C. M. Ramos, María José Morillo Bargues, Fernando Gisbert Roca, Laura Rodriguez Doblado, T. G. Sánchez, L. Mir, Ester Giraldo Reboloso, V. Moreno Manzano, M. M. Pradas
{"title":"Electrical stimulation increases schwann cells proliferation inside hyaluronic acid conduits","authors":"C. M. Ramos, María José Morillo Bargues, Fernando Gisbert Roca, Laura Rodriguez Doblado, T. G. Sánchez, L. Mir, Ester Giraldo Reboloso, V. Moreno Manzano, M. M. Pradas","doi":"10.23919/EMF-MED.2018.8526063","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526063","url":null,"abstract":"After nerve injury in the peripheral nervous system (PNS), application of an appropriate electrical stimulation (ES) may increase the rate and success of nerve repair. Tubular structures to mimic nervous tracts have been conducted with promising results. Schwann cells (SCs) are the main supportive cells of neurons in the PNS. In this work, we used hyaluronic acid (HA) tubular scaffolds with SCs and applied two different current intensities (450 μA and 900 μA) in order to study their effects on cells behaviour. Our data showed a beneficial effect of ES on cell number when applying a current of 450 μA. The application of tissue engineering and ES may accelerate and increase functional recovery in the PNS.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133886177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modeling of Joule heating in tissues induced by high- and low-voltage pulse combinations for gene electrotransfer","authors":"I. Lacković","doi":"10.23919/EMF-MED.2018.8526011","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526011","url":null,"abstract":"Gene electrotransfer is a promising technique for safe and efficient gene therapy. It relies on locally delivered electric pulses to transfer previously injected foreign DNA into the cell. Applied pulses induce electric field in tissue (electroporation) and concomitant heat generation due to Joule effect. In our study we used finite element method to calculate electric field and temperature distribution during typical electrotransfer pulsing protocol (i.e. combination of 100 microsecond high-voltage pulse and 400 millisecond low-voltage pulse with pulse lag time of 1 second) in isotropic tissue (e.g. liver) and anisotropic tissue (e.g. skeletal muscle). For parallel plate electrodes results show negligible temperature rise in tissue bulk due to high voltage pulse and up to a few °C rise due to the low-voltage 400 ms-long pulse, depending on tissue conductivity.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"543 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115272413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Miclaus, G. Mihai, P. Bechet, I. Ardelean, J. Karpowicz, C. Moisescu
{"title":"The thermic response of biogenic magnetite suspensions to frequencies in the (0.1-3) GHz range","authors":"S. Miclaus, G. Mihai, P. Bechet, I. Ardelean, J. Karpowicz, C. Moisescu","doi":"10.23919/EMF-MED.2018.8526078","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526078","url":null,"abstract":"A water-based suspension of biogenic magnetite nanocrystals extracted from cultured magnetotactic bacteria was exposed to a set of electromagnetic stimuli in the range (0.1-3) GHz. Controlled exposure was provided and the heating rate of the suspension was measured in each case, providing a comparison between the thermal response of this suspension and pure water, in order to quantify the role of biogenic magnetite in absorbing the electromagnetic field.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115658840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EMF-Med 2018 Ad Page","authors":"","doi":"10.23919/emf-med.2018.8525999","DOIUrl":"https://doi.org/10.23919/emf-med.2018.8525999","url":null,"abstract":"","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128503513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prakash Parappurath Vasudevan, R. Aminzadeh, N. De Geeter, B. Descamps, L. Dupré, W. Joseph, R. Holen
{"title":"In Vivo Electrical Conductivity Imaging of Animal Tumor Model at 7T using Electrical Properties Tomography","authors":"Prakash Parappurath Vasudevan, R. Aminzadeh, N. De Geeter, B. Descamps, L. Dupré, W. Joseph, R. Holen","doi":"10.23919/EMF-MED.2018.8526051","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526051","url":null,"abstract":"Ex vivo studies have shown that various diseases alter the electrical properties of tissues compared to healthy nearby tissues. Therefore, electrical conductivity can be used as a diagnostic parameter for e.g. tumor diagnosis. For in vivo measurements, magnetic resonance electrical properties tomography (MREPT) was used and electrical conductivity was reconstructed from the B1+ phase. The technique was first evaluated using homogeneous and heterogeneous phantoms. Then a mouse with a tumor was scanned and the conductivity is reconstructed from the B1+ phase map. The reconstructed conductivity in the phantom experiments was in good agreement with the target conductivity map and the conductivity map of the animal revealed good agreement with the co-axial probe measurement. Our work confirms the possibility of accurate in vivo conductivity assessment in disease.