Immunopathologia Persa最新文献_第2页

The correlation of estrogen and progesterone receptor expression with prognostic parameters in women with breast cancer 癌症雌、孕激素受体表达与预后参数的相关性

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Immunopathologia Persa Pub Date : 2023-07-29 DOI: 10.34172/ipp.2023.39486

Shahnaz Eskandari, A. Baradaran, Sarah Ghorbani, Parisa Masoumzade

{"title":"The correlation of estrogen and progesterone receptor expression with prognostic parameters in women with breast cancer","authors":"Shahnaz Eskandari, A. Baradaran, Sarah Ghorbani, Parisa Masoumzade","doi":"10.34172/ipp.2023.39486","DOIUrl":"https://doi.org/10.34172/ipp.2023.39486","url":null,"abstract":"Introduction: Progesterone and estrogen receptor (PR and ER) expression are considered the oldest biomarkers. The presentation of these markers can guide the treatment in breast cancer patients because of their predictive value in hormonal therapy responsiveness and prognosis. Objectives: This study investigated the correlation between estrogen and PR expression with prognostic parameters of breast cancer, including age, grading, staging, tumor size, and lymph node spread. Patients and Methods: This cross-sectional study included 245 cases of breast tumors. Characteristics of patients, including age, the status of ER and PR biomarkers, tumor type, pathological features of cancer, and staging, were documented from case files. Accordingly, SPSS version 27 software was conducted for data analysis. The collected data were analyzed using the Spearman’s correlation, Mann-Whitney U and chi-squared tests. A P value < 0.05 is considered statistically significant. Results: High ER and PR expression (>50%) were found in 56.7% and 40.4% of cases, respectively. Most of the tumors in patients belonged to grade 2 (56.3%) and staging IIA, IIB, and IIIA. We found a significant correlation between ER expression, breast cancer grading, and patients’ age. PR expression was significantly associated with breast cancer staging, grading, size, and lymph node spread. Conclusion: These results highlight the value of ER and PR expression as they can determine the clinicopathological parameters of the tumor, which can be helpful for better-managing breast cancer.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44158211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of hemoperfusion on treatment outcomes in COVID-19 patients with respiratory failure: a prospective study 血液灌流对新冠肺炎呼吸衰竭患者治疗结果的影响：一项前瞻性研究

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Immunopathologia Persa Pub Date : 2023-07-29 DOI: 10.34172/ipp.2023.38457

Effat Rafiee, Samad Ghodrati, Ayoub Pezeshgi, Masumeh Hasanlu, F. Salarpour, Kamyar Mansori, N. Parsamanesh

{"title":"The effect of hemoperfusion on treatment outcomes in COVID-19 patients with respiratory failure: a prospective study","authors":"Effat Rafiee, Samad Ghodrati, Ayoub Pezeshgi, Masumeh Hasanlu, F. Salarpour, Kamyar Mansori, N. Parsamanesh","doi":"10.34172/ipp.2023.38457","DOIUrl":"https://doi.org/10.34172/ipp.2023.38457","url":null,"abstract":"Introduction: COVID-19 emerged as a global clinical threat following an outbreak in China in late 2019. Objectives: The aim of the current study was to assess the effect of hemoperfusion in COVID-19 patients with respiratory failure. Patients and Methods: In this prospective study, a total of 98 patients over the age of 18 with the positive COVID-19 polymerase chain reaction (PCR) test were investigated. The patients were divided into two groups; a control group consisting of 47 patients who did not receive hemoperfusion, and an exposed group consisting of 51 patients who met the criteria for hemoperfusion. Various parameters including complete blood cell counts, serum bilirubin, creatinine, C-reactive protein (CRP), and interleukin 6 (IL-6) levels were evaluated in all patients. Results: The results of our study revealed a statistically significant difference in intensive care unit (ICU) admission between the two groups. Hospitalization time (19.941±1.75 versus 14.615±1.39, P=0.021) and ICU time (14.98±1.30 versus 9.62±1.15; P=0.003) were significantly higher in patients who received hemoperfusion. Regarding the mortality rate, only 36.7% of the patients survived; however, there was no significant difference observed between the two groups (P=0.34). Conclusion: In conclusion, the findings of our study indicate that hemoperfusion in COVID-19 patients with respiratory failure led to a significant increase in hospital stay and ICU stay compared to those without hemoperfusion. Further research is needed to determine the optimal timing and frequency of hemoperfusion to improve treatment outcomes in COVID-19 patients with respiratory failure.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48215374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic and diagnostic roles of serum ferritin level in cancer 血清铁蛋白水平对癌症的预后和诊断作用

