Indian Journal of Pharmaceutical Education and Research最新文献_第10页

The Formation Analysis of Ca (II), Mg (II), Zn (II) and 5-Hydroxysalicylic Acid Binary Complexes in Cetyltrimethylammonium Bromide Cationic Micelles 十六烷基三甲基溴化铵阳离子胶束中Ca (II)、Mg (II)、Zn (II)和5-羟基水杨酸二元配合物的形成分析

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.83

M. Ramanaiah, M. Balakrishna, R. Neeraja, Sattaru Gouthamsri, P. Seetharam

引用次数: 1

Implementation of Analytical Quality by Design Methodology to Develop a UV Spectrometric Technique for Arteether Quantification 用设计方法实现分析质量——建立一种紫外光光谱法测定乙醚含量的方法

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.91

Neha Bajwa, Pallavi Saroch, Ashish Baldi

{"title":"Implementation of Analytical Quality by Design Methodology to Develop a UV Spectrometric Technique for Arteether Quantification","authors":"Neha Bajwa, Pallavi Saroch, Ashish Baldi","doi":"10.5530/ijper.57.3s.91","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.91","url":null,"abstract":"Aim/Background: Analytical Quality by Design refers to applying the Quality by Design idea to the development of analytical procedures. The present study emphasizes the AQbD concept of developing and validating a spectrophotometric technique for detecting α, β-arteether per the ICH Q8 ( R 2 ) requirements for the first time. Materials and Methods: Sample preparation, sample pH, and wavelength were all integrated into the Ishikawa diagram, and essential parameters were obtained. The ratio of ethanolic PBS 6.8 and HCl was taken as factors. At the same time, the drug molecule's absorbance was identified as a critical factor that was further analyzed using a simple mixture design of experiments methodology for method robustness and optimization. The novel, durable, precise, and accurate UV-spectrophotometric method, α, β-arteether, was developed using the Quality by Design principle. By adjusting the HCl concentration (for acid degradation) and ethanolic PBS 6.8, the highest absorption of α, β-arteether was achieved by heating at 50°C for 30 min. Results and Discussion: The percent RSD less than 2, R 2 > 0.99 was recorded for the concentration range of 2–20 μg/mL at λ max 254 nm. The developed method's LOD and LOQ were within acceptable limits. The presented approach might be used at the industrial level as a rapid, precise, accurate, and cost-effective quality control method for a frequent and simultaneous estimate of α, β-arteether.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41908235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Nanoemulsion of the Phenolic Content of Foeniculum vulgare for Antidepressant and Antihypertensive Potentiality 小茴香酚含量纳米乳抗抑郁降压作用的制备及评价

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.75

Sanjita Das, S. Rani

{"title":"Formulation and Evaluation of Nanoemulsion of the Phenolic Content of Foeniculum vulgare for Antidepressant and Antihypertensive Potentiality","authors":"Sanjita Das, S. Rani","doi":"10.5530/ijper.57.3s.75","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.75","url":null,"abstract":"Objectives: Foeniculum vulgare (common name: fennel; family: Umbelifereae) is a well-documented plant with various medicinal properties to manage different types of disease. Depression and hypertension are associated with each other. The study focuses mainly on the evaluation of the antidepressant and antihypertensive effect of the nanoemulsion formulations of the phenolic content of the arial part of Foeniculum vulgare . Materials and Methods: The nanoemulsion formulation (1% and 2% W/V) formulation was formulated and subjected to in vivo screening of its antidepressant activity following forced swim and tail suspension tests in mice, while its antihypertensive effect using salt induces hypertension in wistar rats with BIOPAC power lab. Results: The study measured a significant ( p <0.01) reduction ( p <0.01) by Nanoemulsion of Foeniculum vulgare (NFV) in immobility times in mice, which was well comparable to imipramine (15 mg/kg) and so significant ( p <0.01) normalization ( p <0.01) of increased blood pressure. It was further interpreted significant ( p <0.01) increase in the brain level of dopamine and serotonin exhibiting major mechanism behind the antidepressant and antihypertensive potentiality of Foeniculum vulgare . Conclusion: The study suggested the implementation of the use of NFV in the overall treatment of hypertension associated with depression and vice versa.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46734625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiparticulate Floating Beads an Aid to Enhance Therapeutic Efficacy of Rabeprazole 多关节漂浮珠辅助提高雷贝拉唑疗效

