Indian Journal of Dermatology最新文献

{"title":"Alterations of the Gut Microbiome in Psoriasis before and after Treated with Secukinumab.","authors":"Ling Fang, Shasha Cheng, Cheng Zuo, Liyin Zhang","doi":"10.4103/ijd.ijd_1025_24","DOIUrl":"10.4103/ijd.ijd_1025_24","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory skin disease linked to immune system. Despite its prevalence, the precise aetiology and pathogenesis of psoriasis remain elusive. This study aimed to assess the efficacy and safety of Secukinumab while exploring its impact on the intestinal microbiota in patients with moderate-to-severe plaque psoriasis.</p><p><strong>Materials and methods: </strong>We recruited 60 healthy controls and 110 patients with moderate-to-severe plaque psoriasis who attended outpatient clinics between June 2022 and June 2023. Clinical data (gender, age, BMI, PASI score, PGA, DLQI, Itch NRS, and STAI score) and faecal samples were collected from all groups. Faecal samples underwent PacBio Full-Length Diversity Sequencing and subsequent informatics analysis.</p><p><strong>Results: </strong>Patients were randomly assigned to two groups: Before Secukinumab treatment group (BT, n = 55), After 24 weeks of Secukinumab treatment group (AT, n = 55). Control group (Con) consisting of healthy individuals matched for age, sex, and body mass index (n = 60). Following 24 weeks of Secukinumab treatment, significant reductions in PASI score, PGA, DLQI, Itch NRS, and STAI score were observed in psoriatic patients (<i>P</i> < 0.05). The microbial diversity and composition in the AT group exhibited substantial alterations compared to the BT and Con groups, typified by an elevated abundance of <i>Agathobacter</i> and <i>Anaerobutyricum</i> and a diminished presence of <i>Bacteroides</i> and <i>Phocaeicola</i>.</p><p><strong>Conclusion: </strong>The changes in gut microbiota occur at a slower pace than cutaneous manifestations, necessitating prolonged follow-up and microbiome-based investigations in Secukinumab-treated psoriasis patients to substantiate its therapeutic efficacy.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"36-43"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Validation of Urticaria Control Test (UCT) and Chronic Urticaria Quality of Life (CU-Q2oL) Questionnaires in Hindi.","authors":"Abhishek De, S K Shahriar Ahmed, Shreya Datta, Mehul Mukherjee, Sushil Singh, Priya Kumari, Aarti Sarda, Kiran Godse","doi":"10.4103/ijd.ijd_725_23","DOIUrl":"10.4103/ijd.ijd_725_23","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic urticaria (CU) is a distressing skin condition characterised by pruritic wheals, with or without angioedema, lasting for more than 6 weeks. The disease significantly compromises patients' quality of life, affecting various aspects of daily living. Assessing disease control and quality of life in CU patients is essential for evaluating disease burden and improving therapeutic outcomes. However, there is a lack of tools to assess these parameters in the Hindi-speaking population in India. This study aims to translate, adapt, and validate the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) and Urticaria Control Test (UCT) in Hindi, providing culturally relevant and accurate assessments.</p><p><strong>Methods: </strong>The translation process followed standard procedures, including forward and backward translations, expert committee review, and preliminary pilot testing. The reliability and validity of the translated questionnaires were evaluated. Internal consistency, test-retest reliability, and inter-rater reliability were assessed for both CU-Q2oL and UCT. Construct validity was determined by comparing CU-Q2oL and UCT with an established English Dermatology Life Quality Index (DLQI) score. A cross-sectional study recruited 30 adult patients with CU from an Indian tertiary care hospital. Demographic details and disease parameters were collected, and participants filled the questionnaires at baseline and after 14 days.</p><p><strong>Results: </strong>The mean age of the participants was 37.86 ± 11.69 years, and most were female (63.3%). The Hindi version of CU-Q2oL demonstrated respectable internal consistency (Cronbach's alpha = 0.75) and strong test-retest reliability (intraclass correlation coefficient or Pearson's r = 0.75). Domain 1 (pruritus) and domain 5 (sleep disturbances) were the most affected, while domain 2 (swelling) was the least affected. UCT also showed excellent internal consistency (Cronbach's alpha = 0.82) and acceptable test-retest reliability (Pearson's r = 0.46). Construct validity was established through positive correlation coefficients with DLQI.