Indian Journal of Dermatology最新文献

{"title":"Clinico-dermoscopic and Histopathological Evaluation of Benign Skin, Soft Tissue and Appendageal Tumours of Skin: A Cross-sectional Study from a Tertiary Care Hospital.","authors":"Saika Reyaz, Shagufta Rather, Sheikh Bilal, Taiba Trumboo, Mateen Hussain","doi":"10.4103/ijd.ijd_461_24","DOIUrl":"10.4103/ijd.ijd_461_24","url":null,"abstract":"<p><strong>Background: </strong>Benign skin, soft tissue and appendageal tumours of skin are one of the most frequently encountered skin disorders. An organised systematic approach along with dermoscopic and histopathological examination can aid in the diagnosis of these diverse disorders.</p><p><strong>Objective: </strong>To evaluate clinico-dermoscopic and histopathological findings of benign skin, soft tissue and appendageal tumours of skin in patients attending a tertiary care hospital.</p><p><strong>Methods: </strong>Cross-sectional hospital-based study where patients of all age groups irrespective of gender suspected of having benign skin, soft tissue and appendageal tumours were enrolled. Clinical, dermoscopic and histopathological findings were recorded and the agreements between them were evaluated using the Cohen's Kappa coefficient.</p><p><strong>Results: </strong>The study included a total of 415 patients with a mean age of 37.9 ± 15.59 years and a male to female ratio of 1:1.3. The mean duration of the disease was 4.3 ± 2.14 years. Soft tissue tumours were the commonest (60%), followed by benign skin tumours (24.3%) and benign appendageal tumours (17.1%). A good agreement between dermoscopic and clinical diagnosis was found (Cohen's Kappa = 0.879) and between dermoscopic and histopathological diagnosis was also found (Cohen's Kappa = 0.789).</p><p><strong>Conclusion: </strong>This study infers that benign tumours of the skin include a heterogeneous group of skin disorders affecting a heterogeneous population. Dermoscopy improved the diagnostic accuracy of this large group of skin disorders and reduced the number of unnecessary excisions; however, histopathology remains the benchmark diagnostic tool to differentiate these tumours from other benign tumours and their malignant counterparts.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"50"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partly Pigmented Papule on the Nose: A Friend or Foe?","authors":"Alise Balcere, Laura A Pauliņa, Mihails Ščerbuks","doi":"10.4103/ijd.ijd_1079_23","DOIUrl":"10.4103/ijd.ijd_1079_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"47-49"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Demographic and Clinical Traits in Neurofibromatosis Type 1 Patients: Insights into Vitamin D Levels and Connections with Nevus Anemicus and Neurofibromas.","authors":"Vahid Ahmadi, Nazli Karimi, Arsoy S Evans, Ayşen Karaduman","doi":"10.4103/ijd.ijd_141_24","DOIUrl":"10.4103/ijd.ijd_141_24","url":null,"abstract":"<p><strong>Aim: </strong>This article aims to examine the demographic and clinical traits of neurofibromatosis type 1 (NF1) patients, particularly focusing on the potential links between vitamin D levels, BMI, and dermatological features.</p><p><strong>Methods: </strong>A retrospective review of medical records involving 128 patients diagnosed with neurofibromatosis type 1 (NF1) over a 3-year-period was conducted. The analysis emphasized investigating the demographic and clinical characteristics of the patients while evaluating key parameters.</p><p><strong>Result: </strong>Nevus anemicus was present in 32.8% of NF1 patients, and a significant association was found between nevus anemicus and low vitamin D levels (<i>P</i> = 0.001). We also observed a notable correlation between low vitamin D levels and an increased likelihood of neurofibromas (<i>P</i> < 0.001). Additionally, there appears to be an inverse relationship between serum vitamin D levels and the number of neurofibromas.</p><p><strong>Conclusion: </strong>Our study suggests a correlation between lower vitamin D levels and key dermatological characteristics in neurofibromatosis type 1 (NF1) individuals. Specifically, we observed associations with nevus anemicus prevalence and increased neurofibromas. This observation enriches NF1's understanding, offering practical implications for patient management by emphasizing the importance of monitoring and addressing vitamin D levels.