Indian Journal of Dermatology最新文献

{"title":"Alterations in Gut Microbiome Diversity and Composition in Patients with Epidermolysis Bullosa: A Case-Control Study.","authors":"Suci Widhiati, Hardyanto Soebono, Dewajani Purnomosari, Tri Wibawa","doi":"10.4103/ijd.ijd_191_25","DOIUrl":"10.4103/ijd.ijd_191_25","url":null,"abstract":"<p><p>Epidermolysis bullosa (EB) is a rare inherited genodermatosis that affects both the skin and gastrointestinal tract, potentially leading to altered gut microbiota. This study aimed to assess the diversity and composition of the gut microbiome in EB patients compared to healthy controls. Twelve EB patients-six with dystrophic epidermolysis bullosa patients (pDEB) and six with nondystrophic epidermolysis bullosa patients (pNDEB)-and 12 age- and gender-matched healthy controls were included. Fecal samples were collected, and 16S rRNA gene sequencing (V3-V4 region) was performed. Alpha diversity indices revealed a significant reduction in gut microbiota richness in EB patients, particularly in pNDEB, compared to controls. Beta diversity analysis using unweighted UniFrac showed compositional differences between groups, while weighted UniFrac and principal coordinate analysis revealed overlapping clustering patterns. Genus-level comparisons indicated lower relative abundance of <i>Staphylococcus, Corynebacterium,</i> and <i>Prevotella</i> in EB subgroups. These findings suggest that EB is associated with gut microbiota dysbiosis, warranting further investigation into its potential clinical implications and microbial biomarkers.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"420"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoo-Induced Granulomatous Inflammation Presenting as Koebner Phenomenon in Psoriasis.","authors":"Rucha Herlekar, Apoorva Sharma, Sunil Dogra","doi":"10.4103/ijd.ijd_689_25","DOIUrl":"10.4103/ijd.ijd_689_25","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 5","pages":"416-417"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defective Ala Nasi - Johanson Blizzard Syndrome.","authors":"C Chandrakala, S Sangeetha Devi, R Lakshmi, B Karpagam, P Raju","doi":"10.4103/ijd.ijd_921_24","DOIUrl":"10.4103/ijd.ijd_921_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"316-317"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Brownish Clods: New Dermoscopic Finding in a Rare Case of Solitary Supernumerary Nipple.","authors":"Neenu Kaul","doi":"10.4103/ijd.ijd_931_24","DOIUrl":"10.4103/ijd.ijd_931_24","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"314-315"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Rituximab in Successful Management of Refractory Juvenile Systemic Lupus Erythematosus Complicated with Macrophage Activation Syndrome: A Case Report with Literature Overview.","authors":"Sasmita Mishra, Subhasree Madhual, Maitreyee Panda","doi":"10.4103/ijd.ijd_261_25","DOIUrl":"10.4103/ijd.ijd_261_25","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"324-326"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis in Skin of Colour: A Review.","authors":"Rashmi Sarkar, Damini Verma","doi":"10.4103/ijd.ijd_1014_24","DOIUrl":"10.4103/ijd.ijd_1014_24","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a chronic inflammatory skin condition characterised by intense pruritus, eczematous lesions, and a relapsing-remitting course. While extensively studied in lighter skin types, AD in skin of colour presents unique clinical, pathophysiological, and psychosocial challenges. Patients of Asian ethnicity often display atypical morphologies, including papular or follicular lesions, and more pronounced lichenification, complicating diagnosis and management. Hyperpigmentation and post-inflammatory changes are prominent in these patients, often persisting long after active inflammation subsides, contributing to significant psychosocial distress. Cultural practices, environmental factors, and access to care further impact disease severity and outcomes. This review aims to provide a comprehensive overview of the clinical presentation, diagnostic challenges, and therapeutic approaches for AD in skin of colour, emphasising the need for culturally sensitive care and tailored interventions to improve outcomes in this underserved population. Addressing knowledge gaps through targeted research and education is crucial for advancing equitable dermatologic care.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"266-271"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Nocardia <i>Otitidiscaviarum</i> from a Case of Cutaneous Nocardiosis: A Rare Case Report.","authors":"Bhanu Kanwar, Gautam Neha, Thakur Vibha, Kumar Vipin, Gupta Mudita, Sarma Mrinmoy, Kumar Sanjai","doi":"10.4103/ijd.ijd_1047_24","DOIUrl":"10.4103/ijd.ijd_1047_24","url":null,"abstract":"<p><p><i>Nocardia</i> species are Gram-positive, partially acid-fast, filamentous bacilli commonly found in soil, water, and air. In humans, <i>Nocardia</i> typically causes respiratory, neurological infections and, less frequently, cutaneous infections. While <i>Nocardia brasiliensis</i> is the predominant species implicated in cutaneous nocardiosis, <i>Nocardia otitidiscaviarum</i>-a less commonly isolated species-can cause localized or disseminated infections, even in immunocompetent individuals. Mycetoma is a chronic, disfiguring granulomatous disease caused by various pathogens. Accurate identification of the causative agent is essential for determining the appropriate treatment and prognosis. Culture remains the gold standard for definitive diagnosis. Here, we report a rare case of <i>actinomycetoma</i> caused by <i>Nocardia otitidiscaviarum</i> in a 41-year-old immunocompetent female. The organism was isolated from purulent discharge