Indian Journal of Pharmaceutical Education and Research最新文献

{"title":"Topiramate Versus Acetazolamide for Idiopathic Intracranial Hypertension. A Real-World Data-Based Multicenter Retrospective Study.","authors":"Mahmoud Mohamed Morsy, Ahmed Yasser Azzam, Muhammed Amir Essibayi, Alsaleem Mohammed Abadi, Nasser Abdulmohsen Alsabaani, Safar Abadi Alsaleem, Waleed Abdulwahab Aldhabaan, Hana Jihad Abukhadijah, Mohamed Darwesh Morsy, Aayushi Aarav Garg, David Joseph Altschul","doi":"10.5530/ijper.20261194","DOIUrl":"10.5530/ijper.20261194","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic Intracranial Hypertension (IIH) is a condition marked by elevated intracranial pressure without mass lesions or hydrocephalus, primarily affecting young obese women. Acetazolamide has been the standard treatment, but its side effects often limit use. Topiramate, an anticonvulsant, has gained attention for its dual role as a carbonic anhydrase inhibitor and weight loss promoter. This study compares the efficacy and safety of topiramate versus acetazolamide in IIH management.</p><p><strong>Materials and methods: </strong>This international, multicenter retrospective study analyzed electronic health records of IIH patients from 2009 to 2024 across six countries. Propensity score matching balanced baseline characteristics between groups, with outcomes evaluated over 24 months. Primary endpoints included papilledema resolution, headache control, visual outcomes and the incidence of refractory IIH and surgical interventions.</p><p><strong>Results: </strong>In a cohort of 16,654 propensity-matched patients (8,327 per group), topiramate significantly reduced persistent papilledema at 24 months (16.8% vs. 28.8%; <i>p</i><0.0001) and improved headache control (61.2% vs. 71.3%; <i>p</i><0.0001). Fewer patients in the topiramate group developed refractory IIH or required surgical interventions, such as therapeutic spinal punctures and optic nerve sheath fenestration (<i>p</i><0.0001).</p><p><strong>Conclusion: </strong>Topiramate demonstrated superior efficacy compared to acetazolamide in resolving papilledema, controlling headaches and reducing the need for invasive procedures. It may represent a more effective first-line therapy for IIH. Further randomized trials are needed to validate these findings and optimize treatment protocols.</p>","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"60 2","pages":"614-629"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective","authors":"Suraj Mandal, Bhumika Km Bhumika, Mukesh Kumar, Jiyaul Hak, Prabhakar Vishvakarma, Umesh Kumar Sharma","doi":"10.5530/ijper.58.1.5","DOIUrl":"https://doi.org/10.5530/ijper.58.1.5","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"125 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomal Cosmeceuticals as Skin Protectives and Curatives","authors":"Kajal Barge, S. Tank, B. Parab, Mangal Nagarsenker, Supriya Shidhaye","doi":"10.5530/ijper.58.1.4","DOIUrl":"https://doi.org/10.5530/ijper.58.1.4","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"86 s1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Review","authors":"Kamran Ashraf, Nur Fatin Adlin, Aina Nabila Basri, Wasim Ahmad, Sadia Sultan","doi":"10.5530/ijper.58.1.1","DOIUrl":"https://doi.org/10.5530/ijper.58.1.1","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"95 S1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India","authors":"Abhirami Eby, Raman Dang, Elsa Jacob","doi":"10.5530/ijper.58.1.36","DOIUrl":"https://doi.org/10.5530/ijper.58.1.36","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"39 12","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Knowledge, Attitude and Public Awareness about the Use of Antibiotics and Antibiotic Resistance in Albania","authors":"Eni Bushi, Zehadin Gashi, L. Malaj","doi":"10.5530/ijper.58.1.34","DOIUrl":"https://doi.org/10.5530/ijper.58.1.34","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"66 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway","authors":"Khalid M. Alharthy, Summya Rashid","doi":"10.5530/ijper.58.1.25","DOIUrl":"https://doi.org/10.5530/ijper.58.1.25","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"18 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Changes in Animal Models by Catheters Coated with Saudi Medicinal Herb Evolvulus alsinoides L. Extract in Urinary Tract Infections by Klebsiella pneumoniae","authors":"A. P. Mohideen, Mohammed H. Karrar Alsharif, Muhammad Musthafa Poyil","doi":"10.5530/ijper.58.1.24","DOIUrl":"https://doi.org/10.5530/ijper.58.1.24","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"73 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate","authors":"Varsha Bandil, J. K. Gupta, Manoj Kumar Goyal","doi":"10.5530/ijper.58.1.10","DOIUrl":"https://doi.org/10.5530/ijper.58.1.10","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"35 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silver Nanoparticles Incorporated Chitosan Hydrogel as a Potential Dressing Material for Diabetic Wound Healing in Nursing Care","authors":"Ying Zhao, Qinqin Sun","doi":"10.5530/ijper.58.1.14","DOIUrl":"https://doi.org/10.5530/ijper.58.1.14","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"103 S3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}