Indian Journal of Dermatology最新文献

{"title":"Beyond the Surface: Decoding Pityriasis Versicolor Through Clinical, Dermoscopic and Microbiological Exploration.","authors":"Priya A Dsouza, Rochelle C Monteiro, Meena Dias, Sudhir Haladi Prabhu, Ramesh M Bhat, Jyothi Jayaraman, Jacintha Martis","doi":"10.4103/ijd.ijd_391_24","DOIUrl":"10.4103/ijd.ijd_391_24","url":null,"abstract":"<p><strong>Background: </strong>Pityriasis versicolor (PV) is an asymptomatic, superficial fungal infection caused by the Malassezia species and causes discolouration of the skin leading to altered pigmentation. It is usually a clinical diagnosis, but in doubtful cases wherein potassium hydroxide (KOH) mount is unavailable, alternative modalities like dermoscopy aid in the management.</p><p><strong>Aims and objectives: </strong>To evaluate the clinical and dermoscopic patterns in PV and correlate with the associated risk factors and study the fungal culture.</p><p><strong>Materials and methods: </strong>A cross-sectional observational study was conducted for 12 months. A total of 115 patients clinically diagnosed with PV showing positivity on KOH mount were recruited. Dermoscopy was done, following which the scales were scraped and cultured in the laboratory on Saborauds dextrose agar and modified Dixon media, and the results were analysed after 3 weeks.</p><p><strong>Results: </strong>Among the 115 participants, on clinical evaluation, 79 patients had achromic and 36 patients had chromic lesions. The dermoscopic features were categorized into domains such as scaling, pigmentation and other features. Fine scaling was the most common feature observed in 88.7% of the patients. Pigmentary changes were noted in all the patients with non-uniform pigmentation being the most common. We have also observed and described newer dermoscopic findings such as barbed wire fence appearance of ridges and furrows, fluffy cotton ball appearance of hypopigmented perifollicular lesions and sprinkled pepper appearance of pigmented dispersion. Out of the 115 KOH mount positive cases, 51 (44.3%) showed growth on fungal culture with <i>Malassezia furfur</i> being the most common species to be isolated in 18 patients.</p><p><strong>Conclusions: </strong>Dermoscopy is a new, popular non-invasive diagnostic modality, which shows specific features like fine scaling, pigment alteration, ridges and furrows with perifollicular involvement, and can be used to diagnose doubtful cases of PV as an adjunct or substitute to a KOH mount.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"6-10"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shedding New Light on Cutaneous Horns: A Comprehensive Review and Pitfall of Management.","authors":"Leo Wan, Aileen Park, Kamran Arastu, Amor Khachemoune","doi":"10.4103/ijd.ijd_331_24","DOIUrl":"10.4103/ijd.ijd_331_24","url":null,"abstract":"<p><p>A cutaneous horn, also known as cornu cutaneum, is an uncommon protuberance of highly compacted keratinous material from the stratum corneum, resembling an animal horn. Although the cause and pathogenesis of these lesions were long misunderstood, cutaneous horns are now generally recognised to be reactive skin growths that can result from a variety of infectious, malignant, pre-malignant, and benign conditions. Most cutaneous horns are benign, but approximately 16%-20% are malignant, with squamous cell carcinoma being the most common malignant underlying aetiology. As the identification of the underlying aetiology necessitates microscopic examination of the base of the cutaneous horn, a major potential pitfall in the diagnosis and management of these lesions lies in the use of improper biopsy technique, which leads to inadequate sampling and failure to correctly identify the underlying aetiology of the lesion. This focused and up-to-date comprehensive review addresses the clinical presentations, epidemiology, aetiology/pathogenesis, histopathology, and differential diagnosis for cutaneous horns. In addition, we provide an overview of the many conditions that may underlie cutaneous horns and the management/treatment of cutaneous horns, including a discussion of proper excision/biopsy technique. Our review aims to enhance understanding and shed light on some of the potential pitfalls in the diagnosis and treatment of cutaneous horns, with the goal of improving outcomes for patients presenting with this condition.