Indian Journal of Dermatology最新文献

{"title":"A Randomised Single-Blind Controlled Trial Comparing Efficacy of Intralesional Vitamin D Injection and MMR (Measles, Mumps, Rubella) Vaccine in Treatment of Warts.","authors":"Sushil Singh, Shrayan Pal, Abhishek De","doi":"10.4103/ijd.ijd_890_23","DOIUrl":"10.4103/ijd.ijd_890_23","url":null,"abstract":"<p><strong>Introduction: </strong>Common warts are benign skin lesions caused by human papillomavirus (HPV) infection. They are often resistant to conventional treatments and may cause cosmetic and psychological distress. Immunotherapy is a promising alternative that stimulates the host immune system to clear the virus and the infected cells. This study compared the efficacy and safety of two immunotherapeutic agents, intralesional measles, mumps, and rubella (MMR) vaccine and intralesional vitamin D, in the treatment of common warts.</p><p><strong>Methods: </strong>This was a single-blind randomised controlled trial conducted at a tertiary care hospital in Kolkata, India. Patients aged 12 years or older with common warts were randomly assigned to receive either intralesional MMR vaccine or intralesional vitamin D every 3 weeks for a maximum of three doses or until complete resolution, whichever was earlier. The primary outcome was the reduction in the size of the largest wart. Secondary outcomes included patients' and physicians' global assessment, complete response rate, adverse effects, and recurrence rate.</p><p><strong>Results: </strong>A total of 36 patients were enrolled and analysed. Both MMR and vitamin D groups showed a significant reduction in the size of the largest wart throughout the treatment period (<i>P</i> < 0.0001). There was no significant difference between the two groups in terms of size reduction, patients' and physicians' global assessment and adverse effects. The complete response rate was higher in the MMR group (64.7%) than in the vitamin D group (36.8%); however, the difference was not statistically significant (<i>P</i> = 0.14). The recurrence rate was low in both groups (5.9% in the MMR group and 10.5% in the vitamin D group).</p><p><strong>Conclusion: </strong>Both intralesional MMR vaccine and intralesional vitamin D are effective and safe immunotherapeutic options for the treatment of common warts. MMR vaccine may have a slight advantage over vitamin D in terms of complete response rate; however, further studies with larger sample sizes and longer follow-ups are needed to confirm this finding.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 3","pages":"169"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Granulomatous Periorificial Dermatitis: An Impending Need to Revise the Title?","authors":"Pratika Goyal, Dilip Meena, Manju Daroach, Payal Chauhan","doi":"10.4103/ijd.ijd_140_24","DOIUrl":"10.4103/ijd.ijd_140_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 3","pages":"160-164"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the Mystery of Multiple Swellings and Joint Contractures: Hyaline Fibromatosis Syndrome.","authors":"Chandrasekhar Varshini, Aakash Chandran Chidambaram, Raju Manivannan Dinesh Babu, Krishnamoorthy Vidhyasagar, Benjamin Sagayaraj","doi":"10.4103/ijd.ijd_643_23","DOIUrl":"10.4103/ijd.ijd_643_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 3","pages":"164-165"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simplified Single Kit Technique in the Management of Vitiligo: Non-Cultured Melanocyte Keratinocyte Transplantation-A Case Series.","authors":"Sukanya Gurusamy, Shreya Srinivasan, Ashok Kumar, Raksha Raja Narendra","doi":"10.4103/ijd.ijd_263_23","DOIUrl":"10.4103/ijd.ijd_263_23","url":null,"abstract":"<p><p>Vitiligo is a chronic disease characterised by the development of achromic macules brought on by the death of melanocytes. There are various approaches to address this malady. Many uncomplicated surgical procedures have been used to treat these patients in recent years and transplantation of autologous, non-cultured melanocytes constitutes one of them. Its enormous popularity among dermatologists was a result of numerous adjustments made over the years to make the process simpler and more affordable. Achieving success with this technique requires careful patient selection and strong technical abilities. The process of executing a non-cultured melanocyte-keratinocyte transfer is thoroughly described along with illustrations of cases where this treatment modality was adopted. This article emphasises on using a single use kit to perform melanocyte transfer and highlights its advantages over conventional practices.