Indian Journal of Dermatology最新文献

{"title":"Interscapular Freckling and Comedone-like Lesions in Neurofibromatosis Type 1 with Associated Intestinal Complications.","authors":"Samuel Jeyaraj Daniel, Balaji Ganesh, K Desingh","doi":"10.4103/ijd.ijd_849_24","DOIUrl":"10.4103/ijd.ijd_849_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"420"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Efficacy and Safety of Ixekizumab in the Treatment of Psoriasis: A Case-Series from Indian Sub-Continent.","authors":"Abhishek De, Sk Shahriar Ahmed, Disha Chakraborty, Shrayan Pal","doi":"10.4103/ijd.ijd_133_24","DOIUrl":"10.4103/ijd.ijd_133_24","url":null,"abstract":"<p><p>Psoriasis is a chronic, debilitating disease of inflammatory dermatoses. IL-17 plays a pivotal role in the pathogenesis of psoriasis. It acts as a driving force in psoriasis and has a significant role in keratinocyte proliferation, plaque progression, neutrophil recruitment, forming an amplification loop, and formation of tissue-resident memory T helper cells causing relapse. Ixekizumab is a humanized IgG4 monoclonal anti-IL-17 antibody approved for psoriasis in 2016. We are reporting a series of 22 patients presented with moderate to severe psoriasis treated with ixekizumab. 31.8% of patients had pre-existing comorbidities like Hypertension, diabetes, or hypertriglyceridemia. After 14 weeks of treatment, the Mean ± SD PASI improved from 30.82 ± 7.06 to 2.82 ± 3.12. At the end of treatment (14^th week), PASI75, PASI 90, and PASI 100 were achieved by 95.45%, 68.18%, and 27.27% of patients, respectively. Friedman's ANOVA shows a significant decrease (<i>P</i> < 0.05) in PASI, BSA, and sPGA scores starting from the 1^st follow-up (2 weeks) onwards. Paired <i>t</i>-test shows a significant decrease in PAsI, BSA, and sPGA reduction, <i>P</i> < 0.0001 between baseline and 7^th follow-up visit (14 weeks). No significant side effects were noted in this period. The present study illustrates the experience with ixekizumab in real-world clinical practice, confirming its effectiveness and safety in the management of plaque psoriasis patients.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"410-413"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The story of a <i>Mineral Chameleon</i>: From Johann Rudolf Glauber (1604-1670) to Henry Bollmann Condy (1826-1907).","authors":"Amiya Kumar Mukhopadhyay","doi":"10.4103/ijd.ijd_729_25","DOIUrl":"10.4103/ijd.ijd_729_25","url":null,"abstract":"<p><p>Following the emergence of germ theory and the importance of infection and its prevention, as advocated by various towering authorities such as Louis Pasteur, Robert Koch, and Lord Lister, the focus shifted from the old miasma theory to the role of microorganisms. Consequently, the emphasis was put on disinfectants and antisepsis. Among various chemical disinfecting agents, Condy's solution (potassium permanganate) has remained an important one in the field of dermatology, in particular and medicine in general. The history of Condy's fluid is full of fascinating facts, and the story covers a wide area from the clinic to the court of law. This article is a bird's-eye view of the subject.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"395-397"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical 10% Tranexamic Acid in Topical Steroid-Damaged Faces: A Non-Randomised Interventional Study.","authors":"Pranami Kashyap, Anita Marak, Shikha Verma, Sakshi Kumari","doi":"10.4103/ijd.ijd_121_24","DOIUrl":"10.4103/ijd.ijd_121_24","url":null,"abstract":"<p><strong>Background: </strong>Topical Steroid Damaged/Dependent Face (TSDF) is described as 'the semi-permanent or permanent damage to the skin of the face precipitated by the irrational, indiscriminate, unsupervised, or prolonged use of TCs resulting in a plethora of cutaneous signs and symptoms and psychological dependence on the drug'. Its management is difficult due to the unavailability of a universally accepted treatment regimen, as well as a high rate of rebound after stopping therapy.</p><p><strong>Aim: </strong>To study the efficacy and safety of the application of 10% tranexamic acid solution in Topical Steroid Damaged/Dependent Faces.</p><p><strong>Methods: </strong>In this non-randomised interventional study, 15 cases with TSDF were treated with topical 10% tranexamic acid solution applied once daily for 8 weeks and followed up every 4 weeks up to 12 weeks. Erythema, the hallmark of TSDF, was graded based on the Clinician's Erythema Assessment (CEA) scale, and improvement in this score was recorded at every follow-up visit along with clinical photographs.