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.62

Prajakta Magdhut, P. Dandagi, Umashri A Kokatanur, A. Patil

{"title":"Multiparticulate Floating Beads an Aid to Enhance Therapeutic Efficacy of Rabeprazole","authors":"Prajakta Magdhut, P. Dandagi, Umashri A Kokatanur, A. Patil","doi":"10.5530/ijper.57.3s.62","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.62","url":null,"abstract":"Background: Rabeprazole sodium is a newer generation anti-ulcer drug with short half-life and low bioavailability. Present research work is an attempt to design novel floating beads of Rabeprazole sodium in multiparticulate dosage form to increase residence time and modulate its release behavior for stomach-specific delivery. Materials and Methods: In this present study, Rabeprazole sodium beads were formulated by ionotropic gelation method and effect of variation in sodium alginate and gellan gum concentrations alone and in combination on release properties was examined. Results: Formulated beads were analyzed for particle size, density, entrapment efficiency, swelling index, in vitro buoyancy properties, surface topography, in vitro drug release and release kinetics study. The percentage content and entrapment efficiency of Rabeprazole sodium in beads ranged from 77.06±3.612 to 92.88±5.723 and 57±1.543 to 89±1.089 respectively. In vitro drug release of Rabeprazole sodium from the beads at the end of 12 hr ranged from 69.373% to 97.0142%. The release behavior was best fitted in Korsemeyer-Peppas equation. F9 was optimized depending on entrapment efficiency, in vitro buoyancy properties and in vitro drug release. Modified formulation F9 was also subjected to a series of tests. mucoadhesive study , in vivo X-ray imaging in rabbits and stability study. Conclusion: These studies revealed that beads exihibited 84% mucoadhesion, floating up to 12 hr as well as stability at 25±2°C. Hence Floating bead formulation of Rabeprazole sodium will be a promising drug delivery system to improve drug residence time and patient compliance.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45358021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoemulgel Formulation of Tetrahydrocurcumin with Efficient Anti-inflammatory Effect for the Treatment of Skin Disorders 具有高效抗炎作用的四氢香豆素纳米乳液制剂治疗皮肤疾病

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.61

K. Sharma

{"title":"Nanoemulgel Formulation of Tetrahydrocurcumin with Efficient Anti-inflammatory Effect for the Treatment of Skin Disorders","authors":"K. Sharma","doi":"10.5530/ijper.57.3s.61","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.61","url":null,"abstract":"Introduction: Tetrahydrocurcumin (THC) is a partially reduced white metabolite of curcumin which does not impart yellowish colour on skin due to which it seemed to be a promising topical agent compared to curcumin which discoloured the skin with long lasting visible mark. Objectives: The research work was intended to formulate THC loaded Nano Lipid-based (TNL) Carbopol Gum Gel (TNLCG) also called tetrahydro curcumin nanoemulgel and to investigate its therapeutic efficacy against inflammation using animal model. Materials and Methods: TNLCG was prepared based on pseudoternary phase-diagram with solubilizing capacity of tocopheryl acetate (10% w/w) and emulsifying combination of tween 80: polyethylene-glycol 400 (2:1 in 35% w/w) in 45% w/w aqueous phase with Carbopol 934 gel base. Selected formulations were evaluated for various parameters using in-house developed HPLC analytical method (at 280nm). Results: Nanoemulgel was found to be a stable formulation which significantly improved cellular absorbency with tocopheryl acetate with high concentration of THC for treating skin inflammation. Significant increase in the steady state flux (Jss) of 41µg/cm 2 /h, permeability coefficient (Kp) of 1.08 and Enhancement ratio (Er) of 3.7 were observed. The TNLCG demonstrated 77.36% in vitro drug release, significant skin permeability and optimal properties including spherical shape with 129nm nanosize, adequate zeta potential (-21.45mV), and PDI value of 0.18. Conclusion: This study revealed encouraging outcomes for TNLCG formulation as a novel tool for safe delivery of THC. According to the findings of the preceding research, it can be an effective therapeutic formulation which offers significant inflammation reducing activity with good moisturising quality.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42061341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different Innovative UV-spectroscopic Approaches for Simultaneous Assessment of Celecoxib and Tramadol Hydrochloride in Binary Mixture 同时评价塞来昔布和盐酸曲马多二元混合物的不同创新紫外光谱方法

