Prognostic and diagnostic roles of serum ferritin level in cancer

IF 1.1 Q4 IMMUNOLOGY
M. Barahman, Najmeh Nameh Goshay Fard, M. Bahadoram, E. Akade, Roozbeh Mohghaddar
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引用次数: 0

Abstract

The ferritin level, a protein responsible for iron metabolism and storage, is a sensitive indicator of iron overload in various pathological conditions. In leukemia, ferritin levels increase with disease stages and can predict survival after transplantation. Leukemia-induced dysregulation of the ferroportin-hepcidin regulatory axis results in intracellular iron accumulation, activation of the reactive oxygen species (ROS)-related signaling pathway, and inhibition of hematopoiesis, leading to anemia and increased dependence on red blood cell transfusions, thereby disrupting the physiological cycle. Additionally, ferritin levels rise in other types of cancer, indicating its potential as a target for both diagnosis and treatment. Therefore, understanding the role of ferritin and iron metabolism in leukemia and other diseases is crucial in developing effective treatment strategies to enhance patient outcomes.
血清铁蛋白水平对癌症的预后和诊断作用
铁蛋白水平是一种负责铁代谢和储存的蛋白质,在各种病理条件下是铁过载的敏感指标。在白血病中,铁蛋白水平随着疾病的分期而增加,可以预测移植后的存活率。白血病诱导的铁蛋白-铁调素调节轴失调导致细胞内铁积累、活性氧(ROS)相关信号通路激活和造血抑制,导致贫血和对红细胞输注的依赖性增加,从而破坏生理循环。此外,在其他类型的癌症中,铁蛋白水平升高,这表明它有可能成为诊断和治疗的靶点。因此,了解铁蛋白和铁代谢在白血病和其他疾病中的作用,对于制定有效的治疗策略以提高患者的预后至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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