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 3","pages":"169"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prurigo Pigmentosa: Review of the Literature, Impact of Ketogenic Diets and Proposal of a Hypothesis.","authors":"Deniz Demircioğlu, Emel Öztürk Durmaz, Cüyan Demirkesen, Sedef Şahin","doi":"10.4103/ijd.ijd_464_22","DOIUrl":"10.4103/ijd.ijd_464_22","url":null,"abstract":"<p><p>Prurigo pigmentosa (PP) is characterized by an initially pruritic inflammatory rash on the torso and nape of the neck, which fades subsequently to leave a reticular macular hyperpigmentation. Among the list of suggested potential aetiological factors, ketosis remains an indisputable cause. However, the mechanism(s) linking ketosis and PP remain largely unknown. Recently, dermatologists have been confronted with an outbreak of PP induced by ketogenic diets (KD) and bariatric surgeries. Atypical forms (bullous variant) and localizations have been encountered. Herein, we review the relevant literature on PP, discuss its link to ketosis with current and future perspectives and propose a hypothesis for its aetiopathogenesis.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 3","pages":"146-151"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Fibrosing Alopecia: A Comprehensive Review with Recent Updates.","authors":"Shikha Verma, Anita Marak, Debopriya Paul","doi":"10.4103/ijd.ijd_419_24","DOIUrl":"10.4103/ijd.ijd_419_24","url":null,"abstract":"<p><p>Frontal fibrosing alopecia (FFA) is a progressive scarring alopecia affecting postmenopausal women. FFA is a primary lymphocytic scarring alopecia and is considered a variant of LPP due to similar histopathology findings in both conditions. The exact etiopathogenesis of FFA is not known. However, some genetic, autoimmunity, hormonal and environmental factors are implicated. However, the loss of the immune privilege of hair follicles and the role of cosmetics and sunscreen have been postulated. The disease is characterised by frontal and temporoparietal hairline recession with shiny, atrophic skin with sideburn involvement. The common trichoscopic findings include perifollicular erythema, follicular hyperkeratosis and loss of follicular openings. The histopathology is characterised by lichenoid lymphocytic infiltrate around the upper part of the hair follicle including the bulge area and concentric perifollicular lamellar fibrosis. There are two diagnostic criteria proposed by Tolkachjov <i>et al</i>. and the International FFA Cooperative Group. Many topical and systemic treatment options are available, but none have shown satisfactory results. Recently, many biological agents have been tried including tofacitinib and tildrakizumab.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"115"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanotrichoblastoma Arising on Nevus Sebaceous: A Rare Occurence.","authors":"Apaopa J Thekho, Deepika Uikey, Shanta Passi, V Ramesh","doi":"10.4103/ijd.ijd_1197_23","DOIUrl":"10.4103/ijd.ijd_1197_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"105-106"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotropic Drugs in Dermatology. Part 2: Antipsychotics, Sedative-Hypnotics and Anxiolytics in Dermatology.","authors":"Ankita Choudhary, Shiti Bose, K L Varsha, Bhushan Madke","doi":"10.4103/ijd.ijd_916_23","DOIUrl":"10.4103/ijd.ijd_916_23","url":null,"abstract":"<p><p>Dermatology as a branch is a panoramic canvas with a spectrum of manifestation, and psychodermatology is one emerging paradigm in its epicentre. Traditionally, it was thought that psychiatrists deal with \"internal\" nonvisible disease, while dermatology centres around \"external\" visible dermatoses and cosmetic disfigurement, hence, with this belief, psychodermatology appeared as an oxymoron to many. Management of psychodermatological disorders requires a multidisciplinary approach, which includes a combination of psychopharmacology, psychotherapy and timely referral as and when needed. The commonly available psychotherapeutics at the disposal of dermatologists include antidepressants, mood stabilizers, antipsychotics, anxiolytics and sedative-hypnotics, the last three of which have been focused in this part of the review.