,&nbsp;Nassim Kamar ,&nbsp;Fanny Lanternier ,&nbsp;Pierre Tattevin","doi":"10.1016/j.idnow.2024.104869","DOIUrl":"10.1016/j.idnow.2024.104869","url":null,"abstract":"<div><h3>Background</h3><p>Liver transplant recipients are at risk of tuberculosis, which is particularly difficult-to diagnose and to treat in this population.</p></div><div><h3>Methods</h3><p>Retrospective study of all cases of tuberculosis diagnosed from 2007 to 2022 in the French network of liver transplant sites.</p></div><div><h3>Results</h3><p>Twenty-three liver transplant recipients were diagnosed with tuberculosis (six females, median age 59 years [interquartile range, 54–62]), with a median time lapse of 10 months [5–40.5] after transplant, and 38 days [26–60] after symptoms onset. Primary modes of pathogenesis were latent tuberculosis reactivation (n = 15) and transplant-related transmission (n = 3). Even though most patients with pre-transplant data had risk factors for tuberculosis (11/20), IFN-gamma release assay was performed in only three. Most cases involved extra-pulmonary tuberculosis (20/23, 87 %). With median follow-up of 63 months [24–108], five patients died (22 %), including four tuberculosis-related deaths.</p></div><div><h3>Conclusions</h3><p>Extrapulmonary tuberculosis is a severe disease in liver transplant recipients. Systematic pre-transplant screening of latent tuberculosis may prevent most of them.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104869"},"PeriodicalIF":3.5,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000241/pdfft?md5=72d2854b3a8a0f02fc40f3f46d8348d8&pid=1-s2.0-S2666991924000241-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to infection prevention and control implementation in selected healthcare facilities in Nigeria","authors":"Rachael O.A. Falana ,&nbsp;Oluwakemi C. Ogidan ,&nbsp;Boluwaji R. Fajemilehin","doi":"10.1016/j.idnow.2024.104877","DOIUrl":"10.1016/j.idnow.2024.104877","url":null,"abstract":"<div><h3>Objective</h3><p>While infection prevention and control are of paramount importance, up until recently an assessment of implementation challenges and performance gaps was lacking. This study explored the barriers to infection prevention and control implementation at selected healthcare facilities, the objective being to find ways to improve their programs.</p></div><div><h3>Material and Method</h3><p>A qualitative approach was applied. Purposive sampling was used to select thirty-three healthcare facilities in Ekiti State, Nigeria. They were globally assessed, and an Infection Prevention and Control team, represented by the Infection Prevention and Control referent in each of the selected facilities trained the participants. Data were collected using the Key Informant Interview Guide and analyzed by means of content and thematic analyses using Atlas.ti software.</p></div><div><h3>Results</h3><p>Inadequate infection prevention and control materials, poor waste management, non-compliance of patients with infection prevention and control protocols, and poor infrastructure were identified as major barriers to infection prevention and control implementation.</p></div><div><h3>Conclusion</h3><p>The study concluded that a number of identified factors hindering infection prevention and control implementation in healthcare facilities in Ekiti State needed to be addressed.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104877"},"PeriodicalIF":3.5,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000320/pdfft?md5=630e6f38117955884d38a72cc2601b3d&pid=1-s2.0-S2666991924000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139939958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppressive antibiotic therapy for infectious endocarditis","authors":"T. Lemmet ,&nbsp;M. Bourne-Watrin ,&nbsp;V. Gerber ,&nbsp;F. Danion ,&nbsp;A. Ursenbach ,&nbsp;B. Hoellinger ,&nbsp;N. Lefebvre ,&nbsp;J. Mazzucotelli ,&nbsp;F. Zeyons ,&nbsp;Y. Hansmann ,&nbsp;Y. Ruch","doi":"10.1016/j.idnow.2024.104867","DOIUrl":"10.1016/j.idnow.2024.104867","url":null,"abstract":"<div><h3>Objectives</h3><p>Suppressive antibiotic therapy (SAT) is a long-term antibiotic strategy at times applied when an indicated surgical management of infective endocarditis (IE) is not possible. Our aim was to describe the characteristics and outcomes of patients having received SAT for IE.