Autoimmune thyroid disease in women with ages between 35 to 45 years based on Azar cohort data

IF 1.1 Q4 IMMUNOLOGY
A. Bahrami, F. Ghorbani, Nasser Aghamohammadzadeh, Farzad Najafipur, Vahieh Sadra
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Abstract

Introduction: Autoimmune thyroid diseases are common findings in women of childbearing age that could affect fertility rate, pregnancy outcome and complications after pregnancy. These diseases also correlated with other autoimmune diseases. Objectives: In this study, we aim to evaluate the autoimmune thyroid disease in women aged 35 to 45 years based on Azar cohort study data. Patients and Methods: In this cross-sectional analytical study, 507 women 35-45 years old without previous thyroid disease from Azar cohort study were evaluated. Demographic findings, data related to previous pregnancies, abortion, miscarriage, infertility and gestational diabetes were recorded for all patients. Blood samples were taken from all patients to measure TSH and anti-thyroid peroxidase (anti-TPO) levels. Anti-TPO levels ≥40 IU/mL were considered positive. Results: In the studied women, miscarriage occurred in 5.3%, abortion in 27.6% and infertility in 7.3%. Gestational diabetes was reported in 3.9%. The positive anti-TPO prevalence was 21.5%. Patients with positive anti-TPO compared to those with negative anti-TPO had significantly higher cases of hypothyroidism (P<0.001). There was no difference between patients with and without positive anti-TPO regarding miscarriage (5% versus 6.4%), abortion (27.4% versus 28.4%), infertility (7.5% versus 6.4%) and gestational diabetes (7.9% versus 3.6%) (P>0.05). There was no correlation between age and anti-TPO levels. Conclusion: The prevalence of thyroid antibodies in our study population is higher than previous studies. Anti-TPO positivity has no significant effect on pregnancy outcome in this population. Further studies are necessary to define the exact effect of anti-TPO on pregnancy outcomes.
基于阿扎尔队列数据的35-45岁女性自身免疫性甲状腺疾病
引言:自身免疫性甲状腺疾病是育龄妇女的常见疾病,可能影响生育率、妊娠结局和妊娠后并发症。这些疾病还与其他自身免疫性疾病相关。目的:在本研究中,我们旨在根据阿扎尔队列研究数据评估35-45岁女性的自身免疫性甲状腺疾病。患者和方法:在这项横断面分析研究中,对来自阿扎尔队列研究的507名35-45岁既往无甲状腺疾病的女性进行了评估。记录所有患者的人口学调查结果、与既往妊娠、流产、流产、不孕和妊娠期糖尿病相关的数据。从所有患者身上采集血样,以测量TSH和抗甲状腺过氧化物酶(抗TPO)水平。抗TPO水平≥40 IU/mL被认为是阳性的。结果:研究妇女流产率为5.3%,流产率为27.6%,不孕率为7.3%。妊娠期糖尿病报告率为3.9%。抗TPO阳性率为21.5%。与抗TPO阴性患者相比,抗TPO呈阳性的患者甲状腺功能减退率显著升高(P0.05)。年龄与抗TPO水平无相关性。结论:在我们的研究人群中,甲状腺抗体的患病率高于以往的研究。抗TPO阳性对该人群的妊娠结局没有显著影响。需要进一步的研究来确定抗TPO对妊娠结局的确切影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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