癌症雌、孕激素受体表达与预后参数的相关性

IF 1.1 Q4 IMMUNOLOGY
Shahnaz Eskandari, A. Baradaran, Sarah Ghorbani, Parisa Masoumzade
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引用次数: 0

摘要

引言:孕激素和雌激素受体(PR和ER)的表达被认为是最古老的生物标志物。这些标志物的表现可以指导癌症患者的治疗,因为它们在激素治疗反应性和预后方面的预测价值。目的:本研究探讨了雌激素和PR表达与癌症预后参数(包括年龄、分级、分期、肿瘤大小和淋巴结转移)的相关性。患者和方法:这项横断面研究包括245例乳腺肿瘤。病例档案中记录了患者的特征,包括年龄、ER和PR生物标志物的状态、肿瘤类型、癌症的病理特征和分期。因此,采用SPSS 27版软件进行数据分析。使用Spearman相关性、Mann-Whitney U和卡方检验对收集的数据进行分析。P值<0.05被认为具有统计学意义。结果:ER和PR的高表达率(>50%)分别为56.7%和40.4%。大多数患者的肿瘤属于2级(56.3%)和IIA、IIB和IIIA分期。我们发现ER表达、乳腺癌症分级和患者年龄之间存在显著相关性。PR表达与乳腺癌症的分期、分级、大小和淋巴结转移显著相关。结论:ER和PR的表达可确定肿瘤的临床病理参数,有助于癌症的更好治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The correlation of estrogen and progesterone receptor expression with prognostic parameters in women with breast cancer
Introduction: Progesterone and estrogen receptor (PR and ER) expression are considered the oldest biomarkers. The presentation of these markers can guide the treatment in breast cancer patients because of their predictive value in hormonal therapy responsiveness and prognosis. Objectives: This study investigated the correlation between estrogen and PR expression with prognostic parameters of breast cancer, including age, grading, staging, tumor size, and lymph node spread. Patients and Methods: This cross-sectional study included 245 cases of breast tumors. Characteristics of patients, including age, the status of ER and PR biomarkers, tumor type, pathological features of cancer, and staging, were documented from case files. Accordingly, SPSS version 27 software was conducted for data analysis. The collected data were analyzed using the Spearman’s correlation, Mann-Whitney U and chi-squared tests. A P value < 0.05 is considered statistically significant. Results: High ER and PR expression (>50%) were found in 56.7% and 40.4% of cases, respectively. Most of the tumors in patients belonged to grade 2 (56.3%) and staging IIA, IIB, and IIIA. We found a significant correlation between ER expression, breast cancer grading, and patients’ age. PR expression was significantly associated with breast cancer staging, grading, size, and lymph node spread. Conclusion: These results highlight the value of ER and PR expression as they can determine the clinicopathological parameters of the tumor, which can be helpful for better-managing breast cancer.
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CiteScore
1.70
自引率
0.00%
发文量
65
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3 weeks
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