INDONESIAN JOURNAL OF PHARMACY最新文献_第8页

Comparing Responses of Ursolic Acid in Murine Macrophages Infected with Mycobacterium smegmatis and Mycobacterium avium 熊果酸对耻垢分枝杆菌和鸟分枝杆菌感染小鼠巨噬细胞反应的比较

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-20 DOI: 10.22146/ijp.3507

D. Pitaloka, M. Jihadah

{"title":"Comparing Responses of Ursolic Acid in Murine Macrophages Infected with Mycobacterium smegmatis and Mycobacterium avium","authors":"D. Pitaloka, M. Jihadah","doi":"10.22146/ijp.3507","DOIUrl":"https://doi.org/10.22146/ijp.3507","url":null,"abstract":"Mycobacterium smegmatis and Mycobacterium avium offer an advantage in examining tuberculosis-like effects and host immune defense. Therefore, the study aims to examine the effect of ursolic acid (UA) on the host immune system by analyzing cytokines concentration, such as TNF-α, IL-6, IL-1β, and nitrite oxide produced by murine macrophages infected with Mycobacterium smegmatis and Mycobacterium avium. Femurs of female C57BL/6 mice aged 6–8 weeks were used to culture the Bone marrow-derived macrophages (BMDM). On day 10, BMDM was infected with Mycobacterium smegmatis and Mycobacterium avium using a multiplicity of infection (MOI) amounting to 8:1, then TNF-α, IL-6, and IL-1β were analyzed using ELISA and nitrite oxide with Griess reagent. The results showed that UA decreased the production of three respective pro-inflammatory cytokines used in the study, both in BMDM infected by Mycobacterium smegmatis and Mycobacterium avium. For TNF-α, the reduction was nearly 65%-90% compared to the control. The decrease in the production of IL-6 occurred from 2700 pg/ml to 750 pg/ml for BMDM infected with Mycobacterium smegmatis, while the reduction was more significant in those infected using Mycobacterium avium with approximately 150 pg/ml compared to the control. Moreover, UA reduced by over 90% of IL-1β and this result was in line with the reduction of nitrite. UA decreases the production of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, and nitrite. This result is preliminary but supports further study on the role of UA in immune defense from pathogenic and non-pathogenic mycobacterial infections.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87171165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnopharmacology, Biological evaluation and Chemical composition of Boswellia dalzielii Hutch: A Review 黄花乳香的民族药理学、生物学评价及化学成分研究进展

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-20 DOI: 10.22146/ijp.4279

A. Dogara, A. A. Lema, H. Hama, S. Hamad, Nor Hasima Mahmod Mohammad, Mohammad Moneruzzaman Khandaker, Wandayi Emmanuel Amlabu

{"title":"Ethnopharmacology, Biological evaluation and Chemical composition of Boswellia dalzielii Hutch: A Review","authors":"A. Dogara, A. A. Lema, H. Hama, S. Hamad, Nor Hasima Mahmod Mohammad, Mohammad Moneruzzaman Khandaker, Wandayi Emmanuel Amlabu","doi":"10.22146/ijp.4279","DOIUrl":"https://doi.org/10.22146/ijp.4279","url":null,"abstract":"The Burseraceae family consists of 18 genera and 540 species. Boswellia dalzielii is a medicinal plant used in tropical and subtropical areas for the treatment and management of various ailments. Despite the medicinal value of B. dalzielii, there is no comprehensive documentation. The study aimed to review the ethnopharmacology, biological evaluation and chemical composition of B. dalzielii. Scopus, Web of Science, BioMed Central, Science Direct, PubMed, Springer Link, and Google Scholar were searched to find published articles. The results showed that the leaves, stem bark, and root of B. dalzielii have been traditionally used in Nigeria, Cameroon, Burkina Faso, Benin, Sudan, and Guinee for the treatment and management of antirheumatic, antispasmodic, analgesic, antiseptic, hypotensive, malarial mental illness, ulcer, pain, and fever. It is also found that leaves, stem bark, and root have antioxidant, antibacterial, antifungal, and antimalarial properties with stembark having the highest activity. Chemically, it was revealed the leaf has high contents of monoterpenes hydrocarbons with alpha-pinene as the major compound. The species were largely studied in vitro, according to the literature survey. A well-designed clinical experiment is required to obtain conclusive evidence on the efficacy of stembark. The standard dose and safety of the stembark should be established.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86168862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral acute and subchronic (28-day) toxicity studies of snakehead fish (Channa striata) 黑头鱼口服急性和亚慢性(28天)毒性研究

