INDONESIAN JOURNAL OF PHARMACY最新文献_第9页

IMMUNOMODULATORY ACTIVITY OF BENALU BATU (Begonia medicinalis) ETHANOL EXTRACT IN EXPERIMENTAL ANIMALS 海棠乙醇提取物对实验动物的免疫调节作用

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-09-06 DOI: 10.22146/ijp.3588

M. Zubair, Armini Syamsidi, Ihwan, Evi Sulastri, Idris, A. Rahman, Novia Widyasari, David Pakaya

{"title":"IMMUNOMODULATORY ACTIVITY OF BENALU BATU (Begonia medicinalis) ETHANOL EXTRACT IN EXPERIMENTAL ANIMALS","authors":"M. Zubair, Armini Syamsidi, Ihwan, Evi Sulastri, Idris, A. Rahman, Novia Widyasari, David Pakaya","doi":"10.22146/ijp.3588","DOIUrl":"https://doi.org/10.22146/ijp.3588","url":null,"abstract":"Benalu batu (B. medicinalis) is a plant endemic to Central Sulawesi that has been reported to possess anticancer, antioxidant, and antiviral activities. The mechanism of action of these activities is still unclear. This study aimed to evaluate the immunostimulatory effect of ethanol extract of B. medicinalis on an in vivo model by measuring the macrophage phagocytotic activity and cytokine production of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) on male mice and rats, respectively. The extract was obtained by the maceration method for 3 × 24 h using 70% ethanol. The doses of the extract were 60, 120, and 240 mg/kg body weight (bw). The percentage of macrophage phagocytosis and the TNF-α, and IFN-γ levels were measured on the eighth day, one hour after intraperitoneal injection of Staphylococcus aureus ATCC 25923. The result showed that ethanol extract of B. medicinalis activated macrophage phagocytosis in a dose-dependent manner, with a significant increase in cytokine expression of TNF-α and IFN-γ. The optimal dose was 240 mg/kg bw, with a higher percentage of phagocytic activity and higher levels of TNF-α and IFN-γ than Stimuno® as a positive control and other dosage treatments. This study suggests that B. medicinalis ethanol extract has the effect of an immunomodulator and provides a scientific basis for traditional usage of this herb plant.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81620395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Activity and GC–MS Based Metabolite Profiles of Indonesian Marine Bacillus 印尼海洋芽孢杆菌的抑菌活性及GC-MS代谢物谱

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-08-15 DOI: 10.22146/ijp.3504

T. Murniasih, Masteria Yunovilsa P, Febriana Untari

{"title":"Antibacterial Activity and GC–MS Based Metabolite Profiles of Indonesian Marine Bacillus","authors":"T. Murniasih, Masteria Yunovilsa P, Febriana Untari ","doi":"10.22146/ijp.3504","DOIUrl":"https://doi.org/10.22146/ijp.3504","url":null,"abstract":"Investigating Indonesian marine bacteria producing active compounds is key to finding a cultivable source of marine drugs. Screening the potential strain as well as profiling the active compounds are important steps to identifying the targeted substances. Methods used in this study were isolated some Bacillus strains from several marine environments in Indonesia, evaluated the antibacterial activity, and characterized the secondary metabolite using GC-MS spectroscopy. Several active antimicrobial compounds derived from marine microorganisms were identified using GC-MS such as pyrrolo [1,2-a] pyrazine-1,4-dione, octatriacontyl pentafluoropropionate. We found that some marine bacillus showed antimicrobial activity, such as B. flexus, B. tequilensis, B subtilis, and Bacillus sp. Profiling of metabolites on GC-MS showed the presence of several bioactive compounds in the ethyl acetate extract, which were identified to be nitrogen compounds such as pyrrolo[1,2-a]pyrazine-1,4-dione, phthalates compounds (butyl isohexyl ester and 1,2 benzendicarboxilate bis (2-etilhexyl) ester), and dibutyl phthalate. Some phenolic compounds also were found, such as tris (2,4-di-ter-butilfenil) fosfat, phenol, 2,4-bis (1,1-dimethyl ethyl), and phenol 3,5-bis (1,1-dimethyl ethyl). Finally, fatty acid derivatives such as n-hexadecanoic acid, cis-vaccenic acid, 7-hexadecene, farnesol isomer A, and stigmastan-3,5-diene were also identified in several marine bacillus. ","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74365406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

