Immunopathologia Persa最新文献

{"title":"The role of N-acetyl cysteine and some other clinical antidotes in the treatment of patients with COVID-19; review of the current evidence","authors":"Shafeajafar Zoofaghari, Mohsen Forghani, Gholamali Dorooshi, Asieh MaghamiMehr","doi":"10.34172/ipp.2022.31406","DOIUrl":"https://doi.org/10.34172/ipp.2022.31406","url":null,"abstract":"Anti-viral and anti-cytokine drugs have been proven to be inadequate in ceasing the progression of the novel coronavirus disease, and severe cases are often associated with death or severe chronic injuries. In this respect, N-acetyl cysteine (NAC) has anti-oxidant, anti-inflammatory, and immune-modulating effects and has been revealed to be beneficial in the treatment and prevention of this virus. High-dose oral NAC (1200 mg) can improve adaptive immunity by increasing lymphocyte glutathione levels and regulating neutrophil function during the COVID-19 development. Given that the majority of these patients suffer from hypoxemic respiratory failure and require oxygen supplementation in hospitals, hyperbaric oxygen therapy (HBOT) appears to be an alternative treatment. In fact, HBOT can increase the circulation and delivery of oxygen under high pressures, making the tissue uptake more efficient and improving hypoxia in patients with COVID-19. In addition, low-doses of naltrexone can interact with angiotensin-converting enzyme 2 (ACE2), disrupt the binding of ACE2 to the receptor-binding domain, and have anti-inflammatory and suppressive properties of pro-inflammatory cytokines. Therefore, due to the ability of the low-dose of this drug in preventing the progression of this disease, it can be recommended as an adjunct drug with an immunomodulatory role in combination with other anti-viral drugs in patients with COVID-19. Finally, there appears to be a significant association between vitamin K and thiamine deficiency with the severity of COVID-19. These vitamins play an important role in the coagulation system and suppress inflammation. Therefore, they can be used as a supplement or treatment to improve the outcomes of COVID-19.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43353788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Gleason grade groups: Epidemiologic data from Isfahan, Iran based on the new classification","authors":"A. Nourbakhsh, mohamadali yazdani, Amid Yazdani","doi":"10.34172/ipp.2022.87","DOIUrl":"https://doi.org/10.34172/ipp.2022.87","url":null,"abstract":"introduction: A new five-tier Gleason grade grouping (GGG) has recently been proposed and approved by the World Health Organization. In this new classification, GGG 1 (Gleason score≤6), GGG 2 (Gleason score 3+4=7), GGG 3 (Gleason score 4+3=7), GGG 4 (Gleason score 8) and GGG 5(Gleason score 9-10) are the new grade groups based on the Gleason score. Objective: We examined the epidemiologic data of prostate cancer based on the new Gleason system in Isfahan, Iran. International Society of Urological Pathology (ISUP) proposed the new Gleason grade groups in order to make accurate prognostic classification for prostate cancer. Patients and method: 305 prostate cancer cases diagnosed by biopsy in patients from Noor and Hazrat Ali Asghar hospitals from 2014 to 2016 were included. Pathological examination of the samples was done by pathologists with genitourinary expertise. Results: Among 305 biopsy specimens, 28.6% of cases had a Gleason score less than 6, 23.7% Gleason score 3+4=7, 10.9% Gleason score 4+3=7, only 0.7% Gleason score 4+4=8 and 36.1% Gleason score 9 and 10. conclusion: The new Gleason grade groups provide a simplified, user-friendly and clear classification system for predicting prognosis and disease progression before and after treatment.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44941887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of self-quarantine for preventing COVID 19 involvement in patients with rheumatoid arthritis who used Disease-Modifying Anti-Rheumatic Drugs","authors":"A. Ahmadzadeh, S. Basiri, M. Emam, A. Rajaei, F. Farsad","doi":"10.34172/ipp.2022.31405","DOIUrl":"https://doi.org/10.34172/ipp.2022.31405","url":null,"abstract":"Introduction: Rheumatoid Arthritis (RA) is an autoimmune disorder that is treated with classic Disease-Modifying Anti Rheumatic Drugs (DMARDs), which impair the immune system. It seems that self-quarantine is a good method for CVOID-19 prevention in patients with RA. Objectives: The aim of this study was to assessment the prevalence of self-quarantine for preventing COVID 19 involvement in patients with rheumatoid arthritis who used Disease-Modifying Anti-Rheumatic Drugs Methods and Materials: in this descriptive study that was performed in Loghman-Hakim Hospital (Tehran, Iran), patients with RA who took classic DMARDs and were referred to the hospital were assessed based on age, sex, medications, smoking, history of Covid-19 in a relatives, Covid-19 involvement in the patient, Covid-19 symptoms, and observing self-quarantine. Result: the mean age was 53.84 years old and 27.7% were male of one thousand patients with RA who took classic DMARDs. Covid-19 prevalence among these patients was 10.4%. The prevalence of COVID-19 was 21% among patients who didn’t observe self-quarantine and 9.2% among patients who observed self-quarantine. Self-quarantine lowered the risk of Covid-19 by around 60%. Conclusion: self-quarantine is a good method to reduce the prevalence of COVID-19 among RA patients who used classic DMARDs.