Indian Journal of Pharmaceutical Education and Research最新文献_第8页

Role of Stem Cells in the Management of Type-I Diabetes Mellitus 干细胞在1型糖尿病治疗中的作用

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.116

Arjun Arjun HR, Praveen Halagali, Y Mohammed Tausi, Paramakrishnan N Paramakrishnan, Rakshith UR Rakshith

{"title":"Role of Stem Cells in the Management of Type-I Diabetes Mellitus","authors":"Arjun Arjun HR, Praveen Halagali, Y Mohammed Tausi, Paramakrishnan N Paramakrishnan, Rakshith UR Rakshith","doi":"10.5530/ijper.57.4.116","DOIUrl":"https://doi.org/10.5530/ijper.57.4.116","url":null,"abstract":"Abstract: The paper aims to accent Type-1 DM along with its etiology, pathophysiology, and treatment in this review. Diabetes is considered the chronic ailment of hypoglycemia ensuing from the duo of the dearth of insulin action and secretion of insulin considered as both. Moreover, Type-1 is a result of autoimmune of the cells of islets of the pancreas. The confrontation to the insulin or secretion of insulin lacking due to changes in living standards, habit change, dearth of exercise along with aging also, but one of the most relevant and prevalent reasons is a lifestyle change and also change in food habits along with the stress of the day-to-day life. Stem cell therapy is an expensive treatment and obtaining stem cells also is difficult due to ethical issues and availability is also less. Presently accessible ailment for type-1 is insulin supply therapy but it is also associated with many hitches. Advanced replacements like islets have demonstrated fruitful results in reinstating glucose levels. Moreover, in severe type 1-DMM and it has been delimited due to its high cost, not economic process, shortfall of donors, etc. Replacement of beta-like cells that are obtained from differentiation of human Pluripotent Stem Cells (hPSCs) also exhibited results with flying colors and gained the spotlight, but in stem cell therapy getting beta cells along with complete insulin secretion is decisive. Keywords: Diabetes Mellitus, Stem cells, Hyperglycemia.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganisms 可持续抗微生物纳米材料:一种治疗多种耐药微生物的有前途的方法

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.115

Neha S Raut, Ram Musle, Monika Raut, Rakesh M Kanchhul, Ekant S Taywade, Milind J Umekar

{"title":"Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganisms","authors":"Neha S Raut, Ram Musle, Monika Raut, Rakesh M Kanchhul, Ekant S Taywade, Milind J Umekar","doi":"10.5530/ijper.57.4.115","DOIUrl":"https://doi.org/10.5530/ijper.57.4.115","url":null,"abstract":"Abstract: Antibacterial drugs had an essential role in the treatment of various diseases from a long-time whereas excess use leads to resistance and toxicity which is a great challenge in the health sector. The most important factors responsible for the spread of antibiotic resistance includes globalization, self-medication, repetitive and excess use of antimicrobials, continuous intake of broad-spectrum agents, and less availability of an effective antimicrobial agents. The increased resistance of antibiotic towards many microorganisms threatens further use in the treatment or the increased dose may lead to toxicity. It is also estimated and found that if no new antibiotics or antibacterial drugs discovered in the current situation then there is an urgent need to identify and develop an alternative effective method for the treatment of antibiotic resistant. Green synthesized nanoparticles are most effective, eco-friendly, and efficient on resistant microorganisms. Therefore, the present review is to summarise the mechanisms, classifications, limitations, and applications, of various nanotherapeutics nano formulations as a promising and effective treatment for the repetitive development of antibiotic resistance by different strains of bacteria. Keywords: Nanomaterial, Antibiotic resistant, Microorganism, Metal, Antibacterial, Chemotherapy.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative Action of Woodfordia fruticosa Leaves Containing Woodfruticosin on Biological Redox Imbalance and Anemia in CFA–Induced Arthritic Rats 含木果苷的木果叶对慢性关节炎大鼠生物氧化还原失衡和贫血的缓解作用

