Indian Journal of Pharmaceutical Education and Research最新文献

{"title":"Topiramate Versus Acetazolamide for Idiopathic Intracranial Hypertension. A Real-World Data-Based Multicenter Retrospective Study.","authors":"Mahmoud Mohamed Morsy, Ahmed Yasser Azzam, Muhammed Amir Essibayi, Alsaleem Mohammed Abadi, Nasser Abdulmohsen Alsabaani, Safar Abadi Alsaleem, Waleed Abdulwahab Aldhabaan, Hana Jihad Abukhadijah, Mohamed Darwesh Morsy, Aayushi Aarav Garg, David Joseph Altschul","doi":"10.5530/ijper.20261194","DOIUrl":"10.5530/ijper.20261194","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic Intracranial Hypertension (IIH) is a condition marked by elevated intracranial pressure without mass lesions or hydrocephalus, primarily affecting young obese women. Acetazolamide has been the standard treatment, but its side effects often limit use. Topiramate, an anticonvulsant, has gained attention for its dual role as a carbonic anhydrase inhibitor and weight loss promoter. This study compares the efficacy and safety of topiramate versus acetazolamide in IIH management.</p><p><strong>Materials and methods: </strong>This international, multicenter retrospective study analyzed electronic health records of IIH patients from 2009 to 2024 across six countries. Propensity score matching balanced baseline characteristics between groups, with outcomes evaluated over 24 months. Primary endpoints included papilledema resolution, headache control, visual outcomes and the incidence of refractory IIH and surgical interventions.</p><p><strong>Results: </strong>In a cohort of 16,654 propensity-matched patients (8,327 per group), topiramate significantly reduced persistent papilledema at 24 months (16.8% vs. 28.8%; <i>p</i><0.0001) and improved headache control (61.2% vs. 71.3%; <i>p</i><0.0001). Fewer patients in the topiramate group developed refractory IIH or required surgical interventions, such as therapeutic spinal punctures and optic nerve sheath fenestration (<i>p</i><0.0001).</p><p><strong>Conclusion: </strong>Topiramate demonstrated superior efficacy compared to acetazolamide in resolving papilledema, controlling headaches and reducing the need for invasive procedures. It may represent a more effective first-line therapy for IIH. Further randomized trials are needed to validate these findings and optimize treatment protocols.</p>","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"60 2","pages":"614-629"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing of S100A16 in Cervical Cancer Cells Inhibits Cancer Cell Growth by Inducing Autophagy via PI3K/AKT/ mTOR Signaling Pathway","authors":"Haibin Zhang, Wenhu Xing, Yufeng Li, Xianyun Xu","doi":"10.5530/ijper.20251170","DOIUrl":"https://doi.org/10.5530/ijper.20251170","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"59 4","pages":"1534-1545"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer, Apoptotic, Cell Migration and Invasion Inhibition and in silico Molecular Docking Studies of Naringetol in A-549 Human Lung Cancer Cells","authors":"Jing Li, Beishou Wu, Xuejun Huang, Weizhong Tang","doi":"10.5530/ijper.20250091","DOIUrl":"https://doi.org/10.5530/ijper.20250091","url":null,"abstract":"Aims The main objective of this research work was to investigate the anticancer effects of Naringetol in A-549 human lung cancer cells along with evaluating its effects on cell apoptosis, cell migration and cell invasion and decoding the molecular mechanism of action by studying interactions of this molecule with the target protein using in silico molecular docking studies. Materials and Methods MTT assay was used to study effects on cell viability while as effects on cell colony was evaluated by clonogenic assay. Acridine orange/ethidium bromide, DAPI staining assays using fluorescence microscopy were used to study effects on cell apoptosis. Cell migration and cell invasion inhibition was evaluated by Transwell assay. AutoDoc Vina software used to carry out docking simulation studies using Naringetol and EGFR (epidermal growth factor receptor) protein. Results Results indicated that Naringetol induced dose and time-dependent inhibition of A-549 cancer cell viability along with inhibiting cell colony formation. Fluorescence microscopy revealed that naringetol molecule induced apoptosis like features in A-549 cells including nuclear and chromatin condensation and deformed cell membrane structures. Naringetol also led to a significant inhibition of cell migration and invasion hinting to its anti-metastatic potency. Molecular docking simulation studies indicated potential binding of naringetol with the key amino acid residues of the EGFR target protein with a binding score of -8.5 kcal/mole. Conclusion In conclusion, these results reveal that naringetol inhibits lung cancer cell proliferation through the induction of cell apoptosis and suppression of cell migration and cell invasion. The target protein involved might be the EGFR protein as revealed by in silico molecular docking simulation studies.