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45759145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term outcomes following amniotic membrane and conventional dressing in skin graft donor site; a randomized clinical trial","authors":"J. Kazemzadeh, Houshang Soleimani","doi":"10.34172/ipp.2022.29314","DOIUrl":"https://doi.org/10.34172/ipp.2022.29314","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45570402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of licorice mucoadhesive patches (Aftogel®) on the results of nasopharyngeal swab real-time PCR test of SARS-CoV-2: a randomized triple-blind placebo-controlled clinical trial","authors":"M. Pourahmad, K. Shahzamani, Fatemeh Nikokar, M. Saniei, Matin Saniei, R. Soltani","doi":"10.34172/ipp.2022.31400","DOIUrl":"https://doi.org/10.34172/ipp.2022.31400","url":null,"abstract":"Background and objectives: Up to present no efficacious antiviral medications have been discovered in order to eradicate SARS-CoV-2 in nasopharyngeal tract. In this article, the aim is to evaluate the effectiveness of a new herbal drug product called Aftogel patch, which contains licorice extract, in the eradication of this novel coronavirus in the nasopharyngeal secretions of the patients. Methods: In this triple-blind randomized clinical trial, 125 patients with positive real-time PCR for SARS-CoV-2 and in stage 0 and/or 1 of COVID-19 were studied in two separate groups, namely interventional and placebo, in which they used Aftogel and placebo patches, respectively. At the end of the study, the results of PCR test in aforementioned groups were assessed and compared. Results: Following the application of Aftogel, Real-time PCR was converted to negative in 53.97% of patients which was significantly higher than that of the placebo groups. (27.40%, P= 0.003). Conclusion: It seems that Aftogel mucoadhesive patch (Licorice extract) is effective in the eradication of SARS-CoV-2 which has colonized the nasopharyngeal area. Hence, this drug product has the potential for evaluation as a prophylactic agent against COVID-19.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45113777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of an adult patient with Clinical amyopathic dermatomyositis associated rapid progressive interstitial lung disease triggered by COVID19","authors":"A. Varghaei, Hengameh Mojdeganlou, M. Rabieepour, Amir Mikaeilvand, A. Abbasi","doi":"10.34172/ipp.2022.32406","DOIUrl":"https://doi.org/10.34172/ipp.2022.32406","url":null,"abstract":"ILD is a common manifestation of dermatomyositis (DM) with indolent course but a unique variant of DM called clinically amyopathic DM (CADM) presents with rapid progressive interstitial lung disease (RP-ILD) and is called CADM associated RP-ILD. Here, we report a case of a 52 year old woman with CADM associated RP-ILD occurred 2 weeks after recovery from COVID19 infection but unfortunately died from RP-ILD, almost 5 months later. This is the first report of CADM associated RP-ILD triggered by COVID19 in an adult patient","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43809058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There a Change in Platelet Indices Among Pregnant With Anti Phospholipid Syndrome?","authors":"Wassan Nori, Shaima K. Harmoosh, Roaa Hamed","doi":"10.34172/ipp.2022.32410","DOIUrl":"https://doi.org/10.34172/ipp.2022.32410","url":null,"abstract":"Introduction: Recurrent pregnancy loss (RPL) is a common obstetrical complication, where 50% have undetermined etiology. Antiphospholipid syndrome (APL) is an autoimmune disease documented as a cause of RPL. Thrombophilia, particularly platelet abnormalities, were accredited for RPL. Objectives: The purpose of this study is to determine the change in platelets parameters; specifically, platelet count, mean platelet volume (MPV), platelet distribution width PDW, in patients suffering from RPL caused by the anti-phospholipid syndrome. Patients and Methods: Fifty women with a confirmed diagnosis of APL syndrome having a history of RPL were assigned as a study group and fifty women who gave birth without RPL were set as healthy controls were taken from al Yarmouk teaching hospitals in Baghdad. The personal data were taken by direct interview with patients, and blood samples were taken and analyzed for complete blood counts and platelets indices. Results: Both platelets count and PDW scored significant correlation with the number of pregnancy loss; Pearson's correlation coefficient was (0.74,0.59) respectively for both variables. The ROC evaluated platelets count a cutoff value of 230 ,88%,84% respective sensitivity and specificities, AUC =0.89,and P-value<0.001 respectively. As for PDW it had a cutoff value of 13.6 fl/L,88%,80% respective sensitivity and specificities, AUC=0.87,and P-value<0.001. Conclusions: Platelet indicators may aid gynecologists' in low-resource settings in predicting high-risk pregnancies deemed to suffer from RPL .","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43853393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dilemma of COVID-19 Diagnosis in Pregnancy","authors":"Wassan Nori, Roaa Hamed, W. Akram, Maha Chasib Munshid","doi":"10.34172/ipp.2022.32416","DOIUrl":"https://doi.org/10.34172/ipp.2022.32416","url":null,"abstract":"Coronavirus Disease 2019 is a new and rapidly developing health crisis. Ongoing researches are looking at the prevalence and consequences of COVID-19 in the obstetric community and postnatal period. In COVID 19 era, pregnant mothers are prone to infection with the severe acute respiratory syndrome coronavirus 2, with a higher risk of poor pregnancy outcomes. Therefore, an accurate and early diagnosis is a necessity for this vulnerable group. Screening for asymptomatic carriers is a cornerstone to limit the COVID-19 pandemic. It is vital to evaluate patients’ clinical symptoms and epidemiological history carefully. Although the serological test; Polymerase chain reaction RT-PCR can confirm infection, it cannot determine the degree or severity of the illness. Moreover, it has false-negative results. Imaging tests allow exact diagnosis of lung damage, the severity of the disease, and the classification of patients. Comprehensive analyses of serological and imaging data will assist in the formation of an appropriate clinical diagnosis. This review will discuss the updates and critical points in establishing COVID-19 infection in pregnant women with their pros and cons.