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.131

Ashish Singhai, Yusra Ahmad, Umesh Kumar Patil

{"title":"Palliative Action of Woodfordia fruticosa Leaves Containing Woodfruticosin on Biological Redox Imbalance and Anemia in CFA–Induced Arthritic Rats","authors":"Ashish Singhai, Yusra Ahmad, Umesh Kumar Patil","doi":"10.5530/ijper.57.4.131","DOIUrl":"https://doi.org/10.5530/ijper.57.4.131","url":null,"abstract":"Abstract: Background: Rheumatoid Arthritis (RA) is a chronic disorder affecting musculoskeletal and autoimmune system with inflammatory characteristics. Anemia is most prevailing, among other extra-articular complications in RA. These complications are analogous to exorbitant inflammation and biological redox imbalance which ultimately affects the quality life and life expectancy of RA patients. Objectives: The study was planned to investigate the palliative action of Woodfordia fruticosa (WF) leaf extracts and isolation from active fraction, on articular/ extra-articular complications in rats with Complete Freund’s Adjuvant (CFA) induced arthritis. Materials and Methods: The action of Petroleum ether (WFP) and Ethanolic (WFE) extracts of WF was assessed in CFA induced adult Lewis rats (180-200gm) arthritic rats. In prophylactic treatment they received WF extracts 100mg/kg p.o. for 28 successive days and therapeutic treatment from the 14th day of CFA injection. Active extract was then fractionated by solvent-solvent extraction and chromatographic techniques. The isolated compound was characterized by TLC and various spectroscopic studies. Results: WFP significantly alleviated the severity of arthritis in animals than WFE in 28 days. Remarkable reduction (p< 0.001) in various complications was observed including paw volume (85.42%), loss in body weight, erythrocyte sedimentation rate, anemia, locomotor activity, and lipid peroxidation of hepatic/ synovial tissues and increment in SOD (U/mg) activities. A compound was isolated and characterized by UV, TLC, FTIR, LCMS and NMR spectroscopic techniques. Conclusion: WFP at 100mg/kg was advantageous in the superintendence of RA intricacies which was also confirmed by the histological and radiological studies. And a tannin compound Woodfruticosin was isolated. Keywords: Rheumatoid arthritis, Chromatography, Isolation, Spectroscopy, Woodfruticosin","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucoadhesive Chitosan-Coated PLGA Nanoparticles of Ashwagandha Extract for Colon-Targeted Delivery 黏附壳聚糖包被的印度人参提取物的PLGA纳米颗粒结肠靶向递送

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.119

Abhilash Megaravalli Manjunath, Sneh Priya, Divya Jyothi

{"title":"Mucoadhesive Chitosan-Coated PLGA Nanoparticles of Ashwagandha Extract for Colon-Targeted Delivery","authors":"Abhilash Megaravalli Manjunath, Sneh Priya, Divya Jyothi","doi":"10.5530/ijper.57.4.119","DOIUrl":"https://doi.org/10.5530/ijper.57.4.119","url":null,"abstract":"Abstract: Aim/Background: Withania somnifera (Ashwagandha) belongs to the Solanaceae family, well known for its phyto-pharmacological properties such as anti-inflammatory, antioxidant, anti-stress, immunomodulatory, and anticancer properties. The study aimed to formulate and evaluate chitosan-coated PLGA nanoparticles of ashwagandha extract. The nanoparticle formulation technique was considered in order to rectify the various constraints associated with ashwagandhas, such as intestinal absorption, burst release of the drug, and bioavailability issues. Materials and Methods: The CS-PLGA NPs were prepared by single-emulsion solvent evaporation method and it was optimized by using the Box-Behnken design in Design-Expert Software to determine the influence of independent variables PLGA, chitosan concentration and sonication time on particle size. PDI and entrapment efficiency. Results: The particle size, PDI, and zeta potential of the optimized formulation were found to be 187.1nm, 0.148, and 31.3mV. Optical microscopy and SEM suggest that the particles were smooth, spherical, and uniform in size. The entrapment efficiency of the optimized formulation was found to be 84.28%. In vitro drug release study suggests that the enteric coating of the CS-PLGA NPs formulation prevented the drug release in SGF and showed sustained drug release than pure ashwagandha and the drug release kinetics followed the Korsmeyer-Peppas model. Furthermore, the CS-PLGA NPs were evaluated for in vitro antioxidant activity over DPPH, and in vitro cytotoxicity assay over CaCo-2 cell lines. The results showed enhanced antioxidant activity than pure ashwagandha and better cytotoxicity over CaCO-2 cells. Conclusion: The studies concluded that CS-PLGA NPs showed sustained drug release for a prolonged period. The formulation showed good antioxidant activity and better efficacy in cancer cells. Keywords: Ashwagandha, Nanoparticles, Chitosan, PLGA, Anti-cancer activity.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Sinapic Acid on STZ-induced Depression in Diabetic Wistar Rats 辛酸对stz诱导的糖尿病大鼠抑郁的影响

