电刺激可增加透明质酸导管内雪旺细胞的增殖

2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI:10.23919/EMF-MED.2018.8526063

C. M. Ramos, María José Morillo Bargues, Fernando Gisbert Roca, Laura Rodriguez Doblado, T. G. Sánchez, L. Mir, Ester Giraldo Reboloso, V. Moreno Manzano, M. M. Pradas

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引用次数: 1

摘要

外周神经系统(PNS)损伤后，应用适当的电刺激(ES)可以提高神经修复的速度和成功率。管状结构模拟神经束已经进行了有希望的结果。雪旺细胞(SCs)是PNS中神经元的主要支持细胞。本研究利用透明质酸(HA)管状支架和SCs，分别施加450 μA和900 μA电流，研究其对细胞行为的影响。我们的数据显示，当施加450 μA的电流时，ES对细胞数量有有益的影响。组织工程和胚胎干细胞的应用可以加速和增加PNS的功能恢复。

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Electrical stimulation increases schwann cells proliferation inside hyaluronic acid conduits

After nerve injury in the peripheral nervous system (PNS), application of an appropriate electrical stimulation (ES) may increase the rate and success of nerve repair. Tubular structures to mimic nervous tracts have been conducted with promising results. Schwann cells (SCs) are the main supportive cells of neurons in the PNS. In this work, we used hyaluronic acid (HA) tubular scaffolds with SCs and applied two different current intensities (450 μA and 900 μA) in order to study their effects on cells behaviour. Our data showed a beneficial effect of ES on cell number when applying a current of 450 μA. The application of tissue engineering and ES may accelerate and increase functional recovery in the PNS.

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2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)

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