Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganisms

IF 0.8 4区医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI:10.5530/ijper.57.4.115

Neha S Raut, Ram Musle, Monika Raut, Rakesh M Kanchhul, Ekant S Taywade, Milind J Umekar

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引用次数: 0

Abstract

Abstract: Antibacterial drugs had an essential role in the treatment of various diseases from a long-time whereas excess use leads to resistance and toxicity which is a great challenge in the health sector. The most important factors responsible for the spread of antibiotic resistance includes globalization, self-medication, repetitive and excess use of antimicrobials, continuous intake of broad-spectrum agents, and less availability of an effective antimicrobial agents. The increased resistance of antibiotic towards many microorganisms threatens further use in the treatment or the increased dose may lead to toxicity. It is also estimated and found that if no new antibiotics or antibacterial drugs discovered in the current situation then there is an urgent need to identify and develop an alternative effective method for the treatment of antibiotic resistant. Green synthesized nanoparticles are most effective, eco-friendly, and efficient on resistant microorganisms. Therefore, the present review is to summarise the mechanisms, classifications, limitations, and applications, of various nanotherapeutics nano formulations as a promising and effective treatment for the repetitive development of antibiotic resistance by different strains of bacteria. Keywords: Nanomaterial, Antibiotic resistant, Microorganism, Metal, Antibacterial, Chemotherapy.

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可持续抗微生物纳米材料:一种治疗多种耐药微生物的有前途的方法

摘要:长期以来，抗菌药物在各种疾病的治疗中发挥着至关重要的作用，但过量使用导致耐药性和毒性是卫生领域面临的巨大挑战。造成抗生素耐药性蔓延的最重要因素包括全球化、自我用药、重复和过度使用抗微生物药物、持续服用广谱药物以及有效抗微生物药物的可得性不足。抗生素对许多微生物的耐药性增加威胁到治疗的进一步使用，或者增加剂量可能导致毒性。还估计和发现，如果在目前的情况下没有发现新的抗生素或抗菌药物，那么迫切需要确定和开发一种替代的有效方法来治疗抗生素耐药。绿色合成纳米颗粒对耐药微生物最有效、最环保、最高效。因此，本文综述了各种纳米治疗药物的机制、分类、局限性和应用，纳米制剂作为一种有希望和有效的治疗不同菌株抗生素耐药性重复发展的药物。关键词:纳米材料耐药微生物金属抗菌化疗

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来源期刊

Indian Journal of Pharmaceutical Education and Research 医学-学科教育

CiteScore

1.40

自引率

0.00%

发文量

227

审稿时长

>12 weeks

期刊介绍： The official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967. IJPER, a quarterly publication devoted to publish reviews and research articles in pharmacy and the related disciplines of Pharmaceutical education. It mainly covers the articles of special interest, covering the areas of Pharmaceutical research, teaching and learning, laboratory innovations, education technology, curriculum design, examination reforms, training and other related issues. It encourages debates and discussions on the issues of vital importance to Pharmaceutical education and research. The goal of the journal is to provide the quality publications and publish most important research and review articles in the field of drug development and pharmaceutical education. It is circulated and referred by more than 6000 teachers, 40,000 students and over 1000 professionals working in Pharmaceutical industries, Regulatory departments, hospitals etc.