</p><p><strong>Conclusion: </strong>The translated and validated CU-Q2oL and UCT questionnaires in Hindi provide valuable tools for assessing disease activity and quality of life in CU patients. These questionnaires can aid in research, enhance patient care, and improve disease management in the Hindi-speaking population. Their positive correlation with an established quality of life measure further validates their utility and reliability. Overall, this study should contribute to better healthcare outcomes for patients with CU in India.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"18-23"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary Nodular Lesion Over Face.","authors":"Gopalsing Rameshsing Rajput, Ruchi Hemdani, Archana Reddy, Ann Maria Paulose, Anil Kumar","doi":"10.4103/ijd.ijd_751_24","DOIUrl":"10.4103/ijd.ijd_751_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"80-81"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study on the Measurement Properties (Criterion Validity, Informativity, and Floor and Ceiling Effects) of Dermatology Life Quality Index (DLQI) and Skindex-29.","authors":"Aaqid Siraj Syed, Sheenam Sethi, Shakti Chauhan, Rashmi Jindal","doi":"10.4103/ijd.ijd_738_23","DOIUrl":"10.4103/ijd.ijd_738_23","url":null,"abstract":"<p><strong>Background: </strong>The measurement of health-related quality of life (HRQoL) is essential in dermatology, with the DLQI and Skindex-29 being popular tools for assessment. However, the literature comparing the measuring features of these two questionnaires is lacking.</p><p><strong>Aims: </strong>This study aims to provide a comparison of the measurement properties of DLQI and Skindex-29 in patients with common dermatology conditions such as psoriasis vulgaris (PV), vitiligo vulgaris (VV), leprosy, and acne vulgaris (AV).</p><p><strong>Methods: </strong>In this cross-sectional study, the HRQoL of 301 patients with the four dermatological conditions was measured using the DLQI and Skindex-29 questionnaires at a tertiary care centre located in Dehradun, Uttarakhand, India. Statistical analysis included determining ceiling and floor effects, informativity, and criterion validity.</p><p><strong>Results: </strong>The mean DLQI total scores were: PV (11.03 ± 0.89), VV (4.73 ± 0.78), leprosy (8.97 ± 1.09), and AV (7.79 ± 0.63), and the mean Skindex-29 scores were: PV (37.98 ± 2.82), VV (27.92 ± 2.93), leprosy (45.12 ± 3.63), and AV (27.6 ± 1.08), with a 95% confidence interval. Of the patients with a DLQI score of 0 (n = 66), 64 (96%) had a total score greater than 0 on the Skindex-29. The most troubled areas of HRQoL among patients with a DLQI score of 0 according to the Skindex-29 were item 17 (showing affection; 12.1%), item 9 (worry about scars; 9.1%), item 12, item 13, and item 14 (being ashamed, worrying about worsening, and tending to do things oneself; 7.6%). The ceiling effect was observed in 4.7% of patients for DLQI and 0% for Skindex-29. The floor effect was high for the DLQI total score (22%), whereas Skindex-29 observed only 0.7%. The absolute informativity value of Skindex-29 was 1.66, and that of the DLQI was 1.92. The typical relative informativity value for both was 0.83.</p><p><strong>Conclusion: </strong>Skindex-29 showed better sensitivity to clinical severity, less floor effect, higher absolute informativity, and better coverage of the 'emotion' domain. Skindex-29 was found to be more effective in detecting minor HRQoL impairment than DLQI.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Survival of Acitretin and Methotrexate in Adult Psoriasis Patients.","authors":"Merve Hatun Erkayman, Tülin Ergun","doi":"10.4103/ijd.ijd_1154_23","DOIUrl":"10.4103/ijd.ijd_1154_23","url":null,"abstract":"<p><strong>Background: </strong>Diverse biological therapies have become increasingly prevalent in recent years in the treatment of psoriasis. However, current guidelines continue to recommend non-biological systemic treatments. Real-life data on the survival of acitretin and methotrexate are limited. It is important to determine the appropriate patient candidates before treatment and to determine the factors affecting survival to increase treatment compliance.</p><p><strong>Aims and objectives: </strong>This study aimed to calculate the estimated survival and 1-, 2-, 3-, 5-year survival rates of acitretin and methotrexate and to determine the factors affecting survival. Other purposes include evaluating reasons for treatment cessation, and adverse effects.</p><p><strong>Materials and methods: </strong>Our retrospective study, conducted at a single centre, included 364 adult patients diagnosed with psoriasis who had received at least one of the acitretin or methotrexate and had at least two visit records. The data were obtained from patient records. Response to treatment in the third month, adverse effects, and reasons for treatment discontinuation were recorded. Survival analysis was performed using the Kaplan-Meier method. Log-rank tests and Cox regression analyses were used to assess the predictive factors for survival. <i>P</i> <0.05 was considered significant.