紫外-可见分光光度法测定槲皮素纳米乳药物释放度的验证

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-08-15 DOI:10.22146/ijp.4454

Vania Santika Putri

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引用次数: 0

摘要

为了研究槲皮素负载纳米乳的药物释放谱，建立了一种简便的紫外/可见分光光度法分析槲皮素纳米乳基质释放的方法。槲皮素分析的最大波长为254 nm。方法在4 ~ 12 μg/mL范围内线性良好，相关系数(r)为0.9998。结果表明，该方法准确、精密度高，回收率在99.65 ~ 100.1312%范围内，RSD≤2%。检测限和定量限分别为4.0535 μg/mL和13.5118 μg/mL。所建立的方法可用于分析纳米乳制剂中槲皮素的释放。

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VALIDATION OF UV-VIS SPECTROPHOTOMETRIC METHOD TO DETERMINE DRUG RELEASE OF QUERCETIN LOADED-NANOEMULSION

A simple validated UV/Vis spectrophotometric method to analyze quercetin released from the nanoemulsion matrix has been developed to study the drug release profile of quercetin loaded-nanoemulsion. Quercetin analysis was carried out at a maximum wavelength of 254 nm. The method showed linearity with a correlation coefficient (r) value of 0.9998 in the range of 4 - 12 μg/mL. The results also demonstrated that the procedure is accurate and precise, with recovery (%) in the range of 99.65 - 100.1312 % and RSD (%) as ≤ 2%. The limit of detection (LOD) and limit of quantitation (LOQ) values were found to be 4.0535 μg/mL and 13.5118 μg/mL, respectively. The developed method was found to be valid to analyze quercetin released in nanoemulsion preparations.

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来源期刊

INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.