Indian Journal of Dermatology最新文献

{"title":"Clinical Profile and Predictors of Relapse in Patients with Alopecia Areata: A Follow-Up Study.","authors":"Sumit Khandelwal,Subitha Lakshminarayanan,Telanseri Jayakar Jaisankar,Sivaranjini Ramassamy","doi":"10.4103/ijd.ijd_1060_21","DOIUrl":"https://doi.org/10.4103/ijd.ijd_1060_21","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"1 1","pages":"344-346"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"100 Most-Cited Articles in Vitiligo: A Bibliometric Analysis.","authors":"Zoé Gabrielle Attal,Sapir Itzhaki Gabay,Galia Peles,Amir Horev","doi":"10.4103/ijd.ijd_673_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_673_23","url":null,"abstract":"IntroductionVitiligo is a skin disease affecting melanocytes, characterised by the development of depigmented skin lesions.MethodsWe used bibliometric analysis (BA) to identify high-quality research articles on vitiligo using criteria such as total citations, annual citations (AC) and journal impact factors. We extracted the 100 most-cited articles on vitiligo using the Web of Science database and analysed the results using Microsoft Excel 2019. Our search was limited to manuscript titles or abstracts containing the keyword 'vitiligo'. The data extracted information such as title, author, year of publication, journal of publication, total citations and research area. We also calculated the AC rate to account for bias.ResultsA total of 6,189 studies were retrieved. The 100 most-cited articles were published between 1976 and 2017. Of those, 75 were original articles, with the research foci being mainly pathogenesis (29%) and treatment (26%). The US was the most prolific publisher overall. We separately retrieved the highest cited data from 2018 to 2022 and tabled the top 10. Of those, 50% were original articles.DiscussionOur BA shows that developed countries published most of the vitiligo literature. Additionally, recent research has focused on targeted treatment approaches. We also highlight the increasing paediatric vitiligo research, specifically regarding therapies.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"77 1","pages":"365"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Effect of Psoriasis and Cancer on the Risk of All-Cause Mortality: A Prospective Cohort Study of NHANES Data.","authors":"Zixiang Si,Honglei Zhao,Jieya Ying","doi":"10.4103/ijd.ijd_1095_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_1095_23","url":null,"abstract":"BackgroundThe relationship between psoriasis, cancer, and mortality has been reported in observational studies. Considering the high heterogeneity in systematic review and meta-analysis and inconsistent results in previous studies, the association between psoriasis, cancer, and mortality warrants more investigation. The primary objective of this study was to explore the joint impact of psoriasis and cancer on mortality in a representative cohort of adults residing in the United States.MethodsWe analysed comprehensive data obtained from the National Health and Nutrition Examination Study conducted during the periods of 2003-2006 and 2009-2014. Multivariable logistic regression analyses were performed to assess the relationship between psoriasis and cancer. The vital status of participants was tracked until 31 December 2019. A four-level variable combining information on psoriasis and cancer was created, and survival probability was evaluated using the Kaplan-Meier curve and Cox regression analysis. Hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated to analyse the association between psoriasis/cancer and all-cause mortality.ResultsIn total, this study included 15,234 participants, among whom 418 had psoriasis and 1213 had cancer. The findings from the logistic regression analyses indicated a heightened risk of cancer among individuals with psoriasis in comparison to those without psoriasis. Moreover, the risk of skin cancer was higher in participants with psoriasis compared to those without psoriasis. Compared with individuals without cancer and psoriasis, the all-cause mortality HRs were 1.25 (95% CI: 0.87-1.78) for individuals with psoriasis only, 1.48 (95% CI: 1.20-1.82) for participants with cancer only, and 2.28 (95% CI: 1.12-4.63) for individuals with both psoriasis and cancer.ConclusionThe results of our study demonstrated a noteworthy and positive correlation between psoriasis, cancer, and all-cause mortality. These findings indicate that individuals who have both psoriasis and cancer face an increased likelihood of mortality.