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"50"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Trichoscopic Patterns of Discoid Lupus Erythematosus of Scalp in Patients with Systemic Lupus Erythematosus: An Observational Study.","authors":"Shivani Bhardwaj, Dincy Peter, Leni George, Anu A George, Gauri D Mahabal, Susanne Pulimood, Debashish Danda, Ramya Janardana","doi":"10.4103/ijd.ijd_514_23","DOIUrl":"10.4103/ijd.ijd_514_23","url":null,"abstract":"<p><strong>Background: </strong>Discoid lupus erythematosus (DLE) is a specific cutaneous manifestation of systemic lupus erythematosus (SLE), which results in scarring alopecia of the scalp.</p><p><strong>Methods: </strong>A prospective cross-sectional observational study on scarring alopecia among SLE patients was done between September 2016 and August 2017. The clinical and trichoscopic patterns of scalp DLE among these patients were studied. The DLE lesions were categorised into active and inactive based on clinical features. Trichoscopy was done and photographs were obtained using a non-polarised videodermoscope.</p><p><strong>Results: </strong>There were 26 patients with scalp DLE, out of which 15 patients (57.69%) had active DLE and 11 (42.30%) had inactive DLE. The trichoscopic findings seen were structureless white areas, loss of follicular units, blue-grey dots and globules, follicular keratotic plugs and telangiectasia. The trichoscopic features seen in active versus inactive DLE were blue-grey dots and globules (93.33% vs 63.63%), structureless white areas (93.33% vs 90.90%), loss of follicular units (86.66% vs 72.72%) and follicular keratotic plugs (80% vs 45.45%), yellow dots with arborising vessels (33.33% vs 72.72%), exaggerated honeycomb pigmentation (46% vs 63.63%) and telangiectasia (66.67% vs 54.54%). Scaling (<i>P</i> = 0.033) and blue-grey dots (<i>P</i> = 0.021) were significantly higher in active and yellow dots with arborising vessels (<i>P</i> = 0.047) in inactive DLE.</p><p><strong>Conclusions: </strong>On comparing trichoscopic features between active and inactive DLE scaling and blue-grey dots were significantly higher in active and yellow dots with arborising vessels in inactive DLE.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Ulcerated Polypoidal Cellular Fibrous Histiocytoma and Clustered Multiple Cellular Fibrous Histiocytomas in Segmental Distribution: An Uncommon Presentation with Benign Biological Behaviour.","authors":"Angoori G Rao, M Naresh, Praveen Kumar, Anmisha Bandaru, Shireesha Koolla, Bhavita Bade","doi":"10.4103/ijd.ijd_267_23","DOIUrl":"10.4103/ijd.ijd_267_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"51"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Epidermolysis Bullosa Pruriginosa with Oral Thalidomide: A Case Report of Rare Dystrophic EB Subset.","authors":"Shekhar Neema, Senkadhir Vendhan, Nazir Shah, A W Kashif, Biju Vasudevan","doi":"10.4103/ijd.ijd_269_24","DOIUrl":"10.4103/ijd.ijd_269_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"69 6","pages":"483-485"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNA: The Next Frontier in Dermatology Research and Therapeutics.","authors":"Abheek Sil, Disha Chakraborty","doi":"10.4103/ijd.ijd_568_23","DOIUrl":"10.4103/ijd.ijd_568_23","url":null,"abstract":"<p><p>Engagement of microribonucleic acids (miRNA) in the regulation of cutaneous cellular health and diseases is a rapidly advancing niche in dermatology basic research. miRNAs have been identified to play a key role in the pathogenesis of various cutaneous inflammatory, autoimmune and neoplastic conditions, among others. In addition, their purported role as therapeutic targets and biomarkers in diseased conditions harbours exciting news for the approaching years in clinical research. The current review outlines the possible translational role of miRNA in skin health and diseases (encompassing pathogenesis, diagnosis, biomarkers and therapy) from bench to bedside.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"69 6","pages":"486"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational Study with a New Portable Cryosurgery Device, HYDROZID^®, in Superficial Epidermal Lesions: An Indian Experience.","authors":"H Bangaru, Shivani Mishra, Sonam S Sachan, Sonam Ramrakhiani","doi":"10.4103/ijd.ijd_636_23","DOIUrl":"10.4103/ijd.ijd_636_23","url":null,"abstract":"<p><strong>Background: </strong>Cryosurgery remains an important treatment modality in dermatology practice. HYDROZID^®, a new portable cryosurgery medical device using norflurane as a cryogen, was recently introduced in the Indian market. This paper reports the findings of the phase IV study conducted in India.