Indian Journal of Dermatology最新文献

{"title":"Frontal Fibrosing Alopecia: A Comprehensive Review with Recent Updates.","authors":"Shikha Verma, Anita Marak, Debopriya Paul","doi":"10.4103/ijd.ijd_419_24","DOIUrl":"10.4103/ijd.ijd_419_24","url":null,"abstract":"<p><p>Frontal fibrosing alopecia (FFA) is a progressive scarring alopecia affecting postmenopausal women. FFA is a primary lymphocytic scarring alopecia and is considered a variant of LPP due to similar histopathology findings in both conditions. The exact etiopathogenesis of FFA is not known. However, some genetic, autoimmunity, hormonal and environmental factors are implicated. However, the loss of the immune privilege of hair follicles and the role of cosmetics and sunscreen have been postulated. The disease is characterised by frontal and temporoparietal hairline recession with shiny, atrophic skin with sideburn involvement. The common trichoscopic findings include perifollicular erythema, follicular hyperkeratosis and loss of follicular openings. The histopathology is characterised by lichenoid lymphocytic infiltrate around the upper part of the hair follicle including the bulge area and concentric perifollicular lamellar fibrosis. There are two diagnostic criteria proposed by Tolkachjov <i>et al</i>. and the International FFA Cooperative Group. Many topical and systemic treatment options are available, but none have shown satisfactory results. Recently, many biological agents have been tried including tofacitinib and tildrakizumab.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"115"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanotrichoblastoma Arising on Nevus Sebaceous: A Rare Occurence.","authors":"Apaopa J Thekho, Deepika Uikey, Shanta Passi, V Ramesh","doi":"10.4103/ijd.ijd_1197_23","DOIUrl":"10.4103/ijd.ijd_1197_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"105-106"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotropic Drugs in Dermatology. Part 2: Antipsychotics, Sedative-Hypnotics and Anxiolytics in Dermatology.","authors":"Ankita Choudhary, Shiti Bose, K L Varsha, Bhushan Madke","doi":"10.4103/ijd.ijd_916_23","DOIUrl":"10.4103/ijd.ijd_916_23","url":null,"abstract":"<p><p>Dermatology as a branch is a panoramic canvas with a spectrum of manifestation, and psychodermatology is one emerging paradigm in its epicentre. Traditionally, it was thought that psychiatrists deal with \"internal\" nonvisible disease, while dermatology centres around \"external\" visible dermatoses and cosmetic disfigurement, hence, with this belief, psychodermatology appeared as an oxymoron to many. Management of psychodermatological disorders requires a multidisciplinary approach, which includes a combination of psychopharmacology, psychotherapy and timely referral as and when needed. The commonly available psychotherapeutics at the disposal of dermatologists include antidepressants, mood stabilizers, antipsychotics, anxiolytics and sedative-hypnotics, the last three of which have been focused in this part of the review.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"82-88"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Epithelioid Schwannoma in a Young Female- A Dilemma Set by Morphology; Resolved by Immunohistochemistry-A Rare Case Report.","authors":"K Amita, T Rajani","doi":"10.4103/ijd.ijd_584_23","DOIUrl":"10.4103/ijd.ijd_584_23","url":null,"abstract":"<p><p>Epithelioid morphology spawns myriad of benign and malignant tumors into differential diagnoses, which include epithelioid sarcoma, malignant melanoma, epithelioid malignant peripheral nerves sheath tumor, epithelioid hemangioendothelioma, myoepithelioma, etc. Epithelioid schwannoma (ES), especially the atypical variant has not received much attention in literature. Conclusive diagnosis, important for accurate management is, however, challenging. We describe a case of atypical ES in a 24-year-old female. On clinical and radiological examination, a provisional diagnosis of vascular malformation was made. Atypical epithelioid ESs are rare, but it is important to be aware of this variant to avoid misdiagnosis with other malignant epithelioid tumors. Apart from clinical and morphological features, immunohistochemistry aids in arriving at a decisive diagnosis. Perineurium-like capsule, circumscription, oblong shape of the lesion, and hyalinized blood vessels are pointers toward shwannomatous differentiation of this tumor.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"97-101"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Systemic Oxidative Stress Modulation in Melasma Following Treatment with Yellow Light Laser 577 nm and Topical 0.3% 4N Butyl Resorcinol: A Comparative Prospective Study.","authors":"Neelam Khurana, Mohammad M Mehdi, Mohinder P S Sawhney, Sanjiv K Bansal","doi":"10.4103/ijd.ijd_11_24","DOIUrl":"10.4103/ijd.ijd_11_24","url":null,"abstract":"<p><strong>Background: </strong>Melasma is an acquired hyperpigmentation disorder of the skin. Recent studies suggest that oxidative stress may contribute to the pathogenesis of melasma. Upregulated levels of circulatory antioxidants in blood serum and vascular endothelial growth factors in melasma lesions have been observed. The prospective study was conducted to compare the effect of the treatment of melasma with and without the use of a 577 nm vascular laser on levels of enzymatic antioxidants.</p><p><strong>Aims and objectives: </strong>To compare the modulation in the levels of enzymatic antioxidants in melasma patients treated with 577 nm yellow light laser in combination with topical depigmenting serum as compared to those using depigmenting serum alone.