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.89

A. Sen, Preksha Darji, D. Sen, A. Zanwar, C. Aundhia, R. Maheshwari

引用次数: 0

Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 32 Factorial Design 微波辅助壳聚糖球磨美多索密的制备及全32因子优化

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.64

Atul Shivaji Gurav, A. Kulkarni

{"title":"Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 32 Factorial Design","authors":"Atul Shivaji Gurav, A. Kulkarni","doi":"10.5530/ijper.57.3s.64","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.64","url":null,"abstract":"Introduction: The anti-hypertensive drug Olmesartan Medoxomil (OLM), a BCS II drug, works by inhibiting the action of angiotensin II on AT1 receptors. Objectives: The purpose of the study was to enhance solubility and stability by altering crystalline form, which reduces cost and dose burden of the pharmaceutical industry. In the current study, OLM formulation was prepared by using a full 3 level 2 factorial design with chitosan and neusiline as independent factors. Materials and Methods: Chitosan, a hydrophilic and stabilizing polymer, was used to enhance solubility and stability with the help of neusiline as a surfactant. Formulation was prepare using microwave-assisted ball milled technology. Results and Discussion: In comparison to the pure drug, phase solubility study shows the ternary mixture's saturation solubility was around 12 times higher. Physical interaction between polymer and OLM was confirmed from the FTIR study, DSC graph, SEM surface morphological study and NMR study. The drug's altered crystalline form has been confirmed by XRD, which could alter its solubility and rate of dissolution. The optimized batch obtained from factorial design was used for electrically operated ball milling. This demonstrated a notable improvement in the solubility, stability, and dissolving rate. Conclusion: As a result, using chitosan with a microwave assisted ball milling process can be a novel breakthrough in enhancing the bioavailability of any BSC II medicines.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44801396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Functioning Investigation of Salvia hispanica Seed Mucilage as A Potential Sustained Release Carrier for Water Soluble Drug 鼠尾草种子粘液作为水溶性药物缓释载体的分离与功能研究

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.82

Dibya Sundar Panda, Madhusmruti Khandai

{"title":"Isolation and Functioning Investigation of Salvia hispanica Seed Mucilage as A Potential Sustained Release Carrier for Water Soluble Drug","authors":"Dibya Sundar Panda, Madhusmruti Khandai","doi":"10.5530/ijper.57.3s.82","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.82","url":null,"abstract":"Abstract: Background: Natural biopolymers or hydrogels that are biodegradable and safe from biological point of view along with their capability to retain active principle within their network thus prolonging the release. The present work was undertaken to explore the potential of mucilage from mature seeds of Chia (Salvia hispanica) to sustain the release of water-soluble drugs. Losartan potassium was used as a model to prepare the gelispheres. Materials and Methods: The mucilage was isolated and their physicochemical properties like viscosity, phytoconstituent, FTIR, hydration index were studied. Gelispheres loaded with active drug Losartan Potassium (LP) were prepared using sodium alginate, pectin and CSM in various ratios by polyelectrolyte complexation (Ionic Gelation) method. Micrometric properties, surface contour analysis, ex vivo mucoadhesion study, in vitro drug release study, compatibility, XRD, stability study, statistical analysis was carried out on the prepared gelispheres. Results: The isolated mucilage of mature Chia (Salvia hispanica) seeds possesses immense properties like viscosity modification capacity, consistency, excellent hydration and mucoadhesive nature that can be explored for developing active principal delivery devices. Conclusion: The developed drug loaded gelispheres exhibited good mucoadhesion which enabled sustaining the release of drug for prolonged duration advocating the use of mucilage to design a twice daily losartan potassium sustain release system for management of hypertension. Keywords: Chia seed mucilage, Gelisphere, Mucoadhesion, Losartan potassium, Ionic gelation.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnobotanical Study of Medicinal Plants Used Traditionally for Managing Cuts and Wounds by the Rural People of Kailashpur, Assam, India 印度阿萨姆邦Kailashpur农村人民传统上用于治疗割伤和伤口的药用植物的民族植物学研究

