Immunopathologia Persa最新文献_第10页

Morphological diversity of the corneal small fibers in patients with type 1 diabetes mellitus 1型糖尿病患者角膜小纤维的形态多样性

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Immunopathologia Persa Pub Date : 2022-04-17 DOI: 10.34172/ipp.2022.31336

Anna Bregovskaya, M. Lukashenko, E. Kamaeva, N. Gavrilova, L. Soprun, N. Grigoryeva, I. Pchelin, L. Churilov

{"title":"Morphological diversity of the corneal small fibers in patients with type 1 diabetes mellitus","authors":"Anna Bregovskaya, M. Lukashenko, E. Kamaeva, N. Gavrilova, L. Soprun, N. Grigoryeva, I. Pchelin, L. Churilov","doi":"10.34172/ipp.2022.31336","DOIUrl":"https://doi.org/10.34172/ipp.2022.31336","url":null,"abstract":"Introduction: Diabetic neuropathy (DN) affects up to 50% of patients with type 1 diabetes mellitus (T1DM). Clinical manifestations include painful polyneuropathy with autonomic and orthostatic symptoms. Corneal confocal microscopy (CCM) is one of the promising non-invasive methods for DN evaluation and tracking the effectiveness of treatment. Objectives: To perform the early diagnosis of DN in T1DM patients and describe the morphological changes in nerve fibers during the treatment process. Patients and Methods: This prospective study included 77 T1DM patients and 42 healthy controls. All patients underwent CCM and electroneuromyography (ENMG). Twenty-five patients with T1DM and HbA1c 7-10% underwent strict glycemic control with the correction of insulin therapy and the subsequent CCM and ENMG investigations for the second time. Results: In T1DM patients a decrease in the main nerve trunks with age was revealed, as well as an increase in corneal nerve tortuosity (P<0.05). The number of branches of nerve fibers did not change with the increasing age (P=0.07). After reaching T1DM compensation, patients underwent a course of alpha-lipoic acid therapy. Confocal microscopy of the cornea parameters did not undergo significant changes during therapy since significant positive dynamics were noted only in the tortuosity of nerve fibers (P<0.05), which decreased by 11.8%. Conclusion: In patients with T1DM, strict glycemic control, correction of insulin therapy, and courses of alpha-lipoic acid prescription help to reduce the morphological changes of small fiber neuropathy, which can be evaluated by the confocal microscopy of the cornea.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45918481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of ultrasound findings and fine needle aspiration results between anti-thyroid peroxidase positive and negative patients with nodular goiters 抗甲状腺过氧化物酶阳性与阴性结节性甲状腺肿的超声表现及细针穿刺结果比较

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Immunopathologia Persa Pub Date : 2022-04-17 DOI: 10.34172/ipp.2022.24257

M. Malekian, Nasser Aghamohammadzadeh, F. Najafipour, Reza Javad-Rashid, J. Jalili, M. Halimi, F. Bozorgi, Jalil Houshyar

{"title":"Comparison of ultrasound findings and fine needle aspiration results between anti-thyroid peroxidase positive and negative patients with nodular goiters","authors":"M. Malekian, Nasser Aghamohammadzadeh, F. Najafipour, Reza Javad-Rashid, J. Jalili, M. Halimi, F. Bozorgi, Jalil Houshyar","doi":"10.34172/ipp.2022.24257","DOIUrl":"https://doi.org/10.34172/ipp.2022.24257","url":null,"abstract":"Introduction: Ultrasonography is an optimal approach for thyroid gland evaluation, nodule detection and cancer risk assessment in patients with thyroid nodules. Almost all patients with Hashimoto’s thyroiditis have high levels anti-thyroid peroxidase (anti-TPO) antibodies. Objectives: This study aimed to evaluate the relationship between ultrasonography and fine needle aspiration (FNA) results in anti-TPO antibodies positive and negative patients with nodular goiters. Patients and Methods: This cross-sectional study included 128 patients with nodular goiters, referred to endocrinology clinic of imam Reza hospital, Tabriz, Iran. Anti-TPO levels above and below 16 IU/mL were considered as positive and negative, respectively. All patients underwent thyroid ultrasonography, and eligible nodules were subjected to FNA. Results: Of 128 patients, 33.6% and 66.4% were anti-TPO positive and negative, respectively. FNA was conducted on 196 nodules. A significant relationship was observed between sonographic and FNA results in low and intermediate-suspicion nodules. Chronic lymphocytic thyroiditis (CLT) was more frequently reported in low-suspicion nodules of the anti-TPO positive group (P≤0.0001). In addition, in intermediate-suspicion nodules, CLT was reported in 33.3% of patients in the anti-TPO positive group (P=0.026). No significant difference was observed between other nodules. Conclusion: Based on our findings, when a nodule is classified in low or intermediate-suspicion categories, the possibility of CLT following FNA is significantly higher in the anti-TPO positive group, compared to the anti-TPO negative group.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44297570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune manifestations of the post-COVID-19 condition COVID-19后疾病的自身免疫表现