VALIDATION OF UV-VIS SPECTROPHOTOMETRIC METHOD TO DETERMINE DRUG RELEASE OF QUERCETIN LOADED-NANOEMULSION 紫外-可见分光光度法测定槲皮素纳米乳药物释放度的验证

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-08-15 DOI: 10.22146/ijp.4454

Vania Santika Putri

引用次数: 0

Enhancement Peripheral Regeneration as a Target of Potential Diabetic Neuropathy Treatment from Lumbricus rubellus Fraction DLBS1033N: the role of cell viability and migration 增强外周再生作为潜在的糖尿病神经病变治疗靶点的风疹蚓提取物DLBS1033N:细胞活力和迁移的作用

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-07-27 DOI: 10.22146/ijp.4239

Yesiska Kristina Hartanti, A. Nugroho, R. Tjandrawinata

{"title":"Enhancement Peripheral Regeneration as a Target of Potential Diabetic Neuropathy Treatment from Lumbricus rubellus Fraction DLBS1033N: the role of cell viability and migration","authors":"Yesiska Kristina Hartanti, A. Nugroho, R. Tjandrawinata","doi":"10.22146/ijp.4239","DOIUrl":"https://doi.org/10.22146/ijp.4239","url":null,"abstract":"Diabetic Peripheral Neuropathy (DPN) significantly affects the quality of life with no definitive therapy currently. Given the pathologic basis for DPN treatment, it's critical to promote neuron regeneration while also restricting nerve degeneration. Schwann cells that play pivotal roles against peripheral regeneration manifest cell proliferation and survival inhibition in diabetic patients consecutively decreased peripheral regeneration capacity. DLBS1033N, a protein hydrolysate obtained from Lumbricus rubellus, has been confirmed to promote Schwann cell line RSC96 growth and survival by induction Nerve Growth Factor (NGF) expression via phosphatidylinositol-3‑kinase (PI3K) pathway. This pathway has an important contribution against Schwann cell proliferation and migration. Herein, the contribution of DLBS1033N to peripheral regeneration on high-glucose (50mM)-induced rat Schwann cell line RSC96 injury, a well-known DPN in vitro cell model. RSC96 were treated with high glucose (50mM) with or without DLBS1033N 25, 50, and 100μg/mL for 24, 48, and 72 h. MTS assay kit were used to evaluate cell viability. DLBS1033N significantly improved cell proliferation in 48 h incubation time with a dose-dependent manner (p < 0.05). Furthermore, DLBS1033N 100μg/ml significantly promoted cell migration by 16% in 48 H incubation (p < 0.05) determined by scratch assay, as the beneficial action to accomplish peripheral regeneration. In conclusion, DLBS1033N enhanced peripheral regeneration which could be used as an effective and promising DPN treatment.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74661396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Employment of Real-Time Polymerase Chain Reaction for the Identification of Bovine Gelatin in Gummy Candy 实时聚合酶链反应测定软糖中牛明胶的含量

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-07-22 DOI: 10.22146/ijp.1970

N. Salamah, Y. Erwanto, S. Martono, A. Rohman

{"title":"The Employment of Real-Time Polymerase Chain Reaction for the Identification of Bovine Gelatin in Gummy Candy","authors":"N. Salamah, Y. Erwanto, S. Martono, A. Rohman","doi":"10.22146/ijp.1970","DOIUrl":"https://doi.org/10.22146/ijp.1970","url":null,"abstract":"Gelatin is a hydrocolloid widely used in food products, especially soft candy. It contains essential amino acids - except tryptophan - which is easily digested, not toxic, can form a flexible and robust film layer to produce the right product. However, as a Muslim, it must ensure that what is consumed is halal, from bovine gelatin. The purpose of this study was to identify bovine gelatin in soft candy products using specific primers with real-time PCR methods. The specific DNA primer design is done with PRIMERQUEST and NCBI software and subjected to primer-basic local alignment search tool (BLAST). Analysis for the primer specificity was performed on fresh tissue (cows, pigs, dogs, chickens, goats, and rats) and gelatin sources (beef and pork). RT-PCR method using primer mitochondrial Cytochrome B gene was applied to analyze candies purchased from the market. The method is expected to be specific, sensitive, and reliable for analyzing bovine DNA in candy products. Amplification was also performed on soft candy reference from bovine gelatin. A sensitivity test was performed by measuring amplification at six dilution series (10000, 5000, 1000, 500, 50, and 10 pg) on bovine gelatin candies. The results show that the real-time PCR with primer mitochondrial cytochrome-B gene specifically able to identify the presence of bovine DNA in fresh tissue and gelatin sources at optimum annealing temperature 55,2°C. The limit of detection of porcine DNA was 500 pg. The standard curve of the serial dilution of the bovine gelatin DNA isolate produces a correlation coefficient R-value of 0.992 and an efficiency value (E) of 93.1%. Four products from the market were examined by using the primer showed three bovine DNA was detected. Real-time PCR using cytochrome-B DNA bovine primer (forward: ACTAGCCCTAGCCTTCTCTATC; reverse TGTCAGTAGGTCTGCTACTAGG) can be used for the Analysis of halal soft candy.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72881406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Characterization of Spray Dried Extract Katuk (Sauropus androgynus) Katuk喷雾干燥提取物的特性研究

