Indian Journal of Dermatology最新文献

{"title":"Bedside Monitoring of Mycetoma: A Neglected Undertaking in a Neglected Tropical Disease.","authors":"Sonika Garg, Shreya K Gowda, Arpita Nibedita Rout, Chandra Sekhar Sirka, Victor Semy","doi":"10.4103/ijd.ijd_939_24","DOIUrl":"10.4103/ijd.ijd_939_24","url":null,"abstract":"<p><p>Mycetoma is a prevalent yet neglected tropical disease, particularly in eastern India, where its diagnosis remains challenging due to the low sensitivity of histopathology and culture tests. This manuscript highlights bedside monitoring techniques that aid in assessing therapeutic response, including lesion mapping, girth measurement, sinus count, grain assessment, range of motion evaluation, modified visual analogue scale, and patient-reported outcomes. These methods provide valuable insights for clinicians managing mycetoma, facilitating early detection of treatment response and improving patient care.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"142-144"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy with Oral Doxycycline and Intradermal Botulinum Toxin Type A for Moderate-to-Severe Rosacea: A Randomized Controlled Trial.","authors":"Tuyen T Nguyen, Doanh H Le, Ha T Vu, Luong H Vu, Minh N Vu, Phuong T M Pham","doi":"10.4103/ijd.ijd_654_24","DOIUrl":"10.4103/ijd.ijd_654_24","url":null,"abstract":"<p><strong>Background: </strong>Rosacea is a chronic inflammatory skin disorder, particularly challenging in moderate-to-severe cases, characterized by symptoms such as facial papules, pustules, erythema, flushing, and telangiectasia, which severely impact quality of life. Although oral doxycycline is a primary treatment, its efficacy against erythema is limited, necessitating the exploration of combination therapies. Intradermal botulinum toxin type A (BTX) has shown promise in managing facial erythema and flushing, but its combined use with doxycycline has not been evaluated.</p><p><strong>Objectives: </strong>This study aims to evaluate the effectiveness and safety of combining oral doxycycline with intradermal BTX (combination therapy) versus doxycycline with normal saline (monotherapy) in treating moderate-to-severe rosacea.</p><p><strong>Methods: </strong>A randomized, controlled trial was conducted with 46 participants aged 18 and older, diagnosed with moderate-to-severe rosacea. Participants were randomized to receive either combination therapy (doxycycline and BTX) or monotherapy (doxycycline and normal saline) for three months. Efficacy was assessed using the Clinician Erythema Assessment (CEA), Global Flushing Severity Score (GFSS), Investigator Global Assessment (IGA), telangiectasia degree, and Dermatology Life Quality Index (DLQI). Safety evaluations included monitoring adverse reactions.</p><p><strong>Results: </strong>Both groups showed significant reductions in CEA scores from baseline, with combination therapy demonstrating greater improvement (<i>P</i> < 0.001). Combination therapy also significantly reduced GFSS and IGA scores compared to monotherapy (<i>P</i> < 0.05). No significant changes were observed in the degree of telangiectasia. DLQI scores improved significantly in both groups, with greater reductions in the combination therapy group (<i>P</i> < 0.05). Common adverse events, including injection site pain, erythema, and oedema, were tolerable and comparable between groups.</p><p><strong>Conclusion: </strong>The combination of oral doxycycline and intradermal BTX is more effective than doxycycline monotherapy in reducing erythema, flushing, and inflammatory lesions in moderate-to-severe rosacea, with a comparable safety profile. This combination therapy offers a promising approach for comprehensive management of rosacea symptoms.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"135-141"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study on Cosmetovigilance in India: From the Dermatologist's Perspective.","authors":"Manjula Nayak, Virendra S Ligade","doi":"10.4103/ijd.ijd_973_23","DOIUrl":"10.4103/ijd.ijd_973_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"169"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Metabolic Syndrome in Chronic Spontaneous Urticaria and Associated Risk-Factors-An Analytical Cross-Sectional Study.","authors":"Indrashis Podder, Arunima Dhabal, Himel Mondal, Sankha Subhra Chakraborty","doi":"10.4103/ijd.ijd_885_24","DOIUrl":"10.4103/ijd.ijd_885_24","url":null,"abstract":"<p><strong>Background: </strong>Chronic spontaneous urticaria (CSU) is a persistent low-grade inflammatory condition, which may be associated with metabolic syndrome (MetS).</p><p><strong>Objective: </strong>To estimate the prevalence of MetS in CSU patients and identify associated risk factors.</p><p><strong>Methods: </strong>We conducted a cross-sectional study including 74 CSU patients and 58 age-and-sex-matched healthy controls. Disease duration was assessed in all CSU patients along with disease activity and control using the UAS7 and UCT scores respectively. MetS was diagnosed by NCEP-ATP III criteria in all study participants. Additional biochemical parameters included absolute eosinophil and basophil counts. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), and serum total IgE, to identify potential risk factors for MetS.