</p></div><div><h3>Methods</h3><p>We conducted a retrospective, observational study at Strasbourg University Hospital, France between January 2020 and May 2023. We reviewed all medical files taken into consideration at weekly meetings of the local Multidisciplinary Endocarditis Team (MET) during the study period. We included patients having received SAT following the MET evaluation. The primary endpoint was all-cause mortality at most recent follow-up. Secondary endpoints included all-cause mortality at 3 and 6 months, infection relapse, and tolerance issues attributed to SAT.</p></div><div><h3>Results</h3><p>The MET considered 251 patients during the study time, among whom 22 (9 %) had received SAT. Mean age was 77.2 ± 12.3 years. Patients were highly comorbid with a mean Charlson index score of 6.6 ± 2.5. Main indication for SAT was surgery indicated but not performed or an infected device not removed (20/22). Fourteen patients had prosthetic valve IE, including 9 TAVIs. Six patients had IE affecting cardiac implantable electronic devices. Staphylococcus aureus and enterococci were the main bacteria involved (6/22 each). Median follow-up time was 249 days (IQR 95–457 days). Mortality at most recent follow-up was 23 % (5/22). Three patients (14 %) presented tolerance issues attributed to SAT, and two patients suffered late infectious relapse.</p></div><div><h3>Conclusion</h3><p>Mortality at most recent follow-up was low and tolerance issues were rare for patients under SAT, which might be a palliative approach to consider when optimal surgery or device removal is not possible.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104867"},"PeriodicalIF":3.5,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000228/pdfft?md5=514e05d8ef61a7a1abe95a4065ff582a&pid=1-s2.0-S2666991924000228-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, treatment and outcomes of infected pancreatic necrosis in France: a bicenter study","authors":"Yousra Kherabi ,&nbsp;Claire Michoud ,&nbsp;Khanh Villageois-Tran ,&nbsp;Frédéric Bert ,&nbsp;Mathieu Pioche ,&nbsp;Agnès Lefort ,&nbsp;Philippe Lévy ,&nbsp;Vinciane Rebours ,&nbsp;Virginie Zarrouk","doi":"10.1016/j.idnow.2024.104866","DOIUrl":"10.1016/j.idnow.2024.104866","url":null,"abstract":"<div><h3>Introduction</h3><p>Acute necrotizing pancreatitis (ANP) mortality increases when pancreatic necrosis is infected (IPN). Current treatment of IPN relies on prolonged antibiotic therapies associated with a step-up strategy of drainage. The objective of this study was to analyze IPN treatment outcomes in two referral centers in France.</p></div><div><h3>Methods</h3><p>Data of consecutive patients with documented IPN hospitalized in two expert centers in France between 2014 and 2019 were retrospectively reviewed. The composite primary outcome was the proportion of unsuccessful management outcome, defined as new emergency drainage to treat sepsis with organ failure, an unplanned new antibiotic course, an unplanned prolongation of antibiotic course and/or death by septic shock, within three months following the diagnosis of ANP.</p></div><div><h3>Results</h3><p>All in all, 187 patients (138 males; 74.0%), with documented IPN were included. The most frequently identified microorganism was <em>Escherichia coli</em> (26.2%). Ninety-eight patients (52.4%) were admitted to an intensive care unit or resuscitation ward within the first two days of ANP care. Overall, 126 patients (67.4%) endured an unsuccessful outcome: new emergency drainage to treat acute sepsis (62.0%), unplanned new antibiotic course (47.1%), unplanned prolongation of antibiotic course (44.9%) and/or death by septic shock complicating IPN (8.0%).</p></div><div><h3>Conclusion</h3><p>The unfavorable evolution in two thirds of patients shows that determination of optimal drainage timing and choice of antibiotic therapy remain major challenges in 2024.