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-07-22 DOI: 10.22146/ijp.4443

O. Yunita, Agnes Nuniek Winantari, Ricky Permana Sugiarto, Gunawan Sutanto Prayitna, Lie Hwa

{"title":"Characterization of Spray Dried Extract Katuk (Sauropus androgynus)","authors":"O. Yunita, Agnes Nuniek Winantari, Ricky Permana Sugiarto, Gunawan Sutanto Prayitna, Lie Hwa","doi":"10.22146/ijp.4443","DOIUrl":"https://doi.org/10.22146/ijp.4443","url":null,"abstract":"Katuk (Sauropus androgynus) leaves have been traditionally used in Indonesia for increasing human breast milk production. In the previous research, katuk leaves have high moisture content, therefore katuk leaves extract were being prepared as spray dried S. androgynus extract. The freeze dried leaves were extracted with ultrasonic assisted extraction method using ethanol 80% as a solvent. Then, katuk extract was dried with spray drying method using maltodextrin as a drying aid. To improve the physical characteristics of this extract, it was mixed with mannitol, spray dried lactose, and crospovidone into S. androgynus extract powder. The results showed better physical characteristics, especially on moisture content and flow properties of powders. Metabolic profiles of all samples were analysed by thin layer chromatography (TLC) densitometry method, while the dried extract was dissolved in a suitable solvent and then spotted on GF254 and the plate was developed using a mixture of n-butanol:acetic acid:water (60:22:1.2). Based on TLC profiles, there are three different spots can be seen clearly at 366 nm on chromatogram of S. androgynus leaves, freeze dried leaves, spray dried leaves extract, and leaves extract powder. There is one spot (S3) at Rf 0.80 which is a stable chemical compound that is not affected by all factors in the entire process in S. androgynus extract powder formulations from extraction, drying, to formulation.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83036275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Enoxaparin Effectiveness Based on COVID-19 Severity: A Study in a Secondary Hospital in Bandung, Indonesia 基于COVID-19严重程度的依诺肝素疗效分析:印度尼西亚万隆一家二级医院的研究

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-07-05 DOI: 10.22146/ijp.4133

Budi Suprapti, Liana Debora, Dewi Kusumawati, Arina Dery PS, Gabriella Nathasya T, Mustika Novi Arini, Lusiana Dwi Aryanti