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.133

Shubhangi Pawar, Sheetal Shinde, Ekta Khapare, Rishikesh Bacchav

{"title":"Evaluation of Sinapic Acid on STZ-induced Depression in Diabetic Wistar Rats","authors":"Shubhangi Pawar, Sheetal Shinde, Ekta Khapare, Rishikesh Bacchav","doi":"10.5530/ijper.57.4.133","DOIUrl":"https://doi.org/10.5530/ijper.57.4.133","url":null,"abstract":"Abstract: Objectives: Presently, diabetes is a major chronic metabolic abnormality characterized by sustained hyperglycemia. Diabetic neuropathy, encephalopathy, diabetes induced anxiety, depression is common life-threatening complications in which hyperglycemia mediated oxidative stress plays major role in pathogenesis. Sinapic acid is a phenolic acid, reported with anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anxiolytic activity and also it is proven to be neuroprotective in diabetic neuropathy. Materials and Methods: This study was designed to evaluate anti-depressant activity of Sinapic acid on STZ induced diabetic Wistar rats. Animals were divided into six groups (n=6). Diabetes was induced by single dose of STZ injection 55 mg/kg i.p. and sinapic acid was administered orally (5, 10, 20 mg/kg) after confirmation of hyperglycemia for next 4 weeks. Behavioural parameters like tail suspension test and forced swim test, antioxidant enzymes (SOD, GSH), oxidative stress (NO, MDA), total protein level were estimated and morphology of brain was examined histopathologically. Results: The results suggested that sinapic acid have decreased duration and percent of immobility, oxidative stress and increased antioxidant enzymes and total protein level. Morphological damage and neuronal degeneration in brain tissue was normalised by Sinapic acid. Conclusion: Thus, Sinapic acid shows antidepressant activity in diabetes induced depression. Keywords: Sinapicacid, STZ, Diabetes, Depression.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Anti-inflammatory Effects of Polysaccharide Derived from Plantago ovata Husk on Trinitro Benzenesulfonic Acid-induced Ulcerative Colitis in Mice 车前子壳多糖对三硝基苯磺酸致小鼠溃疡性结肠炎的抗炎作用

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.137

Jiangtao Hu, Siying Wang

{"title":"Evaluation of Anti-inflammatory Effects of Polysaccharide Derived from Plantago ovata Husk on Trinitro Benzenesulfonic Acid-induced Ulcerative Colitis in Mice","authors":"Jiangtao Hu, Siying Wang","doi":"10.5530/ijper.57.4.137","DOIUrl":"https://doi.org/10.5530/ijper.57.4.137","url":null,"abstract":"Abstract: Background: Ulcerative colitis, an idiopathic, chronic inflammatory illness of the intestinal mucosa is primarily fuelled by inflammation and oxidative stress. Aim: The present study aimed to investigate the anti-inflammatory and antioxidant effects of Plantago ovata husk in mice with Trinitro Benzenesulfonic Acid (TNBS)-induced Ulcerative Colitis (UC). Materials and Methods: BALB/c mice were exposed to TNBS intrarectally, causing ulcerative colitis. All mice received diet supplemented with Plantago ovata husk polysaccharide for 6 days, and their clinical symptoms were identified and evaluated. Following sacrifice, analyses of macroscopic and microscopic damage, intestinal oxidative stress levels, and antioxidant enzyme levels were performed. The colon's histological characteristics were also examined. Results: In comparison to the induced group, the highest dose significantly reduced the ulcer index, the histopathologic damage, and levels of NO, LPO, and MPO in tissues. Furthermore, SOD and GSH levels were increased restoring the balance of oxidants in colonic mucosa. The healing of injured tissues was also evident from the histology analysis. Conclusion: In higher doses, P. ovata husk extract significantly lowers mucosal damage and inflammation in mice with UC. P. ovata husk extract showed moderate protective effects and can be beneficial in treating Ulcerative colitis. Keywords: Plantago ovata, Polysaccharide, Ulcerative colitis, TNBS, Inflammation.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Potential Drug Candidates against Plasmodium falciparum (Isolate 3D7) through Targeting ADP-dependent DNA Helicase RecQ: An in silico Approach 利用adp依赖性DNA解旋酶RecQ定位恶性疟原虫(分离物3D7)的潜在候选药物:一种计算机方法