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Immunopathologia Persa Pub Date : 2023-07-04 DOI: 10.34172/ipp.2023.40529

M. Barahman, Najmeh Nameh Goshay Fard, M. Bahadoram, E. Akade, Roozbeh Mohghaddar

引用次数: 0

Recurrent cardiac hydatid cysts with pericardial protrusion; a rare case presentation of Echinococcus granulosus 复发性心脏棘球蚴囊肿伴心包突出；细粒棘球蚴的罕见病例报告

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Immunopathologia Persa Pub Date : 2023-06-20 DOI: 10.34172/ipp.2023.31376

Mahmoud Beheshti Monfared, H. Ghaderi, Zahra Ansari Aval, M. Hekmat, S. Mirjafari, Reza Beheshti Monfared, R. Tirdad

{"title":"Recurrent cardiac hydatid cysts with pericardial protrusion; a rare case presentation of Echinococcus granulosus","authors":"Mahmoud Beheshti Monfared, H. Ghaderi, Zahra Ansari Aval, M. Hekmat, S. Mirjafari, Reza Beheshti Monfared, R. Tirdad","doi":"10.34172/ipp.2023.31376","DOIUrl":"https://doi.org/10.34172/ipp.2023.31376","url":null,"abstract":"Hydatid cyst (HC) is a rare pathology mostly found in less developed, livestock-raising countries. HC can be found anywhere in the body, however it is a rare finding in the heart, and its recurrence in the heart and pericardium is very rare. A 54-year-old woman who had undergone surgery for the removal of HC in another country 11 years before presented with shortness of breath and heaviness in the chest. The examinations and computerized tomography (CT) scan revealed a large mass measuring 60×50 mm in the pericardium cavity originating from the right atrial wall. Infection with Echinococcus granulosus was confirmed with serological enzyme-linked immunosorbent assay (ELISA) test and the patient underwent cardiac surgery. The patient underwent cardiopulmonary bypass, nevertheless did not suffer cardiac arrest, and aortic cross-clamping was not performed for her. The removed mass was filled with daughter cysts. The endocysts were removed and intramural cysts were drained. Following the surgery, the patient received treatment with albendazole for six months. Cardiac hydatid cyst recurrence is a rare but possible incident, and annual follow-ups and echocardiography are recommended.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49181754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between placental thickness, grading, and heterogeneity in fetal growth restriction in the third trimester of pregnancy by ultrasonography and pathology tests and their relationship with estimated fetal weight and neonatal outcome 超声和病理检查显示的妊娠晚期胎儿生长受限胎盘厚度、分级和异质性之间的关系及其与估计胎儿体重和新生儿结局的关系

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Immunopathologia Persa Pub Date : 2023-06-17 DOI: 10.34172/ipp.2023.39471