{"title":"Analysis of Enoxaparin Effectiveness Based on COVID-19 Severity: A Study in a Secondary Hospital in Bandung, Indonesia","authors":"Budi Suprapti, Liana Debora, Dewi Kusumawati, Arina Dery PS, Gabriella Nathasya T, Mustika Novi Arini, Lusiana Dwi Aryanti","doi":"10.22146/ijp.4133","DOIUrl":"https://doi.org/10.22146/ijp.4133","url":null,"abstract":"Li Coagulopathy is a common predictor of mortality in COVID-19. Meanwhile, enoxaparin is an anticoagulant with anti-inflammatory, endothelial protection, and viral antagonist properties. Therefore, thromboprophylaxis with enoxaparin in COVID-19 is common in clinical settings. This study aims to assess enoxaparin's efficacy across different severity levels by examining its effect on primary outcomes comprising Length of stay (LOS), invasive mechanical ventilation, and mortality as well as secondary in the form of D-dimer, platelets, C-reactive protein (CRP), Neutrophil Lymphocyte Ratio (NLR), and Absolute Lymphocyte Count (ALC). During hospitalization, 269 patients received enoxaparin across varying severity levels comprising mild, moderate, and severe, while the Wilcoxon test was used to analyze the efficacy in each group. Additionally, the differences in patient characteristic profiles across the severity levels were determined using the Kruskal-Wallis test. The increase in mortality rate and the need for mechanical ventilation were directly proportional to the level of severity. D-dimer decreased from 1308.87 ng/ml to 979.83 ng/ml (p=<0,001) as well as from 1758.41 ng/ml to 1510.68 ng/ml (p=<0,001) in the mild and moderate levels respectively. The platelet increased from 225.65 to 369.39 x103/µl (p=<0,001) in mild and 256.77 to 398.97 x103/µl (p=<0,001) in moderate. Moreover, CRP improved in both mild 52.62 to 49.58 mg/l (p=0.031) and moderate 92.99 to 42.66 mg/l, (p=<0,001). Based on the results, enoxaparin effectively improves D-dimer, platelet, and CRP levels in mild and moderate but not in severe conditions, however, no effect was found on LOS, NLR, and ALC.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72532776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring the Potency of Jatropha Seed Meal (Jatropha curcas) as a Chemoprevention Agent through Metastatic Inhibition 麻疯树种子粉(麻疯树)作为化学预防剂通过转移抑制的效力的探索

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-06-23 DOI: 10.22146/ijp.3876

Ana Fiin Nangimi, Ahmad Syauqy Tafrihani, Midori Rahmadhany Putri Adisusilo, R. Jenie

{"title":"Exploring the Potency of Jatropha Seed Meal (Jatropha curcas) as a Chemoprevention Agent through Metastatic Inhibition","authors":"Ana Fiin Nangimi, Ahmad Syauqy Tafrihani, Midori Rahmadhany Putri Adisusilo, R. Jenie","doi":"10.22146/ijp.3876","DOIUrl":"https://doi.org/10.22146/ijp.3876","url":null,"abstract":"Jatropha (Jatropha curcas) is often used as biodiesel because of the oil content in its seeds. The production of jatropha oil generates a byproduct in the form of jatropha seed meal, which contains compounds with cytotoxic activity and phorbol esters, as co-carcinogens and tumor promoters. Meanwhile, metastasis is one of the characteristics of cancer where the cells spread to another tissue. This study aimed to determine the potential of jatropha seed meal as a chemoprevention agent, particularly an antimetastatic one, under bioinformatic study and molecular docking. Genecards and DAVID were performed to explore the protein involved in the metastatic process and its gene ontology. The prediction target protein was caught by SwissTargetPrediction. Jatropha seed meal showed the presence of isoamericanol A, myricetin, daidzein, gallic acid, and rutin. There are 11 prediction target proteins correlated to metastatic in extracellular matrix components. Then we were docked to a protein involved in metastasis, matrix metalloproteinase (MMP)-9 (PDB ID: 6ESM) using MOE software. The docking score determined the interaction properties. The docking analysis revealed that isoamericanol A, daidzein, and myricetin exhibited better binding affinity than native ligands and other compounds. Moreover, based on our literature study, the jatropha seed meal contains isoamericanol A, rutin, myricetin, daidzein, and gallic acid, which present anticancer properties by inhibition of cell invasion and migration, cell cycle arrest induction, and suppression of the MMP-9 activity. Overall, jatropha seed meal has potential as an antimetastatic agent. A comprehensive study is needed to explore the possibility of developing it as a supportive agent in combination with a chemotherapeutic agent.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81811565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and High Antioxidant Activity of C-Alkyl Calix[4]resorcinarene and C-Alkyl Calix[4]pyrogallolarene Derivatives c -烷基杯[4]间苯二酚芳烃和c -烷基杯[4]邻苯二酚芳烃衍生物的合成及高抗氧化活性研究

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-06-20 DOI: 10.22146/ijp.2199

J. Jumina, Y. S. Kurniawan, Ratna Sari, Sri Nessy Handayani Br Purba, Hesti Radean, Priatmoko Priatmoko, D. Pranowo, B. Purwono, Jeffry Julianus, A. K. Zulkarnain, E. N. Sholikhah