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"11-17"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidermatomal Unilateral Primary Zosteriform Lichen Sclerosus: A Rare Clinical Presentation.","authors":"Parul Bansal, Bikash R Kar, Manoj K Nayak, Kallolinee Samal, Nibedita Dixit","doi":"10.4103/ijd.ijd_301_24","DOIUrl":"10.4103/ijd.ijd_301_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"51"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea.","authors":"Vibhu Mendiratta, Anuja Yadav, Amit K Meena, Suvarna Samudrala, Ritu Singh, Vishal Parmar","doi":"10.4103/ijd.ijd_1081_23","DOIUrl":"10.4103/ijd.ijd_1081_23","url":null,"abstract":"<p><strong>Background: </strong>Morphoea is a sclerosing disorder of skin and subcutaneous tissue. Paediatric morphoea shows increased prevalence of various auto-immune diseases, bone deformities, and systemic abnormalities. There is paucity of studies on various immunological, skeletal, and thyroid function abnormalities in paediatric morphoea.</p><p><strong>Aims and objectives: </strong>To describe immunological, skeletal, and thyroid function abnormalities present in paediatric morphoea patients.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted from January 2021 to March 2023 in the Dermatology outpatient department in a tertiary care hospital. All paediatric morphoea patients were included in this study. All were subjected to detailed history, clinical examination, and investigations including complete blood count, serum IgE, anti-nuclear antibody, thyroid function tests, anti-thyroid peroxidase antibodies, and radiological investigations.</p><p><strong>Results: </strong>A total of 42 children were recruited, out of which 61.90% were females and 38.09% were males. The majority were in the age group of 4-8 years. The most common type of morphoea was encoup de sabre. Anaemia was present in 14.28% patients. Serum IgE levels were raised in 33.33% patients. Thyroid stimulating hormone was raised in 11.9% patients. 33.33% had raised anti-thyroid peroxidase levels. Anti-nuclear antibody titres and rheumatoid factor were raised in 7.14% and 4.76% patients, respectively. Magnetic resonance imaging brain revealed abnormalities in three patients as hyper-intensities in subcortical white matter.</p><p><strong>Conclusion: </strong>Morphoea in children can be associated with varied immunological, osteoarticular, and neurological abnormalities. This study highlights the multi-system involvement in morphoea and the need for larger data and well-designed therapeutic trials for generating evidence-based treatment of this potentially disfiguring disease.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"50"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roflumilast in Dermatology: A Newer Phosphodiesterase-4 Inhibitor.","authors":"Suvesh Singh, Debopriya Paul, Aditi Snehal","doi":"10.4103/ijd.ijd_261_24","DOIUrl":"10.4103/ijd.ijd_261_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"38-41"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Surface: Decoding Pityriasis Versicolor Through Clinical, Dermoscopic and Microbiological Exploration.","authors":"Priya A Dsouza, Rochelle C Monteiro, Meena Dias, Sudhir Haladi Prabhu, Ramesh M Bhat, Jyothi Jayaraman, Jacintha Martis","doi":"10.4103/ijd.ijd_391_24","DOIUrl":"10.4103/ijd.ijd_391_24","url":null,"abstract":"<p><strong>Background: </strong>Pityriasis versicolor (PV) is an asymptomatic, superficial fungal infection caused by the Malassezia species and causes discolouration of the skin leading to altered pigmentation. It is usually a clinical diagnosis, but in doubtful cases wherein potassium hydroxide (KOH) mount is unavailable, alternative modalities like dermoscopy aid in the management.</p><p><strong>Aims and objectives: </strong>To evaluate the clinical and dermoscopic patterns in PV and correlate with the associated risk factors and study the fungal culture.</p><p><strong>Materials and methods: </strong>A cross-sectional observational study was conducted for 12 months. A total of 115 patients clinically diagnosed with PV showing positivity on KOH mount were recruited. Dermoscopy was done, following which the scales were scraped and cultured in the laboratory on Saborauds dextrose agar and modified Dixon media, and the results were analysed after 3 weeks.</p><p><strong>Results: </strong>Among the 115 participants, on clinical evaluation, 79 patients had achromic and 36 patients had chromic lesions. The dermoscopic features were categorized into domains such as scaling, pigmentation and other features. Fine scaling was the most common feature observed in 88.7% of the patients. Pigmentary changes were noted in all the patients with non-uniform pigmentation being the most common. We have also observed and described newer dermoscopic findings such as barbed wire fence appearance of ridges and furrows, fluffy cotton ball appearance of hypopigmented perifollicular lesions and sprinkled pepper appearance of pigmented dispersion. Out of the 115 KOH mount positive cases, 51 (44.3%) showed growth on fungal culture with <i>Malassezia furfur</i> being the most common species to be isolated in 18 patients.