Comparison between Direct Electrical and Optogenetic Subthalamic Nucleus Stimulation

Abstract

Subthalamic nucleus deep brain stimulation is a treatment for Parkinson’s disease. In this study, a computational model of a plateau-potential generating subthalamic nucleus neuron (Otsuka-model) and a four-state ChR2(H134R) model (Williams-model) are combined, in order to compare electrical and optogenetic neuromodulation capabilities. The impact of the stimulation modality (optogenetic or electric) on firing rates, strength-duration curves and action potential shape is investigated. First, in contrast to electrical stimulation, mean instantaneous firing rates saturate for optical stimulation at intensities higher than 0.1 W/cm2. Second, rheobase and chronaxie are 175% and 9.6% larger in optogenetic stimulation compared to electrical stimulation, respectively. Third, action potential shape is not significantly impacted by the neurostimulation modality.