F. Farahbod, E. Zarean, S. Khanjani, M. Moezzi, Fereshteh Mohammadizadeh, S. Shabanian

{"title":"Relationship between placental thickness, grading, and heterogeneity in fetal growth restriction in the third trimester of pregnancy by ultrasonography and pathology tests and their relationship with estimated fetal weight and neonatal outcome","authors":"F. Farahbod, E. Zarean, S. Khanjani, M. Moezzi, Fereshteh Mohammadizadeh, S. Shabanian","doi":"10.34172/ipp.2023.39471","DOIUrl":"https://doi.org/10.34172/ipp.2023.39471","url":null,"abstract":"Introduction: The placenta is the influencing factor on the fetal weight and is as the first organ that reveals the pathological changes of pregnancy. Therefore, placental ultrasound findings influence the diagnosis of fetal growth restriction (FGR). Objectives: This study examines the relationship between placental thickness, grading and heterogeneity during ultrasound and placental pathology in third trimester FGR fetuses and its effect on neonatal outcome. Patients and Methods: This prospective observational study included 67 pregnant women with FGR fetuses in the third trimester of pregnancy with the mean gestational age of 34.52 ± 2.65 weeks and possible termination of pregnancy within the next seven days. The placental thickness, grading, and heterogeneity in ultrasonography were examined and compared with thickness and grading. Their effect was also considered in neonatal outcome and the results were analyzed. Results: In this study, there is a significant relationship between the thickness of the placenta before and after birth with the weight of the placenta, weight and Apgar score, neonatal arterial pH at birth and fetal growth restriction grading in ultrasound, and neonatal outcome. Conclusion: This study shows that ultrasonic placental findings can be effective in determining the final weight of the placenta and fetus and also the final outcome of the baby at birth. Therefore, ultrasound of the placenta should be performed along with pregnancy ultrasound.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45391928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does folate deficiency alter sperm parameters in infertile males? 叶酸缺乏会改变不育男性的精子参数吗?

Immunopathologia Persa Pub Date : 2023-05-17 DOI: 10.34172/ipp.2023.39480

Saeideh Sadat Alamdari, Maryam Derakhshan, Marzieh Derakhshan, Parvin Mahzouni

{"title":"Does folate deficiency alter sperm parameters in infertile males?","authors":"Saeideh Sadat Alamdari, Maryam Derakhshan, Marzieh Derakhshan, Parvin Mahzouni","doi":"10.34172/ipp.2023.39480","DOIUrl":"https://doi.org/10.34172/ipp.2023.39480","url":null,"abstract":"Introduction: There is not enough evidence regarding the influence of folate deficiency in the etiology of idiopathic male infertility. Objectives: The objective of the current study was to examine whether there is an association between serum levels of folate and sperm parameters among infertile males. Patients and Methods: This cross-sectional study was undertaken on a sample of infertile males referring to an infertility treatment clinic in Isfahan province, Iran. Semen parameters, comprising sperm concentration, progressive/total motility, morphology, semen leukocyte, agglutination, and vitality were assessed based on standard protocols. The sperm DNA fragmentation assay (SDFA) and sperm chromatin maturity assay (SCMA) were also assessed by the sperm chromatin dispersion and aniline-blue tests respectively. Results: In general, 70 infertile males including 46 with sufficient serum folate level and 24 with insufficient serum folate level were examined. Subjects with sufficient serum folate level had a significantly higher mean of sperm concentration, vitality, progressive motility, total motility, SDFA, and SCMA (P<0.05). Higher serum folate level was also associated with lower risk of abnormal sperm agglutination (OR: 0.09, 95% CI: 0.01-0.65), and morphology (OR: 0.12, 95% CI: (0.02-0.60) after adjustment for potential confounders. Conclusion: The present study found a significant association between serum folate level and infertility among Iranian infertile males. However, prospective large-scale population-based research is required to confirm the finding.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135916716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of delivery type (vaginal delivery versus cesarean section) on intraocular pressure and retinal nerve fiber layer thickness in healthy women 分娩方式(阴道分娩与剖宫产)对健康妇女眼压和视网膜神经纤维层厚度的影响

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Immunopathologia Persa Pub Date : 2023-05-16 DOI: 10.34172/ipp.2023.39478