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"82-88"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Epithelioid Schwannoma in a Young Female- A Dilemma Set by Morphology; Resolved by Immunohistochemistry-A Rare Case Report.","authors":"K Amita, T Rajani","doi":"10.4103/ijd.ijd_584_23","DOIUrl":"10.4103/ijd.ijd_584_23","url":null,"abstract":"<p><p>Epithelioid morphology spawns myriad of benign and malignant tumors into differential diagnoses, which include epithelioid sarcoma, malignant melanoma, epithelioid malignant peripheral nerves sheath tumor, epithelioid hemangioendothelioma, myoepithelioma, etc. Epithelioid schwannoma (ES), especially the atypical variant has not received much attention in literature. Conclusive diagnosis, important for accurate management is, however, challenging. We describe a case of atypical ES in a 24-year-old female. On clinical and radiological examination, a provisional diagnosis of vascular malformation was made. Atypical epithelioid ESs are rare, but it is important to be aware of this variant to avoid misdiagnosis with other malignant epithelioid tumors. Apart from clinical and morphological features, immunohistochemistry aids in arriving at a decisive diagnosis. Perineurium-like capsule, circumscription, oblong shape of the lesion, and hyalinized blood vessels are pointers toward shwannomatous differentiation of this tumor.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"97-101"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Systemic Oxidative Stress Modulation in Melasma Following Treatment with Yellow Light Laser 577 nm and Topical 0.3% 4N Butyl Resorcinol: A Comparative Prospective Study.","authors":"Neelam Khurana, Mohammad M Mehdi, Mohinder P S Sawhney, Sanjiv K Bansal","doi":"10.4103/ijd.ijd_11_24","DOIUrl":"10.4103/ijd.ijd_11_24","url":null,"abstract":"<p><strong>Background: </strong>Melasma is an acquired hyperpigmentation disorder of the skin. Recent studies suggest that oxidative stress may contribute to the pathogenesis of melasma. Upregulated levels of circulatory antioxidants in blood serum and vascular endothelial growth factors in melasma lesions have been observed. The prospective study was conducted to compare the effect of the treatment of melasma with and without the use of a 577 nm vascular laser on levels of enzymatic antioxidants.</p><p><strong>Aims and objectives: </strong>To compare the modulation in the levels of enzymatic antioxidants in melasma patients treated with 577 nm yellow light laser in combination with topical depigmenting serum as compared to those using depigmenting serum alone.</p><p><strong>Materials and methods: </strong>Sixty patients with melasma of both sexes were randomly divided into groups of 30 each. Group A patients were treated with yellow light laser 577 nm (wavelength) once every 4 weeks for 4 sittings and topical depigmenting serum (4n butyl resorcinol) daily for 24 weeks. Group B patients were treated only with topical depigmenting serum. Levels of total antioxidant capacity (TAC), superoxide dismutase (SOD), inducible nitric oxide synthase (iNOS), glutathione peroxidase (GPx) and malondialdehydes (MDA) were estimated at 0 and 24 weeks.</p><p><strong>Results: </strong>Mean difference in lowering of the antioxidant levels in Group A and B was SOD1 (0.73 versus 0.12), GPX1, (0.62 versus 0.30), iNOS (1.56 versus 0.52), MDA, (0.73 versus 0.38), TAC (2.24 versus 1.28). A significantly higher mean of difference was observed in patients treated with combination therapy.</p><p><strong>Conclusion: </strong>Significantly higher reduction of enzymatic antioxidants with 577 nm yellow light laser in combination with 4 N-butyl resorcinol as compared to topical depigmenting agent alone recommends that combination therapy in melasma may target different aspects of a condition to enhance overall effectiveness.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 2","pages":"57-62"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}