{"title":"Mechanistic Insights on Skin ageing and Dermatologic Interventions to Slow Ageing Process.","authors":"Rajashree Sriram, V Gopal","doi":"10.4103/ijd.ijd_210_24","DOIUrl":null,"url":null,"abstract":"<p><p>The skin which is a robust predictor of age-related diseases, undergoes morphological and physiological alterations, because of synergistic effects of Intrinsic or Chronological (Age-dependent decline of cell function) and Extrinsic (environmental insults) ageing factors. Ageing is a preordained process that can be determined as the collection of various deleterious changes in cells and tissues. Skin that ages as a consequence of the combination effect of intrinsic and extrinsic factors is characterized by coarseness, wrinkling, hyperpigmentation, telangiectasia, burns and skin sagging. Despite the structural and pathophysiological differences, both types of ageing share several molecular similarities, with the emergence of reactive oxygen species and matrix metalloproteinases induction reflecting as the key aspects of skin ageing. This review elucidates the skin ageing mechanism with a focus on the management of dermatologic ageing that includes treatment strategies and trends in the use of invasive procedures, and energy-based devices which are aimed at addressing skin ageing phenotypes.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"70 3","pages":"135-145"},"PeriodicalIF":1.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139627/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/ijd.ijd_210_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/8 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The skin which is a robust predictor of age-related diseases, undergoes morphological and physiological alterations, because of synergistic effects of Intrinsic or Chronological (Age-dependent decline of cell function) and Extrinsic (environmental insults) ageing factors. Ageing is a preordained process that can be determined as the collection of various deleterious changes in cells and tissues. Skin that ages as a consequence of the combination effect of intrinsic and extrinsic factors is characterized by coarseness, wrinkling, hyperpigmentation, telangiectasia, burns and skin sagging. Despite the structural and pathophysiological differences, both types of ageing share several molecular similarities, with the emergence of reactive oxygen species and matrix metalloproteinases induction reflecting as the key aspects of skin ageing. This review elucidates the skin ageing mechanism with a focus on the management of dermatologic ageing that includes treatment strategies and trends in the use of invasive procedures, and energy-based devices which are aimed at addressing skin ageing phenotypes.
期刊介绍：
The journal publishes information related to skin-pathology and different modes of therapeutics, including dermatosurgery and cosmetic dermatology. Likewise, it carries articles on leprosy, STI and HIV/AIDS. The editorial board encourages the authors to publish articles addressing emerging techniques and developments in the subject specialty, in the form of Original investigations, Narrative and Systematic Reviews as well as Case Reports. The journal aims at publishing Editorials and Commentaries from eminent personalities on a regular basis.
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