S. Nazari, A. Smaeili, A. Kasiri, Parivash Jelodarian

{"title":"The effect of delivery type (vaginal delivery versus cesarean section) on intraocular pressure and retinal nerve fiber layer thickness in healthy women","authors":"S. Nazari, A. Smaeili, A. Kasiri, Parivash Jelodarian","doi":"10.34172/ipp.2023.39478","DOIUrl":"https://doi.org/10.34172/ipp.2023.39478","url":null,"abstract":"Introduction: Pregnancy imposes physiological stress and significantly changes human body. This change may have potential effects on visual system. Little is known about pregnancy effects on intraocular pressure (IOP) and glaucoma. Objectives: The present study tended to evaluate and compare the effect of normal vaginal delivery (NVD) versus cesarean section (CS) on IOP and retinal nerve fiber layer thickness (RNFLT) in healthy women. Patients and Methods: Sixty pregnant women participated in this prospective cross-sectional study. The participants were assigned to two groups; the first group consisted of 30 candidates for NVD and the second group of 30 candidates for CS. Then, IOP in three states before delivery, during delivery, and six weeks after delivery then RNFLT were measured and compared by optical coherence tomography (OCT) in two states before delivery and six weeks after delivery. Results: Based on the results, there was no significant difference in the RNFLT in left and right eyes, before and after delivery in the NVD and CS groups (P=0.081 and P=0.090, respectively). Additionally, following the comparison of NVD and SC groups, no significant difference in the RNFLT between two groups was detected (P>0.05). According to IOP measurements in both eyes, IOP during delivery was significantly higher than before and after delivery in NVD group (P=0.05 and P=0.048, respectively) and CS group (P=0.028 and P=0.035, respectively). In addition, IOP in NVD group was higher than CS group in all states, but no statistically significant difference was seen among them (P>0.05). Conclusion: In general, the results showed that delivery type does not significantly affect RNFLT and IOP. It is also possible that an increase in IOP will lead to different results in women with pre-existing glaucoma or risk factors for it. Therefore, in cases with a positive background of glaucoma, specialized examinations and delivery under the supervision of a specialist are recommended.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46787092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological complications as the hallmark symptoms of thrombotic thrombocytopenic purpura in sickle cell disease 镰状细胞病血栓性血小板减少性紫癜的标志性症状是神经系统并发症

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Immunopathologia Persa Pub Date : 2023-05-16 DOI: 10.34172/ipp.2023.39490

M. Bahadoram, B. Keikhaei, Shahram Rafie, E. Akade, Najmeh Nameh Goshay Fard, Roozbeh Moghaddar

引用次数: 0

Silver resistance in Pseudomonas aeruginosa and Acinetobacter baumannii isolated from burn patients 烧伤患者铜绿假单胞菌和鲍曼不动杆菌对银的耐药性

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Immunopathologia Persa Pub Date : 2023-05-16 DOI: 10.34172/ipp.2023.39498

