Optimization of Polysorbate 80 and Sorbitan Monooleate 80 aas Emulsifiers in Foundation Makeup Containing Ethyl Cinnamate

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Ungsari Rizki Eka Purwanto, Intan Martha Cahyani, Y. Purwaningsih, Berliana Ganita Fatika Sandhi, Fitria Febryana
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Abstract

Cosmetic foundation is a type of decorative makeup and commonly include a sunscreen agent. Ethyl cinnamate is one of the potential organic essential oil sunscreens. Nevertheless, there is little study on ethyl cinnamate usage in cosmetics, particularly oil-in-water foundation cream. Using an emulsifier in oil-in-water foundation cream a higher concentration does not guarantee higher oil phase recovery. However, using two combinations of emulsifier such as polysorbate 80 and sorbitan monooleate 80 with the optimum combination can be the right solution. This study aims to optimize polysorbate 80 and sorbitan monooleate 80 in a cream foundation using ethyl cinnamate as an active ingredient designed to have an effective ability to protect facial skin from ultraviolet radiation and are safe to use. The optimization formulas design of the emulsifier combination in foundation cream was made using the Simplex Lattice Design method with help Design Expert version 10.0.1. Parameter optimization were the value of pH, viscosity, spreadability, adhesion, and Sun Protection Factor (SPF) value. The stability test and skin irritation test of optimum formula were also conducted. As a positive control, Revlon Colorstay Foundation as a brand cosmetic foundation was used (National Food and Drug Agency of Indonesia number : NA18140300519). The optimum ratio of polysorbate 80 and sorbitan monooleat 80 were 9.565 and 1.435 with the physical characteristics of pH 6.478+0.008; viscosity 5844.2+31.82 cPs; spreadability 6.16+0.11 cm; adhesion 3.346+0.14 seconds; SPF Value 22.385+0.48, and no irritation symptoms. The ethyl cinnamate foundation created was physically stable, had a pleasing look, and did not irritate the skin, making it safe to wear. It also provides efficient UV radiation protection.
聚山梨酯80和单油酸山梨酯80作为肉桂酸乙酯粉底化妆品乳化剂的优化
化妆粉底是一种装饰性化妆品,通常含有防晒剂。肉桂酸乙酯是一种潜在的有机精油防晒剂。然而,很少有研究肉桂酸乙酯在化妆品中的使用,特别是水包油粉底霜。在水包油粉底霜中使用乳化剂,即使浓度较高,也不能保证油相回收率较高。然而,使用两种乳化剂组合,如聚山梨酯80和山梨糖单油酸80,最佳组合可能是正确的解决方案。本研究旨在以肉桂酸乙酯为活性成分,优化霜底中的聚山梨酯80和山梨糖单油酸80,使其具有有效保护面部皮肤免受紫外线辐射的能力,并且使用安全。在design Expert 10.0.1版的帮助下,采用单纯形点阵设计法对粉底霜乳化剂组合进行优化配方设计。优化的参数包括pH值、粘度、涂抹性、附着力和防晒系数(SPF)。并对最佳配方进行了稳定性试验和皮肤刺激性试验。作为阳性对照,使用露华浓Colorstay粉底作为品牌化妆粉底(印尼国家食品药品监督管理局编号:NA18140300519)。聚山梨酸80和山梨糖单酸80的最佳配比为9.565和1.435,物理特性pH为6.478+0.008;粘度5844.2+31.82 cPs;铺展性6.16+0.11 cm;附着力3.346+0.14秒;SPF值22.385+0.48,无刺激性症状。肉桂酸乙酯粉底物物理稳定,外观美观,不刺激皮肤,可以安全使用。它还提供有效的紫外线辐射防护。
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来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
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