</p><p><strong>Results: </strong>Erythema, photosensitivity and telangiectasia were present in all our subjects, followed by pigmentary abnormalities, acneiform eruptions, hypertrichosis and atrophy. Based on the reduction in CEA, we recorded a statistically significant improvement in erythema at week 4, and complete resolution of the same in 100% of our subjects by week 8.</p><p><strong>Conclusions: </strong>Topical 10% tranexamic acid solution is a novel, promising, safe and efficacious modality in the treatment of TSDF.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"360-365"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of CD68-Positive Congenital Granular Cell Epulis.","authors":"Tapas Kanti Parida, M Shameema Farween, Akash Bihari Pati, Manita Tamang, Pavithra Ayyanar","doi":"10.4103/ijd.ijd_769_24","DOIUrl":"10.4103/ijd.ijd_769_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"420"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a Link Between Dermatosis Papulosa Nigra and Metabolic Syndrome: A Cross-Sectional Exploratory Study.","authors":"Aishwarya Satyanarayana, Sowmya Kaimal","doi":"10.4103/ijd.ijd_816_24","DOIUrl":"10.4103/ijd.ijd_816_24","url":null,"abstract":"<p><strong>Background: </strong>Dermatosis papulosa nigra (DPN) is a benign, pigmented tumour presenting as tiny papules on the face and neck, mostly in individuals with darker skin types. It is considered a variant of seborrheic keratosis (SK). The metabolic syndrome (MetS), a complex of metabolic abnormalities, is associated with increased risk of cardiovascular disease and diabetes mellitus. There are established cutaneous markers of MetS, such as acanthosis nigricans and skin tags. Furthermore, acanthosis nigricans, skin tags, seborrheic keratosis and dermatosis papulosa nigra (DPN) have been described in diabetics. To our knowledge, there are no studies reported on the association between MetS and seborrheic keratosis/DPN. This study intends to explore the possibility of DPN being a cutaneous marker of MetS.</p><p><strong>Aims and objectives: </strong>To estimate the prevalence of MetS and its components among patients with dermatosis papulosa nigra and to correlate the prevalence of MetS with the number/severity of DPN.</p><p><strong>Materials and methods: </strong>A hospital-based cross-sectional study was performed on 100 patients with more than 5 DPNs. Consenting patients were subjected to detailed evaluation, including history, anthropometric measurements and blood investigations, to detect metabolic syndrome. MetS was diagnosed by the presence of three or more of the harmonized criteria given in 2009.</p><p><strong>Results: </strong>The prevalence of MetS in DPN patients was 64%, which is much higher than the prevalence in the general population (30%). The prevalence of MetS was significantly higher in males compared to females (80.6% vs 54.7%, <i>P</i> = 0.01). Among the components of metabolic syndrome, reduced high density cholesterol was the most common positive finding (75%).</p><p><strong>Conclusion: </strong>The prevalence of MetS in DPN patients was much higher compared to the prevalence in the general population, and further studies with a control population are necessary to establish the association between DPN and metabolic syndrome.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"386-391"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targetoid, Arciform, and Annular Lesions on the Trunk and Extremities.","authors":"Yan J Chen, Lin Wang","doi":"10.4103/ijd.ijd_221_25","DOIUrl":"10.4103/ijd.ijd_221_25","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"418-419"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Epidermal Elafin Immunohistochemistry as a Diagnostic Biomarker of Acute Skin GVHD.","authors":"Gauri D Mahabal, Leni George, Dincy C V Peter, Mandeep S Bindra, Meera Thomas, Aby Abraham, Biju George, Vikram Mathews, Alok Srivastava, Susanne Pulimood","doi":"10.4103/ijd.ijd_219_25","DOIUrl":"10.4103/ijd.ijd_219_25","url":null,"abstract":"<p><strong>Background: </strong>Acute skin graft-versus-host disease (GVHD) is a common and early complication of haematopoietic stem cell transplantation (HSCT). Diagnosing GVHD through histopathology alone can be challenging due to overlap with other conditions. Tissue elafin immunohistochemistry (IHC) has shown potential as a diagnostic tool, but studies report conflicting results.