Role of Antioxidants in Melasma: A Systematic Review.

IF 1 4区 医学 Q4 DERMATOLOGY
Indian Journal of Dermatology Pub Date : 2025-05-01 Epub Date: 2025-05-08 DOI:10.4103/ijd.ijd_473_24
Rashmi Sarkar, Anjali Sahu
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引用次数: 0

Abstract

Melasma is a common skin disorder characterized by facial hyperpigmentation, often aggravated by sun exposure. Antioxidants are being studied as a treatment option for their potential to reduce oxidative stress and improve skin pigmentation. A comprehensive literature search was conducted in PubMed for articles published over the past decade, up to January 31, 2024, on the use of antioxidants in melasma treatment. The systematic review, conducted by two independent investigators, included 30 studies on antioxidants in melasma, covering vitamin C, cysteamine, silymarin, PLE, tomato extract/lycopene, zinc sulfate, melatonin, and other antioxidants. Findings indicated that combining vitamin C with physical therapies, such as peels and lasers, yielded better results. Cysteamine, a naturally occurring aminothiol, showed efficacy comparable to hydroquinone with fewer side effects. Silymarin was effective in reducing melasma severity with minimal adverse effects. PLE showed mixed results but potential as an effective antioxidant when combined with other treatments. Lycopene from tomato extract demonstrated significant improvements in melasma when used as an adjuvant therapy. Zinc sulfate showed some effectiveness but was less potent than hydroquinone. Melatonin had antioxidant capabilities but showed no statistically significant improvement. Glutathione is emerging as a new antioxidant therapy showing efficacy in melasma in combination with other topicals and microneedling. Other antioxidants, including combinations of vitamins C, E, and ferulic acid, showed potential as adjuncts in melasma treatment. These findings highlight the diverse efficacy of antioxidants in managing melasma, suggesting their potential as safe and effective treatments.

抗氧化剂在黄褐斑中的作用:系统综述。
黄褐斑是一种常见的皮肤疾病,以面部色素沉着为特征,常因日晒而加重。人们正在研究抗氧化剂作为一种治疗选择,因为它们具有减少氧化应激和改善皮肤色素沉着的潜力。在PubMed上进行了全面的文献检索,检索了截至2024年1月31日的过去十年中发表的关于使用抗氧化剂治疗黄褐斑的文章。该系统综述由两名独立调查人员进行,包括30项关于黄褐斑抗氧化剂的研究,涵盖维生素C、半胱胺、水飞蓟素、PLE、番茄提取物/番茄红素、硫酸锌、褪黑素和其他抗氧化剂。研究结果表明,将维生素C与物理疗法(如去皮和激光)相结合,效果更好。半胱胺是一种天然存在的氨基硫醇,其疗效与对苯二酚相当,副作用更少。水飞蓟素能有效降低黄褐斑的严重程度,副作用最小。PLE的结果好坏参半,但当与其他治疗方法联合使用时,它有可能成为有效的抗氧化剂。从番茄提取物中提取的番茄红素作为辅助治疗,对黄褐斑有显著改善。硫酸锌有一定效果,但效果不如对苯二酚。褪黑素具有抗氧化能力,但没有统计学上的显著改善。谷胱甘肽是一种新的抗氧化治疗方法,与其他外用药物和微针联合治疗黄褐斑。其他抗氧化剂,包括维生素C、E和阿魏酸的组合,在黄褐斑治疗中显示出潜在的辅助作用。这些发现强调了抗氧化剂在治疗黄褐斑方面的不同功效,表明它们可能是安全有效的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Dermatology
Indian Journal of Dermatology Medicine-Dermatology
CiteScore
1.80
自引率
0.00%
发文量
217
审稿时长
47 weeks
期刊介绍: The journal publishes information related to skin-pathology and different modes of therapeutics, including dermatosurgery and cosmetic dermatology. Likewise, it carries articles on leprosy, STI and HIV/AIDS. The editorial board encourages the authors to publish articles addressing emerging techniques and developments in the subject specialty, in the form of Original investigations, Narrative and Systematic Reviews as well as Case Reports. The journal aims at publishing Editorials and Commentaries from eminent personalities on a regular basis.
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