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"20 1","pages":"317-327"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmentary Changes in Systemic Sclerosis are Associated with More Severe Cutaneous Sclerosis and Severity of Other Systems: A Cross-sectional Study from India","authors":"Setu Mittal, Binod K. Khaitan, M. Ramam, Neena Khanna, Rahul Mahajan, Ashu Seith Bhalla, Manoj K. Singh, V. Sreenivas","doi":"10.4103/ijd.ijd_251_24","DOIUrl":"https://doi.org/10.4103/ijd.ijd_251_24","url":null,"abstract":"<h3>Background: </h3>\u0000<p>Pigmentary changes of the skin in systemic sclerosis in the form of diffuse hyperpigmentation and salt-and-pepper pigmentation are well documented in the literature; however, its association with disease severity and extent of underlying internal organ involvement has not been well studied.</p>\u0000<h3>Aims: </h3>\u0000<p>To assess the correlation between morphology and extent of pigmentary changes with the degree of cutaneous sclerosis and frequency and degree of major organ involvement.</p>\u0000<h3>Methods: </h3>\u0000<p>This was a cross-sectional descriptive study conducted in a tertiary care teaching hospital from December 2014 to November 2016. Consecutive patients of systemic sclerosis attending the outpatient department were screened, and patients satisfying the diagnosis as per the American Rheumatism Association criteria were recruited. Skin sclerosis was quantified using modified Rodnan skin score (MRSS), whereas pigmentary changes were calculated in terms of percentage of body surface area involved by rule-of-nine method. Investigations were carried out depending on organ involvement and as per respective specialty consultations with focus on pulmonary, cardiac, and gastrointestinal systems.</p>\u0000<h3>Results: </h3>\u0000<p>Of the 50 patients recruited, all had cutaneous involvement in the form of binding down of skin, followed by pigmentary changes. MRSS was significantly higher in patients with any pigmentary alteration (<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> = 0.03) compared to those without any pigmentary changes. There was a rising trend in between the MRSS severity and the proportion of patients with hyperpigmentation, and it was statistically significant (<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> = 0.04). Among systemic involvement, lung was involved in the form of interstitial lung disease in 94% patients (n = 47). However, skin pigmentation of any type was associated with lower high-resolution computed tomography scores (<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> = 0.02).</p>\u0000<h3>Conclusion: </h3>\u0000<p>This study shows that in systemic sclerosis patients presenting with pigmentary skin manifestations, cutaneous sclerosis is significantly higher.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"174 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Trichoscopic Features of Alopecia Areata between Adults and Children and between Different Body Parts (Scalp, Beard, Eyebrow, and Moustache)","authors":"Aula Raheem, Muhsin Al-Dhalimi","doi":"10.4103/ijd.ijd_346_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_346_23","url":null,"abstract":"<h3>Background: </h3>\u0000<p>Round patches of baldness on the scalp or entire body are typically caused by the common, non-scarring hair loss condition known as alopecia areata (AA). Follicular units with two to four terminal hairs and one or two vellus hairs can be seen on a healthy, typical scalp trichoscopy.</p>\u0000<h3>Aim of the Study: </h3>\u0000<p>To compare trichoscopic features between adults and children and between different body parts.</p>\u0000<h3>Patients and Methods: </h3>\u0000<p>A cross-sectional observational study was performed on 90 patients; AA of the scalp and other body parts attended the dermatology out-patient clinic. A Gen Dermlite D100 Dermoscope was used to examine AA lesions and compare their features according to age and different body parts.</p>\u0000<h3>Results: </h3>\u0000<p>Scalp was the most common area among all patients, 65.6% (among adults, it was 50%, and among children, it was 85%), with a significant difference, <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> = 0.001. The most common trichoscopic feature among all patients was empty follicular opening in 74 (82.2%) lesions; among children, it was honeycomb pigment in 35 (87.5%) lesions, while among adults, it was empty follicular opening in 40 (80%) lesions. Tulip hair was significantly higher among adults, <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> = 0.036. At the same time, honeycomb pigment patterns and pohlpinkus constriction were significantly higher among children, <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> = 0.044 and <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> &lt; 0.001, respectively.</p>\u0000<h3>Conclusion: </h3>\u0000<p>The most common trichoscopic feature of adult lesions was empty follicular opening, while honeycomb pigment was dominant among children. Tulip hair was higher among adults, while honeycomb pigment patterns and pohlpinkus constriction were higher among children.