叶酸缺乏会改变不育男性的精子参数吗?

IF 1.1 Q4 IMMUNOLOGY
Saeideh Sadat Alamdari, Maryam Derakhshan, Marzieh Derakhshan, Parvin Mahzouni
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引用次数: 0

摘要

目前还没有足够的证据表明叶酸缺乏对特发性男性不育症病因的影响。目的:本研究的目的是研究在不育男性中血清叶酸水平和精子参数之间是否存在关联。患者和方法:这项横断面研究是在伊朗伊斯法罕省不孕不育治疗诊所的不育男性样本上进行的。根据标准方案评估精液参数,包括精子浓度、进行性/总运动性、形态、精液白细胞、凝集和活力。用精子染色质分散试验和苯胺蓝试验分别评价精子DNA片段化试验(SDFA)和精子染色质成熟度试验(SCMA)。结果:共检测70例不育男性,其中血清叶酸充足者46例,血清叶酸不足者24例。血清叶酸水平充足的受试者精子浓度、活力、进行性运动性、总运动性、SDFA和SCMA的平均值显著高于对照组(P<0.05)。在调整潜在混杂因素后,较高的血清叶酸水平也与较低的精子异常凝集风险(OR: 0.09, 95% CI: 0.01-0.65)和形态(OR: 0.12, 95% CI: 0.02-0.60)相关。结论:本研究发现伊朗不育男性血清叶酸水平与不育之间存在显著关联。然而,需要前瞻性的大规模人群研究来证实这一发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does folate deficiency alter sperm parameters in infertile males?
Introduction: There is not enough evidence regarding the influence of folate deficiency in the etiology of idiopathic male infertility. Objectives: The objective of the current study was to examine whether there is an association between serum levels of folate and sperm parameters among infertile males. Patients and Methods: This cross-sectional study was undertaken on a sample of infertile males referring to an infertility treatment clinic in Isfahan province, Iran. Semen parameters, comprising sperm concentration, progressive/total motility, morphology, semen leukocyte, agglutination, and vitality were assessed based on standard protocols. The sperm DNA fragmentation assay (SDFA) and sperm chromatin maturity assay (SCMA) were also assessed by the sperm chromatin dispersion and aniline-blue tests respectively. Results: In general, 70 infertile males including 46 with sufficient serum folate level and 24 with insufficient serum folate level were examined. Subjects with sufficient serum folate level had a significantly higher mean of sperm concentration, vitality, progressive motility, total motility, SDFA, and SCMA (P<0.05). Higher serum folate level was also associated with lower risk of abnormal sperm agglutination (OR: 0.09, 95% CI: 0.01-0.65), and morphology (OR: 0.12, 95% CI: (0.02-0.60) after adjustment for potential confounders. Conclusion: The present study found a significant association between serum folate level and infertility among Iranian infertile males. However, prospective large-scale population-based research is required to confirm the finding.
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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