</p><p><strong>Objectives: </strong>To examine the utility of elafin IHC in skin biopsies for accurate acute skin GVHD diagnosis in HSCT recipients.</p><p><strong>Methods: </strong>Consecutive allogenic HSCT recipients in a tertiary care centre in South India, who developed rash within the first 100 days post-HSCT during a 17-month period were recruited. Skin biopsies were taken on the day of rash and epidermal elafin IHC was done. Staining of >50% of the epidermis was considered positive. The final diagnosis of skin GVHD was assigned using a composite criteria of clinical features, histopathology and response to treatment. We evaluated the accuracy of elafin IHC in GVHD diagnosis.</p><p><strong>Results: </strong>Sixty-eight skin biopsies from 58 patients (median age 14 years; range 1-53; 46 males) were analyzed. Median day of rash onset was 23.5 (range: 5-98). GVHD was confirmed in 45 (66.2%) episodes. Elafin IHC was positive in all GVHD and 9/23 non-GVHD cases, six of which were engraftment syndrome. The sensitivity and specificity of elafin IHC were 100% and 58.3%, respectively. There was a significant correlation between positive elafin IHC and GVHD (<i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>Tissue elafin is a highly sensitive IHC marker for diagnosis of acute skin GVHD, including cases without classic histopathological findings. However, its utility is limited in distinguishing GVHD from engraftment syndrome.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"354-359"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potency of Artificial Intelligence in Diagnosing and Evaluating the Severity of Vitiligo: A Systematic Review and Meta-Analysis.","authors":"Maureen M Stella, Arief Budiyanto, Agnes Rp Sari, Shinta T Dewi, Yohanes W Wirohadidjojo","doi":"10.4103/ijd.ijd_430_25","DOIUrl":"10.4103/ijd.ijd_430_25","url":null,"abstract":"<p><p>Neural networks (NNs), a subset of artificial intelligence (AI), have the ability to assess the severity of vitiligo and improve diagnosis accuracy. In contrast to human physicians' diagnosis, which is primarily based on subjective assessment, standardised and objective diagnostic methods are needed to provide an accurate diagnosis and grade the severity of vitiligo. The aim of this study is to analyse the sensitivity and specificity of AI in vitiligo diagnosis and severity assessment. The PRISMA 2020 protocol was followed to screen literature in several databases: Proquest, PubMed, Taylor and Francis, SAGE, JSTOR, and ScienceDirect. Human studies that investigated the potential of AI in vitiligo diagnosis were included in vitiligo diagnosis were included. Statistical analysis was carried out using RevMan 5.4 and RStudio, and risk of bias tools were used to assess study bias. Certainty of evidence was analysed using GRADE. The systematic review consisted of 15 studies, and seven studies were statistically analysed. The most studied NNs were Inception V3 (n = 2), visual geometry group (n = 2), and ResNet (n = 2). The overall sensitivity ranged from 72.5% to 99.7%, with a pooled sensitivity of 95.5%. Specificity ranged from 72% to 99.9%, with a pooled specificity of 97%. Among the evaluated models, Inception V3 showed the highest diagnostic performance. The summary receiver operating characteristics curve (SROC) from multiple analyses showed an area under the curve of 0.96. AI showed potential in diagnosing and evaluating the severity of vitiligo.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"335-347"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional Vitamin D in Dermatology: An Evidence-Based Review of Utility.","authors":"Subuhi Kaul, Piyush Kumar, Anupam Das","doi":"10.4103/ijd.ijd_232_24","DOIUrl":"10.4103/ijd.ijd_232_24","url":null,"abstract":"<p><p>Vitamin D has been used in a gamut of medical conditions, including dermatology. Intralesional Vitamin D, however, is not a common therapeutic option in dermatological disorders. This review is an attempt to summarise the evidence available for using intralesional vitamin D in warts, molluscum, keloids, and vitiligo.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"398-402"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}