IF 0.8

Immunopathologia Persa Pub Date : 2022-04-17 DOI: 10.34172/ipp.2022.31339

V. Ryabkova, Anna Bregovskaya, L. Soprun, N. Gavrilova, L. Churilov

引用次数: 0

The confocal microscopy of the cornea in post-COVID syndrome; the clinical observation covid - 19综合征后角膜共聚焦显微镜观察临床观察

IF 0.8

Immunopathologia Persa Pub Date : 2022-04-17 DOI: 10.34172/ipp.2022.31338

M. Lukashenko, L. Soprun, Anna Bregovskaya, N. Gavrilova, V. I. Utekhin

{"title":"The confocal microscopy of the cornea in post-COVID syndrome; the clinical observation","authors":"M. Lukashenko, L. Soprun, Anna Bregovskaya, N. Gavrilova, V. I. Utekhin","doi":"10.34172/ipp.2022.31338","DOIUrl":"https://doi.org/10.34172/ipp.2022.31338","url":null,"abstract":"One of the most important complications of the post-COVID-19 syndrome may be a small fiber neuropathy, which cannot be evaluated by a routine electroneuromyography. Confocal microscopy of the cornea (CCM) may be a promising method for early neuropathy verification. To study the possibility of the small fiber neuropathy evaluation using the CCM in a patient with the post-COVID-19 condition. The patient is a female of 61 years old, which suffered from a COVID-19 infection in October 2020. After a month, she noted the presence of myalgia and polyneuropathy. A year after the onset of the disease, in addition to myalgia, headaches, neuropathy pain, the patient also experienced bowel disorders and stomach aches, which cannot be explained with an alternative diagnosis. The patient underwent CCM to assess the structure of nerve fibers to prove the presence of the small fiber neuropathy as a complication of the COVID-19 infection. The presence of the small fiber neuropathy was evaluated in the patient as well as enlarged Langerhans cells in the cornea. Considering the pivotal role of these cells in the immunological processes, the \"activated\" dendritic cells in post-COVID-19 patients may serve as another evidence of the autoimmune nature of this complication and possibly, a method for the monitoring treatment effectiveness of this disease. In this clinical case of a 61-year-old patient with the post-COVID-19 syndrome, the possibility of application of the confocal microscopy of the cornea for the diagnosis of neuropathy of small fibers and monitoring of the patient›s condition is shown.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48052548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could inadvertent intravenous injection of COVID-19 vaccines cause severe adverse events? 无意中静脉注射COVID-19疫苗会导致严重不良事件吗?

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Immunopathologia Persa Pub Date : 2022-04-17 DOI: 10.34172/ipp.2022.31392

Z. Tajabadi, S. A. A. Safavi-Naini, B. Kwatra, A. Safavi-Naini

引用次数: 0

Primary Burkitt lymphoma of breast presented by bilateral breast enlargement 双侧乳腺肥大表现的原发性乳腺伯基特淋巴瘤

IF 0.8

Immunopathologia Persa Pub Date : 2022-03-04 DOI: 10.34172/ipp.2022.29283

Rahim Asghari, A. Abbasi, Hengameh Mojdeganlou, Yasin Farrokhi, Leila Mahmoodzadeh

引用次数: 1

Correlation of exposure to environmental tobacco smoke and periodontitis in passive smokers; a systematic review 被动吸烟者接触环境烟草烟雾与牙周炎的相关性；系统综述