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-20 DOI: 10.22146/ijp.3905

H. Sasongko

{"title":"Oral acute and subchronic (28-day) toxicity studies of snakehead fish (Channa striata)","authors":"H. Sasongko","doi":"10.22146/ijp.3905","DOIUrl":"https://doi.org/10.22146/ijp.3905","url":null,"abstract":"Food and drug control authorities in each country have issued warnings about the toxic effect potential of using commonly consumed traditional medicines. The safety assurance, standardization, and market regulation of herbal medicines being sold need to be determined. This study's goal is to investigate the acute and subchronic toxicity of cold-processed snakehead fish (Channa striata) flesh. In-vivo rats models were given dosages of 350, 1400, and 5600 mg/kg processed snakehead fish (SF) and were monitored for toxic symptoms and mortality for 14 days. Meanwhile, regarding subchronic toxicity, doses of 350, 700, and 1400 mg/kg SF were administered orally for 28 days. Afterward, the animal subjects were sacrificed for histopathological, hematological, and biochemical examinations. There were no evidence of toxicity or mortality in rats during the acute examination, which lasted 14 days. The subchronic toxicity results showed no significant changes in most of the hematological, biochemical, and histological profiles of the organs. Some changes observed in blood biochemistry and relative organ weight were assumed as a temporary effect and not a sign of toxicity. The overall results showed that the SF was non-toxic up to 1400 mg/kg, which can be considered a safe dose for the application of health supplement raw materials.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81464148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE PHARMACOGNOSTIC STANDARDS, ANTIOXIDANT ACTIVITY, AND HEPATIC SAFETY PROFILE OF AN INDONESIAN ANTIDIABETIC POLYHERBAL FORMULATION 印度尼西亚抗糖尿病复方草药配方的生药学标准、抗氧化活性和肝脏安全性

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-20 DOI: 10.22146/ijp.3243

D. Hartanti

{"title":"THE PHARMACOGNOSTIC STANDARDS, ANTIOXIDANT ACTIVITY, AND HEPATIC SAFETY PROFILE OF AN INDONESIAN ANTIDIABETIC POLYHERBAL FORMULATION","authors":"D. Hartanti","doi":"10.22146/ijp.3243","DOIUrl":"https://doi.org/10.22146/ijp.3243","url":null,"abstract":"The excessive oxidative processes and the lack of cellular antioxidative mechanisms are significantly observed in diabetes. In addition, long-term medication required for the treatment might harm the hepatic tissues. This study evaluated the selected pharmacognostic characters, antioxidant activities, total phenolic content, and the hepatic safety of a polyherbal formulation containing seven plant constituents used by Klinik Wisata Kesehatan Jamu Kalibakung, Tegal, Indonesia, to treat diabetes patients. The pharmacognostic properties of the formulation were characterized according to the WHO quality control methods for herbal materials. The 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH RSA), ferric reducing antioxidant power (FRAP), and total phenolic content (TPC) were evaluated as per the standard method. The effect of formulation on the hepatic HepG2 cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The pharmacognostic properties of the formulation specified as follow: foreign matters (1.32±0.05%), loss on drying (11.50±0.07%), total ash (5.68±0.07%), acid-insoluble ash (0.94±0.04%), water-soluble extractable (18.22±0.60%), and ethanol-soluble extractable (16.90±0.77%). The ethanol extract showed a superior DPPH RSA (960.70±2.58 mM Trolox equivalent (TE)/ g dry weight (DW)), FRAP (1112.69±8.39 mM TE/g DW), and TPC (1768.40±32.40 mg gallic acid equivalent (GAE)/g DW) over its water counterpart. However, the water extract was safer for HepG2 cells than the ethanol one, with the IC50 values of 218.25±14.03 and 40.24±3.53 µg/ml, respectively. This study set the pharmacognostic standards for an antidiabetic polyherbal formulation with excellent antioxidant activities, in which its traditional use as a decoction was safe for the hepatic cells.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83767881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Favourable drug-lead pharmacokinetic features for designing gallic acid-standardized Syzygium polyanthum aqueous extract-based product 设计没食子酸标准多花参水提物的有利药铅药动学特征

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-20 DOI: 10.22146/ijp.3639

Hassan Fahmi Ismail, A. Fadhlina, Siti Nurazwa Zainol, Archan Kumar Mamillapalli, Vijayabalaji Venkatesan, Rajesh Eswarappa, Renuka Pillai, Fadzilah Adibah Abdul Majid