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.124

Marya Ahsan, Ayaz Khurram Mallick

{"title":"Identifying Potential Drug Candidates against Plasmodium falciparum (Isolate 3D7) through Targeting ADP-dependent DNA Helicase RecQ: An in silico Approach","authors":"Marya Ahsan, Ayaz Khurram Mallick","doi":"10.5530/ijper.57.4.124","DOIUrl":"https://doi.org/10.5530/ijper.57.4.124","url":null,"abstract":"Abstract: Background: The malarial scenario has significantly varied in the past few decades; whether it is funding or the range of sophisticated life-saving tools that have been improved, the disease burden has reduced, and even a few nations are on the verge of their elimination. Despite these, drug resistance is the major hurdle in the fight against malaria. Aim: Identifying new drug candidates with negligible toxicity are imperative to overcome the existing problem. The proposed study aims to identify new potential lead molecules via targeting the ADP-dependent DNA helicase RecQ of Plasmodium falciparum (isolate 3D7) using Target-Based Virtual Screening (TBVS), molecular docking, and dynamics simulations. Materials and Methods: Ligand molecules were retrieved from a comprehensive digital library of the MCULE database having millions of investigational compounds. Pfizer’s rule of five and the number of halogen atoms (3-5) were considered the basic primary filters of TBVS. The AutoDockVina (ADV) and GROningenMAchine for Chemical Simulations software were used to assess the molecular interactions and stability of protein-ligand complexes, respectively. Results: The primary filters of the TBVS work-pipeline depicted 2,597,040 chemical hits from over a hundred million small molecules. The toxicity tool sifted twenty-one molecules whose HIA and BBB permeation were evaluated through the Egan-Egg model. Five ligand hits were shortlisted with zero violation of drug-likeness and contain three or more hydrogen bonds. ADME, docking, and MD parameters depicted a molecule MCULE-1255186442-0-1 as a promising drug candidate. Conclusion: Druggable properties of identified ligands are inferred purely from the in silico experiments, so before its therapeutic implications, wet-lab validations are imperative. Keywords: Malaria, Plasmodium falciparum, DNA helicase, PfWrn, Docking, MD simulation.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Pluronic F-127 Assisted Carboplatin Cubosomes Pluronic F-127辅助卡铂立方体体的制备及评价

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.150

Jawaher Abdullah Alamoudi, Yosif Almoshari, Hadil Faris Alotaibi

{"title":"Formulation and Evaluation of Pluronic F-127 Assisted Carboplatin Cubosomes","authors":"Jawaher Abdullah Alamoudi, Yosif Almoshari, Hadil Faris Alotaibi","doi":"10.5530/ijper.57.4.150","DOIUrl":"https://doi.org/10.5530/ijper.57.4.150","url":null,"abstract":"Abstract: Objectives: The objective of this study was to prepare carboplatin-loaded cubosomes using high sheer homogenization technique. Materials and Methods: The cubosomes were prepared using Glyceryl Monooleate (GMO) as a lipophilic carrier along with pluronic F-127 (PF-127) and tween 80 as additive of the formulation. All the ingredients were subjected to chemical compatibility studies by Fourier Transform Infra-Red (FTIR) spectroscopy, thermal analysis using Differential Scanning Calorimetry (DSC), whereas X-ray Diffraction (XRD) studies were performed to evaluate the nature of drug in pure form as well as in formulation. The prepared cubosomes were characterized for their size and surface charge, surface morphology, drug release studies and drug permeation studies. Results: FTIR has confirmed the chemical compatibilities of the ingredients, while DSC has exhibited the thermal stabilities of the drug in alone as well as in cubosomes. The XRD has reviled that drug was crystalline, but upon incorporation in cubosmes, the crystallinity has reduced remarkably. The prepared cubosomes were of nanosized (diameter of 227 nm) and cubical in shape. The in vitro drug release and drug permeation studies have showed that concentration of both GMO and PF-127 has effected the release as well as permeation of the drug. However, in 3 hr studies the maximum amount of drug release was ~84% and that of permeation was ~74%. Conclusion: Conclusively, the selected composition of the formulation was suitable enough to prepare the nanosized cubosomes showing suitable entrapment efficiency of the drug.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"186 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Application of the Blended Teaching Mode in the Curriculum of Pharmacokinetics 药物动力学课程混合式教学模式的设计与应用