</p><p><strong>Results: </strong>A total of 437 treatment courses of 364 patients were evaluated. The median follow-up was 39.5 (21.00-64.75) months. The median survival was calculated as 14 months for acitretin and 20 months for methotrexate. One-year drug survival rates for acitretin and methotrexate were 49.5% and 62.7%, respectively. Treatment response was the most important determinant of drug survival for both medications, whereas advancing age and arthritis had a positive effect on methotrexate survival.</p><p><strong>Conclusion: </strong>Survival rates of acitretin and methotrexate were generally low in practice compared with published data on biological treatments, but as a response to treatment increased, the survival of both drugs improved. Better strategies need to be developed to increase treatment response and survival.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"24-29"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Epidermal Cysts Following Resolution of Hidradenitis Suppurative on the Legs in a Patient with Crohn's Disease.","authors":"Tatsuhiko Mori, Nobuyuki Kikuchi, Toshiyuki Yamamoto","doi":"10.4103/ijd.ijd_510_24","DOIUrl":"10.4103/ijd.ijd_510_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"74-75"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is Masquerading as a Nail Tumour.","authors":"Seema Rani, Snigdha Saxena, Purnima Malhotra","doi":"10.4103/ijd.ijd_944_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_944_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"82-84"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12844544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes: A Comprehensive Exploration of their Beneficial, Detrimental, and Ambiguous Roles in Intercellular Communication and Pathophysiological Processes - Do They Justify the Enthusiasm?","authors":"Rinky Kapoor, Depti Bellani, Raji Patil, Michael Gold, Debraj Shome","doi":"10.4103/ijd.ijd_407_25","DOIUrl":"10.4103/ijd.ijd_407_25","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"55-57"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Landscape of Food Allergies in Pediatric Atopic Dermatitis: A Cross-Sectional Study in Iran.","authors":"Mohadese Mahdavi, Saber Gharagozlou, Masoud Movahedi, Nima Parvaneh, Arash Kalantari, Mohadese Sadat Mousavi Khorshidi, Mehdi Shokri, Fatemeh Alizadeh, Mahshid Movahedi, Mohammad Gharagozlou","doi":"10.4103/ijd.ijd_91_24","DOIUrl":"10.4103/ijd.ijd_91_24","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of food allergy (FA) in Iranian children with atopic dermatitis (AD) is unknown. This study aims to determine the prevalence and kind of FA in Iranian children with AD.</p><p><strong>Materials and methods: </strong>The present investigation was the conducted as a cross-sectional study, with a total of 252 children diagnosed with the AD enrolled as participants. The impression of FA for these patients was made based on history and performing specific immunoglobulin E (IgE) tests. Based on the IgE test results, an oral food challenge (OFC) was performed to confirm the food hypersensitivity.</p><p><strong>Results: </strong>In AD patients, the prevalence of FA was 28.2%, while the rate of food sensitization was 44.8%. The frequency of food allergies was reported as follows: egg: 10.3%, milk: 9.5%, wheat: 2.8%, tree nut: 2.4%, peanut: 0.4%, soya: 0.4%, and fish: 0.4%.</p><p><strong>Conclusion: </strong>The prevalence of FA in these Iranian children with AD was determined to be 28.2%, while the prevalence of food sensitization was 44.8%. Egg and milk were found to be the most prevalent food allergens among patients with AD.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"30-35"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox: Skin Lesion Spread From Initial Contact in Three Cases.","authors":"Lusheng Miao, Guofei Yang, Jizhao Yao, Ying Zhang, Jin Hao","doi":"10.4103/ijd.ijd_407_24","DOIUrl":"10.4103/ijd.ijd_407_24","url":null,"abstract":"<p><p>Monkeypox is a zoonosis caused by the monkeypox virus. In 2022, the World Health Organization declared monkeypox a Public Health Emergency of International Concern due to its unprecedented global spread. Since June 2023, several new cases have re-emerged in mainland China, underscoring the ongoing transmission risk. Our three cases, confirmed by real-time quantitative polymerase chain reaction with dermoscopic and histopathological findings supporting diagnosis, exhibited atypical symptoms consistent with skin contact-mediated transmission. We propose that, in some patients, lesions may initially develop at the site of contact without preceding systemic symptoms and later disseminate to other body regions.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 1","pages":"85"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}