{"title":"Favourable drug-lead pharmacokinetic features for designing gallic acid-standardized Syzygium polyanthum aqueous extract-based product","authors":"Hassan Fahmi Ismail, A. Fadhlina, Siti Nurazwa Zainol, Archan Kumar Mamillapalli, Vijayabalaji Venkatesan, Rajesh Eswarappa, Renuka Pillai, Fadzilah Adibah Abdul Majid","doi":"10.22146/ijp.3639","DOIUrl":"https://doi.org/10.22146/ijp.3639","url":null,"abstract":"In this study, Syzygium polyanthum was standardized against gallic acid (GA), and a complete pharmacokinetic test was conducted using in vitro and in vivo models against this phytochemical. High-performance liquid chromatography showed that GA is a major phytochemical in aqueous extract of S. polyanthum. It exhibited a low equilibrium solubility and physiochemical stability at pH 2.0 and 7.4, but it deteriorated rapidly at pH 9.2. It showed low permeability toward Caco-2 intestinal absorption with eight times slower absorption in oral than intravenous administration. GA was unstable in mouse, rat, and dog plasma sera with in vitro half-lives (t1/2) of 60, 53, and 56 min, respectively, but was relatively stable in human plasma serum (t1/2 = 185 min). Approximately 5.6% of GA (10 µM) bound to the human plasma proteins. GA was stable in mouse, rat, dog, and human microsomal extracts with in vitro microsomal intrinsic clearance values of 72, 68, 6, and 22 µL/min/mg, respectively. GA selectively inhibited or stimulated the activity of the tested CYP450 enzymes. The in vivo oral bioavailability of GA was 54%, with short elimination half-life and a high volume of distribution. Thus, the mention pharmacokinetic features of GA must be considered during the development of GA-based products to yield the optimum dosage and pharmacological effect.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89492957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Network Pharmacological Analysis Identifies the Curcumin Analog CCA-1.1 Targeting Mitosis Regulatory Process in HER2-Positive Breast Cancer 网络药理学分析确定姜黄素类似物CCA-1.1靶向her2阳性乳腺癌有丝分裂调节过程

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-07 DOI: 10.22146/ijp.4453

Dhania Novitasari, R. Jenie, Jun Kato, E. Meiyanto

{"title":"Network Pharmacological Analysis Identifies the Curcumin Analog CCA-1.1 Targeting Mitosis Regulatory Process in HER2-Positive Breast Cancer","authors":"Dhania Novitasari, R. Jenie, Jun Kato, E. Meiyanto","doi":"10.22146/ijp.4453","DOIUrl":"https://doi.org/10.22146/ijp.4453","url":null,"abstract":"Recent studies present that the CCA-1.1 (a curcumin derivative) impedes the proliferation of breast cancer cells (luminal, HER2-overexpressed, and TNBC cells). Currently, we analyze the possible target of action of CCA-1.1, particularly in breast cancer cells with HER2 amplification using bioinformatics analysis. The differentially expressed genes (DEGs) of HER2-positive breast cancer were retrieved from TCGA-BRCA data (via UALCAN). We used three web-based tools (Swiss Target Prediction, BindingDB, and TargetNet) to predict the potential target of CCA-1.1 using the SMILE-similarity feature. The functional annotation and network enrichment were processed in WebGestalt. The alteration of selected genes was observed in CBioPortal. The protein-protein interaction (PPI) network was constructed in STRING, then ranked based on the degree score using Cytohubba feature in Cytoscape. The survival analysis from the hub-gene was collected in GEPIA2 with selection only for HER2-positive breast cancer cases. The correlation between the hub genes and tumor-infiltrating immune markers was determined using TIMER web tools. The pathway network analysis highlighted the cell cycle regulation in mitosis as affected signaling amid the putative CCA-1.1 targets. We denoted eight potential genes that could be responsible for inhibiting mitosis regulation upon CCA-1.1 treatment, including AURKA, AURKB, PLK1, TPX2, KIF11, MELK, CDK1, and CHEK1. Several of the potential markers (AURKB, AURKA, CDK1, and CHEK1) revealed to be correlated with the immune cells’ infiltration markers. CCA-1.1 might regulate mitosis to induce cell cycle arrest and lead to cell death. The predicted targets of CCA-1.11 gave insight into the potency of CCA-1.1 to be with immunotherapy. Further validation of the data presented in the study is essentially needed to develop CCA-1.1 for breast cancer.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80844675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Optimization of Polysorbate 80 and Sorbitan Monooleate 80 aas Emulsifiers in Foundation Makeup Containing Ethyl Cinnamate 聚山梨酯80和单油酸山梨酯80作为肉桂酸乙酯粉底化妆品乳化剂的优化