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43243060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Toll-like receptors expression profile in peripheral blood mononuclear cells in COVID-19 patients in Iran","authors":"A. Tabibzadeh, Mohamad hadi Karbalai niya, H. Keyvani, Sajad Karampour, Parastoo Yousefi, Mohammad Hossein Razizadeh, Maryam Esghaei, Abdulhussain Kadhim Jawaziri, ahanbakhsh Khamseh","doi":"10.34172/ipp.2022.32405","DOIUrl":"https://doi.org/10.34172/ipp.2022.32405","url":null,"abstract":"Background: Coronavirus disease2019 (COVID-19) spread all around the world and leads to many new infection cases and mortality. A better understanding of the SARS-CoV-2 pathogenesis could lead to more efficient therapeutic approaches. The current study aimed to investigate the Toll-like receptors expression profile in peripheral blood mononuclear cells in COVID-19 patients in Iran. Materials and methods: In this cross-sectional study, we evaluate 32 patients. At the admission time based on the disease severity patients were divided into two groups severe and mild COVID-19. A group of 16 normal people was evaluated as the control. Blood samples were collected before any treatment from patients at the admission time. The Blood samples were used for PBMC isolation. RNA extracted from PBMCs and use for the cDNA synthesis. The expression level of TLR-3, 4, and 7 were evaluated by using semi-quantitative real-time PCR. Results: The patient's mean age was 57.12±3.08 years and 15 (47%) were male. The background disorders represent two patients in the severe group with respiratory disorders, 4 patients with cardiovascular disease, and seven patients with diabetes. The TLRs expression levels represent a higher expression of TLR-4 in COVID-19 in comparison with controls for TLR-4 (p=0.00), TLR-3 and 7 also represent up-regulation but there were no statistically significant differences in the relative fold changes (RFC) between groups for all other evaluated TLRs (p>0.05). Conclusion: The study highlights the importance of the TLR-4 in COVID-19 patients in expression level. Further studies for a clear conclusion about TLRs expression levels are recommended.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44034821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saccharomyces boulardii plus azithromycin is superior to azithromycin alone in reducing the duration of diarrhea in children with acute colitis: a double-blind randomized placebo-controlled trial","authors":"M. Ahmadi, N. Mohtasham, A. Shamsizadeh, H. Javaherizadeh, B. Cheraghian, Masumeh Alizadeh","doi":"10.34172/ipp.2022.31397","DOIUrl":"https://doi.org/10.34172/ipp.2022.31397","url":null,"abstract":"Introduction: Diarrheal disorders remain a major disease burden throughout the world in pediatrics that remains a health problem. Several treatment methods have been proposed to treat diarrhea, however each of them has some problems. Objectives: The aim of this study was the evaluation the effect of oral Saccharomyces boulardii on the duration and severity of colitis. Patients and Methods: This randomized clinical trial study included ninety-four patients with acute colitis were enrolled. The children were divided randomly into case and control groups. The control group received supportive treatment including intravenous or oral fluid therapy (ORS solution), antibiotic treatment with azithromycin suspension, and zinc sulfate syrup daily for five days. In addition to the mentioned treatments, the intervention group received S. boulardii as a probiotic capsule. Then, the duration and severity of diarrhea based on the Vesikari score were evaluated for all the patients for five first days. Results: The mean of Vesikari score after the first day in both groups was similar, while after the third and fifth day in the probiotic group this score was lower than the control group (5.11 ± 1.73 versus 6.13 ± 2.25, P=0.031 and 2.36 ± 1.16 versus 4.28 ±1.19, P<0.001, respectively). Furthermore, the number of diarrhea per day in the probiotic group was significantly lower after the first day in contrast to the control group, which remains significant at the end of the fifth day (2.32 ± 0.51 versus 2.83 ± 1.23, P=0.047). Moreover, we found that the diarrhea duration (P<0.001), fever duration (P=0.029), and duration of hospitalization (P=0.006) were statistically lower in the case group as compared to the control. Conclusion: Saccharomyces boulardii had a beneficial effect as a probiotic agent in reducing the severity and duration of diarrhea, which could be beneficial for the treatment of colitis. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20161026030525N2); https://www.irct.ir/trial/24229; ethical code: IR.AJUMS.REC.1395.54.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69815146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}