Association of Helicobacter pylori infection with chronic obstructive pulmonary disease

IF 1.1 Q4 IMMUNOLOGY
Saeid Hosseininia, Susan Mohammadi-Kebar, F. Pourfarzi, M. Bahadoram, Masoud Aslani
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引用次数: 0

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is a disease that is systematically characterized by an abnormal inflammatory response affecting the airways, interstitium and vascular bed through reactions to gas and particles, especially cigarette smoking. Recent studies have shown an association between Helicobacter pylori infection and various inflammatory diseases. H. pylori is a gram-negative, microbial bacterium that can be resistant to acidic stomach conditions and can interfere with gastric urease production. In this study, we examined the relationship between H. pylori infection in patients with COPD and the prevalence of H. pylori infection. Objectives: Determining the association between H. pylori infection and COPD. Patients and Methods: This case-control study is based on the Persian cohort study of patients who were referred to the digestive disease research center after being identified in the pulmonary clinic for H. pylori fecal antigen. Information on demographic variables and other related variables were obtained. Finally, the collected information was entered into SPSS software version 24 and the results were displayed descriptively using distribution and frequency tables and graphs and analytical statistics were analyzed using t test and logistic regression. Results: Out of 250 patients, 134 (53.6%) tested positive for H. pylori and 116 (46.4%) tested negative. Out of a total of 250 non-infected people; 106 patients (42.4%) were positive and 144 patients (57.6%) were negative. The two groups were statistically significantly different based on the chi-square test (P = 0.012). Conclusion: Our study showed a direct and significant relationship between H. pylori and COPD, which can be due to the effect of bacteria on lung growth in early life and also the development of systemic inflammation throughout life.
幽门螺杆菌感染与慢性阻塞性肺疾病的关系
引言:慢性阻塞性肺病(COPD)是一种系统性疾病,其特征是通过对气体和颗粒物的反应,特别是吸烟,影响气道、间质和血管床的异常炎症反应。最近的研究表明,幽门螺杆菌感染与各种炎症性疾病之间存在关联。幽门螺杆菌是一种革兰氏阴性微生物,对酸性胃条件具有耐药性,并可干扰胃脲酶的产生。在这项研究中,我们检测了COPD患者幽门螺杆菌感染与幽门螺杆菌患病率之间的关系。目的:确定幽门螺杆菌感染与COPD之间的关系。患者和方法:这项病例对照研究基于波斯队列研究,这些患者在肺部诊所被鉴定为幽门螺杆菌粪便抗原后被转诊到消化道疾病研究中心。获得了人口统计变量和其他相关变量的信息。最后,将收集到的信息输入SPSS软件版本24,并使用分布和频率表和图表描述结果,并使用t检验和逻辑回归分析分析统计数据。结果:在250名患者中,134名(53.6%)幽门螺杆菌检测呈阳性,116名(46.4%)检测呈阴性。在总共250名未感染者中;阳性106例(42.4%),阴性144例(57.6%)。根据卡方检验,这两组患者在统计学上有显著差异(P=0.012)。结论:我们的研究表明,幽门螺杆菌与COPD之间存在直接而显著的关系,这可能是由于细菌在早期对肺部生长的影响,以及在一生中全身炎症的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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