</p><p><strong>Conclusions: </strong>Dermoscopy is a new, popular non-invasive diagnostic modality, which shows specific features like fine scaling, pigment alteration, ridges and furrows with perifollicular involvement, and can be used to diagnose doubtful cases of PV as an adjunct or substitute to a KOH mount.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"6-10"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shedding New Light on Cutaneous Horns: A Comprehensive Review and Pitfall of Management.","authors":"Leo Wan, Aileen Park, Kamran Arastu, Amor Khachemoune","doi":"10.4103/ijd.ijd_331_24","DOIUrl":"10.4103/ijd.ijd_331_24","url":null,"abstract":"<p><p>A cutaneous horn, also known as cornu cutaneum, is an uncommon protuberance of highly compacted keratinous material from the stratum corneum, resembling an animal horn. Although the cause and pathogenesis of these lesions were long misunderstood, cutaneous horns are now generally recognised to be reactive skin growths that can result from a variety of infectious, malignant, pre-malignant, and benign conditions. Most cutaneous horns are benign, but approximately 16%-20% are malignant, with squamous cell carcinoma being the most common malignant underlying aetiology. As the identification of the underlying aetiology necessitates microscopic examination of the base of the cutaneous horn, a major potential pitfall in the diagnosis and management of these lesions lies in the use of improper biopsy technique, which leads to inadequate sampling and failure to correctly identify the underlying aetiology of the lesion. This focused and up-to-date comprehensive review addresses the clinical presentations, epidemiology, aetiology/pathogenesis, histopathology, and differential diagnosis for cutaneous horns. In addition, we provide an overview of the many conditions that may underlie cutaneous horns and the management/treatment of cutaneous horns, including a discussion of proper excision/biopsy technique. Our review aims to enhance understanding and shed light on some of the potential pitfalls in the diagnosis and treatment of cutaneous horns, with the goal of improving outcomes for patients presenting with this condition.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"50"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Trichoscopic Patterns of Discoid Lupus Erythematosus of Scalp in Patients with Systemic Lupus Erythematosus: An Observational Study.","authors":"Shivani Bhardwaj, Dincy Peter, Leni George, Anu A George, Gauri D Mahabal, Susanne Pulimood, Debashish Danda, Ramya Janardana","doi":"10.4103/ijd.ijd_514_23","DOIUrl":"10.4103/ijd.ijd_514_23","url":null,"abstract":"<p><strong>Background: </strong>Discoid lupus erythematosus (DLE) is a specific cutaneous manifestation of systemic lupus erythematosus (SLE), which results in scarring alopecia of the scalp.</p><p><strong>Methods: </strong>A prospective cross-sectional observational study on scarring alopecia among SLE patients was done between September 2016 and August 2017. The clinical and trichoscopic patterns of scalp DLE among these patients were studied. The DLE lesions were categorised into active and inactive based on clinical features. Trichoscopy was done and photographs were obtained using a non-polarised videodermoscope.</p><p><strong>Results: </strong>There were 26 patients with scalp DLE, out of which 15 patients (57.69%) had active DLE and 11 (42.30%) had inactive DLE. The trichoscopic findings seen were structureless white areas, loss of follicular units, blue-grey dots and globules, follicular keratotic plugs and telangiectasia. The trichoscopic features seen in active versus inactive DLE were blue-grey dots and globules (93.33% vs 63.63%), structureless white areas (93.33% vs 90.90%), loss of follicular units (86.66% vs 72.72%) and follicular keratotic plugs (80% vs 45.45%), yellow dots with arborising vessels (33.33% vs 72.72%), exaggerated honeycomb pigmentation (46% vs 63.63%) and telangiectasia (66.67% vs 54.54%). Scaling (<i>P</i> = 0.033) and blue-grey dots (<i>P</i> = 0.021) were significantly higher in active and yellow dots with arborising vessels (<i>P</i> = 0.047) in inactive DLE.</p><p><strong>Conclusions: </strong>On comparing trichoscopic features between active and inactive DLE scaling and blue-grey dots were significantly higher in active and yellow dots with arborising vessels in inactive DLE.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Ulcerated Polypoidal Cellular Fibrous Histiocytoma and Clustered Multiple Cellular Fibrous Histiocytomas in Segmental Distribution: An Uncommon Presentation with Benign Biological Behaviour.","authors":"Angoori G Rao, M Naresh, Praveen Kumar, Anmisha Bandaru, Shireesha Koolla, Bhavita Bade","doi":"10.4103/ijd.ijd_267_23","DOIUrl":"10.4103/ijd.ijd_267_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 1","pages":"51"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}