</p><p><strong>Materials and methods: </strong>Sixty patients with melasma of both sexes were randomly divided into groups of 30 each. Group A patients were treated with yellow light laser 577 nm (wavelength) once every 4 weeks for 4 sittings and topical depigmenting serum (4n butyl resorcinol) daily for 24 weeks. Group B patients were treated only with topical depigmenting serum. Levels of total antioxidant capacity (TAC), superoxide dismutase (SOD), inducible nitric oxide synthase (iNOS), glutathione peroxidase (GPx) and malondialdehydes (MDA) were estimated at 0 and 24 weeks.</p><p><strong>Results: </strong>Mean difference in lowering of the antioxidant levels in Group A and B was SOD1 (0.73 versus 0.12), GPX1, (0.62 versus 0.30), iNOS (1.56 versus 0.52), MDA, (0.73 versus 0.38), TAC (2.24 versus 1.28). A significantly higher mean of difference was observed in patients treated with combination therapy.</p><p><strong>Conclusion: </strong>Significantly higher reduction of enzymatic antioxidants with 577 nm yellow light laser in combination with 4 N-butyl resorcinol as compared to topical depigmenting agent alone recommends that combination therapy in melasma may target different aspects of a condition to enhance overall effectiveness.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"57-62"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy of Intradermal Tranexamic Acid and Topical Triple Combination Modification in Decreasing the Severity Score of Melasma: A Meta-analysis.","authors":"Anindia Indraswari, Diah Mira Indramaya, Maylita Sari, Budi Utomo, Evy Ervianti, Trisniartami Setyaningrum, Astindari Astindari, Menul Ayu Umborowati","doi":"10.4103/ijd.ijd_1002_23","DOIUrl":"10.4103/ijd.ijd_1002_23","url":null,"abstract":"<p><p>Melasma is a symmetrical chronic hypermelanosis that affects the skin of the face, characterised by brownish patches with uneven margins, particularly in areas regularly exposed to sunlight. Although topical triple combination modifications are good first-line therapy for melasma, they have a wide range of negative effects. Consequently, new effective treatments with fewer side effects are required. It has been observed that intradermal tranexamic acid (TA) has low adverse effects and a good therapeutic response in treating melasma. This study aimed to assess the degree of the melasma area and severity index in patients treated with topical triple combination modifications and intradermal tranexamic acid therapy. Electronic databases were searched for relevant articles based on predetermined eligibility requirements. The statistical analysis was conducted using the Review Manager (RevMan) v5.4 software. Randomized controlled trials were used in designing three investigations with a total of 184 patients. After intervention, there was a significant difference in the MASI score between the intradermal tranexamic acid group and the modified topical triple combination group, with a mean difference (MD) of -0.81 (95% CI [-1.05, -0.57]), a combined result of 6.54 with <i>P</i> < 0.00001 and low heterogeneity (I2 = 0%). The intradermal tranexamic acid group also demonstrated a lower MASI score, and the funnel plot revealed no publication bias. This study found that intradermal tranexamic acid is more effective than topical triple combination modifications and has fewer side effects. Therefore, it can serve as an alternative primary therapy option for melasma.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"89-96"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De-Novo Keloid-Like Presentation in Lepromatous Leprosy.","authors":"M Bhagyashree, B Sreeja, Ashok Rao Matety","doi":"10.4103/ijd.ijd_1080_23","DOIUrl":"10.4103/ijd.ijd_1080_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"112-114"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid Profile Scores Predict Severity of Pemphigus: A Cross-Sectional Study.","authors":"Maryam Fallah, Anahita Najafi, Mahsa Ranjbar, Kamran Balighi, Maryam Daneshpazhooh, Soraiya Ebrahimpour-Koujan","doi":"10.4103/ijd.ijd_372_24","DOIUrl":"10.4103/ijd.ijd_372_24","url":null,"abstract":"<p><strong>Background: </strong>There is little evidence about the relationship between lipid indices and the severity of pemphigus vulgaris (PV) disease. In this cross-sectional study, we try to find out the exact relationship between three dietary lipid indices (PUFA/SFA ratio and ω-6/ω-3 index) and the severity of PV disease.</p><p><strong>Methods: </strong>In this hospital-based cross-sectional study, a total of 138 pemphigus vulgaris cases were studied, of which 108 had PDAI ≤15, and 30 had PDAI>15. Dietary intakes were measured a valid 168-item FFQ. To calculate the lipid indices, the data received from diet were used.</p><p><strong>Results: </strong>After adjusting for potential confounders, people with the highest ω-6/ω-3 index had 32% lowest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 0.68; 95% CI: 0.24-1.93, <i>P</i> _trend = 0.47). Moreover, people with the highest PUFA/SFA index had 9% highest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 1.09; 95% CI: 0.34-3.51, <i>P</i> _trend = 0.88).</p><p><strong>Conclusion: </strong>The evidence of our study shows that the relation between PUFA/SFA ratio and ω-6/ω-3 index is not significant. However, case-control studies are needed to confirm these findings.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"63-74"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Use of Tofacitinib in Paediatric Prurigo Nodularis: A Report of Four Cases.","authors":"Shreya K Gowda, Bhini Ameta, Sonika Garg, Biswanath Behera","doi":"10.4103/ijd.ijd_842_24","DOIUrl":"10.4103/ijd.ijd_842_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"102-104"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular Fibrous Histiocytoma Presenting as Basal Cell Carcinoma.","authors":"Weifang Zhou, Xiaoyong Man, Wei Li","doi":"10.4103/ijd.ijd_178_23","DOIUrl":"10.4103/ijd.ijd_178_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"107-110"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}