Indian Journal of Dermatology最新文献

{"title":"Comprehensive Assessment of Symptoms, Comorbidities, and Treatment Response in Individuals with Atopic Dermatitis Treated at a Referral Centre between 2018 and 2022.","authors":"Olga Lucia Agudelo Rojas, María José Calle Salazar, Liliana María Tamayo Quijano, Margarita Velásquez-Lopera, Elsa María Vásquez Trespalacios, Juliana Madrigal-Cadavid, Angela María Londoño García","doi":"10.4103/ijd.ijd_836_24","DOIUrl":"10.4103/ijd.ijd_836_24","url":null,"abstract":"<p><strong>Introduction: </strong>Atopic dermatitis (AD) is a chronic and recurrent inflammatory disease that begins in childhood and can persist into adulthood, with a significant impact on quality of life. However, there is a lack of data on its characteristics and treatment in Colombia and Latin America.</p><p><strong>Objective: </strong>To describe the clinical and sociodemographic characteristics, quality of life, and treatment responses in patients with AD at a referral centre in the city of Medellín, Colombia.</p><p><strong>Materials and methods: </strong>A retrospective descriptive study was conducted analysing demographic, clinical, and treatment response data, including biologic therapy, in patients with AD treated at the Comprehensive Clinical Program for Immune-Mediated Skin Diseases (CLIPSO) during the period 2018-2022 in Medellín, Colombia.</p><p><strong>Results: </strong>A total of 301 patients, including children and adults, with a mean age of 26.76 years were studied; 32.2% were under 18 years old. The average follow-up was 33.23+/- 22.11 months. Psychiatric disorders were detected in 7.3% of patients and cardiovascular comorbidities in 10.6%. At baseline, moderate-to-severe disease severity was observed. A 50% reduction in pruritus was associated with adequate disease control by therapy. Additionally, patients treated with dupilumab experienced a 30% decrease in clinical evaluation scores during follow-up.</p><p><strong>Conclusion: </strong>Understanding the characteristics of a disease in both children and adults is crucial for comprehensive and personalised management. It is important to know data such as age of onset, symptoms, common lesion locations according to age, comorbidities, and treatment responses. This information is fundamental for selecting appropriate therapies, ensuring effective follow-up, and improving quality of life.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"120-126"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Habit Reversal Therapy in Treatment of Lichen Simplex Chronicus (Neurodermatitis): A Comparative, Pilot Study.","authors":"Naveen Kumar Kansal, Ramesh Pratap Anuragi, Riti Bhatia, Vikram Singh Rawat, Tarun Narang, Neirita Hazarika","doi":"10.4103/ijd.ijd_594_24","DOIUrl":"10.4103/ijd.ijd_594_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Lichen simplex chronicus (LSC) is a common dermatosis with a habitual itch-scratch cycle and associated psychological elements. Therefore, psychological methods, such as habit reversal, to break the scratching behaviour may have a therapeutic benefit in this condition. Our objective in this study was to assess additional clinical effects of habit reversal therapy when combined with standard therapeutic measures (i.e. topical corticosteroids, antihistamines, and emollients).</p><p><strong>Patients and methods: </strong>Thirty-four patients with LSC were divided into two groups: group A (standard therapy with adjunctive habit reversal therapy, the intervention group) and group B (standard therapy alone). The patients were taught the habit reversal therapy and followed up for 4 months. Clinical assessment and Dermatology Life Quality Index (DLQI) questionnaire were performed at every visit.</p><p><strong>Results: </strong>In various parameters of LSC, including induration, skin markings, itching, and scratching, a significantly better response was seen in group A. Group A also had a better DLQI score. Patients' perception of the psychological intervention was good.</p><p><strong>Conclusions: </strong>The addition of habit reversal therapy with standard treatments of LSC significantly improved the treatment outcome. Therefore, combining psychological interventions with approved therapies may benefit chronic dermatological conditions in appropriate clinical settings.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"103-108"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Delayed 'Turkey Ear' Caused by Earlobe Piercing: What is New About an Existing Phenomenon?","authors":"Qi-Hao Yao, Ze-Hu Liu","doi":"10.4103/ijd.ijd_581_24","DOIUrl":"10.4103/ijd.ijd_581_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"155-157"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Erythematous Plaque on the Left Breast of a 22-Year-Old Woman.","authors":"Xiao Ma, Dong-Lai Ma","doi":"10.4103/ijd.ijd_434_24","DOIUrl":"10.4103/ijd.ijd_434_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"167-168"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Blue-Coloured Nodules on the Whole Body.","authors":"Kyung Ho Lee, Joo Ho Jeong, Chul Jong Park, Yoon-Seob Kim","doi":"10.4103/ijd.ijd_383_24","DOIUrl":"10.4103/ijd.ijd_383_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"169"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Tranexamic acid Microneedling versus Intradermal Injection of Tranexamic Acid in the Treatment of Melasma - A Randomised Controlled Trial.","authors":"M Srijha, Damayandhi Kaliyaperumal, Jude Ernest Dileep, Sheela Kuruvila","doi":"10.4103/ijd.ijd_1041_24","DOIUrl":"10.4103/ijd.ijd_1041_24","url":null,"abstract":"<p><strong>Background: </strong>Melasma is a pigmentary disorder that typically appears on the face. Given its tendency to relapse, resistance to treatment and significant impact on social and emotional well-being, melasma poses considerable challenges.</p><p><strong>Objectives: </strong>To compare the effectiveness and adverse effects of tranexamic acid (TXA) in reducing modified Melasma Area and Severity Index (mMASI) scores when given along with microneedling versus intradermal injections in the treatment of melasma.