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-12-05 DOI: 10.22146/ijp.3308

Ungsari Rizki Eka Purwanto, Intan Martha Cahyani, Y. Purwaningsih, Berliana Ganita Fatika Sandhi, Fitria Febryana

{"title":"Optimization of Polysorbate 80 and Sorbitan Monooleate 80 aas Emulsifiers in Foundation Makeup Containing Ethyl Cinnamate","authors":"Ungsari Rizki Eka Purwanto, Intan Martha Cahyani, Y. Purwaningsih, Berliana Ganita Fatika Sandhi, Fitria Febryana","doi":"10.22146/ijp.3308","DOIUrl":"https://doi.org/10.22146/ijp.3308","url":null,"abstract":"Cosmetic foundation is a type of decorative makeup and commonly include a sunscreen agent. Ethyl cinnamate is one of the potential organic essential oil sunscreens. Nevertheless, there is little study on ethyl cinnamate usage in cosmetics, particularly oil-in-water foundation cream. Using an emulsifier in oil-in-water foundation cream a higher concentration does not guarantee higher oil phase recovery. However, using two combinations of emulsifier such as polysorbate 80 and sorbitan monooleate 80 with the optimum combination can be the right solution. This study aims to optimize polysorbate 80 and sorbitan monooleate 80 in a cream foundation using ethyl cinnamate as an active ingredient designed to have an effective ability to protect facial skin from ultraviolet radiation and are safe to use. The optimization formulas design of the emulsifier combination in foundation cream was made using the Simplex Lattice Design method with help Design Expert version 10.0.1. Parameter optimization were the value of pH, viscosity, spreadability, adhesion, and Sun Protection Factor (SPF) value. The stability test and skin irritation test of optimum formula were also conducted. As a positive control, Revlon Colorstay Foundation as a brand cosmetic foundation was used (National Food and Drug Agency of Indonesia number : NA18140300519). The optimum ratio of polysorbate 80 and sorbitan monooleat 80 were 9.565 and 1.435 with the physical characteristics of pH 6.478+0.008; viscosity 5844.2+31.82 cPs; spreadability 6.16+0.11 cm; adhesion 3.346+0.14 seconds; SPF Value 22.385+0.48, and no irritation symptoms. The ethyl cinnamate foundation created was physically stable, had a pleasing look, and did not irritate the skin, making it safe to wear. It also provides efficient UV radiation protection.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85298115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALGESIC AND ANTI-INFLAMMATION ACTIVITY OF Urena lobata LEAF EXTRACT: STUDY IN VIVO AND IN SILICO 白莲叶提取物的体内和体外抗炎活性研究

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-09-30 DOI: 10.22146/ijp.2145

Y. Purnomo, Andri Tilaqza

{"title":"ANALGESIC AND ANTI-INFLAMMATION ACTIVITY OF Urena lobata LEAF EXTRACT: STUDY IN VIVO AND IN SILICO","authors":"Y. Purnomo, Andri Tilaqza","doi":"10.22146/ijp.2145","DOIUrl":"https://doi.org/10.22146/ijp.2145","url":null,"abstract":"Pulutan (Urena lobata) is a medicinal plant used to treat fever, infection and swelling traditionally, although the pre-clinical study about the herbs as analgesic and anti-inflammatory are still limited. The objective of this study is to measure analgesic and anti-inflammatory activity of U. lobata leaf extract through in vivo study and in silico. This study was performed using male wistar rats divided into eight groups (two control groups and six test groups) (n=5). U. lobata leaf was extracted by water and ethanol, each prepared in dose of 125, 250, 500 mg/kg body weight. Anti-inflammatory activity was evaluated by plethysmometer for 6 hours, meanwhile analgesic activity was examined by analgesymeter for 4 hours. The data was analyzed using one way ANOVA test continued with LSD test (p < 0.05). Following active compound identification using Liquid Chromatography-Mass Spectra (LC-MS/MS), several compounds were used in an in silico study using docking server. Both aqueous and ethanolic extract of U.lobata at 125 and 250 mg/kg bw inhibited paw edema with an Area Under Curve (AUC) volume about 10 % and 5%, respectively, compared to control group (p<0.05). For analgesic activity, aqueous extract of U. lobata were able to increase the AUC for pain threshold of about 30-100 % compared to control group (p<0.05), whereas the activity of ethanolic extract lower than aqueous extract. Stigmasterol and beta-sitosterol in U. lobata potentially inhibited Cycloxygenase-2 (COX-2) as a pro-inflammatory mediator and pain. Aqueous and ethanolic extract of U. lobata have analgesic activity and anti-inflammation, the mechanism was predicted through inhibitory activity of COX-2.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82855351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of trough-based vancomycin therapy in achieving targeted area under the curve in haemodialysis cases. 以槽型万古霉素治疗血液透析患者曲线下靶面积的评价。

