Indian Journal of Dermatology最新文献

Evaluation of the Association Between Statin Exposure and Skin Cancer: A Nationwide Case-Control Study in South Korea. 评价他汀类药物暴露与皮肤癌之间的关系：韩国一项全国病例对照研究

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_1134_23

Dong Y Oh, Minkook Son, Seung M Ko, Ye J Jang, Kwang H Kim, Kwang J Kim, Eun J Park

{"title":"Evaluation of the Association Between Statin Exposure and Skin Cancer: A Nationwide Case-Control Study in South Korea.","authors":"Dong Y Oh, Minkook Son, Seung M Ko, Ye J Jang, Kwang H Kim, Kwang J Kim, Eun J Park","doi":"10.4103/ijd.ijd_1134_23","DOIUrl":"10.4103/ijd.ijd_1134_23","url":null,"abstract":"Background: Several studies have reported the association between statin use and skin cancer; however, the results have been conflicting. Furthermore, no large-scale studies have reported the relationship between statin exposure and skin cancer in Asian countries.Aims: The aim of this study was to investigate the association between statin exposure and skin cancer in Korea.Methods and material: This nationwide population-based case-control study used data from the National Health Insurance Service database between 2007 and 2018. We enrolled 109,327 patients in the skin cancer group and extracted 109,327 controls using 1:1 propensity score matching. Data on statin exposure within 5 years were collected, and multivariable-adjusted conditional logistic regression analysis was performed.Results: Statin exposure was present in 29.6% of patients in the skin cancer group and 22.3% of patients in the control group, with a statistically significant difference between the two groups. The adjusted odds ratio (OR) (95% confidence interval [CI]) for the association between statin exposure and skin cancer was 1.71 (1.67-1.75). All types of statins, especially lipophilic statins (adjusted OR, 1.58; 95% CI, 1.54-1.62), were associated with skin cancer. However, the association with skin cancer was not statistically significantly different between lipophilic and hydrophilic statins. Subgroup analyses according to age, sex and comorbidity showed a significant association between statin exposure and skin cancer, regardless of subgroup.Conclusions: Our study revealed an association between statin exposure and skin cancer in Korea.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 5","pages":"240-245"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Thiol/Disulfide Homeostasis and İschemia-modified Albumin Levels in Symptomatic Dermographism. 评价症状性皮肤病中硫醇/二硫稳态和İschemia-modified白蛋白水平。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_770_24

Mahmut Sami Metin, Tuğba Tehçi, İlkay Kolukırık, Serkan Akoğul, Ümran Öner, Zühal Metin

{"title":"Evaluation of Thiol/Disulfide Homeostasis and İschemia-modified Albumin Levels in Symptomatic Dermographism.","authors":"Mahmut Sami Metin, Tuğba Tehçi, İlkay Kolukırık, Serkan Akoğul, Ümran Öner, Zühal Metin","doi":"10.4103/ijd.ijd_770_24","DOIUrl":"10.4103/ijd.ijd_770_24","url":null,"abstract":"Background: Symptomatic dermographism (SD) is the most common chronic inducible urticaria (CIndU) type. Thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels are indicators of oxidative stress.Aim: Our study aims to investigate the role of thiol/disulfide balance and IMA levels in the pathogenesis of SD. This focus guides our research and helps us to better understand the disease.Materials and methods: This cross-sectional study, conducted with utmost care and precision, included 50 SD patients and 50 healthy volunteers. The patients and controls were meticulously evaluated regarding IMA, native thiol, total thiol, and disulfide levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios, ensuring a thorough and reliable understanding of the data.Results: In our study, the patient group demonstrated significantly higher levels of native thiol, total thiol, disulfide, and IMA values than the control group (P < 0.05).Conclusions: In patients with SD, impaired TDH and increased IMA suggest that oxidative stress may play a significant role in the disease pathogenesis, underscoring the importance of our findings.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 5","pages":"246-251"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratosis Pilaris Unveiled: Insights into its Origin, Management Strategies and Research Frontiers. 毛角化病的起源、管理策略和研究前沿。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_51_25