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Immunopathologia Persa Pub Date : 2022-03-04 DOI: 10.34172/ipp.2022.29308

Sona Rafieyan, M. Sadighi Shamami, Vian Shateri, M. Ghojazadeh, F. Salehnia

{"title":"Correlation of exposure to environmental tobacco smoke and periodontitis in passive smokers; a systematic review","authors":"Sona Rafieyan, M. Sadighi Shamami, Vian Shateri, M. Ghojazadeh, F. Salehnia","doi":"10.34172/ipp.2022.29308","DOIUrl":"https://doi.org/10.34172/ipp.2022.29308","url":null,"abstract":"Introduction: Smoking is a major health hazard. Cigarette smoke is produced by burning of complex organic compounds that include highly toxic components. Passive smokers are non-smoker individuals that are exposed to second-hand smoke (SHS) or environmental tobacco smoke (ETS). Passive or involuntary smoking is currently a major public health dilemma worldwide. Considering the increasing number of passive smokers in today’s world, it is imperative to assess the potential adverse effects of passive smoking on oral health and periodontal tissue. Objectives: This study aimed to assess the correlation between exposure to ETS and periodontitis in passive smokers. Methods: In this systematic review, the Google Scholar, PubMed and Scopus databases were searched for relevant articles published from 1990 to 2020. The extracted data were tabulated. Results: Search of the literature yielded 77 articles based on the searched keywords. After assessing the abstracts and excluding the duplicates, 68 articles remained. After accurate assessment by the examiners, 21 articles were selected for the full-text review. Finally, seven eligible articles remained in the study for the final review. Conclusion: Cigarette smoke affects the immune system and aggravates periodontal destruction as such. Despite the available evidence regarding the correlation of periodontal parameters and exposure to ETS in passive smokers, more comprehensive studies on this topic are still required to achieve a definite therapeutic protocol considering the small number of available studies on this topic, methodological flaws and the existing controversies.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41845175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Benralizumab substitution monotherapy in symptomatic relapsing asthma-dominant eosinophilic granulomatosis with polyangiitis 苯那利珠单抗替代单药治疗复发性哮喘为主的嗜酸性肉芽肿病伴多血管炎

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Immunopathologia Persa Pub Date : 2022-02-20 DOI: 10.34172/ipp.2022.31373

M. Onuigbo, B. Libman, M. Lazarovich

{"title":"Benralizumab substitution monotherapy in symptomatic relapsing asthma-dominant eosinophilic granulomatosis with polyangiitis","authors":"M. Onuigbo, B. Libman, M. Lazarovich","doi":"10.34172/ipp.2022.31373","DOIUrl":"https://doi.org/10.34172/ipp.2022.31373","url":null,"abstract":"There is increasing interest in biologicals in steroid-resistant or steroid-dependent eosinophilic granulomatosis with polyangiitis (EGPA). We describe successful benralizumab monotherapy in asthma-dominant EGPA. Sixteen years ago, a 38-year-old male was diagnosed with multisystemic illness with asthma, arthralgias, Bell’s palsy and nephrotic syndrome, with 20.3% eosinophilia (absolute count 1160 K/µL), ESR 50 mm/hour, albumin 2.3 g/dL, serum creatinine 1.1 mg/dL, slightly above baseline and negative immunology work. Kidney biopsy demonstrated diffuse podocyte foot process effacement with minimal change disease, without vasculitis and EGPA was diagnosed. He achieved early remission with corticosteroids and intravenous cyclophosphamide and was maintained on prednisone and mycophenolate mofetil. Nevertheless, he repeatedly experienced severe asthma exacerbations, falls in FEV-1% and recurrent relapsing eosinophilia. He was successfully started on benralizumab and was weaned off mycophenolate mofetil and prednisone. Eosinophilia was corrected and FEV-1% normalized. We support calls for larger trials of the biologicals in EGPA.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42938208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ki-67 proliferative index in immunoglobulin A nephropathy; A pilot study 免疫球蛋白A肾病的Ki-67增殖指数；试点研究

IF 0.8

Immunopathologia Persa Pub Date : 2022-02-19 DOI: 10.34172/ipp.2022.31369

M. Barahman, Elham Emami, M. Biglari Abhari, E. Ahmadian, M. Mubarak, M. Bahadoram, A. Maghsoudi, A. Baradaran, Niloufar Hooshyar