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"5 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Open-Label, Investigator-Initiated, Single-Centre Pilot Study to Determine the Safety and Efficacy of Tofacitinib in Resistant Chronic Spontaneous Urticaria.","authors":"Abhishek De,Shrayan Pal,Sushil Singh,Disha Chakroborty,Kiran Godse","doi":"10.4103/ijd.ijd_1085_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_1085_23","url":null,"abstract":"BackgroundChronic spontaneous urticaria (CSU) is a distressing skin condition characterized by the recurrent appearance of itchy hives. A subset of CSU patients remains resistant to conventional treatment with high-dose antihistamines. Tofacitinib, a Janus kinase inhibitor, has shown promise in various inflammatory skin diseases. We aimed to evaluate the efficacy of oral tofacitinib in patients with CSU resistant to antihistamines.MethodsThis study examined data retrospectively from seven patients who were diagnosed with CSU and were treated with tofacitinib for at least six months. These patients initially exhibited resistance to treatment with four-fold up-dosed antihistamines. One of the patients was already on omalizumab, and another was tried on cyclosporine. The patients were administered oral tofacitinib at a dosage of 5 mg twice daily for six months. Patients were followed up monthly for disease control and side effects. The response to treatment was evaluated using the urticaria activity score over 7 days (UAS7) and urticaria control test (UCT). Paired t-tests were conducted to determine the statistical significance of the results using SPSS version 25 software.ResultsSix out of the seven patients demonstrated a significant improvement in both UAS7 and UCT scores after six months of treatment with oral tofacitinib. The mean UAS7 score decreased from 24.86 at baseline to 3.83 at the study endpoint (P < 0.0001). Similarly, the mean UCT score increased from 0.57 at baseline to 14 at the study endpoint (P < 0.0001). The standard deviations for both measures were 4.85 and 0.98 at baseline and 3.1 and 3.1 at the study endpoint for UAS7 and UCT, respectively.ConclusionIn this six-month follow-up study, oral tofacitinib demonstrated significant efficacy in treating CSU patients' resistant to high-dose antihistamines. Most patients experienced a remarkable reduction in urticaria activity and an improvement in disease control. These findings suggest that tofacitinib holds promise as a potential therapeutic option for this challenging subset of CSU patients. However, larger, randomized controlled trials are warranted to further investigate the long-term safety and effectiveness of tofacitinib in this population.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"31 1","pages":"312-316"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Sensory and Autonomic Neuropathy-Report of Two Cases in Siblings and Review of Literature.","authors":"Shreya K Gowda,Sonika Garg,Biswanath Behera,Bevan Priyadharsan,Vishal Thakur","doi":"10.4103/ijd.ijd_1179_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_1179_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"119 1","pages":"366"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walking a Tight Rope: Occult Lymphoma in a Case of Resistant Dermatomyositis Complicated by Tubercular Lymphadenitis and Gumma","authors":"Namrata Chhabra, Jemshi S. Rahim, Satyaki Ganguly","doi":"10.4103/ijd.ijd_214_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_214_23","url":null,"abstract":"<p>Dermatomyositis (DM) is an autoimmune inflammatory disease, characterized by symmetrical proximal myopathy and cutaneous manifestations. DM is associated with upto a 6-fold increased risk of cancer. Complications secondary to underlying cancer are a leading cause of mortality in DM. Here, we discuss the two year clinical course of an elderly male with recalcitrant DM. This case was complicated by tubercular lymphadenitis followed by gumma. Subsequently, he was diagnosed with lymphoma and succumbed to death. This case emphasizes the need to do extensive malignancy screening at regular intervals in DM.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"5 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Severe Facial Swelling Mimicking Facial Nerve Paralysis after Cryotherapy to the Basal Cell Carcinoma in a Xeroderma Pigmentosum Patient.","authors":"Yavuz Semiz,Avni Akin Bayram,Ezgi Aktas","doi":"10.4103/ijd.ijd_972_22","DOIUrl":"https://doi.org/10.4103/ijd.ijd_972_22","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"74 1","pages":"366"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Oral Tofacitinib in the Treatment of Pediatric Vitiligo: A Case Series.","authors":"Anisha Biswal,Ishan Agrawal,Maitreyee Panda","doi":"10.4103/ijd.ijd_515_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_515_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"5 1","pages":"366"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}