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128825448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulated Effects of Specific Absorption Rate and Thermal Variations on Keratinocytes and Epidermis Exposed to Radio-Frequency","authors":"G. Paolini, D. Masotti, A. Costanzo","doi":"10.23919/EMF-MED.2018.8526054","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526054","url":null,"abstract":"Wearable wireless sensors are nowadays intensively investigated for continuous monitoring of biomedical parameters and are expected to be pervasively distributed on-body in the next future. In this work, a simulation model for the prediction of the Specific Absorption Rate (SAR) and the temperature variations of keratinocytes in vitro and epidermis in vivo is developed as a preliminary tool for predicting exposure effects of these wearable electronics. Skin cells in a culture medium and in a multi-layered tissue model consisting of epidermis, fat and muscle, have been exposed to electromagnetic (EM) fields generated by patch antennas at 1.8, 2.4 and 60 GHz, that are the most probable frequency bands that will be exploited for wearable applications, accounting for the dispersive models of the different tissues.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114335816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Schoeters, T. Tarnaud, W. Joseph, L. Martens, R. Raedt, E. Tanghe
{"title":"Comparison between Direct Electrical and Optogenetic Subthalamic Nucleus Stimulation","authors":"R. Schoeters, T. Tarnaud, W. Joseph, L. Martens, R. Raedt, E. Tanghe","doi":"10.23919/EMF-MED.2018.8526018","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526018","url":null,"abstract":"Subthalamic nucleus deep brain stimulation is a treatment for Parkinson’s disease. In this study, a computational model of a plateau-potential generating subthalamic nucleus neuron (Otsuka-model) and a four-state ChR2(H134R) model (Williams-model) are combined, in order to compare electrical and optogenetic neuromodulation capabilities. The impact of the stimulation modality (optogenetic or electric) on firing rates, strength-duration curves and action potential shape is investigated. First, in contrast to electrical stimulation, mean instantaneous firing rates saturate for optical stimulation at intensities higher than 0.1 W/cm2. Second, rheobase and chronaxie are 175% and 9.6% larger in optogenetic stimulation compared to electrical stimulation, respectively. Third, action potential shape is not significantly impacted by the neurostimulation modality.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114432103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Dürrenberger, K. Meya, Martin Schmid, J. Fröhlich
{"title":"EMF Applications in Cosmetics and Wellness","authors":"G. Dürrenberger, K. Meya, Martin Schmid, J. Fröhlich","doi":"10.23919/EMF-MED.2018.8526012","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526012","url":null,"abstract":"Currently cosmetic and wellness devices do not fall under medical regulation. It is unknown, whether consumer-devices using electromagnetic fields as therapeutic agent pose a health hazard. In this paper, we present preliminary results of a study investigation the issue. Overall, there is limited evidence for health risks. However, further studies regarding electric muscle and brain stimulation as well as neuromodulation are needed to ensure the safe use of these devices. Otherwise, regulations have to guarantee that only educated personnel carry out certain therapies.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114200373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Bellizzi, M. Paulides, T. Drizdal, G. V. van Rhoon, L. Crocco, T. Isernia
{"title":"Sparsity Promoted Antenna Selection in Hyperthermia Treatment Planning","authors":"G. Bellizzi, M. Paulides, T. Drizdal, G. V. van Rhoon, L. Crocco, T. Isernia","doi":"10.23919/EMF-MED.2018.8526062","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526062","url":null,"abstract":"Since the cost of hyperthermia equipment is largely dependent on the number of amplifiers, new applicators are being developed that allow to exploit during treatment only a subset of antennas among those constituting the device. The selection of the optimal subset is a part of the treatment planning procedure and requires proper approaches to be carried out. In this contribution, we propose and test a new procedure that pursues the selection goal by embedding the sparsity promotion paradigm within an optimal treatment planning approach based on constrained power optimization. Thanks to such an integration, the proposed approach enables the simultaneous selection of the optimum antennas subset and the determination of their excitation feeding for maximizing target SAR while constraining the SAR elsewhere.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126584117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}