</p><p><strong>Materials and methods: </strong>This was a hospital-based randomised controlled study conducted in the outpatient Department of Dermatology, Venereology and Leprosy, Aarupadai Veedu Medical College, among patients with melasma, between November 2022 and April 2024. In Group A (<i>n</i> = 35), patients received microneedling with TXA (4 mg/mL) and intradermal injections of TXA (4 mg/mL) in Group B (<i>n</i> = 35). Treatment was administered every 4 weeks for four sessions and followed-up once a month for 2 months.</p><p><strong>Results: </strong>The baseline characteristics of the study groups did not vary significantly by age (in years), gender, Fitzpatrick skin type, precipitating factors, clinical type of melasma, and pattern of melasma. Both groups showed significant reduction in mMASI scores from baseline to 20 weeks (7.1 ± 2.3 to 4.6 ± 0.5 in Group A and 7.0 ± 3.1 to 5.3 ± 0.7 in Group B, respectively). From 12^th week onwards, Group A had significantly lower mMASI scores than Group B (<i>P</i> < 0.05). A total of 83% of Group A patients had nearly cleared melasma compared to 37.0% in Group B (<i>P</i> < 0.05). Photographic documentation revealed that over 75.0% of Group A patients had more than 50.0% improvement, against 40.0% in Group B (<i>P</i> < 0.05). Adverse events such as erythema, pain, burning sensation, and pigmentation were slightly more common in Group B, but the difference was not statistically significant.</p><p><strong>Conclusion: </strong>The study highlights microneedling with TXA as a promising and effective treatment option for melasma, offering substantial clinical improvement and patient satisfaction.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"109-114"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Insight into Gorlin-Goltz Syndrome.","authors":"M Madhu","doi":"10.4103/ijd.ijd_1165_23","DOIUrl":"10.4103/ijd.ijd_1165_23","url":null,"abstract":"<p><p>Gorlin-Goltz syndrome, also called Basal cell nevus syndrome (BCNS), Nevoid basal cell carcinoma syndrome (NBCCS), or Basal nevus cell carcinoma syndrome (BNCCS) is a rare, inherited, autosomal dominant genodermatoses, with variable expression and complete penetrance, characterized by the occurrence of multiple basal cell carcinomas (BCCs) at a young age, palmoplantar pits, keratocystic odontogenic tumors, intracranial ectopic calcifications, facial dysmorphism, and ocular and skeletal anomalies. It occurs due to a defective hedgehog cell signaling pathway, caused by heterozygous germ-line mutations in either Patched 1 (PTCH1), Suppressor of fused (SUFU), Smoothened (SMO), or Patched 2 (PTCH2) genes, leading to tumorigenesis and various developmental anomalies. Because of variable phenotypic expression, the syndrome is difficult to diagnose and is often diagnosed late, increasing the risk of morbidity and rarely mortality in the patients. The gene mutated also determines the phenotypic expression of the syndrome. Detection of the gene mutated plays an important role in, antenatal diagnosis, confirming the diagnosis when in doubt clinically and predictive diagnosis in family members of the affected individuals, which helps us to diagnose the syndrome early, hence screen for various clinical manifestations at the appropriate age according to the gene that is mutated and initiate early treatment to reduce morbidity and mortality.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"87-93"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Kaposi Sarcoma Masquerading as Tuberculosis: A Case Report.","authors":"Biju Vasudevan, Senkadhir Vendhan, Shekhar Neema, A W Kashif, Tilak Tvsvgk","doi":"10.4103/ijd.ijd_669_24","DOIUrl":"10.4103/ijd.ijd_669_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"152-155"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Features of Porocarcinoma: Report of 11 Cases and Review of the Literature.","authors":"Kodai Miyamoto, Teruki Yanagi, Takuya Maeda, Keiko Tokuchi, Che Yuan Hsu, Hideyuki Ujiie","doi":"10.4103/ijd.ijd_455_24","DOIUrl":"10.4103/ijd.ijd_455_24","url":null,"abstract":"<p><p>Porocarcinoma is a rare skin cancer that originates in cutaneous intraepidermal ducts of the sweat glands. Although dermoscopy is often helpful to make a diagnosis of skin tumors such as melanoma, dermoscopic features of porocarcinoma have not been investigated in detail. We aimed to identify dermoscopic features of porocarcinoma and to determine if they are distinguishable from other diseases. We examined the dermoscopic features of 11 cases of porocarcinoma, which were diagnosed using histopathological observations. Also, we reviewed previous case reports describing dermoscopic characteristics of porocarcinoma. Pink-white structureless areas were observed focally in all 11 cases. Ten cases showed polymorphous vascular patterns, in which two or more vascular patterns, such as linear-irregular, glomerular, dotted, and hairpin vessels, were present. None of the leaf-like vessels, coiled vessels, arborizing vessels, comedo-like openings, milia-like cysts, cerebriform patterns, or pigment networks were observed in any cases. In the previously reported 14 cases of porocarcinoma, the \"white-to-pink halo\" and the \"polymorphous vascular pattern\" were the most frequent dermoscopic findings (13 cases). \"Pink-white structureless areas\" was the third most common finding (11 cases). In cases displaying polymorphous vascular patterns, the main component was linear-irregular vessels (9 cases). Our 11 and 14 reported cases suggest that \"pink-white structureless areas\" together with \"polymorphous vascular patterns\" should be considered critical dermoscopic features of porocarcinoma. The findings could be helpful to distinguish porocarcinoma from tumors like eccrine poroma.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"145-150"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented Lesion in an Elderly Man: An Unusual Diagnosis.","authors":"Daniele C de Freitas Zernow, Hugo M Faver, Flávia P S C de Oliveira, Daniel L Obadia","doi":"10.4103/ijd.ijd_929_24","DOIUrl":"10.4103/ijd.ijd_929_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 2","pages":"165-166"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}