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.77

Pal Gogoi, Saikat Sen

{"title":"Ethnobotanical Study of Medicinal Plants Used Traditionally for Managing Cuts and Wounds by the Rural People of Kailashpur, Assam, India","authors":"Pal Gogoi, Saikat Sen","doi":"10.5530/ijper.57.3s.77","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.77","url":null,"abstract":"Abstract: Background: Folk medicinal knowledge of plants is vital in primary health care management system, predominantly in rural and remote areas. Managing cuts and wounds continues to be a significant healthcare issue, and it becomes even more critical when left untreated or improperly treated. The objective of this study is to carry out a survey on the use of medicinal plants for treating cuts and wounds in the village of Kailashpur in Assam. Materials and Methods: The information was collected through a semi-structured questionnaire from 30 informants in Kailashpur, Assam, India. Quantitative analysis of these data to find Use Value (UV), Frequency of Citation (FC), Relative Frequency of Citation (RFC), Family Use Value (FUV), Consensus Index (CI), Rehman's Similarity Index (RSI) and Jaccard Index (JI) also completed. Results: The present study documented 45 medicinal plant species belonging to 30 families and their mode of application. Compositae (5 species), Orchidaceae (4 species) and Leguminosae (3 species) were dominant families. Leaves were the most frequently used plant part (PPV 0.50). Curcuma longa and Ocimum tenuiflorum (UV 0.33) were the species most commonly used by the local people. Highest FC was calculated for Ageratum conyzoids (5.27), followed by Tagetes erecta (4.51). JI and RSI indicated that plant species reported in our study were more similar to the Tezpur region of Assam, India. Conclusion: The findings emphasize the significance of specific plant species in the treatment of cuts and wounds, and suggest that further scientific investigation can be pursued to discover potential therapeutics. Keywords: Ethnomedicinal survey, Kailashpur village, Medicinal plants, Cuts, Wounds.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats 异叶丁香在den诱导的白化Wistar大鼠肝细胞癌中促进抗氧化防御系统，调节糖酵解酶并保护膜完整性

IF 0.8 4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-08-23 DOI: 10.5530/ijper.57.3s.78

D. Kavitha, R. Padmini, M. Dhanaraju, C. Gopi, D. Thiyagarajan, Alekkhya Veeramaneni

{"title":"Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats","authors":"D. Kavitha, R. Padmini, M. Dhanaraju, C. Gopi, D. Thiyagarajan, Alekkhya Veeramaneni","doi":"10.5530/ijper.57.3s.78","DOIUrl":"https://doi.org/10.5530/ijper.57.3s.78","url":null,"abstract":"Background: Syringodium isoetifolium seagrass has bioactive constituents with potential pharmacological uses, but their use is limited owing to scarce scientific evidence. The in vivo anti-cancer activity of Syringodium isoetifolium against DEN-induced hepatocellular carcinoma in Wistar albino rats is described in this work for the first time. Materials and methods: Wistar albino rats were used as test subjects to examine the anti-cancer properties of Syringodium isoetifolium against DEN-induced hepatocellular carcinoma at the dose of 50 mg/kg body weight. The experimental rats were split into five groups (Group I-V). Except for group I, remaining all animals received DEN and Phenobarbitone during the experiment. Group I and Group II acted as normal and diseased control groups respectively. The extracts were administered to the satellite group III and IV orally with the dose of 250 and 500 mg/kg body weight respectively. 5 fluorouracil 20mg/ kg was administered to group V orally and considered as a standard. The total experimental period lasted for 14 weeks. Results: The findings show that Syringodium isoetifolium significantly reduces liver tumor volume, burden and numbers in experimental rats ( p <0.05) when compared to the control group. Besides, the extracts treated groups restored the pathological parameters close to normal values ( p <0.05). The histological analysis also showed that the extract-treated animals' livers had recovered their normal architecture. Conclusion: The study concludes that Syringodium isoetifolium inhibits the cancer growth in hepatocellular carcinoma by altering the antioxidant defense system, glycolysis and protecting the membrane architecture by inhibiting the elevated levels of haematological, biochemical parameters and biomarker values.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47477195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0