Komalpreet Kaur, Amrinder Kaur, Vandna Kalsi, Shivalika Kasav

{"title":"Keratosis Pilaris Unveiled: Insights into its Origin, Management Strategies and Research Frontiers.","authors":"Komalpreet Kaur, Amrinder Kaur, Vandna Kalsi, Shivalika Kasav","doi":"10.4103/ijd.ijd_51_25","DOIUrl":"10.4103/ijd.ijd_51_25","url":null,"abstract":"Follicular hyperkeratosis is frequently known as keratosis pilaris (KP). Small, folliculocentric keratotic papules with possible erythematous borders are its defining features. It is a common, asymptomatic skin disorder. The tiny papules give the skin a stippled, gooseflesh-like appearance. The disorder most frequently affects the exterior portions of the upper arms, upper legs and buttocks. It is caused by prolonged exposure to the sun and people suffering from dry skin. The consequences of KP disease are mainly triggered by dryness and rough skin, which results in bumpy skin, redness, irritation, itching and hyperpigmentation. It can affect persons of any age, but it is more prevalent in children and teenagers. While the classic KP is known, the other variants are also there which have particular effects on the different parts of the body. To alleviate symptoms, apply moisturizers, exfoliates and topical treatments containing urea, lactic acid or salicylic acid. This critical issue must be addressed; there have been very few clinical studies, and this study will assist researchers in carrying out more clinical trials and studies on KP disorder. Being aware of KP is a very important point while it is not entirely preventable, using regular moisturizer, keeping gentle exfoliation and the use of light cleansers can all help to manage and reduce its appearance. There are a few current therapies used to treat the disease, including laser and blue light treatments, and photodynamic therapies.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 5","pages":"267-274"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Plasma Cell Cheilitis Successfully Managed with Photodynamic Therapy. 光动力疗法成功治疗浆细胞性舌炎1例。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_592_24

Xiukuan Xu, Lijia Su

引用次数: 0

Cutis Laxa Type 1 B with Recurrent E57K Variation. 1型皮肤松弛症伴复发性E57K变异。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_350_22

Ankur Singh, G Janani, Abhishek Abhinay, Rajniti Prasad

引用次数: 0

Evaluation of Short-to-medium Term Efficacy of Guselkumab and Secukinumab in Overweight and Obese Patients with Moderate to Severe Plaque Psoriasis: A 24-Week Single-center Retrospective Study. guelkumab和Secukinumab治疗超重和肥胖中至重度斑块型银屑病患者的中短期疗效评估：一项为期24周的单中心回顾性研究

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_663_23

Xiuqiu Lin, Min Ou, Yang Li, Junjie Lin, Yunling Yan, Xiaohua Wang

{"title":"Evaluation of Short-to-medium Term Efficacy of Guselkumab and Secukinumab in Overweight and Obese Patients with Moderate to Severe Plaque Psoriasis: A 24-Week Single-center Retrospective Study.","authors":"Xiuqiu Lin, Min Ou, Yang Li, Junjie Lin, Yunling Yan, Xiaohua Wang","doi":"10.4103/ijd.ijd_663_23","DOIUrl":"10.4103/ijd.ijd_663_23","url":null,"abstract":"Background: Overweight and obesity are common in patients with psoriasis and are associated with increased disease severity and declined treatment response.Aims: To evaluate the short-to-medium term (24w) efficacy and safety of two biologics, including Guselkumab and Secukinumab, in overweight and obese patients (body mass index [BMI] ≥25 kg/m2) with moderate to severe psoriasis.Materials and methods: We retrospectively analyzed the data of patients with moderate to severe plaque psoriasis treated with Guselkumab or Secukinumab in Dermatology Hospital of Southern Medical University in 2020. Totally 34 and 67 patients were treated with Guselkumab and Secukinumab, respectively; the patient groups with BMI ≥25 kg/m2 comprised 16 and 33 cases, respectively. Baseline demographics and clinical characteristics were recorded, and Psoriasis Area and Severity Index (PASI) scores, adverse events, and biochemical parameters were assessed at weeks 12, 16, and 24.Results: Both Guselkumab and Secukinumab demonstrated good clinical efficacy. In patients with BMI ≥25 kg/m2, there was a higher percentage of cases achieving PASI 100 at week 16 in the Secukinumab group; however, at week 24, the proportion of patients treated with Guselkumab achieving PASI 100 was significantly higher than that of cases treated with Secukinumab (P = 0.037 and P < 0.001, respectively).Conclusions: Guselkumab and Secukinumab demonstrated good short-to-medium-term efficacy in Chinese patients with moderate to severe plaque psoriasis. In patients with a BMI ≥25 kg/m2, Secukinumab demonstrated a faster onset of efficacy, while Guselkumab demonstrated significantly higher efficacy at week 24.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 5","pages":"252-256"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact on Quality of Life in Various Dermatoses of the Adolescent Age Group- A Pilot Observational Study at a Tertiary Care Centre. 青少年不同皮肤病对生活质量的影响——三级医疗中心的一项试点观察研究。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_571_24