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104866"},"PeriodicalIF":3.5,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000216/pdfft?md5=3375a01cb8cce18c19b1c83182b49952&pid=1-s2.0-S2666991924000216-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning to predict antimicrobial resistance: future applications in clinical practice?","authors":"Yousra Kherabi ,&nbsp;Michaël Thy ,&nbsp;Donia Bouzid ,&nbsp;David B. Antcliffe ,&nbsp;Timothy Miles Rawson ,&nbsp;Nathan Peiffer-Smadja","doi":"10.1016/j.idnow.2024.104864","DOIUrl":"10.1016/j.idnow.2024.104864","url":null,"abstract":"<div><h3>Introduction</h3><p>Machine learning (ML) is increasingly being used to predict antimicrobial resistance (AMR). This review aims to provide physicians with an overview of the literature on ML as a means of AMR prediction.</p></div><div><h3>Methods</h3><p>References for this review were identified through searches of MEDLINE/PubMed, EMBASE, Google Scholar, ACM Digital Library, and IEEE Xplore Digital Library up to December 2023.</p></div><div><h3>Results</h3><p>Thirty-six studies were included in this review<strong>.</strong> Thirty-two studies (32/36, 89 %) were based on hospital data and four (4/36, 11 %) on outpatient data. The vast majority of them were conducted in high-resource settings (33/36, 92 %). Twenty-four (24/36, 67 %) studies developed systems to predict drug resistance in infected patients, eight (8/36, 22 %) tested the performances of ML-assisted antibiotic prescription, two (2/36, 6 %) assessed ML performances in predicting colonization with carbapenem-resistant bacteria and, finally, two assessed national and international AMR trends. The most common inputs were demographic characteristics (25/36, 70 %), previous antibiotic susceptibility testing (19/36, 53 %) and prior antibiotic exposure (15/36, 42 %). Thirty-three (92 %) studies targeted prediction of Gram-negative bacteria (GNB) resistance as an output (92 %). The studies included showed moderate to high performances, with AUROC ranging from 0.56 to 0.93.</p></div><div><h3>Conclusion</h3><p>ML can potentially provide valuable assistance in AMR prediction. Although the literature on this topic is growing, future studies are needed to design, implement, and evaluate the use and impact of ML decision support systems.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 3","pages":"Article 104864"},"PeriodicalIF":3.5,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000198/pdfft?md5=319eed89f5174e2313b66e6555d0ba0e&pid=1-s2.0-S2666991924000198-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of IgM ELISA and 56 kDa gene PCR in management of pediatric acute encephalitis syndrome associated with scrub typhus","authors":"Pooja Bhardwaj ,&nbsp;Vishal Yadav ,&nbsp;Alok Sharma ,&nbsp;Shahzadi Gulafshan ,&nbsp;Sthita Pragnya Behera ,&nbsp;Gaurav Raj Dwivedi ,&nbsp;Hirawati Deval ,&nbsp;Vijayachari Paluru ,&nbsp;Manoj Murhekar ,&nbsp;Rajeev Singh","doi":"10.1016/j.idnow.2024.104865","DOIUrl":"10.1016/j.idnow.2024.104865","url":null,"abstract":"<div><h3>Objectives</h3><p>To identify the potential target genes for detection of <em>Orientia tsutsugamushi</em> (OT) in pediatric acute encephalitis syndrome (pAES).</p></div><div><h3>Methods</h3><p>DNA was extracted from whole blood of 100 pAES cases having tested positive (n = 41) and negative (n = 59) for scrub typhus (ST) by IgM ELISA. These samples were subjected to standard PCR for 56 kDa, 47 kDa, 16 s rRNA, groEL, traD genes and the newly identified 27 kDa gene.</p></div><div><h3>Results</h3><p>Among the selected gene targets, 56 kDa demonstrated its superiority for OT detection over the other tested genes. The presence of OT was confirmed via PCR targeting 56 kDa gene in 17 out of the 41 (41.4 %) IgM-positive ST AES cases and 38 out of the 59 (64.4 %) ST IgM negative cases. None of the other gene targets were amplified.</p></div><div><h3>Conclusion</h3><p>Integration of serological diagnosis with molecular diagnostics targeting the 56 kDa gene for routine testing of AES patients would facilitate detection of OT in AES endemic regions.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104865"},"PeriodicalIF":3.5,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000204/pdfft?md5=3b12ec2a3b2063f17e1d1baf0c57a90d&pid=1-s2.0-S2666991924000204-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}