collected from draining sinuses on her foot. Identification was achieved through microscopic examination and culture, with species confirmation performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"333"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Dermoscopic Features of Pigmentary Changes in Scleroderma and Its Association with Systemic Involvement - A Descriptive Study from a Tertiary Care Centre in South India.","authors":"N Shijini, Anza Khader, Devi Keerankulangara, O Fathimathusalma, D Amrutha","doi":"10.4103/ijd.ijd_31_25","DOIUrl":"10.4103/ijd.ijd_31_25","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Systemic sclerosis (SSc) is a multisystem disease with the highest case-specific mortality among other autoimmune diseases. Dermatological manifestations include skin thickening, Raynaud's phenomenon, digital ulcers, pitted scarring and pigmentary abnormalities. Vascular abnormalities in systemic sclerosis are responsible for various systemic complications including pulmonary hypertension and scleroderma renal crisis. The underlying vascular pathology responsible for organ involvement might also result in skin manifestations including Raynaud's phenomenon and digital ulcers. However, vascular abnormalities resulting in pigmentary changes in systemic sclerosis have not been well studied. Pigmentary changes, which are more common among the darker phenotypes, may act as an early marker for the identification of patients at risk for subsequent organ damage. We aim to study various clinical and dermoscopic features of pigmentary abnormalities in systemic sclerosis and its association with systemic features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;A cross-sectional study was conducted on 60 patients with scleroderma who attended the autoimmune clinic at the Department of Dermatology and Venereology Government Medical College, Kozhikode. Detailed clinical examination and investigations were performed for dermatological manifestations with special emphasis on pigmentary changes. Pigmentary changes were examined with the help of a digital dermoscope, and the different patterns observed were classified into pigmentary, vascular and scale patterns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the present study, a female predominance was observed. The mean age of the study group was 44 ± 13 years. Out of the 60 patients, 52 (86.7%) had limited cutaneous disease and 8 (13.3%) had diffuse cutaneous disease. The MRSS varied from 3 to 32 with a mean of 14.22 ± 5.76. The most common type of pigmentary change observed was vitiligo like macules (70%) followed by salt and pepper pigmentation (61.6%). Other types of pigmentation were localised diffuse hyperpigmentation, reticulate hyperpigmentation, localized hypopigmentation, melasma like hyperpigmentation and periorbital hyperpigmentation. On dermoscopy, the most common pigmentary pattern in vitiligo like macules was the petaloid pattern (57%). White homogenous areas and perifollicular pigment (89.2%) were the predominant findings in salt and pepper pigmentation. More than 50% of patients with salt and pepper pigmentation, melasma like and periorbital pigmentation and more than 25% of patients with vitiligo like macules and reticulate pigmentation had red structureless areas on dermoscopy. Only 10% of patients with localised diffuse hyperpigmentation had red structureless areas. About 70% of patients with vitiligo like macules, salt and pepper and localised diffuse hyperpigmentation had digital ulcers. Around 20% of patients with vitiligo like macules and salt and pepper pigmentation and","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"272-279"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Overview on Alopecia Areata with Review on Advances in Genetics and Treatment.","authors":"Sudip Das, Apeksha Singh, Sk Shahriar Ahmed","doi":"10.4103/ijd.ijd_296_25","DOIUrl":"10.4103/ijd.ijd_296_25","url":null,"abstract":"<p><p>Alopecia areata (AA) is a chronic autoimmune disorder characterised by sudden, non-scarring hair loss due to the immune system mistakenly attacking hair follicles. It affects approximately 2% of the population and can manifest in various patterns, ranging from small patches to total loss of scalp and body hair. While the exact cause remains unknown, genetic predisposition and environmental triggers play a significant role in its development. Hair follicles in affected individuals become arrested in later stages of the hair growth cycle, leading to premature transition to the catagen or telogen phase and impaired regrowth. Though not life-threatening, AA has profound psychological and emotional effects, impacting self-esteem and quality of life. Various treatment options, including corticosteroids, immunotherapy, and emerging biologic therapies, aim to manage symptoms and promote hair regrowth, but no definitive cure exists. Ongoing research continues to explore the genetic and immunological mechanisms underlying the condition to develop more effective treatments. Awareness and support for individuals with AA remain crucial in helping them cope with the physical and emotional challenges associated with the disorder. This article provides a comprehensive overview of the genetics, causes, and treatment options for AA.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"257-265"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Ill-Defined Hypopigmented Scaly Plaques on the Leg in an 8-Year-Old Girl.","authors":"Vishal Gaurav, Pavani Gowda, Deepika Yadav, Nita Khurana","doi":"10.4103/ijd.ijd_647_25","DOIUrl":"10.4103/ijd.ijd_647_25","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"71 4","pages":"333"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}