F. Farajzadeh, K. Diba, J. Kazemzadeh, Shohreh Afshar Yavari

{"title":"Silver resistance in Pseudomonas aeruginosa and Acinetobacter baumannii isolated from burn patients","authors":"F. Farajzadeh, K. Diba, J. Kazemzadeh, Shohreh Afshar Yavari","doi":"10.34172/ipp.2023.39498","DOIUrl":"https://doi.org/10.34172/ipp.2023.39498","url":null,"abstract":"Introduction: Burn infections are a serious obstacle to the patient’s recovery. Infection is estimated to account for 75% of burn patient mortality. Widespread and often indiscriminate administration of antibiotics and lack of basic infection control methods are major factors in the emergence of drug-resistant bacteria. Due to the growing and serious threat of antibiotic resistance, interest in silver compounds has grown in modern medicine. Objectives: The aim of this descriptive study was to evaluate the frequency of sil genes and its phenotypic expression in Pseudomonas aeruginosa and Acinetobacter baumannii isolates isolated from the burn ward of Imam Khomeini hospital in Urmia. Patients and Methods: P. aeruginosa (n=16) and A. baumannii (n=32) isolates were collected from burn wound samples in an 8-month period from August to March 2017 from the burn ward of the hospital. The minimum inhibitory concentration of silver nitrate on the clinical isolates was determined using microdilution method. The presence of silP, silE and silS silver resistance genes was investigated by polymerase chain reaction (PCR). Results: The results of minimum inhibitory concentration (MIC) test showed that 62.5% (n = 10) of P. aeruginosa isolates and 56.25% (n = 18) of A. baumannii isolates showed MIC above 512 mg/ml. Polymerase chain reaction results revealed that only one P. aeruginosa isolate had silE gene and among A. baumannii isolates, 20 isolates had silE gene and six isolates had silS gene. None of the isolates showed positive results for the silP gene. Conclusion: Based on the results, A. baumannii was the most common microorganism of burn wounds in the burn ward of our hospital in Urmia. This study showed a high degree of phenotypic resistance to silver in A. baumannii and P. aeruginosa isolates which silE and silS genes were also observed in some isolates.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47789887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galbanic acid of Ferula assa-foetida L, as a regulator of the AMPK pathway in reduction of lipid accumulation in HepG2 cells 阿魏中Galbanic酸在减少HepG2细胞脂质积累中的AMPK通路调节作用

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Immunopathologia Persa Pub Date : 2023-05-16 DOI: 10.34172/ipp.2023.39479

H. Musavi, H. Shokri-Afra, Prof. Dr. Soleiman Mahjoub, Abbas Khonakdar-Tarsi, A. Bagheri, Zahra Memariani

{"title":"Galbanic acid of Ferula assa-foetida L, as a regulator of the AMPK pathway in reduction of lipid accumulation in HepG2 cells","authors":"H. Musavi, H. Shokri-Afra, Prof. Dr. Soleiman Mahjoub, Abbas Khonakdar-Tarsi, A. Bagheri, Zahra Memariani","doi":"10.34172/ipp.2023.39479","DOIUrl":"https://doi.org/10.34172/ipp.2023.39479","url":null,"abstract":"Introduction: Hepatic fat accumulation is a complication of non-alcoholic fatty liver disease (NAFLD). An AMP-activated protein kinase (AMPK) reduces the synthesis of fatty acids by inhibiting sterol regulatory element-binding transcription factor 1-c (SREBP1-C) and acetyl COA carboxylase (ACC). Objectives: We aimed to investigate the impress of galbanic acid (Gal) from the Ferula plant on AMPK and its inhibitory effect on lipogenic enzymes in HepG2 cells. Materials and Methods: In an applied-fundamental study, HepG2 cells were treated for 24 hours with Gal in palmitate (Pal). Resveratrol (RSV) was conducted as a positive control. Fatty acid synthase (FAS) and SREBP1-C gene expression were evaluated by reverse transcription polymerase chain reaction (RT-PCR). FAS, phospho-acetyl-CoA carboxylase (P-ACC), P-AMPK, AMPK, SREBP-1c, and ACC protein levels were measured by western blotting. Lipid accumulation was investigated qualitatively and semi-quantitatively with oil red. Results: The semi-quantitative results of oil revealed a substantial reduction (P<0.004) in lipid accumulation for treatment with Gal. The significant increase in the protein level of P-AMPK (P<0.001) and P-ACC (P=0.054) and significant decrease in FAS (P<0.003), SREBP-1c (P<0.001) and ACC (P<0.011) due to the effect galbanic acid was observed. FAS gene expression decreased significantly (P<0.009), while the decrease in SREBP-1c gene expression was not significant (P=0.303). Conclusion: These findings direct that galbanic acid can be a new regulator of AMPK. Hence, the present study may introduce galbanic acid as a new plan to positively regulate the AMPK pathway, which leads to the regulation of various cellular processes.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48710032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0