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-09-15 DOI: 10.22146/ijp.4433

F. Keshavarzi, Vithyah Nadaraja, Aliza Alias, M. Farrukh, C. S. Yap

{"title":"Evaluation of trough-based vancomycin therapy in achieving targeted area under the curve in haemodialysis cases.","authors":"F. Keshavarzi, Vithyah Nadaraja, Aliza Alias, M. Farrukh, C. S. Yap","doi":"10.22146/ijp.4433","DOIUrl":"https://doi.org/10.22146/ijp.4433","url":null,"abstract":"Background & Objectives: Recently published IDSA guidelines on vancomycin dosing no longer advocates the use of trough concentrations as surrogate markers for clinical efficacy. Protocols developed prior to revised targets may not reflect to the true efficacy marker for vancomycin that is AUC/MIC 400-600. This study aimed to evaluate the local vancomycin dosing protocol in achieving the target trough concentration and extrapolated AUC/MIC of 400-600 in patients with haemodialysis. \u0000Methods: A retrospective analysis of therapeutic drug monitoring forms and individual medical records of haemodialysis patients was conducted. Vancomycin AUC of each individual was extrapolated via the use of a pharmacokinetic modelling software, PrecisePK®. Chi-square test of independence was used to determine the association of factors affecting AUC/MIC. A p value of 0.05 was considered statistically significant. \u0000Results: A total number of 80 haemodialysis-dependent cases who were on vancomycin were recruited. More than 62% of haemodialysis patients showed AUC/MIC > 800. AUC/MIC was heavily influenced by minimum inhibitory concentration of the infecting microorganism. Interpretation & Conclusions: Exclusive trough-guided dosing may not translate well in achieving clinical efficacy of vancomycin in haemodialysis patients. Other contributing factors, especially MIC should be factored, as small MIC values account for greater reciprocal AUC/MIC values that increase the risk of loss of residual kidney function; a factor which is associated with overall mortality of HD patients.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86368878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin Analogues as Novel Anti-Alzheimer's Candidates: Synthesis Development Strategy, In Vitro, Cell-Based and In Vivo Studies 姜黄素类似物作为新的抗阿尔茨海默病候选物:合成开发策略，体外，细胞和体内研究

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-09-08 DOI: 10.22146/ijp.4432

Yance Anas, Ratna Asmah Susidarti, Nunung Yuniarti, Ronny Martien

{"title":"Curcumin Analogues as Novel Anti-Alzheimer's Candidates: Synthesis Development Strategy, In Vitro, Cell-Based and In Vivo Studies","authors":"Yance Anas, Ratna Asmah Susidarti, Nunung Yuniarti, Ronny Martien","doi":"10.22146/ijp.4432","DOIUrl":"https://doi.org/10.22146/ijp.4432","url":null,"abstract":"Alzheimer's disease (AD) is a neurological illness that causes a wide range of cognitive symptoms linked to amyloid plaque deposition, neurofibrillary tangles, oxidative stress, and neuron death in the whole brain. Curcumin has shown promising efficacy in preclinical studies for AD treatment. However, it failed to exhibit expected clinical outcomes in clinical studies. Besides, this molecule has low stability, solubility, and bioavailability properties. Hence, scientists have synthesized several curcumin analogues to improve their bioavailability and biological activity. The purpose of this narrative review is to discuss the development of curcumin analogue synthesis published in 2016-2021 and its efficacy that reveals its effect as an anti-Alzheimer's candidate through in vitro, cell-based and in vivo studies. Pubmed and Scopus database search engine with the keywords \"curcumin\" AND \"analogues\" OR \"analogs\" AND \"Alzheimer's\" were used to find the relevant studies. In our review, we include sixteen eligible journal articles to discuss. Fifteen curcumin analogues exhibited promise efficacy in preclinical studies and are suitable for development as anti-Alzheimer's candidates. Further study should explore to confirm the curcumin analogues toxicity, develop an appropriate dosage form, and initiate clinical trials.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84980999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0