{"title":"Ki-67 proliferative index in immunoglobulin A nephropathy; A pilot study","authors":"M. Barahman, Elham Emami, M. Biglari Abhari, E. Ahmadian, M. Mubarak, M. Bahadoram, A. Maghsoudi, A. Baradaran, Niloufar Hooshyar","doi":"10.34172/ipp.2022.31369","DOIUrl":"https://doi.org/10.34172/ipp.2022.31369","url":null,"abstract":"Introduction: IgA nephropathy (IgAN) regarded as the main type of primary glomerulonephritis globally. It has a diverse clinical course and unpredictable prognosis. Traditionally, clinical and pathological features are conducted to prognosticate the outcome of the disease. Recently, attention has been directed towards other indices that may have prognostic implications for IgAN progression. The Ki-67 index have been extensively detected as a proliferation marker of malignant cells for several years. Objectives: In this study, we aimed to determine the prognostic impact of Ki-67 expression in IgAN biopsies. Patients and Methods: This cross-sectional study was conducted on 18 biopsy-proven IgAN patients. IgAN was diagnosed by significant IgA deposits and according to the morphologic variables of Oxford (MEST) classification for this disease. The expression of Ki-67 in the glomeruli, interstitium and tubules was described as the intensity percentage of the immunohistochemical staining. Results: In all of the eighteen cases with biopsy-proven IgAN, the mean ± SD of age, degree of proteinuria and serum creatinine were 36.3±17 years, 1600±733 mg/day and 1.2±0.4 mg/dL, respectively. In this study, we found a significant correlation between glomerular Ki-67 immunohistochemical staining and MEST scores (r: 0.780, P< 0.001). We also detected a significant correlation between interstitial Ki-67 staining and MEST scores (r: 0.700, P=0.001). Moreover, Ki-67 immunohistochemical staining of the interstitium had a significant relationship with IgM deposits (r=0.544, P=0.02). Conclusion: In this pilot study, we found that interstitial and glomerular Ki-67 immunohistochemical staining had positive and significant associations with MEST scores. Our data also showed that interstitial Ki-67 staining had a significant relationship with IgM deposits. These preliminary results require further investigation in large-scale studies.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42956143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of supplemental oxygen on 6-minute walk test in chronic obstructive pulmonary disease patients 补充氧对慢性阻塞性肺疾病患者6分钟步行试验的影响

IF 0.8

Immunopathologia Persa Pub Date : 2022-02-18 DOI: 10.34172/ipp.2022.25262

Farzin Ghiasi, Fatemeh Sajjadfar, S. Sadeghi

{"title":"The effect of supplemental oxygen on 6-minute walk test in chronic obstructive pulmonary disease patients","authors":"Farzin Ghiasi, Fatemeh Sajjadfar, S. Sadeghi","doi":"10.34172/ipp.2022.25262","DOIUrl":"https://doi.org/10.34172/ipp.2022.25262","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease that associated with abnormal airflow during respiration. It has been demonstrated that supplemental oxygen used in the time of exercise testing has a considerable positive effect in cases with COPD. Objectives: Present study was aimed to investigate the possible effects of supplemental oxygen on the outcomes of 6-minute walk test (6MWT). Patients and Methods: COPD cases were randomly divided into two groups (n= 50/each). Group1; patients who received nasal oxygen during the 6MWT, and group two were patients who did not receive supplemental oxygen during the test. Results: The Shapiro-Wilk test showed that the distribution of all parameters in two groups followed the normal distribution. The total distance walked was 431.54±40.76 m in the intervention group and 399.08±49.94 m in the control group, with a significant difference between the two groups (P= 0.001). After 6MWT, the mean of SpO2 in the intervention group was significantly higher than the control group (P= 0.002) and the degree of dyspnea was significantly lower than the control group (P= 0.031). Conclusion: Overall, supplemental oxygen has significant positive effects in COPD patients, but definitive commentary is needed for further studies. Trial registration: The trial protocol was approved by the Thai Clinical Trials Registry (identifier: TCTR20220122001; https://www.thaiclinicaltrials.org, ethical code; IR.MUI.MED.REC. 1396.308.3).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46774423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0