</p><p><strong>Results: </strong>CSU patients (mean age 35.4 ± 11.5 years, M: F 36:38) showed a higher prevalence of MetS, vs. healthy controls (mean age 31.9 ± 9.7 years, M: F 20:38), although statistically comparable [cases vs. controls 24.3% vs. 20.7%, <i>P</i> = 0.8]. CSU patients had higher diastolic blood pressure (<i>P</i> = 0.004) and lower HDL level (<i>P</i> = 0.014), (vs. controls). The median (IQR) duration of CSU was 6 (4-12) months and every third patient presented with uncontrolled CSU (UCT <12). There was no significant association between MetS and clinical disease characteristics such as duration, angioedema, symptomatic dermographism, disease severity, and control. However, CSU patients with metabolic syndrome had significantly higher age (<i>P</i> = 0.0002), higher serum total IgE (<i>P</i> = 0.0001), and higher mean platelet volume (<i>P</i> = 0.04), compared to those with normal metabolic status. Multivariate regression analysis revealed higher age (OR 1.2, <i>P</i> = 0.004) and higher fasting blood sugar (OR 1.5, <i>P</i> = 0.03) to be significant risk factors for MetS.</p><p><strong>Conclusion: </strong>MetS is more prevalent in CSU patients compared to healthy controls, although statistically comparable. All CSU patients need screening for underlying MetS, independent of their disease characteristics. Notably, higher age at presentation, higher total serum IgE, higher MPV, and raised FBS may aggravate the risk for MetS.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"127-134"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Colitis Associated with Immune-Related Adverse Events and Immune Reconstitution Inflammatory Syndrome by Cytomegalovirus.","authors":"Yasuaki Ikuno, Toshifumi Takahashi, Satona Rikitake, Yasuhiro Maeda, Takahiro Koike, Akihiko Yamaguchi, Akiko Arakawa, Takayuki Imai, Hiroshi Matsumoto, Noriki Fujimoto","doi":"10.4103/ijd.ijd_783_23","DOIUrl":"10.4103/ijd.ijd_783_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"161-162"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive GATA-3 Positive Primary Cutaneous Peripheral T-Cell Lymphoma - Not Otherwise Specified Masquerading as CD-4 Positive Small/Medium T-Cell Lymphoproliferative Disorder: Where is the Line of Delineation?","authors":"Igor Kapetanovic, Martina Bosic, Dubravka Zivanovic","doi":"10.4103/ijd.ijd_294_24","DOIUrl":"10.4103/ijd.ijd_294_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"159-160"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the Mystery: A Rare Case of a Cutaneous Horn with Dermoid Cyst at the Oral Commissure.","authors":"Palak Borade, Ashok Vikey, Jaya Joshi, Sakshi Arora","doi":"10.4103/ijd.ijd_659_24","DOIUrl":"10.4103/ijd.ijd_659_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"151-152"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowen's Disease of Skin Over Thigh Treated with Electron Beam Radiotherapy- A Case Letter.","authors":"K N Srinivasan, Gowthami Venugopal, Sudha Kaliappan, N Lalitha Rani","doi":"10.4103/ijd.ijd_334_23","DOIUrl":"10.4103/ijd.ijd_334_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"162-164"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicomycological and Dermoscopic Study of 300 Cases of Dermatophytosis in a Tertiary Care Hospital in Dehradun, India.","authors":"Neenu Kaul, Neeti Kumari, Shiv Darshan Singh Rawat, Reshmi Roy, Sulekha Nautiyal","doi":"10.4103/ijd.ijd_178_24","DOIUrl":"10.4103/ijd.ijd_178_24","url":null,"abstract":"<p><strong>Context: </strong>Dermatophytosis has recently emerged as a major health problem because of its chronic, recalcitrant, widespread nature causing a considerable psychosocial and financial impact among the patients.</p><p><strong>Aims: </strong>The purpose of the study was to assess the clinicomycological and dermoscopic profile of dermatophyte infection.</p><p><strong>Settings and design: </strong>This cross-sectional study included 300 clinically diagnosed cases of dermatophyte infection.</p><p><strong>Materials and methods: </strong>Dermlite 3G dermoscope was used for bedside evaluation of the lesions. Potassium hydroxide mount and fungal culture were done in each case to confirm the diagnosis.</p><p><strong>Statistical analysis: </strong><i>P</i> value less than or equal to 0.05 was considered significant.</p><p><strong>Results: </strong>There were 167 females and 133 males with an age range of 3 months to 80 years. Homemakers constituted most patients (37.33%) followed by students (25%). The total number of clinical patterns seen in 300 patients was 404. Tinea corporis was the most common clinical pattern. On dermoscopic examination in tinea corporis, erythematous background, red dots, and reddish-brown globules were overrepresented (<i>P</i> < 0.05) in lesions of shorter duration, whereas grey background, interfollicular scales, brown-black globules, broken hair, and hypopigmented terminal hair were appreciated more (<i>P</i> < 0.05) in lesions of long duration. Dermoscopy identified features like a reddish background, white scales in skin furrows, and scales in adjoining dermatoglyphics in tinea pedis and tinea manuum. Onychoscopy revealed two new patterns like lamellar microsplitting and white fluffy shadows. The characteristic trichoscopic features were perifollicular scales, black dots with corkscrew, comma shaped, easily deformable, short vellus, and morse code hairs. Trichophyton mentagrophyte was the most common dermatophyte species isolated.</p><p><strong>Conclusions: </strong>Dermoscopy serves as a simple noninvasive and rapid diagnostic tool to complement clinical diagnosis, thus helping to initiate early treatment. Fungus culture helps mainly to identify the dermatophyte species.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"94-102"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nevoid Hyperkeratosis of Nipple and/or Areola: A Rare Entity.","authors":"Biswas Soumi, Achar Arun","doi":"10.4103/ijd.ijd_217_24","DOIUrl":"10.4103/ijd.ijd_217_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"157-158"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}