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"59 1","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ijper.org/sites/default/files/IndJPhaEdRes-59-1-221.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lidocaine Alleviates Myocardial Ischemia-Reperfusion Injury in Rats through JNK Signaling Pathway","authors":"Jie Qi, Xiangkong Song, Qingdao Zhang, Qianqian Yang, Zhang Qingtan, Meiling Liu, Yuxia Gao","doi":"10.5530/ijper.20250322","DOIUrl":"https://doi.org/10.5530/ijper.20250322","url":null,"abstract":"Aim/Background This study aimed to explore the impact of lidocaine on rats subjected to MIR injury and to elucidate the underlying mechanisms involved in this process. The objective was to examine how lidocaine affects the physiological and biochemical responses in these rats, providing insights into its potential therapeutic benefits and the specific pathways through which it exerts its effects. Materials and Methods 30 Sprague-Dawley rats were randomly divided into three groups: a sham group (n=10), a reperfusion group (n=10), and a lidocaine group (n=10). The MIR model was established in both the reperfusion and lidocaine groups. Following reperfusion, various cardiac function indexes were measured. Additionally, serum levels of LDH and CK were determined, and the infarct size was assessed using chemical colorimetry. To evaluate the expressions of JNK and NF-κB, WB and RT-PCR were performed. Changes in myocardial cell morphology, cardiac mesenchyme, and myofilaments were observed via HE staining. Results Compared with reperfusion group, lidocaine group exhibited increased LVSP, FS and EF, decreased LVEDP, raised serum LDH and CK levels and reduced myocardial infarct size. According to the WB results, the expression of p-JNK protein declined, while that of NF-κB rose in lidocaine group in comparison with those in reperfusion group (p <0.05). Conclusion Lidocaine can regulate the JNK signaling pathway to alleviate the MIR injury in rats.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"59 1","pages":"400-406"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ijper.org/sites/default/files/IndJPhaEdRes-59-1-400.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-142-5p Suppresses Ovarian Cancer Metastasis by Inhibiting the Epithelial-Mesenchymal Transition via DNMT1","authors":"Qian Qiu, Yi Huan, Jianrong Song, Hui Zheng, Xiangqin Zheng","doi":"10.5530/ijper.20251283","DOIUrl":"https://doi.org/10.5530/ijper.20251283","url":null,"abstract":"Aim/Background Ovarian Cancer (OC) accounts for the highest number of deaths among gynecological cancers. Our research is focused on investigating the therapeutic potential and the fundamental mechanism by which miR-142-5p exerts its effects in the treatment of OC. Materials and Methods The GSE53829 and GSE83693 data sets were collected for targeted miRNA identification. RT-qPCR was conducted to evaluate the expression levels of miRNA, N-cadherin, ZO-1, Claudin-1, E-cadherin, and DNMT1 mRNA expressions. Additionally, the protein expressions of these mentioned molecules were quantified using western blot analysis. The invasion and migratory abilities of OC cells were assessed through transwell and wound healing assays. Additionally, the possible interaction between miR-142-5p and DNMT1 was identified and confirmed using the Targetscan database in conjunction with a luciferase assay. Results The mRNA levels of miR-142-5p showed a notable reduction in both OC cell lines and metastatic tumors, as compared to their counterparts of normal ovarian cancer cells and non-metastatic tumors, respectively. Besides, the inhibition or overexpression of miR-142-5p had a significant impact on the migration, invasion ability, and Epithelial-Mesenchymal Transition (EMT) process of OC cells. The levels of DNMT1 were significantly increased in metastatic tumors and were notably affected by the expression of miR-142-5p. Moreover, interaction between DNMT1 mRNA and miR-142-5p was confirmed, and the knockdown of DNMT1 effectively counteracted the significant reversal in OC cell migration, invasion, and EMT caused by miR-142-5p suppression. Conclusion The role of miR-142-5p on OC metastasis is attributed to its ability to suppress EMT through DNMT1, indicating the promising therapeutic potential of miR-142-5p in the treatment of OC.