</p><p><strong>Aims: </strong>This is a prospective phase IV study to evaluate its safety and efficacy in the treatment of superficial epidermal and dermal lesions.</p><p><strong>Methods: </strong>The study was conducted across 4 centres in India. The cryosurgery cycles were decided based on the skin lesion considered for the treatment. Safety and efficacy parameters were assessed at day 1, day 7, day 14, day 30 (±2) (end of treatment), and day 60 (±2) after the initial cryosurgery treatment. The local skin reactions scale, pain VAS scale, and Vancouver scale for assessment of pigmentation and scarring were used for the assessment of cutaneous reactions. Assessment of efficacy was done by evaluating the total disappearance of skin lesions at the end of the study visit.</p><p><strong>Results: </strong>Ninety-seven patients completed the study. The reported post-procedural pain was mild to moderate and subsided over the period of 24 hours. There was no pain observed in 84.76% of patients at the end of 24 hours. Complete disappearance of the lesion was seen in 47.4% of patients at the end of the study, while the reduction in the diameter of skin lesions by more than 50% was observed in 79.38% of patients.</p><p><strong>Conclusion: </strong>The data from this study support good clinical tolerability and safety of the Hydrozid^® portable cryo device.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"69 6","pages":"425-431"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Keystone Flap in Armory of Dermatosurgeons.","authors":"Abhinav Singh, Rohini Singh, Gaurav Chaturvedi, Malika Singh, R B Singh","doi":"10.4103/ijd.ijd_953_23","DOIUrl":"10.4103/ijd.ijd_953_23","url":null,"abstract":"<p><strong>Purpose and background: </strong>To create awareness among dermatosurgeons about the versatility of keystone flaps in re-surfacing post-excisional small, medium and large skin defects.</p><p><strong>Aims and objectives: </strong>Single-staged tension-free re-surfacing of various sized skin defects using keystone flap and to have least donor site morbidity, primary healing and maximum functional outcome.</p><p><strong>Material and methods: </strong>This retrospective study was conducted, between October 2021 - January 2023 in Department of Plastic Surgery, PGIMS Rohtak, on 15 males and 1 female aged between 18 - 65 years. Sixteen Keystone flaps (type IIA <i>n</i>=13, Omega cum Sydney melanoma unit modification <i>n</i>=3) were utilized for resurfacing skin defects arising after excision of basal cell carcinoma (<i>n</i>=3) and benign hairy nevus (<i>n</i>=2) on cheek, basal cell carcinoma forehead (<i>n</i>=1), electric burns on deltoid (<i>n</i>=2), giant neurofibroma back (<i>n</i>=1), tattoo forearm (<i>n</i>=3), chronic non-specific granuloma thumb (<i>n</i>=2) and pilonidal sinus disease (<i>n</i>=2). Skin with maximum expansibility was chosen as donor site with utmost care of facial lines and its aesthetic subunits. Flaps were dissected all around preserving maximum number of hand-held Doppler-identified perforators in pedicular area. Sutures were removed on 10th to 15th post-operative day. Follow-ups ranged from 2 to 15 months.</p><p><strong>Results: </strong>None had wound dehiscence or loss of flap.</p><p><strong>Conclusion: </strong>Keystone flaps have defect-adaptive design, simple bio-geometry, technical simplicity, decreased downtime, cost effectivity and efficiency and can be designed to resurface post-excisional skin defect from head to toe with acceptable results, therefore should strongly be considered by dermatosurgeons while excising skin lesions.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"69 6","pages":"432-441"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and Post-Exposure Prophylaxis in Sexually Transmitted Diseases: An Uncharted Territory.","authors":"Atreyo Chakraborty","doi":"10.4103/ijd.ijd_828_22","DOIUrl":"10.4103/ijd.ijd_828_22","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"69 6","pages":"471-474"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Misdiagnosis of Erythroderma Secondary to Lichen Planus: A Case Report.","authors":"Zhixuan Guo, Jianchi Ma, Xiqing Li","doi":"10.4103/ijd.ijd_41_24","DOIUrl":"10.4103/ijd.ijd_41_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"69 6","pages":"479-481"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}