Rutoo Polra, Mauli Shah, Dharmesh Parmar, Pragya A Nair

引用次数: 0

A Hospital-based Clinical Study of Various Cutaneous and Venereal Diseases in Pregnancy. 妊娠期多种皮肤病和性病的医院临床研究

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_274_23

Pichano E Khuvung

{"title":"A Hospital-based Clinical Study of Various Cutaneous and Venereal Diseases in Pregnancy.","authors":"Pichano E Khuvung","doi":"10.4103/ijd.ijd_274_23","DOIUrl":"10.4103/ijd.ijd_274_23","url":null,"abstract":"Introduction: Pregnancy can affect the skin in numerous ways. Further, it can impact the clinical course and successional changes of long-standing skin diseases. Thus, classifying pregnancy dermatosis into physiological, general and specific categories may give a proper understanding of the diseases and their outcomes.Objective: To demonstrate the clinical aspect and frequency of various cutaneous and venereal diseases observed during pregnancy.Materials and methods: This cross-sectional study was conducted in the Department of Dermatology, Venereology and Leprosy in Tamil Nadu for 2 years from November 2019 to October 2021. The study included 114 pregnant women who attended the outpatient department (OPD) as well as inpatients and referral cases from the Department of Obstetrics and Gynecology. All data were analysed using the Statistical Package for the Social Sciences (SPSS) version 20.0 and tabulated based on age, gravida, trimester and diseases.Result: Of 114 cases encountered, 21 (18.4%) were of specific dermatosis, 23 (20.2%) of infections, 56 (49.1%) of sexually transmitted infections and 14 (12.3%) of non-specific dermatosis. Incidence was higher in primigravida (68.4%) than in multigravida (31.6%). Here, the most frequent specific dermatosis of pregnancy reported was pruritic urticarial papules and plaques of pregnancy (PUPP) (10.5%). We also reported scabies (6.1%) and seropositive venereal disease research laboratory (VDRL) with TPHA+ (13.2%) as the most common infection and sexually transmitted infections (STIs), respectively.Conclusion: A prospective collaborative study of all skin and venereal diseases in pregnancy is required for better understanding, earlier diagnosis, more favourable outcome and optimal treatment.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 5","pages":"223-229"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiopathogenesis and Current Management of Oncogenic Pruritus - A Narrative Review. 致癌性瘙痒症的发病机制及当前治疗综述。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_523_24

Sahana Srihari, Shreya Poddar, Najeeba Riyaz, S Praveen Kumar, Deepti Chigullapalli, Vikas Shankar, Kapil Vyas, Raejesh Verma, Prabhakar Sangolli, Kumar Mittal, Indrashis Podder

{"title":"Etiopathogenesis and Current Management of Oncogenic Pruritus - A Narrative Review.","authors":"Sahana Srihari, Shreya Poddar, Najeeba Riyaz, S Praveen Kumar, Deepti Chigullapalli, Vikas Shankar, Kapil Vyas, Raejesh Verma, Prabhakar Sangolli, Kumar Mittal, Indrashis Podder","doi":"10.4103/ijd.ijd_523_24","DOIUrl":"10.4103/ijd.ijd_523_24","url":null,"abstract":"Oncogenic pruritus or malignancy associated pruritus is an emerging cause of systemic pruritus in patients with malignancies. It is a debilitating condition and worsens the patient's quality of life, often interfering with their palliative care. Oncogenic pruritus can arise de-novo in such patients due to release of pruritogens and other inflammatory mediators from tumour cells into blood stream, or it may present as a component of paraneoplastic syndrome. A detailed history and clinical examination are necessary to rule out other causes of systemic pruritus. Objective evaluation of itch is recommended using various scales to evaluate the treatment response and assessing its severity. There is lack of clinical trials concerning the management of oncogenic pruritus and most information is derived from sporadic case reports. Despite being an important and emerging cause of pruritus during malignancy, this diagnosis is often missed and remains under-reported due to lack of awareness about this entity. This narrative review highlights the current understanding of this condition focusing on its causes, pathogenesis, diagnosis, and management, along with newer investigational drugs. These authors hope that the present review will generate awareness about this condition among treating physicians and enable its early diagnosis and appropriate management.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 5","pages":"257-266"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized Vitiligo Arising Within Giant Congenital Melanocytic Nevus. 巨大先天性黑素细胞痣引起的局部白癜风。

IF 1.3 4区医学

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI: 10.4103/ijd.ijd_543_23

Sri Vaishnavi Renukuntla, Ketan Kallappa Kolekar, Yoganand J Phulari

引用次数: 0