{"title":"Synthesis and High Antioxidant Activity of C-Alkyl Calix[4]resorcinarene and C-Alkyl Calix[4]pyrogallolarene Derivatives","authors":"J. Jumina, Y. S. Kurniawan, Ratna Sari, Sri Nessy Handayani Br Purba, Hesti Radean, Priatmoko Priatmoko, D. Pranowo, B. Purwono, Jeffry Julianus, A. K. Zulkarnain, E. N. Sholikhah","doi":"10.22146/ijp.2199","DOIUrl":"https://doi.org/10.22146/ijp.2199","url":null,"abstract":"In the present work, we reported a successful synthesis and high antioxidant activity of C-alkylcalix[4]resorcinarene and C-alkylcalix[4]pyrogallolarene derivatives. The C-alkylcalix[4]resorcinarenes were prepared from a cyclization reaction of resorcinol and either pentanaldehyde or octanaldehyde in acidic condition. Meanwhile, the C-alkylcalix[4]pyrogallolarenes were prepared from a cyclization reaction of pyrogallol with pentanaldehyde or octanaldehyde. Four synthesized products, i.e. nBu-CR, nHep-CR, nBu-CP, and nHep-CP, were successfully prepared in 92.4-96.4% yield. The chemical structure of these products was elucidated by Fourier transform infrared (FTIR), liquid chromatography-mass spectrometry (LC-MS), and proton nuclear magnetic resonance (1H-NMR) analysis. The antioxidant activity assay of these compounds was evaluated through an in vitro assay employing 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. From the DPPH assay, it was found that the half-maximal inhibitory concentration (IC50) values of nBu-CR, nHep-CR, nBu-CP, and nHep-CP compounds were 25.1, 22.9, 11.5, and 21.9 µg mL-1, respectively. The IC50 value of the synthesized compounds was 2.0-4.3 times lower than the IC50 value of butylated hydroxytoluene (BHT) as the positive standard (49.9 µg mL-1), which is remarkable. This finding demonstrates that either C-alkylcalix[4]resorcinarenes or C-alkylcalix[4]pyrogallolarenes are better antioxidant agents than BHT. The nHep-CR compound was found as the best antioxidant agent from the other compounds due to weaker intramolecular and intermolecular hydrogen bonding as well as longer alkyl chain.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83791542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Green Technology On The Virgin Coconut Oil Production Using Enzyme From Pineapple Waste 利用菠萝废酶生产初榨椰子油的绿色技术

IF 0.4

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-06-20 DOI: 10.22146/ijp.1133

S. Harimurti, Naurah Nadhifa, Fera Rizki Febrianti, Facetha Intan Pramana, Sevina Riska Wahita, Dyani Primasari Sukamdi, Annisa Krisridwany, Hari Widada, A. Amid

{"title":"Green Technology On The Virgin Coconut Oil Production Using Enzyme From Pineapple Waste","authors":"S. Harimurti, Naurah Nadhifa, Fera Rizki Febrianti, Facetha Intan Pramana, Sevina Riska Wahita, Dyani Primasari Sukamdi, Annisa Krisridwany, Hari Widada, A. Amid","doi":"10.22146/ijp.1133","DOIUrl":"https://doi.org/10.22146/ijp.1133","url":null,"abstract":"Virgin coconut oil (VCO) is widely used for the pharmaceutical and cosmetic industries. The high lauric acid content is very beneficial in the pharmaceutical field, such as for antiviral and antibiotic. Also, this VCO is very useful for cosmetic formulation. VCO production can be done by several methods, which are chemical, physical, and enzymatic methods. By the increase of VCO demand at the national and international levels, this study proceeded with the production of VCO using an enzymatic way that was efficiently conducted and environmentally friendly. The purpose of this research is to study the enzymatic process of VCO production by using pineapple waste, including pineapple crowns, pineapple fruit skins, pineapple leaves, and pineapple trunks. The pineapple waste used contains the enzyme bromelain to break down protein emulator in coconut milk cream. From the number of experiments with variations in substrate volume and temperature, the optimal VCO formation was obtained at 50oC with the ratio between the substrate and enzyme material was 9 to 1. The quality of VCO was evaluated as water content, free fatty acid concentration, and saponification numbers. Based on the evaluation results, the quality of VCO produced was similar to the standard of APCC, SNI, and Codex.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78481212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0