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.141

Zhongbing Liu, Shuzao Wang, Yan Lin, Meiling Zhou, Pei Jing, Zhirong Zhong

{"title":"Design and Application of the Blended Teaching Mode in the Curriculum of Pharmacokinetics","authors":"Zhongbing Liu, Shuzao Wang, Yan Lin, Meiling Zhou, Pei Jing, Zhirong Zhong","doi":"10.5530/ijper.57.4.141","DOIUrl":"https://doi.org/10.5530/ijper.57.4.141","url":null,"abstract":"Abstract: Introduction: Pharmacokinetics is one of the main courses of pharmacy majors in medical colleges and universities. The course is highly practical involving multidisciplinary collaboration, with strong logical reasoning and complex calculations. But the widespread traditional teaching methods resulted in poor practical application ability, self-learning ability, and problem-solving ability of students. Objectives: To enhance the students' knowledge and problem-solving ability, we focused on the curriculum reform of pharmacokinetics. Materials and Methods: It was based on the online and offline mixed teaching mode including revising the training program and syllabus, reconstructing the teaching staff, constructing online courses, designing class teaching, and careful teaching implementation, and construction of evaluation system. Finally, questionnaire survey was conducted to evaluate the implementation effect about the \"online + offline\" hybrid teaching mode. Results: It showed that the mixed online and offline teaching mode can help to solve the problem of difficulty in both teaching and learning the pharmacodynamics course. It changed the students' rigid learning methods that are not conducive to the cultivation of applied high-quality pharmaceutical talents. Moreover, this teaching reform enhanced the students' problem-solving ability. It achieved the course goals of cultivating students to be competent in medication guidance, drug quality control, and supervision positions, and to have the basic ideas and abilities to innovatively research and solve drug quality problems. Conclusion: This blended teaching mode may be an effective alternative to conventional approaches in pharmaceutical education. Keywords: Curriculum, Blended teaching mode, Pharmacokinetics, Pharmaceutical students.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Citrollenol Abrogates Neuroinflammatory Pathway Regulated via Induction of NF-kB in AlCl3 Induced Alzheimer’s Disease – Molecular Approach Citrollenol在AlCl3诱导的阿尔茨海默病中通过诱导NF-kB调节的神经炎症通路-分子方法

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.127

Xiaoli Zhou, Hesham S Almoallim, Balasubramani Ravindran, Rui Qin

{"title":"Citrollenol Abrogates Neuroinflammatory Pathway Regulated via Induction of NF-kB in AlCl3 Induced Alzheimer’s Disease – Molecular Approach","authors":"Xiaoli Zhou, Hesham S Almoallim, Balasubramani Ravindran, Rui Qin","doi":"10.5530/ijper.57.4.127","DOIUrl":"https://doi.org/10.5530/ijper.57.4.127","url":null,"abstract":"Abstract: Background: Alzheimer's Disease (AD), a neurodegenerative disorder characterized by dementia, is linked to ROS-induced stress, neuroinflammation, and gut microbiota imbalance. Objectives: The antioxidant and anti-inflammatory properties of citrollenol have already been reported. The current research was aimed at discovering the salutary properties of citrollenol against Aluminum Chloride (AlCl3 )-induced AD in rats. Materials and Methods: The AlCl3 was used to induce the AD in rats and then treated with citrollenol (25 and 50 mg/kg/bw). The behavioral tests were conducted on both control and treated rats. The levels of antioxidants and acetylcholine esterase were assessed using kits. The histopathological and immunohistochemical analyses were performed on the brain tissues. Results: The findings revealed that the AlCl3 -induced group had a loss of memory capability as well as an increase in the production of proinflammatory and neurodegenerative disorder-related AD proteins; otherwise, these characteristics were contrasted in the citrollenol-treated groups. Citrollenol-induced rats showed higher production of antioxidant enzyme levels and lower MDA status. Additionally, citrollenol abrogates proinflammatory mediator expression by suppressing NF-κB signaling and regulating microglial activation. Conclusion: Citrollenol can drawnback the AD brain tissue appearance of pathology study by leaking dysfunction in memory, learning capability, production of higher antioxidant enzymes levels, changing immunomodulatory cytokines levels in AlCl3 induced rats, exhibiting that AD pathogenesis may be represented by treatment with citrollenol via the neurodegenerative disorder causes from AD. Keywords: Alzheimer’s, AlCl3 , NF-kB, Malonaldehyde, Citrollenol, Neuroinflammation","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0