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"59 1","pages":"164-174"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ijper.org/sites/default/files/IndJPhaEdRes-59-1-164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing PDCD4 Mediates TFEB Overexpression Promoting Proliferation, Migration and Invasion of Cervical Cancer HeLa Cells","authors":"Xing Gao, Ziying Liang, Yanan Yuan, Wenbo Liu","doi":"10.5530/ijper.58.4.145","DOIUrl":"https://doi.org/10.5530/ijper.58.4.145","url":null,"abstract":"Aim/Background: Cervical cancer is a common gynecologic malignant tumor, its occurrence and development are related to genetic and environmental factors. Recent studies have shown that Programmed Cell Death 4 (PDCD4) and Transcription Factor EB (TFEB) plays crucial roles in the pathogenesis of cervical cancer. The interaction between PDCD4 and TFEB and their regulatory mechanism on cellular functions in cervical cancer have not been fully explored. Materials and Methods: Therefore, this study utilized the Hela cell line as a cervical cancer model to investigate the changes in TFEB expression levels and the proliferation, migration, invasion and EMT processes of cervical cancer cells through the silencing of PDCD4. Real-time quantitative PCR and Western blot were employed to assess the expression levels of PDCD4 and TFEB, while CCK-8, scratch assay, Transwell invasion assay and Western blot were used to evaluate changes in cell proliferation, migration, invasion capabilities and EMT processes. Results: The experimental results demonstrated that silencing PDCD4 significantly increased the expression level of TFEB. Simultaneously, silencing PDCD4 also significantly accelerated the proliferation rate of Hela cells, enhanced the cells’ migration, invasion capabilities and promoted the EMT processes. Further experimental results showed that silencing TFEB could partially reverse the promoting effects of PDCD4 silencing on cell proliferation, migration and invasion. In cervical cancer, silencing PDCD4 can lead to TFEB overexpression, thereby promoting the proliferation, migration and invasion of Hela cells. Conclusion: These findings provide crucial clues for the in-depth study of molecular mechanisms in cervical cancer and indicate that the PDCD4-TFEB pathway could potentially serve as a target for the treatment and prevention of this disease.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"58 4","pages":"1348-1355"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ijper.org/sites/default/files/IndJPhaEdRes-58-4-1348.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective","authors":"Suraj Mandal, Bhumika Km Bhumika, Mukesh Kumar, Jiyaul Hak, Prabhakar Vishvakarma, Umesh Kumar Sharma","doi":"10.5530/ijper.58.1.5","DOIUrl":"https://doi.org/10.5530/ijper.58.1.5","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"125 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomal Cosmeceuticals as Skin Protectives and Curatives","authors":"Kajal Barge, S. Tank, B. Parab, Mangal Nagarsenker, Supriya Shidhaye","doi":"10.5530/ijper.58.1.4","DOIUrl":"https://doi.org/10.5530/ijper.58.1.4","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"86 s1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Review","authors":"Kamran Ashraf, Nur Fatin Adlin, Aina Nabila Basri, Wasim Ahmad, Sadia Sultan","doi":"10.5530/ijper.58.1.1","DOIUrl":"https://doi.org/10.5530/ijper.58.1.1","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"95 S1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India","authors":"Abhirami Eby, Raman Dang, Elsa Jacob","doi":"10.5530/ijper.58.1.36","DOIUrl":"https://doi.org/10.5530/ijper.58.1.36","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"39 12","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}